JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2023
·
IF 5
Yanchao Liu,Yingying Ma,Linying Xue,Wenhao Guan,Yancai Wang
To better address the etiology of lung infections and the delivery limitations that exist, the development of a pulmonary inhalation formulation with antibacterial and mucolytic effects is necessary. This study was conducted using multidrug dry powder in one step to treat pulmonary infections. The optimal ratio of drugs for antibacterial activity was determined by the checkerboard method. The appearance of the dry powder for inhalation was yellow, and SEM images revealed that the powder was sphere-like, with a controlled particle size of 6 μm or less, good dispersion and a wrinkled and depressed surface. Confocal laser scanning microscopy (CLSM) images revealed that curcumin nanoparticles were uniformly distributed in the dry powder inhalation. Both the twin stage impinger (TSI) and Next Generation Impactor (NGI) showed that the multidrug powder has excellent aerosol performance, with a fine particle fraction (FPF) ranging from 68.93% to 77.75%. The multidrug powder presented satisfactory antibacterial effects at low doses, thereby reducing systemic toxicity due to high-dose delivery. In vitro drug release experiments also demonstrated that the powder had great release properties. In conclusion, a multidrug codelivery system of curcumin nanosuspensions and ciprofloxacin with N-acetylcysteine dry powder was prepared that was suitable for lung infection therapy.
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Analytical Methods
·
2023
·Vol. 15
·期 19
·2376-2381
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IF 3.1
Lei Jiang,Lin Yuan,Shan Gao,Yingying Xiang,Fei Song,Wensi Ma,Jing Wan,Xiuling Ji,Yujiao Tu
Pesticides are enormously important to industry requirements and in agriculture for improving yields. Parathion is widely used to control pests in vegetables, fruits, and flowers. However, excessive use of parathion poses a threat to food safety, the environment, and human health. Due to low cost, ease to use, and high selectivity and sensitivity, a fluorescent nanoprobe is a candidate for parathion detection. Blue fluorescent carbon dots were prepared by a hydrothermal method with rutinum and o-phenylenediamine as precursors. The Rut-CDs were purified by using dialysis, thin layer chromatography, and a chromatographic column. Excellent linear ranges of 0–7.5 μg L−1 and 12.5–62.5 μg L−1 parathion were obtained with a low detection limit of 0.11 ng mL−1. In addition, the quenching mechanism of parathion to the fluorescence of Rut-CDs was illuminated. Furthermore, the nanoprobe was efficiently applied to determine the parathion content in Chinese cabbage, cantaloupe, and cowpea samples. It shows great potential to detect parathion.
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COMBUSTION AND FLAME
·
2023
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IF 4.4
Yitong Zhai,Qiang Xu,Beibei Feng,Can Shao,Zhandong Wang,S. Mani Sarathy
Low-temperature (low-T) oxidation experiments of n -heptane –with and without NO addition– were experimentally and numerically investigated at stoichiometric conditions in a jet-stirred reactor. Experiments were performed at atmospheric pressure over a temperature range of 500–800 K. Reactants, intermediates, and products, were measured using synchrotron vacuum ultraviolet photoionization mass spectrometry . A detailed kinetic model was developed to gain insight into the chemical effect of NO on low-T oxidation chemistry of n -heptane. Taking 650 K as the transition temperature, the results revealed that NO addition exhibited an inhibiting effect on fuel reactivity below 650 K and a promoting effect above 650 K. The reactions of ROO + NO = RO + NO 2 and HO 2 + NO = OH + NO 2 at different temperature regions were responsible for the inhibition and promotion effects, respectively. Evidence gathered from both experimental measurements and kinetic model predictions indicated that NO addition had a significant inhibitory effect on the formation of cool flame species during the low-T oxidation process. NO suppressed low-T oxidation via the reaction of ROO + NO = RO + NO 2 , which impeded the subsequent isomerization, O 2 addition, OH-, and HO 2 -elimination reaction, and influenced product distribution of the cool flame species. The experimental observations provided detailed information about these reactive intermediates, which offered new insights into low-T oxidation phenomena and clarified the importance of NO reactions which prevent the formation of cool flame products during low-T oxidation.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Zhigang Di,Qifeng Zhao,Hui Xu,Kang Wu,Yan Yan,Xi Jin,Haiying Shen,Yiqian Lv,Boyuan Ran
