CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ying Xu,Genkuo Nie,Xiao Jiang,Hongyu Wang,Guihua Yang,Ziyi Yan,Ji-Jun Zou,Hailong Yu,Shitao Yu,Yu Liu
Metal-metal oxide catalysts are robust in selective hydrodeoxygenation of biomass derives. Herein, 1-hexanol in total yield about 76 % is firstly achieved by high selective hydrodeoxygenation of 5-hydroxymethylfurfural over Ni/MCM-41 and Pt-WO X /t-ZrO 2 . By controlling the amount ratio of Ni/Ni 2+ to 0.46, a 99.9 % yield of 2,5-tetrahydrofurandimethanol was achieved from 5-hydroxymethylfurfural by Ni/MCM-41. Subsequently high yield of 76 % of 1-hexanol was obtained by competing pathways of tandem reactions beginning at SN2 reaction at the epoxy atom of 2,5-tetrahydrofurandimethanol to enol/tautomer intermediates and ending with controllable selective hydrogenation. The reaction mechanism is explored and the reaction-oriented regulation is realized by the additional strong BrÖnsted acid sites generated by electron transfer from W to Pt and the appropriate amount of Pt 0 sites of Pt-WO X /t-ZrO 2 , where the ratios of W 5+ /W 6+ and Pt 0 /Pt 2+ are 0.31 and 4.58 respectively. This work provides a new and green method for the synthesis of 1-hexanol and expands the utilization of metal–metal oxide in making value-added products using sustainable feedstocks.
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BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Suiqing Mai,Jiale Ke,Shiqin Lin,Rongrong Huang,Fengxin Zheng,He Jiao,Hong Wang,Shuqin Zhang,Mengying Mao,Qiuping Li,Zean Zhao,Jianxin Pang,Qun Zhang
A high-purine diet is an important factor in the development of hyperuricemia (HUA), in which the intestinal tract is the main site of dietary purine absorption. Inhibition of intestinal concentrative nucleoside transporter 2 (CNT2) can inhibit dietary purine-induced elevation of serum uric acid (sUA) levels. However, there is a lack of research on CNT2 inhibitors for the treatment of HUA. By using high throughput virtual screening from an in-house natural product database, the natural active component 5-methylvisammioside (MeV) in Saposhnikovia divaricata (Turcz.) Schischk was predicted to be an effective CNT2 inhibitor with the highest docking score. In vitro , MeV showed the strongest inhibitory activity against CNT2, with IC 50 value of 11.22 ± 2.18 μM. Moreover, MeV showed little or almost no inhibitory effect on other nucleoside transporters CNT3 and equilibrative nucleoside transporters (ENTs), as well as on uric acid (UA) transporter-related targets. In vivo , MeV significantly reduced sUA, inhibited adenosine uptake, and had an ameliorative effect on pathological changes in the liver, kidney, and intestinal tract. Moreover, MeV improved serum and intestinal indices related to inflammation and oxidative stress in mice, reduced intestinal permeability. Through our further study, we found that MeV inhibited the activation of reactive oxygen species (ROS) and NF-κB P65, reduced the production of the NOD-like receptor protein 3 (NLRP3) inflammasome, and improved intestinal injury in a high UA environment. The study suggests that MeV is a potent CNT2 inhibitor for the treatment of HUA and also protects intestinal function by inhibiting the ROS/NF-κB/NLRP3 pathway.
