Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 23
·14108-14117
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IF 10.733
Dan Li,Xiukai Cao,Qinmei Zhang,Xingang Ren,Lei Jiang,Dawei Li,Wei Deng,Haitao Liu
This paper reports the fabrication of a highly sensitive and reusable substrate for surface-enhanced Raman scattering (SERS) analysis. Core–shell metal–organic framework (MOF; HKUST-1)@Ag nanoparticles (NPs) are prepared on a screen-printed carbon electrode (SPCE) via in situ electrodeposition. The morphology and Ag coverage of core–shell structures can be easily controlled by electrodeposition potential and time without substrate motion. The HKUST-1(Cu)@Ag composites combine abundant SERS “hot spots” among the high-density Ag NPs and the excellent adsorption performance of the MOF, resulting in effective pre-concentration of analytes in close proximity to these “hot spots” and enhancement of SERS sensitivity. The optimized polyhedral HKUST-1@Ag structures exhibit high SERS activity for detecting 4-aminothiophenol at a concentration as low as 5 × 10−10 M. More importantly, the polyhedral HKUST-1@Ag composites provide high sensitivity for detection of polycyclic aromatic hydrocarbons (PAHs) while preserving the cyclability and selectivity required for reliable quantitative analysis. The method is effective over a wide range of PAH concentrations (0.5 nM to 0.5 M), with detection limits as low as hundreds of pM. This study offers a new method to tailor the structure of MOF-based SERS substrates for on-site screening or point-of-care applications.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Wei Zhang,Min Chen,Xinjian Cheng,Jie Yang,Jumei Li
In this study, we demonstrated an efficient solar photocatalyst, g-C 3 N 4 modified hollow Ag/ZrO 2 core–shell composites (Ag/hZrO 2 /CN) using polymethylacrylic acid (PMAA) nanospheres as sacrificial template. The optimized Ag/hZrO 2 /CN catalyst demonstrated substantial photocatalytic performance, achieving 97.6 % degradation of methylene blue (MB) and 99.5 % degradation of thiram (TRM) within 90 min under simulated sunlight using a 500 W Xe lamp. The improved property is likely attributed to the synergistic effect among three constituents and the effective segregation of photogenerated electron-hole pairs in ZrO 2 , g-C 3 N 4 and Ag NPs, as confirmed by photocurrent and EIS analysis. Based on free radical scavenging studies (e − , h + , OH and O 2 − ), the mechanism underlying the boosted photocatalytic activity was suggested. Moreover, Ag/hZrO 2 /CN presented excellent surface enhanced Raman scattering activity, achieving quantitative sensing of MB and TRM with limits of detection of 5 × 10 −8 and 10 −6 mol/L, respectively, and a favorable linear correlation between SERS intensities and logarithmic concentration (R 2 ≥ 0.97). Additionally, Ag/hZrO 2 /CN accomplished recyclable SERS detection of MB and TRM through stimulated sunlight irradiation, which is significant for the recyclable SERS detecting through fast sunlight-powered procedure.
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Biosensors-Basel
·
2022
·Vol. 13
·期 1
·7
·
IF 5.743
Huiping Fu,Ning Ding,Dan Ma,Qing Xu,Bingyong Lin,Bin Qiu,Zhenyu Lin,Longhua Guo
In this work, a simple, low-cost, green, and mild method for the preparation of three-dimensional nanocomposite materials of gold nanorods (Au NRs)@TiO2is reported. The surface of Au NRs was coated with TiO2in situ reduction at room temperature without a complicated operation. The synthetic Au NRs@TiO2nanocomposites were used as surface-enhanced Raman spectroscopy (SERS) active substrates for the reusable and sensitive detection of environmental pollutants. The results showed that the pollutants on Au NRs@TiO2nanocomposites have higher SERS activity and reproducibility than those on the Au NR substrate without the presence of TiO2. Moreover, the SERS substrate can be readily recycled by UV-assisted self-cleaning to remove residual analyte molecules. Malachite green (MG) and crystal violet (CV) were used as examples to demonstrate the feasibility of the proposed sensor for the sensitive detection of environmental pollutants. The results showed that the limit of detections (LODs) were 0.75 μg/L and 0.50 μg/L for MG and CV, respectively, with the recoveries ranging from 86.67% to 91.20% and 83.70% to 89.00%. Meanwhile, the SERS substrate can be easily regenerated by UV light irradiation. Our investigation revealed that within three cycles, the Au NRs@TiO2substrates still maintained the high SERS enhancement effect that they showed when first used for SERS detection. These results indicated that the method can be used to detect MG and CV in really complex samples. Due to the high sensitivity, reusability, and portability and the rapid detection property of the proposed sensor, it can have potential applications in the on-site detection of environmental pollutants in a complex sample matrix.Keywords:surface-enhanced Raman spectroscopy (SERS);self-cleaning;photocatalytic activity;recyclable;environmental pollutants
