NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.5
Jingjie Hu,Guofu Zeng,Xiaoyan Long,Xiaoyan Lin
Amidated collagen (A-COL) with good biocompatibility was synthesized via carbodiimide-mediated coupling of L-arginine to native collagen (COL). The structure and charge type of A-COL and COL were characterized by FTIR, zeta potential analysis and elemental analysis (EA). A-COL was incorporated into the foam detergent as both an antibacterial agent and foam stabilizer. The antibacterial activities of A-COL against E. coli and S. aureus were analyzed, along with its impact on, and mechanism for enhancing, the detergent's foaming capacity and foam stability. The results showed that A-COL inhibited both bacteria, with MIC values of 0.312 mg mL−1 and 0.078 mg mL−1, respectively. The antimicrobial mechanism of A-COL involves its positively charged and synergistically active structure, which enhances electrostatic interactions and destroys the cell's integrity. Foam stability with A-COL was 1.43-fold higher than without A-COL. The addition of A-COL enhances the foam stability of the foam detergent through its long-chain molecules forming an interweaving network structure. The detergent containing A-COL exhibited no skin irritation, excellent biocompatibility, and a predicted shelf life of over 3 years as determined by accelerated thermal stability testing. The dual-functional A-COL significantly enhances the detergent's antibacterial efficacy, storage stability, foam-stabilizing capacity, and biocompatibility, demonstrating considerable potential for application in biomass-based detergents.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 4.3
Yuanyuan Ma,Sunan Tian,Quanlin Ma,Jinrong Liu,Guoyue Bi,Yifang Yan,Xiaoxin Yang,Ziqiang Lei
In arid and semi-arid regions, farmland salinization poses a significant challenge to agricultural productivity and economic development. This study developed a highly water-absorbing gel material (PN-MA-L-Glu/PAA) through the synthesis of N-maleoyl-L-glutamic acid (N-MA-L-Glu) and its subsequent copolymerization with acrylic acid. The material exhibited remarkable water absorption capacities of 2880 g/g in deionized water, 272 g/g in tap water, and 175 g/g in a 0.9 % NaCl solution. Experimental results demonstrated that incorporating 0.15 % of the material significantly enhanced soil nutrient retention by 52.1 % and improved moisture retention by 73.74 %. Salt exclusion tests revealed that the material effectively reduced the concentrations of both cations and anions, with its anion adsorption performance aligning well with theoretical predictions. In pot experiments, the addition of 0.15 % and 0.2 % of the material resulted in germination rates of 86.2 % and 100 %, respectively. Notably, 0.2 % of the material reduced the total salt content in the soil surface layer by 59.1 %, decreased the pH by 0.67, and lowered the electrical conductivity (EC) by 3928.4 μS/cm. This innovative material effectively mitigates the migration of soil moisture and salts while stabilizing salt ions through chelation and adsorption mechanisms. Furthermore, its biodegradable properties make it an ideal solution for addressing soil salinization in arid and semi-arid regions, offering a promising approach for soil remediation and sustainable agricultural management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Dongdong Guo,Wenlida Mu,Chang Liu,He Qian
Three colloidal systems (LP-CP, SC-CP, CYC-CP) were systematically compared for encapsulating curcumin- Brassica rapa L. polysaccharide mixture (CP). • SC-CP exhibited the highest curcumin loading capacity, superior curcumin thermal stability, and peak colonic accumulation of curcumin in vivo . • SC-CP significantly promoted the production of acetate, propionate, and butyrate during in vitro colonic fermentation, outperforming LP-CP and CYC-CP. • In a mouse model, SC-CP enriched beneficial genera, including Lachnospiraceae_NK4A136_group and Akkermansia and increased cecal butyrate levels. • The choice of colloidal carrier fundamentally governs the colonic delivery efficiency and gut microbiota remodeling capacity of the curcumin-polysaccharide mixture. The therapeutic potential of curcumin is severely constrained by its poor physicochemical stability and low oral bioavailability. Co-formulation with Brassica rapa L. polysaccharide offers a promising strategy to enhance its functionality; however, the impact of different colloidal delivery systems on the encapsulation performance and subsequent biological fate of this mixture remains unclear. In this study, we systematically compared three spray-dried delivery platforms, including liposomes (LP-CP), sodium caseinate nanoparticles (SC-CP), and β-cyclodextrin inclusion complexes (CYC-CP), for encapsulating CP. Our results demonstrated that the carrier system critically determined