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JOURNAL OF THE ENERGY INSTITUTE
·
2025
·
IF 6.2
Chenyu Yang,Xinru Ma,Yaohui Fan,Feiyu Zou,Wenjuan Bai,Dianming Chu,Haoxi Ben,Zhaoying Li,Yan He
The urgent need to address global energy shortages and environmental pollution has accelerated the development of renewable algal bio-oils. Spirulina stands out as an ideal feedstock for hydrothermal liquefaction (HTL) owing to its high carbon sequestration rate, non-competition with arable land, and rich protein-lipid content. However, Spirulina-derived bio-oil typically suffers from high oxygen content and low heating value. To overcome these limitations, this study developed a microwave-assisted two-stage HTL process integrated with a Ni-loaded, alkali-modified HZSM-5 catalyst. Unlike conventional catalysts that often rely on costly noble metals or suffer from diffusion limitations in microporous structures, this system employs earth-abundant nickel on a hierarchically structured zeolite to enhance both cost-effectiveness and catalytic efficiency. HZSM-5 was treated with NaOH to create mesoporosity, followed by Ni impregnation to introduce hydrogenation functionality. The effects of NaOH concentration and Ni loading on catalyst properties were systematically investigated. Process optimization was performed via response surface methodology using a 3 % sulfuric acid medium, and bio-oil composition was analyzed by GC/MS. Modification with 1 mol/L NaOH increased hydrocarbon content to 32.9 %, while subsequent loading with 5 wt% Ni synergistically boosted the yield to 48.1 %. Molecular dynamics simulations provided mechanistic insights into bond cleavage and conversion pathways of Spirulina-derived model compounds in subcritical water. Compared with existing catalytic systems, this study significantly improves the quality of biofuels, providing an efficient catalytic strategy and fundamental insights for the production of high-quality bio-oil from spirulina.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shasha Wang,Yanan Chang,Shengyu Wang,Xuexuan Zhong,Xiaoxuan Li,Jianchun Bao,Jie Zhang,Xiaozhi Liu,Ying Liu
The 5-hydroxymethylfurfural oxygen reaction (HMFOR) is an appealing alternative to the oxygen evolution reaction (OER) for cost-effective hydrogen production, while 2,5-furandicarboxylic acid (FDCA) represents one of the most promising value-added chemicals. Nevertheless, it still suffered from limited HMF adsorption and sluggish reaction kinetics. Herein, we integrated the low-temperature microwave method and plasma bombardment strategy, and developed an advanced P/Mn–Ni(OH)2 nanosheet array on the surface of carbon cloth. The heterogeneous Mn dopant improves the growth and structural stability of Ni(OH)2 nanosheet arrays, while the plasma treatment optimizes the atomic sequence and induces abundant oxygen vacancies. Further theoretical calculation and in situ Raman, Bode diagram tests manifest that these oxygen vacancies together with the Mn dopant, coherently downshift the d-band center of P/Mn–Ni(OH)2 (from −3.71/–0.31 eV (spin-up/spin-down) to −5.23/–1.78 eV, respectively), balance the adsorption of HMF and OH–, and enhance the redox kinetics of HMFOR. Benefiting from these favorable factors, the P/Mn–Ni(OH)2 achieves remarkable HMFOR electrocatalytic activity, with an impressive HMF conversion rate of 99.8%, FDCA selectivity of 97.4%, and Faraday efficiency of 96.1% at an applied potential of 1.42 V (vs RHE). Meanwhile, the P/Mn–Ni(OH)2 also demonstrates robust stability with only slight decay after five cycles of testing. When further coupled with HER, the assembled HER||HMFOR electrolyzer requires only 1.35, 1.46, and 1.57 V to deliver 10, 50, and 100 mA cm–2, respectively, outperforming the traditional HER||OER device (requesting 1.55, 1.65, and 1.70 V, respectively), confirming the brilliant electrocatalytic ability of the P/Mn–Ni(OH)2. Such plasma bombardment and heterogeneous atom implantation comodulated electrocatalytic strategy may provide new insight into the construction of advanced catalysts for diverse energy-related applications.