To improve the anti-corrosion performance and mechanical properties of waterborne epoxy, we synthesized new N-CQDs and introduced them into the coating to prepare N-CQDs/EP. Based on SEM, Micro FT-IR, EIS, NSS, adhesion Tester, and LSCM, the long-term corrosion resistance, mechanical, and fluorescence properties of N-CQDs/EP were studied carefully. The cross-sectional SEM results indicated that N-CQDs could improve the internal cross-linking density and reduce the pore size of N-CQDs/EP. EIS results showed that composite coating could provide excellent anti-corrosion to steel in both 3.5 wt% NaCl solution and simulated seawater. The highest impedance value of N-CQDs/EP was still maintained at 10 9 Ω cm 2 after 30 d immersion. N-CQDs also enhanced the adhesion force, and the highest value was 6.8 MPa. Meanwhile, the N-CQDs/EP fluorescence intensity was increased with the appearance of N-CQDs. Hence, this work can provide theoretical support for developing new epoxy coatings and accelerate the industrial application of long-term coatings.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 48
·期 3
·1372-1380
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IF 3.3
Peng Sun,Menglu Zhang,Yue Liu,Jiahua Zhao,Jiawei Yang,Yufeng Wang,Yongfei Wang,Zhiqiang Zhang
Lithium-ion batteries have been regarded as a promising power source for various electronic devices. Compared to the traditional graphite anode material, MoSe2 possesses a higher theoretical capacity. However, MoSe2 anode materials are limited by low electronic conductivity and large volume changes during cycling. This study reports 1T–2H MoSe2/N-doped rGO nanocomposites, fabricated through a hydrothermal method. The 1T–2H MoSe2/N-doped rGO electrode delivers a high reversible capacity of 483.6 mA h g−1 after 1000 cycles at 1000 mA g−1. It also possesses a high reversible capacity of 474.9 mA h g−1 even at a current density of 2000 mA g−1, thus, making it an important potential lithium-ion battery anode.
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Nanomaterials
·
2023
·Vol. 13
·期 7
·1188
·
IF 5.3
Lina Sun,Liping Sun,Lihua Huo,Hui Zhao
H2O2generation via an electrochemical two-electron oxygen reduction (2e−ORR) is a potential candidate to replace the industrial anthraquinone process. In this study, porous carbon catalysts co-doped by nitrogen and oxygen are successfully synthesized by the pyrolysis and oxidation of a ZIF-67 precursor. The catalyst exhibits a selectivity of ~83.1% for 2e−ORR, with the electron-transferring number approaching 2.33, and generation rate of 2909.79 mmol g−1h−1at 0.36 V (vs. RHE) in KOH solution (0.1 M). The results prove that graphitic N and –COOH functional groups act as the catalytic centers for this reaction, and the two functional groups work together to greatly enhance the performance of 2e−ORR. In addition, the introduction of the –COOH functional group increases the hydrophilicity and the zeta potential of the carbon materials, which also promotes the 2e−ORR. The study provides a new understanding of the production of H2O2by electrocatalytic oxygen reduction with MOF-derived carbon catalysts.Keywords:porous carbon;two-electron reduction of oxygen;hydrogen peroxide;electrocatalyst
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TALANTA
·
2023
·
IF 6.1
Yichen Lu,Chengrun Du,Hongmei Ying,Yunfan Lin,Qinying Gu,Fangfang Kong,Hongli Zhao,Minbo Lan
The development of facilely synthetic materials acts an essential role in glycoproteome analysis, especially for the highly efficient enrichment of N-linked glycopeptides . In this work, a facile and timesaving route was introduced in which COF TP-TAPT served as a carrier and poly (ethylenimine) (PEI) and carrageenan (Carr) were successively coated on the surface via electrostatic interaction . The resultant COF TP-TAPT @PEI@Carr showed remarkable performance in glycopeptide enrichment with high sensitivity (2 fmol μL −1 ), high selectivity (1:800, molar ratio of human serum IgG to BSA digests), large loading capacity (300 mg g −1 ), satisfactory recovery (102.4 ± 6.0%) and reusability (at least eight times). Due to the brilliant hydrophilicity and electrostatic interactions between COF TP-TAPT @PEI@Carr and positively charged glycopeptides , the prepared materials could be applied in the identification and analysis in the human plasma of healthy subjects and patients with nasopharyngeal carcinoma. As a result, 113 N-glycopeptides with 141 glycosylation sites corresponding to 59 proteins and 144 N-glycopeptides with 177 glycosylation sites corresponding to 67 proteins were enriched from 2 μL plasma trypsin digests of the control groups and patients with nasopharyngeal carcinoma, respectively. 22 glycopeptides were identified only from the normal controls and 53 glycopeptides were detected only from the other set. The results demonstrated that this hydrophilic material was promising on a large scale and further N-glycoproteome research.