encapsulation performance, with SC-CP exhibiting superior curcumin loading capacity (7.24%), curcumin thermal stability (82.87% retention at 95 °C), and favorable hygroscopicity profiles. Notably, SC-CP facilitated enhanced colonic accumulation in vivo , achieving a peak accumulation of 53.45% at 8 h post-gavage, representing a 15-fold increase compared to curcumin from unencapsulated CP. By integrating in vitro fermentation models with in vivo animal experiments and employing 16S rRNA sequencing alongside short-chain fatty acid (SCFA) analysis, we systematically elucidated the carrier-specific modulatory effects on the gut microbiota. In the in vitro fermentation system, SC-CP significantly promoted the production of acetate, propionate, and butyrate, while enriching butyrate-producing genera such as Lachnospiraceae_NK4A136_group . In the in vivo animal model, SC-CP intervention resulted in a 1.6-fold increase in cecal butyrate levels and a marked increase in the abundance of beneficial genera, including Akkermansia , demonstrating superior modulation of microbial community structure and metabolic function. Collectively, these findings establish that the selection of a colloidal carrier not only dictates the physicochemical stability of the curcumin-polysaccharide mixture but also governs its spatiotemporal distribution within the gastrointestinal tract and its prebiotic capacity to remodel the gut microecology. This study provides a theoretical foundation for the rational selection of delivery systems to maximize the functional efficacy of bioactive ingredients in functional food applications. Download: Download high-res image (195KB) Download: Download full-size image
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Bo Zhang,Liqun Shen,Cheng Yu,Zhibo Leng,Zhihong Zhu,Lingfei Hua,Zijie Li
d-Allose, one of important rare sugars, has attracted increasing attention due to its low caloric value and remarkable physiological activities. l-Rhamnose isomerase (L-RI) catalyzes the reversible conversion of d-allulose to d-allose. However, its industrial application is limited by inadequate catalytic efficiency. In this study, L-RI from Clostridium thermosuccinogenes was identified and systematically characterized. Using a semirational protein engineering strategy, loop residues adjacent to the catalytic core and potential active sites predicted by the HotSpot Wizard web server were targeted. The resultant triple mutant N137Q/D258R/A265I achieved a d-allose conversion rate of 21.8% and a productivity of 130.8 g·L–1·h–1 within 1 h using 600 g·L–1 d-allulose. Molecular dynamics (MD) simulations revealed that modulation of loop flexibility enhanced the enzyme turnover rate. By fine-tuning loop flexibility while maintaining the structural integrity of the enzyme, this engineered mutant reduces the risk of enzyme inactivation during prolonged high-temperature catalysis. Collectively, these results highlight its potential for industrial d-allose production and provide valuable insights for the modification of L-RIs and related enzymes.
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高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Haodong Wang,Yangping Sun,Qi Liu,Mengci Ma,Long Hu,Gehong Wei,Chun Chen
BACKGROUND Soybean production is severely affected by the soil-borne phytopathogenic, Fusarium oxysporum , which causes root rot disease. Artificial nanoplatforms have attracted attention as a sustainable strategy to promote crop growth and protection. RESULTS In this study, mesoporous silica nanoparticles (MSNs) loaded with lipopeptide (Lip), referred to as Lip@MSNs, were synthesized with a diameter of approximately 50 nm and a Lip loading capacity of 22.40 wt%. Lip@MSNs demonstrated potent antifungal activity against F. oxysporum , inducing cell membrane disruption, permeability alterations, nuclear damage, and subsequent cell death. Pot experiment showed that Lip@MSNs significantly reduced the severity of soybean root rot disease by 43.10% while enhancing plant growth and root development. Metabolomic analysis revealed that Lip@MSNs modulated critical metabolic pathways, including zeatin and pyrimidine metabolic pathways in roots. Furthermore, Lip@MSNs recruited beneficial endophytic bacteria, such as antagonistic genera ( Sphingomonas , Variovorax , and Streptomyces ) and growth-promoting genera ( Rhizobium , Ensifer , and Nocardioides ). Correlation analysis highlighted the role of these bacteria in nitrogen fixation and phytohormone production (e.g., trans -zeatin), contributing to reduced root rot disease severity and improved plant health. CONCLUSION These findings demonstrate that the silicon-based delivery system could serve as an effectively tool to control soil-borne phytopathogenic diseases and promote the development of sustainable agriculture. © 2025 Society of Chemical Industry.