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Marine Drugs
·
2025
·Vol. 23
·期 7
·289
·
IF 5.4
Shijie Bi,Yating Cao,Shiyuan Fang,Yanyan Chu,Zixuan Zhang,Meng Li,Rilei Yu,Jinbo Yang,Yu Tang,Peiju Qiu
The internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) is associated with high recurrence and mortality rates in acute myeloid leukemia (AML), making it a critical target for anti-AML therapies. Plinabulin is a diketopiperazines derivative that exhibits extensive anti-cancer potency by targeting β-tubulin. We designed and synthesized a novel FLT3 inhibitor, namely5-3, based on the structure of plinabulin and evaluated its effect on FLT3-ITD mutant AML cells. The results indicated that5-3potently and selectively inhibits the growth of mutant FLT3-expressingleukemia cells, and had no effect on FLT3 wide-type cancer cells, suggesting the antiproliferative activity of5-3depends highly on FLT3-ITD expression. Mechanically,5-3significantly suppressed the phosphorylation of FLT3 signaling pathway, including STAT5, Erk and Akt. Moreover, the efficiency of compound5-3is not associated with Plinabulin’s typical target, β-tubulin. In conclusion, the study identified diketopiperazine derivative as a novel FLT3-ITD selective inhibitor. These results demonstrated that5-3might be a drug candidate for the treatment of FLT3-ITD-positive AML.
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GREEN CHEMISTRY
·
2025
·
IF 9.2
Wei Ji,Wenjie Zhang,Chen Deng,Yuwei Xiong,Qi HAO,Hao Zhang,Bing Song,Wenlei Zhu,Dekui Shen,Jason Chun-Ho Lam,Richen Lin
Nickel-based electrocatalysts are pivotal for converting biomass-derived 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid (FDCA), a key renewable precursor for biopolymers. However, their industrial adoption is limited by sluggish proton transfer kinetics, which restricts current density (targeting ≥200 mA cm-2) and triggers catalyst corrosion via proton accumulation, reducing stability. Inspired by biological phosphate buffers that regulate protons to stabilize intracellular pH, we engineered a phosphate-built protective layer (PO4-BPL) on a CuNiO catalyst. The PO4-BPL serves dual roles: creating rapid proton channels to enhance proton-coupled electron transfer and protecting the catalyst from proton-induced corrosion. The PO4-BPL/CuNiO delivers a current density exceeding 700 mA cm-2 with FDCA Faradaic efficiency above 90% over 36 cycles, showcasing 7-fold stability improvement versus unmodified catalysts. In a continuous-flow electrolyzer, PO4-BPL/CuNiO operates for 70 h, far exceeding the 6 h lifetime of the CuNiO. Density functional theory calculations confirm PO4-BPL lowers proton migration energy barriers, enhancing mass transfer and preventing structural damage. This biomimetic strategy not only enables robust electrocatalysts for high current density applications, but also represents a green advance toward the sustainable and efficient production of biopolymer precursors.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jiaru Ma,Qian Xiong,Fei Tian,Hengyu Wu,Fengqi Xie,Yanfen Chen,Qinglin Tang,Yuqin Zou,Xinyan Huang,Yousheng Liu,Guangguo Ying
Benzotriazoles (BTRs), widely used as tire additives, pose a significant challenge as persistent aquatic pollutants due to their recalcitrance to conventional biological degradation. This study elucidated methanol (ME)-enhanced co-metabolic degradation of 1H-benzotriazole (BT) and 5-chlorobenzotriazole (CBT) by green microalgae. Among the six microalgal species evaluated, Chlorella pyrenoidosa demonstrated superior removal of BT and CBT under 1 % ME supplementation, achieving efficiencies of 33.50 % and 89.67 %, respectively. ME functioned as an electron donor, which favored the reductive dechlorination of CBT, leading to a 2.85-fold higher removal efficiency compared to BT. Biotransformation was identified as the dominant removal mechanism, with 11 and 10 transformation products (TPs) detected for BT and CBT, respectively. An integrated analysis of TPs and transcriptomic data revealed that ME activates a metabolic enzyme-photosynthetic machinery, enhancing electron transport, energy generation, cytochrome P450 (CYP450) expression, and extracellular polymeric substance (EPS) production, thereby facilitating efficient pollutant removal. The proposed degradation pathways further confirmed the role of ME in facilitating specific biotransformation reactions. These findings provide mechanistic insights and establish a theoretical foundation for the development of ME-microalgae co-metabolism systems as a sustainable technology for remediating persistent pollutants in aquatic ecosystems.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaochen Qi,Fuli Li,Chih-Huang Weng,Kai Liu,Renchuan Fu,Na Liu,Longzhen Ding