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ENVIRONMENTAL POLLUTION
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2023
·
IF 8.9
Zhixin Chen,Yijie Wang,Liming Hu
Thermal desorption technology can effectively remediate fuels-contaminated clayey soil. However, the microscopic mechanism for the contaminant desorption on clay is still unclear, especially with the existence of water on clay surfaces. In this study, a combination method including TGA experiments, multi-phase and multi-component kinetic models, and MD simulation was proposed to reveal the thermal desorption mechanism of n -dodecane in unsaturated clay. Results showed that the thermal desorption behavior of the free nonaqueous phase liquid (NAPL) and the adsorbed phase of n -dodecane or water could be identified by the multi-phase and multi-component kinetic models based on the desorption process rate obtained by thermogravimetric analysis (TGA) experiments. The activation energy of the NAPL phase (49–69.9 kJ/mol) was lower than the adsorbed phase (90 kJ/mol). The activation energy of the NAPL phase had the same linear relationship with its mass on kaolinite and montmorillonite , while adsorbed phase only existed on the kaolinite surface. MD simulation showed that water demonstrated competitive adsorption with n -dodecane on montmorillonite surfaces and prevented the formation of the adsorbed phase while having little influence on the n -dodecane adsorption on kaolinite surface, which agrees well with the kinetic analysis of the TGA experiments. With the combination of macroscopic experimental analysis and microscopic molecular simulation, it can be concluded that the mass of the NAPL phase limited the desorption behavior, while the interaction between the clay mineral surface and n -dodecane was the key factor that dominated the thermal desorption behavior of the adsorbed phase. The presented results provide new insight into the desorption mechanism of hydrocarbon on clay minerals, which is of significance for the design of thermal desorption remediation.
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CRYSTENGCOMM
·
2023
·Vol. 25
·期 11
·1648-1656
·
IF 3.1
Songjie Li,Shilong Su,Yun Tian,Yuanyuan Li,Xiaomei Yu,Panfei Sun,Jin You Zheng
Molybdenum carbide (Mo2C) has become a promising candidate for electrocatalytic hydrogen production from water splitting due to its low price and platinum-like electrocatalytic properties. In this work, Mo2C nanotubes (Mo2C NTs) with ultrathin imbricate structure were successfully synthesized by carburizing polydopamine organic layer covered molybdenum trioxide (MoO3) nanowire templates at elevated temperature through organic–inorganic hybridization. The inner diameter and wall thickness of the as-synthesized Mo2C NTs are about 150 nm and 100 nm, respectively. Two-dimensional Mo2C nanoflakes with a thickness of about 10 nm were composed of nanoclusters with a size of 2 nm. Furthermore, N–MoxC was facilely prepared by nitrogen doping into the prepared Mo2C by chemical vapor deposition and the enhanced electrocatalytic activity was obtained with an overpotential of 120 mV at a current density of 10 mA cm−2. An enlarged specific surface area of 189 m2 g−1 was achieved for N–MoxC, which provides more electrocatalytic active sites for water reduction. More importantly, the interface optimization of Mo2C and MoC was expected to modify the electronic structure and accelerate the electron transfer for improved water splitting performance.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Shangjun Lin,Wentao Liu,Xuehe Hou,Zhenyun Peng,Zhencheng Chen,Fangrong Hu
As an organic substance, n -propanol gas has been paid attention to in environmental monitoring and exhalation of lung cancer patient. In this paper a rapid detection method for n -propanol gas is developed based on molecularly imprinted polymers (MIP) and terahertz (THz) metasurface sensors. We first prepared a MIP suitable for detecting the n -propanol gas. And then the n -propanol MIP was modified to the THz metasurface sensor for detecting the n -propanol gas. Since the MIP adsorbed with n -propanol changes the dielectric environment of the sensor, the resonance frequency of the sensor also change. So we based on the n -propanol concentration was analyzed according to the change in resonance frequency. The experimental results showed that the sensor can effectively detect the n -propanol concentration in the range of 50–500 ppm (parts per million). In addition, we also verified the specificity and repeatability of the sensor. This work provides a new idea and method for the sensitive and specific detection of n -propanol gas.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Hui Jiang,Zijian Zhao,Ning Yu,Yi Qin,Zhengwei Luo,Wenhua Geng,Jianliang Zhu
