Biomaterials Advances
·
2025
·
IF 6
Jingyi Ma,Lu Wang,Aimeng Dong,Shiqi Zhang,Tao Guo,Yiling Han,Menglu Jiang,Pan Fan,Wulian Song,Fenghua Zhang,Jinsong Leng,Huiping Yuan
Bleb fibrosis remains the most common reason for glaucoma surgery failure. Although mitomycin C (MMC) is often used to inhibit fibrosis during glaucoma drainage device (GDD) implantation, the effective reaction time of anti-fibrosis could not cover the dynamic process of wound healing. To enable noninvasive dynamic ocular drug release, we fabricated MMC-loaded thermos-responsive fiber membranes using polylactic acid (PLA) and tributyl citrate as a plasticizer. The fibers exhibited a transition temperature of 41.5 °C. To regulate drug delivery, the fiber was first stretched, coated on the GDD surface, and then implanted in rabbit eyes. The thermal-responsive fiber recovered to its original morphology upon exposure to a 43 °C stimulus in filtering bleb area one week postoperatively. The release profiles in vitro were described best by the first-order kinetics. The release rate constants were k origin = 0.11 ± 0.01 day −1 and k stretched = 0.09 ± 0.02 day −1 , respectively. The controlled release system effectively reduced the bleb fibrosis in rabbit conjunctiva. This MMC-controlled delivery system successfully inhibited scarring after GDD implantation surgery.
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DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Bangqian Wang,Jianjun He,Congcong Zhu,Bangcai Huang,Haijun Chen,Shan Guo,Fuzhong Wu,Guanghui Liu,Yong Deng,Xinyi Dai
The monoclinic Li 3 V 2 (PO 4 ) 3 cathode demonstrates significant promise for high-performance lithium-ion batteries (LIBs) technologies, primarily due to its outstanding energy density and enhanced safety performance. However, its practical application was hindered by inherent limitations, particularly, intrinsically restricted electron mobility and pronounced capacity fading during cycling at voltages exceeding 4.6 V. To overcome these challenges, this study employs a facile sol-gel method to synthesize carbon-coated Li 3 V 2 (PO 4 ) 3 materials while introducing In 3+ substitution for partial V 3+ sites. Electrochemical evaluations substantiate that the optimal In 3+ doping level of Li 3 V 2 (PO 4 ) 3 (LVP/C-In0.09) exhibits significantly enhanced performance. Specifically, the LVP/C-In0.09 sample delivers remarkable capability, sustaining 131.4 mAh g −1 at 10 C while maintaining 88.4 % of initial capacity after 500 cycles, surpassing the undoped LVP/C sample (initial capacity: 106.5 mAh g −1 ; retention: 75.7 %). XRD analysis indicates that incorporating In 3+ effectively broadens Li + diffusion channels. XAFS characterization reveals that the unit cell expansion is attributed to an increased V-V interatomic distance. Additionally, the controlled In 3+ doping effectively decreases the electrochemical resistance while substantially improving Li + diffusion kinetics. This study proposes a potential strategy to boost the practical application of Li 3 V 2 (PO 4 ) 3 in LIBs.
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高影响因子
Nanoscience and Nanotechnology Letters
·
2018
·Vol. 10
·期 4
·520-527
·
IF 2.917
Deng Yan,Du Xueting,Ma Yuchan,Zhang Kunlei,Zhang Xi,Li De-Lei,Bai Ruyan,Hu Rong,Yang Yun-Hui
In this paper, an ultrasensitive electrochemical immunoassay based on porous covalent organic framework materials and Au NPs-CoS/graphene oxide (GO) nanocomposite was developed for the detection of C-reactive protein (CRP). Au NPs-CoS/graphene oxide (GO) nanocomposite was synthesized,
and employed as substrate because of their high conductivity to immobilize CRP antibody. A new porous covalent organic framework material (COF-LZU8) was functionalized by gold nanoparticles and doped with thionine (Thi) as the electron transfer mediator to obtain nanocomposite. The reduction
peak signal of Thi/Au NPs-COF-LZU8 at –0.2 V could be directly detected by highly sensitive differential pulse voltammetry (DPV). Due to the high surface area of COF-LZU8, a great quantity of Thi could be adsorbed on the surface of COF, thus, the signal could be greatly amplified. Moreover,
Thi/Au NPs-COF-LZU8 has strong adsorption capacity to the anti-CRP protein macromolecules due to the large specific surface area and good bio-affinity. The concentration of CRP antigen was proportional to the response current, so the quantitative detection of CRP was realized. Under the optimum
conditions, the linear range of CRP was 0.05–150 ng/mL with the detection limit of 0.016 ng/mL (S/N = 3). This immunosensor provides a more effective and sensitive method for detection of CRP.