2-(2-Hydroxy-5-methylphenyl) benzotriazole (UV-P), a high-production and structurally complex benzotriazole derivative, has an uncertain degradation pathway and transformation dynamics in aquatic environments, raising concerns about its potential toxicological risks to human health and the ecological systems. This study investigated the oxidative degradation of UV-P by ferrate(VI) in aqueous solution under controlled experimental conditions. The results demonstrated that ferrate(VI) efficiently degraded UV-P under alkaline conditions, achieving a maximum removal efficiency of 91.76 % at pH 8.0. Furthermore, the influence of various environmental factors, including pH, oxidant dosages, inorganic ions (HCO 3 − , Cl − , Br − , NO 3 − , Ca 2+ , K + , Mg 2+ , and NH 4 + ), and humic acid, on the ferrate(VI)-mediated oxidative degradation of UV-P were systematically examined. The results indicated that although inorganic ions and humic acid partially inhibited the degradation process, a satisfactory degradation efficiency was still attained. The intermediate identification results indicated that the ferrate(VI)-mediated oxidative degradation of UV-P primarily proceeded via bond cleavage, oxygen atom transfer, and radical coupling reactions, resulting in the formation of cleavage products, hydroxylated derivatives, and polymeric compounds. The oxidative degradation pathway of UV-P and key reactive sites targeted in the ferrate(VI) degradation system were examined through quantum chemical methods, including analyses of atomic charge distribution and frontier electron density. The toxicity assessment highlighted the need to focus on the chronic toxicity of specific aminated degradation products. This study is essential for elucidating the degradation mechanism of the benzotriazole compound UV-P in aquatic environments and comprehensively assessing its potential biotoxicity.
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FUEL
·
2025
·
IF 7.5
Ying Li,Haibo Zhao
Ethylene production via chemical looping oxidative dehydrogenation (CL-ODH) of ethane faces a critical challenge in balancing conversion efficiency and selectivity due to competing oxygen species requirements. Here, we present a bifunctional composite catalyst (CrH/BiCZ) by physically integrating a Cr-HZSM5 (Cr-H) dehydrogenation (DH) catalyst with a Bi 2 O 3 -Ce 0.4 Zr 0.6 O 2 (Bi-CZ) selective hydrogen combustion (SHC) catalyst. This tandem system decouples ethane activation and hydrogen combustion, promoting the DH process of ethane through the in situ hydrogen combustion of the SHC catalyst. The Ce-Zr solid solution in Bi-CZ acts as an oxygen reservoir, enabling complete H 2 combustion within 3 min and suppressing carbon deposition. This rapid hydrogen combustion shifts the reaction equilibrium towards ethylene production. At 650 °C, the optimized CrH/BiCZ catalyst achieves 84.1 % ethylene selectivity at 43.0 % ethane conversion, and maintains exceptional stability over 36 redox cycles. This work establishes a scalable chemical looping strategy for efficient ethylene synthesis.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2024
·
IF 5.8
Liqiang Zhang,Ningmin Zhu,Chaochao Wang,Rongzheng Cui,Riyi Lin