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ACS Omega
·
2023
·
IF 4.1
Lei Ding,Xuan Zhou,Xiaojie Liang,Yujin Dong,Cunbao Fang,Yueming Wu,Beixing Li,Wei Mu,Jin Lin,Yuekun Li
Pesticide residue has become the main technical barrier that restricts the export of Chinese wolfberry. Can we achieve high efficacy and low safety risk by balancing pesticide deposition on the leaves and fruits of Chinese wolfberry? In this research, the structural characteristics and wettability of leaves and fruits of Chinese wolfberry at different growth stages were studied. The adaxial and abaxial surfaces of leaves were hydrophobic, whereas the fruit surfaces were hydrophilic. Adding spray adjuvant could increase the retention of droplets on the leaf surfaces of Chinese wolfberry by 52.28–97.89% and reduce the retention on the fruit surfaces by 21.68–42.14%. A structural equation model analysis showed that the adhesion tension was the key factor affecting the retention of the solutions among various interface behaviors. When the concentrations of Silwet618, AEO-5, Gemini 31551, and 1227 were 2–5 times higher than their CMCs, the retention of pesticide solutions (pyraclostrobin and tylophorine) on Chinese wolfberry leaves significantly increased, and the control efficacies on aphids and powdery mildew also dramatically improved (65.90–105.15 and 41.18–133.06%, respectively). Meanwhile, the retention of pesticides on the fruit of Chinese wolfberry was reduced. This study provides new insights into increasing the utilization of pesticides in controlling pests and improving food safety.
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FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Siyi Peng,Jiajia Zhao,Yaru Wang,Fang Chen,Xiaosong Hu,Lingjun Ma,Junfu Ji
L-menthol-containing food products generally show the flavor loss during storage due to their high volatility. The hydrophobicity of L-menthol also causes the inadequate flavor release during rehydration. In this study, the stability of L-menthol was enhanced by microencapsulation and the effect of different powder drying techniques was also investigated. The highest efficiency (76.58–78.66 %) and loading content (18.58–28.35 mg/g) of encapsulations were obtained by using a mass ratio of 2:1(α-LA: GA). Then they were dried by non-thermal spray freeze drying (SFD) technique compared to spray drying (SD) and freeze-drying (FD) process. The SFD particles were shown to be spherical and porous with the highest porosity (86.82 %). α-LA/GA based microparticles with spherical shapes were demonstrated to largely enhance flavor retention during high humidity storage. In addition, the porous structures of SFD powders could cause rapid rehydration in liquid models, and the release behaviors of loaded L-menthol followed the Fickian diffusion. Consequently, the SFD technique shows great potential to produce microparticles by regulating the release behaviors of L-menthol during storage and rehydration.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Hua Huang,Ling Wang
The alteration of surface microstructures and chemical composition in cuticle of papaya fruit in response to chilling stress were comparatively studied between cultivars of ‘Risheng’ and ‘Suihuang’ after harvest. Fruit surface was covered by fissured wax layers in both cultivars. The presence of granule crystalloids was cultivar dependent, with higher abundance in 'Risheng' and lower in 'Suihuang'. Various typical very-long-chain aliphatics i.e., fatty acids, aldehydes, n -alkanes, primary alcohols, and n -alkenes dominated waxes; and cutin monomers were prominently 9/10,16-dihydroxyhexadecanoic acid in papaya fruit cuticle. Chilling pitting symptom was accompanied by modification of granule crystalloids into flat appearance and decreased primary alcohols, fatty acids, and aldehydes in ‘Risheng’, but no evident changes in ‘Suihuang’. The response of cuticle to chilling injury in papaya fruit might be not directly related to the overall amount of waxes and cutin monomers, but more likely to the alteration of appearance morphologies and chemical composition in cuticle.
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Advanced Healthcare Materials
·
2023
·
IF 10
Xinchan Liu,Yubo Hou,Mingxi Yang,Xirui Xin,Yu Deng,Ruobing Fu,Xingchen Xiang,Niuben Cao,Xiaomeng Liu,Weixian Yu,Bai Yang,Yanmin Zhou
Periodontitis is a type of chronic inflammatory oral disease characterized by the destruction of periodontal connective tissue and progressive alveolar bone resorption. As oxidative stress is the key cause of periodontitis in the early periodontal microenvironment, antioxidative therapy has been considered a viable treatment for periodontitis. However, more stable and effective reactive oxygen species (ROS)-scavenging nanomedicines are still highly needed due to the instability of traditional antioxidants. Herein, a new type of N -acetyl- l -cysteine (NAC)-derived red fluorescent carbonized polymer dots (CPDs) has been synthesized with excellent biocompatibility, which can serve as an extracellular antioxidant to scavenge ROS effectively. Moreover, NAC-CPDs can promote osteogenic differentiation in human periodontal ligament cells (hPDLCs) under H 2 O 2 stimulation. In addition, NAC-CPDs are capable of targeted accumulation in alveolar bone in vivo, reducing the level of alveolar bone resorption in periodontitis mice, as well as performing fluorescence imaging in vitro and in vivo. In terms of mechanism, NAC-CPDs may regulate redox homeostasis and promote bone formation in the periodontitis microenvironment by modulating the kelch-like ECH-associated protein l (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This study provides a new strategy for the application of CPDs theranostic nanoplatform for periodontitis.
