FIBERS AND POLYMERS
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2025
·
IF 2.3
Chen Kexin,Hu Yinchun,Zhang Yan,Jin Zhibin,Lei Qi,Li Yongcun,Zhou Qiong,Wang Yingying
Aramid fiber/unsaturated polyester resin (AF/UP) composites suffer from weak interfacial adhesion which limits their applications in demanding environment. This study proposes a synergistic modification strategy utilizing polydopamine (PDA) and \(\gamma\) -methacryloxypropyltrimethoxysilane (KH570) which constructs a dual-mechanism interface combining mechanical interlocking and covalent bonding. PDA layer was first formed on AF surface via dopamine (DA) oxidative self-polymerization. KH570 formed covalent bonds with PDA layer to yield KH570–PDA–AF. Multi-scale characterization revealed that PDA and KH570 were successfully grafted on AF surface. KH570–PDA–AF/UP composite achieved an interfacial strength of 35.03 MPa (a 57.4% enhancement) due to copolymerization between KH570 and UP. The tensile strength of KH570–PDA–AF/UP reached 1054.86 MPa (a 47.62% increase) and Young's modulus was 23.64 GPa (a 135.93% enhancement) compared to AF/UP. Dynamic mechanical analysis showed reduced loss modulus above 76 °C which signified optimized interfacial energy dissipation mechanisms. These results manifest that PDA–KH570 synergistic modification strategy effectively optimizes interfacial bonding of AF/UP which offers a novel approach for designing high-performance fiber-reinforced composites with both theoretical innovation and engineering applicability.
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npj Clean Water
·
2025
·Vol. 8
·期 1
·1-12
·
IF 11.4
Zhao Che,Xiao Yaoxin,Gu Ying,Wang Yazhuo,Lian Xixi,Liang Dong,Shan Rui,Yuan Haoran
Interfacial solar desalination has been widely considered as a promising technology for fresh water production because of its green, pollution-free and sustainable characteristics. Compared with the 2D solar evaporator, the 3D solar evaporator has a larger evaporation area. But traditional 3D evaporators could not utilize solar energy effectively due to its inefficient internal and peripheral spaces. Consequently, based on silk cocoon shell and its natural cavity structure, a 3D solar evaporator with internal and external double evaporation interface was designed and manufactured in this paper. The prepared evaporator had double evaporation surfaces which increased the actual evaporation area and the conversion efficiency of solar energy. Besides, the evaporator of Up-FSCE exhibited excellent thermal management performance, its evaporation rate reached 2.32 kg m −2 h −1 under 1 sun illumination. This study offers new insights into the structural design of 3D solar evaporators and further promotes the practical application of interfacial solar desalination.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 22
·1-15
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IF 2.8
Zhou Hengqing,Li Xiao,Gao Guoqi,Sun Huajun,Liu Xiaofang
BiOBr/PVDF composite films with different precursor doping amounts were successfully prepared by in situ deposition phase conversion technology. The physicochemical properties of the composite films were analyzed in detail, and their piezoelectric-photocatalytic performance was systematically investigated. The experimental results showed that BP-0.8 (with a doping amount of 0.8 mmol for the BiOBr precursor) exhibited the best catalytic performance. Under the synergistic effect of visible light irradiation and ultrasonic vibration, the degradation rate of BP-0.8 for 50 mL of 40 mg/L Rhodamine B (Rh B) solution within 60 min could reach 96.73%, and the apparent reaction rate constant (k) of this sample was 0.06198 min⁻ 1 . It was 3.81 times and 27.06 times that of photocatalysis alone and piezoelectric catalysis alone, respectively. The radical capture experiment proved that the main active groups involved in the reaction were h⁺ and ·OH, and the mechanism of piezoelectric photocatalysis of BiOBr/PVDF composite thin films was proposed. In addition, compared with powder catalysts, flexible BiOBr/PVDF membranes were easier to recycle, did not require complex treatment, and still maintained good catalytic activity after ten cycles of testing. This work demonstrated the contribution of the piezoelectric effect to photocatalytic water purification and provided a promising strategy to utilize solar and mechanical energy.