Two-step catalytic pyrolysis of Nannochloropsis sp (NS) was conducted with SBA-15 and ZSM-5. Thermogravimetric analyzer (TG) and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) were used to investigate the effects of SBA-15 and ZSM-5 on the two-step pyrolysis of NS. The comparative study showed that ZSM-5 and SBA-15 had different effects on the pyrolysis characteristic of NS because of their different property. ZSM-5 had no effects on the kinetic mechanism, but SBA-15 obviously changed DTG curves and the reaction order of the low temperature pyrolysis stage. SBA-15 increased the contents of amines and alkanes to 19.40% and 5.62% in the first step compared with those of the one-step pyrolysis (1.95% and 1.83%). Due to the stronger acid sites, ZSM-5 improved the content of olefins (33.79%) and esters (10.79%) in the first step and the contents of nitriles (11.75%) and aromatic hydrocarbons (31.01%) in the second step compared with those of one-step pyrolysis (10.61%, 5.41%, 0.00%, 8.42%). Acid catalyst had no positive effects on the generation of N-heterocyclic compounds. This study is expected to provide a reference for the efficient pyrolysis utilization of microalgae.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Abdul Qayum,Karim Harrath,Xueqi Wang,Pengfei Xie,Yanran Cui,Yuanyuan Li,Junyan Zhang,Zili Wu,Xiangbei Wan,Amani Ebrahim,Sainan Yuan,Zhenglong Li
Developing electrocatalysts with heterointerface for biomass valorization represents a promising strategy to achieve better performance. Unfortunately, despite significant advances in the heterointerface catalyst for 5-hydroxymethylfurfural (HMF) oxidation, these catalysts still suffer from complex and multistep fabrication techniques and low activity, particularly in the low-bias region. Furthermore, the majority of these catalysts are synthesized as powders and require an additional procedure to passivate on the electrode substrates (current collector) via directly adding polymeric binders. Herein, we report the synthesis of a Cu x O/CoO x catalyst, synthesized on a raw Cu foam via galvanic replacement assisted in situ solution combustion method ( I SCS). Interestingly, the two approaches work synergistically to engineer a self-standing Cu x O/CoO x heterointerface catalyst for the efficient oxidation of HMF to furanedicarboxylic acid (FDCA). Physicochemical and electrochemical characterizations, along with density functional theory (DFT) calculations, reveal strong electronic coupling between Cu x O and CoO x , facilitating accelerated HMFOR kinetics through enhanced charge transfer and adsorption of HMF and OH – . Specifically, Cu x O/CoO x catalyst demonstrates low onset potential (∼1.0 V RHE ) and high current density ( j ), reaching 46.6, 172.8 and 361.9 mA cm −2 at small voltages of 1.2, 1.3 and 1.4 V RHE , respectively, with excellent selectivity and Faradaic efficiency for FDCA (∼98 % and ∼ 96.7 %, respectively). This study presents a novel synthesis route and offers valuable insights for designing efficient heterointerface electrocatalysts for value-added biomass conversion.
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MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 17
·期 4
·1600262
·
IF 3.68
Qin Yun,Si Song Wang,Shan Xu,Jin Ping Yang,Juan Fan,Ling Lin Yang,Yue Chen,Shao Zhi Fu,Jing Bo Wu
Colorectal peritoneal carcinomatosis (CRPC) is a common systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy against CRPC is at present the preferred treatment. The aim of this study is to develop a novel hydrogel drug delivery system through the combination of 5-fluorouracil (5-FU) loaded polymeric micelles and cisplatin (DDP) in biodegradable thermosensitive chitosan (CS) hydrogel. The prepared CS hydrogel drug is a free-flowing solution at room temperature and forms a stationary gel at body temperature. Therefore, a CRPC mouse model is established to investigate the antitumor activity of CS hydrogel drug system. The results suggest that intraperitoneal administration of CS hydrogel drug can inhibit tumor growth and metastasis, and prolong survival time compared with other groups, thus improving the chemotherapeutic effect. Ki-67 immunohistochemical analysis reveals that tumors in the CS hydrogel drug group has lower cell proliferation in contrast to other groups ( P < 0.001). Furthermore, hematoxylin-eosin staining of liver and lung tissue indicates that the CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung. Hence, the work highlights the potential clinical applications of the CS hydrogel drug.
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