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RSC Advances
·
2014
·Vol. 4
·期 68
·36218-36225
·
IF 3.708
Huan-Huan Li,Jia-Wei Wang,Xing-Long Wu,Hai-Zhu Sun,Feng-Mei Yang,Kang Wang,Lin-Lin Zhang,Chao-Ying Fan,Jing-Ping Zhang
A novel method was developed to successfully prepare mesoporous Si/C nanocomposites with yolk–shell structures (MSi@C). Different from the reported methods, this approach was unique, straightforward and easily scaled up. A plausible mechanism for the formation of MSi@C nanocomposites was proposed, which was in accordance with the results of transmission electron microscopy (TEM). When the mixture of mesoporous Si (M-Si) and citric acid was heated up, the volume of air adsorbed by the M-Si expanded, and the viscoelastic citric acid layers inflated just like balloons, directly leading to the formation of the yolk–shell structured MSi@C nanocomposites during the carbonization. The MSi@C nanocomposites possessed an M-Si core with diameter ∼150 nm and a carbon shell with diameter ∼230 nm. Such nano and mesoporous structure combined with voids between the M-Si core and carbon shell not only provides enough space for the volume expansion of M-Si during lithiation, but also accommodates the mechanical stresses/strains caused by the volume inflation and contraction. Moreover, partial graphitization of the carbon contributed to the improved electrical conductivity and rate performance of MSi@C. As a result, the prepared MSi@C exhibited an initial reversible capacity of 2599.1 mA h g−1 and maintained 1264.7 mA h g−1 even after 150 cycles at 100 mA g−1, with high coulombic efficiency (CE) above 99% (based on the weight of M-Si in the electrode). Therefore, this work provided an alternative method to fabricate yolk–shell nanostructured materials with great potential as anode materials for lithium ion batteries.
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DOI
高影响因子
DYES AND PIGMENTS
·
2023
·
IF 4.5
Peiyu Wu,Shengxiong Zhang,Wenjun Zhang,Weijie Song
Dual functional electrochromic (EC)/electrofluorochromic (EFC) materials play a pivotal role in wearable and smart electronic equipments. Developing new materials with high performance of EC/EFC properties is still a big challenge. Here a new D-A structure polymer PPDOTTPD based on thieno(3,4-c)pyrrole-(4,6)dione ( TPD ) was synthesized by Stille coupling, and the EC/EFC properties were investigated for the first time. PPDOTTPD film exhibits reversible color changes from purple neutral state to transparent colored state in the process of reversible redox. Photophysical and electrochemical studies revealed that the polymer has outstanding EC properties, including high optical contrast (52%), fast response time (0.5 s/0.7 s), high coloring efficiency (427.1 cm 2 C −1 ) and good stability. What's more, PPDOTTPD exhibited EFC phenomenon. PPDOTTPD film showed an intense red near-infrared fluorescence with a peak of 672 nm, which gradually doped with the increase of applied potential with a maximum contrast ratio of 12.9. The EC/EFC dual-functional device based on PPDOTTPD was also successfully fabricated, which exhibited high optical and fluorescence contrast. The fine dual-functional performance indicates TPD can be further explored as potential acceptors for synthesizing high performance D-A molecules for intelligent optical devices.