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Earth Systems and Environment
·
2025
·
IF 4.7
Irfan Muhammad,ul Hasan Israr Masood,Jafir Muhammad,Hu Jie,Li Chang,Moeen ud din Muhammad,Zhu Yixing,Hussain Khalid,Zheng Liugen
Arsenic (As) contamination in water supplies poses severe risks to human health and ecosystems, necessitating high-efficiency, regenerable, and cost-effective adsorbents. In this study, a bimetallic layered double hydroxide hybrid (MnFe-LDH/BC@H3BTC) was constructed using biochar (BC) and 1,3,5-benzenetricarboxylic acid (H3BTC) as a ligand-regulated structure for enhanced arsenite [As(III)] removal. MnFe-LDH/BC@H3BTC exhibited 99.4% As(III) removal at pH 7 within 2 h equilibrium, showed superior adsorption capacity (2.99 mgg −1 ) compared to MnFe-LDH (2.2 mgg −1 ) and MnFe-LDH/BC (2.58 mgg −1 ). Characterization (XRD, FTIR, 2D-COS, BET, and XPS) revealed synergistic contributions from redox-active Mn²⁺/Mn³⁺ and Fe²⁺/Fe³⁺, ligand exchange with -OH and -COOH groups, and a BET surface area enhancement from 4.15 to 122.17 m 2 g −1 . Kinetic and isotherm modelling followed pseudo-second-order (R²=0.99) and Langmuir monolayer adsorption, confirming a chemisorption mechanism. HPLC speciation demonstrated time-resolved As(III) to As(V) oxidation. Real water application tests confirmed 2.82 mg g −1 As(III) removal, and regeneration studies confirmed high stability over five cycles with minimal metal leaching. This study provides a scalable, multifunctional strategy for As(III) remediation and contributes to understanding ligand-mediated redox-adsorption mechanisms in hybrid sorbents. Graphical The graphical abstract presents a visual summary of the synthesis, mechanistic pathways, and real-world performance of MnFe-LDH/BC@H3BTC for efficient arsenic removal from contaminated water. In the Preparation phase, manganese-iron layered double hydroxide (MnFe-LDH) is integrated with biochar and functionalized using trimesic acid (H3BTC), forming a porous and reactive hybrid structure. This composite material is engineered to provide abundant active sites for interaction with arsenic species. The Oxidation and Removal section details the mechanistic transformations involved in arsenic remediation. Arsenite (As(III)) undergoes oxidation to arsenate (As(V)) facilitated by redox-active Mn species, while multiple removal pathways electrostatic attraction, ligand exchange, complexation, and hydrogen bonding-contribute to the stable immobilization of arsenic on the material surface. This segment depicts the transformation and sorption processes, emphasizing the synergy between functional groups and structural components. In the Performance section, experimental data show that MnFe-LDH/BC@H3BTC achieves rapid removal of As(III), with a sorption efficiency of 99.4% within just 2 h, outperforming the individual or partially modified components. The MnFe-LDH/BC@H3BTC composite demonstrates excellent potential as a practical and scalable solution for arsenic remediation in real water systems, offering a combination of rapid kinetics, high efficiency, and multifunctional removal mechani
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PLANT GROWTH REGULATION
·
2025
·
IF 3.9
Ling Qingyan,Zhang Beihong,Xiao Zufei,Shen Yao,Jiang Junfei,Xu Zhiwei,Liu Qingqing,Xiao Changlong,Zeng Rong,Liu Yuanqiu,Jin Zhinong
Citral-type Camphora officinarum ( C. officinarum ) exhibits high economic value due to its branch and leaf essential oil enriched with citral, yet the low natural concentration of this compound necessitates urgent strategies to enhance yield and quality. Methyl jasmonate (MeJA), a recognized safe elicitor, stimulates aromatic compound accumulation in plants and promotes monoterpene synthesis in C. officinarum suspension cells. However, it remained unclear whether foliar MeJA application enhances monoterpene biosynthesis in C. officinarum . This study evaluated the effects of near-harvest