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2023
·Vol. 54
·期 2
·712-733
·
IF 3
Zhang Xi,Na Hao,Liu Pengyao,Wang Yajun,Li Junguo,Meng Qian,Li Guopeng
Regulating the phase transformation of γ → β in dicalcium silicate (C 2 S) can effectively improve the hydration activity and recycling rate of AOD slag; however, the evolution law for γ → β in C 2 S has not been extensively investigated. In this study, a novel “two-step” γ → α ′ L → β phase transformation method in C 2 S was designed based on the study of the pure C 2 S phase at a nonequilibrium state in the low- and middle-temperature ranges. The “two-step” method can be used to realize the transformation from needle-like nanostructured γ -C 2 S grains to lamellar-structured β -C 2 S grains, exhibiting the trend of interlaminar peeling accompanied by expansion of the particle volume and leading to the appearance of macroscopic lamellar cracking in β -C 2 S particles. In addition, the β -C 2 S mass fraction in AOD slag treated by water cooling at 680 °C reaches a maximum value of 47.5 wt pct, while the treated AOD slag presents abundant holes and defects, which can effectively enlarge the hydration contact area.
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FOOD HYDROCOLLOIDS
·
2023
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IF 10.7
Jingjing Huang,Manling Yu,Shaoyun Wang,Xiaodan Shi
Jicama, Pachyrhizus erosus L., is a kind of widely cultivated but underutilized crop across the world. It contains considerable amounts of starch and non-starch polysaccharides (NSPs), which have not been well studied. As the key characteristics for the processing, physicochemical and rheological properties of starch-based systems can be affected by the blending of NSPs. In the current study, jicama NSPs (named as PEP) were firstly fractionated to two sub-fractions (PEP-3P and PEP-6P) using gradient ethanol precipitation method. The three fractions showed differences in molecular weight ( M w ) and monosaccharide compositions. Then, the three jicama NSPs were introduced into the jicama starch (PES) system to explore their effects on PES. Results showed that jicama NSPs with larger M w promoted the leaching of amylose from PES, formed a denser and more uniform gel network structure. The pasting, thermal, and rheological tests indicated that the blending starch systems with jicama NSPs had lower viscosity, weaker thermal stability, and gel strength compared with the pure PES system. In addition, PEP-6P and PES blending systems had the strongest gel strength, which may be due to the narrower distribution of M w . In the in vitro system, the content of resistant starch of the complexes decreased after jicama NSPs were added. Analysis of the interaction force showed that the PES/PEP-6P complex had stronger hydrogen bonding and electrostatic interaction. These results provided new knowledge on underlying interaction mechanism between natural starch and NSPs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Yi Zhang,Wenjie Wang,Zongju Chen,Huihong Shi,Wenzhe Zhang,Xiucheng Zhang,Xin Hua
Artificial bone materials are in great need due to a lot of bone injuries. Herein, collagen/nano-hydroxyapatite (Col/nHA, C-H) composite nanospheres were obtained by in-situ mineralization, and poly L-lactic acid/collagen/nano-hydroxyapatite (PLLA/Col/nHA, P-C-H) was further prepared by high-speed shear emulsification method. The interfacial properties and structure between PLLA and nHA are regulated by the adhesive property of Col. The morphology, structure and properties of P-C-H microsphere were characterized in detail by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) and simulated degradation of PBS in vitro. The results show that C-H is uniformly distributed in P-C-H microspheres, and a mesoporous material with a “pomegranate” structure and a particle size of 5–30 μm is self-assembled based on C-H multiple composite microspheres. It is beneficial to the sustained-release degradation of P-C-H and the retention/release of Ca 2+ . The 60-day PBS degradation shows that PLLA delays the degradation of nHA, making the degradation rate of P-C-H basically consist with the human bone healing cycle. The co-culture of P-C-H with MC3T3-E1 cells shows that P-C-H has high biocompatibility and no cytotoxicity. The cell viability is higher than 100 % in 72 h, indicating P-C-H has a proliferation effect on cell growth. Alkaline phosphatase and quantitative real-time PCR test show a positive promotion of P-C-H in cell proliferation and differentiation. The multi-layered P-C-H microspheres have an application potential in bone tissue engineering.
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