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RSC Advances
·
2015
·Vol. 5
·期 85
·69854-69860
·
IF 3.84
Suyun Tian,Jing Sun,Siwei Yang,Peng He,Shengju Ding,Guqiao Ding,Xiaoming Xie
Rapid thermal exfoliation/reduction of graphite oxide is a fast and easy method among the oxidation–reduction approaches for graphene synthesis. In this research, we firstly demonstrated that graphene can be obtained with a surface area of 550 to 700 m2 g−1 and a yield of approximately 50% through one-step rapid thermal treatment in air from 450 to 550 °C, without vacuum or protective gas through a self-protection process. Then, we further demonstrated the effective two-step thermal annealing to significantly improve the C/O ratio from ca. 7.3 to 25.9 in air at the relatively low temperature of 600 °C. The smart self-protecting and enhanced-oxygen-removal mechanisms were discussed.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Benqiang Cui,Ye Tian,Yongchao Gao,Shaoyi Hua,Yanhui Shi,Changsheng Cao
Direct introduction of silyl radicals to forge C–Si bonds is of central importance in organic synthesis, owing to the formidable potential of silyl groups as coupling partners for further derivatization reactions to achieve more valuable compounds. Cleavage of heteroaromatic endocyclic carbon–heteroatom bonds to assemble C–Si bonds is scarce. Here, we demonstrate a dearomatization silylation of benzofurans and furopyridines via silyl radical addition and C(2)–O bond scission under metal-catalyst-free and mild conditions. Preliminary mechanistic experiments suggest that these transformations involve radical/single-electron transfer and [1,5]-Brook rearrangement processes. This protocol for the total synthesis of Doxepin and oxyresveratrol derivatives is carried out. The silylated products in several transformation reactions have proven to be useful as synthetic intermediates.
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PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 112
·111539-111548
·
IF 3.289
Hui Deng,Shi-Xi Zhao,Xia Wu,Lei Wei,Yu-Feng Deng,Ce-Wen Nan
The chief drawback of Li2MnSiO4 cathode materials is structural instability deriving from the transformation of [MnO4] tetrahedra to [MnO6] octahedra during oxidation from Mn(II) to Mn(III) and the Jahn–Teller effect especially from Mn(III) to Mn(IV). Based on the theory that Ni2+ could keep the [NiO4] ligand unchanged and stable during oxidation/reduction, [NiO4] tetrahedra may behave as a regional structural framework to support the total crystal lattice and alleviate structural distortion partially. In this paper we synthesize nano-Li2Mn1−xNixSiO4/C samples with a small amount of Ni as the dopant via a hydrothermal route. Firstly, we discuss the existential state of Ni through XPS spectra, and demonstrate that both Ni2+ and metallic Ni coexist, especially Ni2+ could improve structural stability. The influence of Ni doping on morphology, structural stability, and electrochemical performance is discussed through Raman spectroscopy and electrochemical tests below. It is confirmed that there exists an optimal Ni content under which the optimal performance is displayed. In our work, the optimum Ni content is 5.0%, and the maximal discharge capacity achieved is 235 mA h g−1 for the 5.0% Ni doped sample in the first cycle.
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高影响因子
CELL PROLIFERATION
·
2021
·Vol. 55
·期 1
·e13173
·
IF 6.831
Jinping Huang,Xiao Sheng,Zhangpeng Zhuo,Danqing Xiao,Kun Wu,Gang Wan,Haiyang Chen
Objectives Adult stem cells uphold a delicate balance between quiescent and active states, which is crucial for tissue homeostasis. Whereas many signalling pathways that regulate epithelial stem cells have been reported, many regulators remain unidentified. Materials and Methods Flies were used to generate tissue-specific gene knockdown and gene knockout. qRT-PCR was used to assess the relative mRNA levels. Immunofluorescence was used to determine protein localization and expression patterns. Clonal analyses were used to observe the phenotype. RNA-seq was used to screen downstream mechanisms. Results Here, we report a member of the chloride channel family, ClC - c , which is specifically expressed in Drosophila intestinal stem/progenitor cells and regulates intestinal stem cell (ISC) proliferation under physiological conditions and upon tissue damage. Mechanistically, we found that the ISC loss induced by the depletion of ClC - c in intestinal stem/progenitor cells is due to inhibition of the EGFR signalling pathway. Conclusion Our findings reveal an ISC-specific function of ClC - c in regulating stem cell maintenance and proliferation, thereby providing new insights into the functional links among the chloride channel family, ISC proliferation and tissue homeostasis.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Yang Liu,Zhuo Chen,Wenhan Xie,Feng Qiu,Yang Zhang,Shaokun Song,Chuanxi Xiong,Lijie Dong