foliar MeJA application at gradient concentrations 0 μmol/L (control, M0), 100 μmol/L (M100), 250 μmol/L (M250), and 500 μmol/L (M500) on growth, oil gland morphology, and essential oil composition in citral-type C. officinarum . The results demonstrated that: M100 treatment significantly increased plant height, branch biomass, leaf biomass, and total biomass compared to the control M0. M250 treatment induced structural modifications in oil cells, enlarging their diameter and increasing density, resulting in an 11.83% increase in essential oil yield per unit fresh leaf weight. Both M100 and M250 treatments enhanced citral content by 3.6% and 3.31%, respectively, while total essential oil production surged by 12.31% (M100) and 15.46% (M250). Principal component analysis (PCA) collectively demonstrated that 100–250 μmol/L MeJA (M100/M250) represented the optimal induction concentration for enhancing essential oil yield and promoting citral synthesis, whereas 500 μmol/L (M500) induced detrimental osmotic stress. These findings demonstrate that MeJA serves as a safe agricultural regulation approach for enhancing essential oil yield and citral content, offering valuable insights for other aromatic plant species.
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PhotoniX
·
2025
·Vol. 6
·期 1
·1-15
·
IF 19.1
Hu Qihong,Zhang Jieyi,Emusani Ramya,Yang Junchao,Zuo Xin,Wang Yiran,Huang Yonggang,Xiang Dong
Highly efficient controlling the individual atomic migration is the basis of the modern atomic manufacturing. Although one-by-one atom migration can be realized precisely by STM technique, such a delicate operation is time consuming and restrictive conditions ( e.g ., high-vacuum) needed to be satisfied. Here, we reported that individual metal atoms can be efficiently transferred from the nanoparticle surface to the underneath substrate via instantaneous laser irradiation under ambient conditions. By inserting self-assembled monolayer (SAM) molecules into nanoparticle-on-mirror (NPoM) structures, a pronounced resonance shift that depends on the dipole moments of the SAM molecules, was observed upon laser irradiation. Assisted by the in-situ measurement of Raman spectra, synchronously capturing dark-field (DF) scattering spectra and DF imaging, it is clarified that the laser-induced localized surface plasmons, which generates strong dipole–dipole interactions, play a critical role in triggering atomic migration. Our study opens an avenue for the highly efficient fabrication of atomic patterns.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-23
·
IF 12.6
Fei Weidong,Xin Yu,Qian Wenqiang,Liu Mingqi,Zheng Caihong,Liu Yunxi,Chen Danfei,Zhou Ying,Xu Shanshan,Wu Xiaodong,Zhao Mengdan
Due to the insidious onset of ovarian cancer, the majority of patients are diagnosed at advanced stages, often presenting with extensive pelvic and abdominal metastasis. A significant proportion of these patients exhibit primary or acquired drug resistance, limiting improvements in the five-year survival rate. In this study, an analysis of patient-derived samples demonstrated a strong correlation between cholesterol levels and ovarian cancer progression. Membrane lipid therapy, a strategy that targets the composition, structure, and function of the cell membrane, has demonstrated notable potential in tumor therapy. Subsequently, a novel cholesterol oxidation-mediated membrane lipid therapy employing PLGA microspheres co-loaded with miriplatin (MiR) and cholesterol oxidase (COD) was proposed for drug-resistant advanced ovarian cancer therapy. The microspheres had a particle size of approximately 2.58 μm, with encapsulation efficiencies of 82.98 ± 0.09% for MiR and 32.83 ± 4.30% for COD. In vitro experiments demonstrated that COD-induced cholesterol oxidation modulated the membrane rigidity and fluidity of SKOV3-TR cells, thereby compromising membrane structural integrity and attenuating tumor cell migration. Additionally, the