Using N -methyl-D-glucosamine (NMDG) as the functional monomer , glycidyl methacrylate (GMA) as the connecting monomer, functionalized Fe 3 O 4 nano-particles (NPs) as the support, three adsorbents were prepared including direct polymer GMA-NMDG, magnetic GMA-NMDG polymer (MGN), and boron magnetic ion-imprinted polymer (BMIIP). Based upon the optimization of synthesis conditions, the prepared adsorbents and intermediate products were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscope, energy dispersive spectroscopy, X-ray diffraction, vibrating sample magnetometer, and Brunauer–Emmett–Teller to investigate the synthesis process, the morphological structure and the functional properties of the materials. The optimum performances of GMA-NMDG, MGN and BMIIP were obtained in the initial neutral solution (pH of 6.5). Moreover, GMA-NMDG and MGN reached the maximum adsorption capacity at 120 min, whereas BMIIP reached adsorption saturation at 60 min. The pseudo-second-order kinetic model was more suitable for the adsorption of boron using the adsorbents. The maximum adsorption capacity of GMA-NMDG was found to be 43.4 mg·g −1 , while those of MGN and BMIIP were 32.5 and 28.3 mg·g −1 , respectively. The Langmuir isotherm model was more appropriate to describe the adsorption process . The adsorbents maintained satisfactory adsorption performance within a certain temperature range. Competing ions had little effect on the adsorption of boron, and would be adsorbed simultaneously, due to which, the effect of co-adsorption can be considered. The adsorption capacity of GMA-NMDG was high, while the adsorption selectivity of BMIIP was much better. Furthermore, BMIIP showed good adsorption after five cycles of adsorption and desorption. The comparison of adsorbents showed that GMA-NMDG had the highest adsorption capacity and was suitable for co-adsorption. MGN had a high adsorption capacity, good comprehensive performance and magnetic properties. BMIIP had better adsorption rate, adsorption selectivity and recyclability. Through the optimization of synthesis conditions, the adsorption capacity of the traditional monomer NMDG polymer was increased, and the magnetism was given to facilitate rapid recovery. Combined with the ion imprinting technology, it showed higher boron adsorption selectivity in the presence of competitive ions.
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DIAMOND AND RELATED MATERIALS
·
2023
·
IF 4.1
Jiying Shi,Linlin Zang,Long Zhang,Jingzhen Wang,Qing Xu,Yanhong Zhang,Liguo Sun
Porous carbon supported metal nanoparticles as supercapacitor electrode materials have attracted extensive attention. In this paper, cobalt nitrate/polystyrene microspheres/chitosan(Co(NO 3 ) 2 /PS/CS) balls were fabricated by emulsion encapsulation and self-assembly process. After carbonization, Co nanoparticles (NPs) loaded on porous ball-in-ball N-doped carbon (Co/BNC) were prepared. Co/BNCs with high surface area profit formation of sufficient active sites and facilitate ion transport due to the interconnected and interpenetrating porous carbon structure. The electrochemical performances of Co/BNCs are affected by Co NPs content and the Co/BNC with the optimal Co NPs content (Co/BNC-2) possesses a commendable specific capacitance of 1120 F g −1 at 1 A g −1 . Moreover, the capacitance retention of the asymmetric supercapacitors assembled by Co/BNC-2 and activated carbon is about 85.38 % after 5000 cycles. Remarkably, the device exhibits a maximum energy density of 60.9 Wh kg −1 at 764 W kg −1 and maintains 37.8 Wh kg −1 at 7878 W kg −1 . Co/BNCs mentioned here have the potential to be candidates for high-performance supercapacitor electrode materials.
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