Microwave absorbers with broadband absorption and lightweight features are highly desirable in electromagnetic interference and pollution treatment. Here, porous and hollow CoNi@C (CNC) microspheres derived from metal-organic frameworks (MOFs) are fabricated by a facile solvothermal route and subsequent annealing process. The morphology, structure, microwave absorption properties and their internal relationship are systematically investigated. For the porous and hollow CNC microspheres, the minimum RL can reach −44.8 dB at 10.7 GHz and the ultra-wide effective absorption bandwidth can reach up to 13.3 GHz (4.7–18.0 GHz) within the thickness of 1.6–4.0 mm. The CNC microspheres exhibit superior microwave absorption performance, attributing to the improved impedance matching and attenuation ability. The hollow structure, interfacial polarization, the synergistic effect between CoNi alloy and graphitized carbon simultaneously account for the microwave absorption mechanisms. Therefore, the present work provides the promising options on the design and preparation of lightweight and high-efficient microwave absorber with tunable component and specific morphology.
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高影响因子
Reaction Chemistry & Engineering
·
2020
·Vol. 5
·期 5
·886-895
·
IF 3.441
Xing-Gang Si,Yun-Peng Zhao,Qing-Lu Song,Jing-Pei Cao,Rui-Yu Wang,Xian-Yong Wei
A highly efficient Ni/N–C catalyst was synthesized by facile pyrolysis of a Ni-containing metal–organic framework (Ni-MOF), and its catalytic hydrogenolysis performance towards C–O bonds in lignin was evaluated in detail using diphenyl ether (DPE) as a model compound. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses show that the flower-like nanosheets of the Ni-MOF shrink, forming a loose and ordered spherical structure during pyrolysis. Under the optimal conditions, DPE was completely converted and the selectivity to monomers (benzene, cyclohexanol and cyclohexane) reached 99.1%. During the catalytic hydrogenolysis conversion (CHC) of DPE, the direct cleavage of the Caromatic–O bond affording benzene and phenol is the major reaction pathway, and a low H2 pressure is crucial to increase the monomer selectivity. Furthermore, Ni/N–C-450 shows high hydrogenolysis activity for other lignin-derived aryl ethers, such as benzyl phenyl ether, dibenzyl ether, dinaphthalene ether, benzyl 2-naphthyl ether and 3-methoxyphenol.
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高影响因子
JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Zhaoyu Zhang,Yufei Zhang,Minghui Ye,Yongchao Tang,Xiaoqing Liu,Cheng Chao Li
SiO x /C composites are highly potential anode alternatives for next-generation lithium-ion batteries (LIBs) owing to their low cost and high theoretical capacity. However, the sluggish lithium-ion diffusion kinetics severely limit their practical capacity and rate performance. Herein, a high-capacity and high-rate anode based on commercial SiO x /C is facilely achieved by in situ constructing a Li + conductive interphase (LCI) to simultaneously boost the transport efficacy of Li + ions and buffer the volume expansion. The as-designed, LCI-protected SiO x /C anode delivers an exceptionally high capacity of 1420.9 mAh g −1 at 0.2 A g −1 , excellent rate performance (91.4% capacity retention from 0.2 A g −1 to 1 A g −1 ) and long cycling stability, substantially outstripping the pristine SiO x /C counterpart and most recently reported Si-based electrodes. More importantly, taking advantages of the fast and stable lithiation/delithiation processes, this electrode can also be adapted to further applications at large current densities (766.44 mAh g −1 at 5 A g −1 ) or high mass loadings (5.02 mAh cm −2 at 0.1 A g −1 , ∼3.5 mg cm −2 ). A full battery with satisfactory electrochemical performance is also demonstrated. The strategy of building ion conductive interphase to subtly tailor the transport behavior of Li + ions is anticipated to unlock the practical deployment of Si-based LIBs.
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