reactive oxygen species generated during cholesterol oxidation disrupted mitochondrial membrane potential and adenosine triphosphate production. The resulting energy deficiency and compromised membrane integrity reduced the expression and function of drug resistance-associated proteins, thereby enhancing chemosensitivity. Moreover, the combined effects of reactive oxygen species and MiR drove resistant cells towards apoptosis. In vivo studies demonstrated that the large-particle PLGA formulation effectively resided in the peritoneal cavity, resulting in superior therapeutic outcomes against drug-resistant metastatic ovarian tumor, as evidenced by fewer peritoneal metastatic nodules and diaphragmatic colonization sites, more extensive tumor tissue destruction, and prolonged survival. More importantly, PLGA encapsulation significantly decreased the toxic side effects associated with continuous platinum-based chemotherapy. Overall, cholesterol oxidation-mediated membrane lipid therapy represented a promising approach for treating advanced ovarian cancer. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-25
·
IF 12.6
Han Yuhan,Gu Jiacheng,Xu Miaomiao,Ma Yufei,Weng Weiji,Feng Qiyuan,He Zhenghui,Qi Wenlan,Mao Qing,Jiang Jiyao,Feng Junfeng
Microglia play a critical role in neuroinflammation, a key secondary injury mechanism following traumatic brain injury (TBI). The colony-stimulating factor 1 receptor (CSF-1R) inhibitor PLX5622 has shown promise in suppressing neuroinflammation by depleting microglia, but it lacks specificity in targeting microglia at the injury site. To overcome this limitation, we developed PLX5622 nanoparticles functionalized with the CAQK peptide for lesion-specific targeting and combined them with a hydrogel (GelMA-PPS) that possesses potent reactive oxygen species (ROS) scavenging capabilities. This nanoparticle-hydrogel drug delivery system (GelMA-PPS/P) significantly enhanced the delivery efficiency and therapeutic efficacy of PLX5622 in TBI treatment. Localized administration of this system effectively depleted microglia at the injury site, suppressed neuroinflammation, and reduced the release of inflammatory cytokines. Its ROS scavenging ability was also validated in vitro and in vivo. Together, these effects synergistically improved neurological function recovery in TBI mouse models. This innovative strategy offers a comprehensive and targeted approach to managing neuroinflammation after TBI, providing a promising avenue for advancing TBI therapies.
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PubMed
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EMBO Molecular Medicine
·
2025
·
IF 8.3
FengShengyong,MaEnhao,NaXiaona,WangZongmei,TaiWanbo,BaoXinhui,WangMao,ChangHan,WuBaolei,LiuMiaoxi,LiJuzhen,ShiHuicheng,YangCeli,XiMenglu,YangHaibing,LiYuhan,ZhuYibin,WangPenghua,ZhaoLing,ZhaoAi,ChengGong
Vaccination offers the most effective protection against contagious infectious diseases primarily by inducing humoral immunity. Vaccination efficacy is influenced by various factors. We report that dietary administration of arachidonic acid (ARA) significantly boosts rabies vaccine-induced production of neutralizing antibodies and protection against lethal rabies virus (RABV) infection in mice. In human volunteers, oral supplementation of ARA accelerates the expression of neutralizing antibodies to the levels sufficient for protection against RABV as early as one week after primary immunization. Mechanistically, ARA is enriched in lymph nodes and metabolized into immune modulators there. One of the ARA metabolites, prostaglandin I2 (PGI2), via the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) axis, upregulates the expression of costimulatory molecule CD86, and activates activation-induced cytidine deaminase (AID) in B cells. These results suggest that ARA can be a potent dietary adjuvant to foster germinal center (GC) B cell response and humoral immunity.
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Communications Biology
·
2025
·Vol. 8
·期 1
·1-13
·
IF 5.1
Liang Congying,Lin Lu,Wang Xiaoyan,Zhu Wenping
The secretion of ligninolytic enzyme provides a competitive advantage for microbial survival. These enzymes are commonly transported to the extracellular milieu via signal peptides for the catabolism of lignin, which cannot be translocated through the cell membrane. However, some bacterial ligninolytic enzymes lack signal peptides, yet they can still be secreted. It remains unclear how these unconventional proteins cross the cell membrane. Here, we reveal a secretion mechanism for the unconventional B-type dye-decolorizing peroxidase (DypB) in Pseudomonas putida A514. Type VI secretion system (T6SS) mediates the inner membrane channel, where interaction of DypB with the T6SS components VgrG and Hcp accounts for periplasmic delivery. Once in the periplasm, DypB is allocated into outer membrane vesicles (OMVs) and released to the extracellular space. The crosslinked translocation model for DypB delivery represents an ingenious mechanism by which bacteria harness extant systems to thrive in a nutrient-poor environment. Moreover, we develop an OMV-surface display platform to improve DypB secretion and further enhance lignin utilization, exemplifying the applicability of OMVs as a lignin biocatalytic nanoreactor. Our study demonstrates the previously unrecognized crosslinking of T6SS and OMVs for the secretion of unconventional ligninolytic peroxidase and provides new perspectives on its biotechnological applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-19
·
IF 15.7
Shen Xuecheng,Qiao Wenxuan,Yan Wei,Xie Hao,Zhang Chenyang,Sun Yang,Luo Qiong,Xu Qiang
IL-17 signaling contributes to the pathogenesis of psoriasis; however, IL-17 involvement in keratinocyte hyperactivation of epidermis remains unclear. Here, we describe an IL-17A-induced, skin-specific, positive feedback loop, which operates independently of canonical chemokine production, thus untangling skin inflammation and epithelial hyperproliferation in psoriasis. We show that IL-17A-induced, keratinocyte-specific KLK8 interacts with IL-17R to promote histone H4 lysine lactylation (H4K12la) catalyzed by the acetyltransferase HAT1. H4K12la further promotes IL-17A-mediated keratinocyte proliferation and the expression of KLK8 and IL-17R, creating a feedback loop that drives psoriasis progression. Importantly, excessive lactate in the microenvironment exacerbates H4K12la and psoriasis severity, thereby impairing the efficacy of anti-IL-17A antibody. Silencing KLK8, HAT1, or inhibiting lactate accumulation attenuates psoriasis in mice. Moreover, combining lactylation inhibition with anti-IL-17A therapy exhibits synergistic effects against antibody-resistant psoriasis. Thus, our findings unveil a lactylation-driven, keratinocyte-specific IL-17A signaling and offer a promising approach for psoriasis treatment, particularly in patients with comorbid metabolic syndrome.
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CELLULOSE
·
2025
·
IF 4.8
Yuan Quan,Li Chunxuan,Gao Dejun,Zhang Guimei,Li Kunhan,Yang Qiang,He Liping,Xu Shiwei
As a bio-based environmentally friendly material, microcrystalline cellulose (MCC) can be applied to automotive trims instead of traditional plastics; However, its flammable properties limit the application scope. In this paper, a multi-component environmentally friendly and efficient halogen-free flame retardant (APMMCC) was prepared by amino silicone oil (ASO)/phosphoric acid (H 3 PO 4 )/melamine (MEL) co-modification. The synergistic modification not only made the surface morphology of microcrystalline cellulose smoother, but also introduced ASO molecules, phosphoric acid and melamine groups, which altered its chemical structure. Thermal degradation tests showed that the thermal stability and char-forming ability of APMMCC were greatly improved. Compared with MCC, APMMCC had stronger combustion-resistance under the flame and showed significant flame retardancy. When the addition content of MCC and MEL is 1:1, the heat release rate, total heat release rate, and smoke release rate of APMMCC were minimized in the current research range. Moreover, the residual char of APMMCC at different temperatures was analyzed by Fourier transform infrared, and a condensed phase and gas phase synergistic flame retardant mechanism was proposed. Graphical abstract
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危险品化学品经营许可证（带存储）