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Advanced Materials Interfaces
·
2021
·Vol. 8
·期 18
·2101055
·
IF 6.147
Changchang Xing,Shichuan Zhong,Dilong Liu,Tao Zhang,An Cao,Pan Zeng,Dandan Men,Cuncheng Li,Weiping Cai,Yue Li
A facile route to fabricate the hydrogel film@Au nanoparticle array composite for a surface-enhanced Raman scattering (SERS) substrate with high signal sensitivity and signal uniformity based on self-assembly co-assisted by electrostatic reaction and hydrogel-shrinkage is developed. First, the positive-charged Au nanoparticles (NPs) are self-assembled on the hydrogel film with opposite charges due to electrostatic attraction to obtain non-close-packed Au NP films on both surface sides of the hydrogel film. Then, the non-close-packed Au NP films are densified to further form hexagonal close-packed Au NP arrays on both surfaces due to the principle of minimum free energy during the hydrogel-shrinkage process. The shrinkage of hydrogel film is proved to be a key process to form hexagonal close-packed Au NP arrays by densifying the non-closely packed Au NPs achieved by electrostatically self-assembled on the hydrogel film. Constructed SERS substrate exhibits high signal sensitivity, colorant molecule amaranth with a concentration as low as 10 −8 m can be detected. This is caused by the uniform array structure with active gaps between neighboring NPs on a large area. Overall, this work paves a way to fabricate functional NP arrays on soft hydrogel, which will be highly helpful to prepare the micro/nano-structured devices.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Yudie Sun,Aobo Feng,Ruilai Zhang,Kehong Quan,Zefeng Hua,Kui Zhang
Bacterial contamination is a very serious health and environmental problem, with the main source of toxicity being lipopolysaccharides in the cell walls of Gram-negative bacteria. Therefore, the development of effective analytical methods is crucial for the detection of lipopolysaccharide content. This work facilitates the efficient generation of precisely adjustable dual-mode signals for LPS detection in surface-enhanced Raman spectroscopy (SERS) and electrochemiluminescence (ECL) by inducing anisotropic morphological evolution of Au@Ag nanocubes (Au@AgNCs) through poly-cytosine (poly-C) DNA. In the presence of LPS, the released probe triggers rolling circle amplification (RCA) and generates cyclic poly-C DNA, which subsequently induces the etching of Ag composites on Au@AgNCs. This etching process leads to changes in both the morphology and composition of Au@AgNCs composite materials, resulting in a decrease in SERS signals. The poly-C DNA was subsequently adsorbed with Ag + and then reduced to silver nanoclusters (AgNC) by NaBH 4 , serving as an ECL signal source. Under optimal experimental conditions, both SERS and ECL demonstrated linear ranges spanning from 1 fg/mL to 1 ng/mL, with detection limits of 0.29 fg/mL and 0.14 fg/mL, respectively. Moreover, the SERS-ECL dual-mode sensor facilitates the accurate discrimination of Gram-negative bacteria in diverse real samples. It demonstrates promising applications in the areas of food safety, water quality monitoring, and clinical bacterial detection.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Peishan Hu,Yuxuan Zhang,Haiyan Wei,Wei Zhang,Liqun Song,Mengping Zhang,Xiao Meng,Ming Shang,Cuijuan Wang
Phthalic acid esters (PAEs) are ubiquitous environmental contaminants, and their real-time monitoring and removal remain challenging. Herein, a point-of-use (POU) device integrating adsorption, surface-enhanced Raman spectroscopy (SERS), and removal strategy was developed and realized ultrafast on-site determination of PAEs and cleanup of them from water. A piece of flexible melamine sponge (MS) was coated with gold nanostars (AuNSs) and metal–organic frameworks (MOFs), thus obtaining SERS activity and adsorption capacity. Based on this multifunctional AuNSs@MOFs/MS composite, clear trends were observed between SERS signal intensity and concentration of di(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP). The method detection limits of DEHP and DBP were calculated to be 0.75 × 10–7 and 0.67 × 10–7 M in water, respectively, proving good sensitivity. Furthermore, this POU device exhibited satisfactory adsorption capacity (∼82.3 g/g for DBP and ∼90.0 g/g for DEHP), high adsorption efficiency (equilibrium in 100 s), and good regeneration capability (removal efficiency >70% after 5 cycles). The applicability of this device was verified by its good determination and removal performance in real environmental water matrices. The whole process could be completed within 5 min. This approach provides a new POU alternative for real-time monitoring and removal of PAEs in water.
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TALANTA
·
2024
·
IF 5.6
Yiquan Liao,Yichang He,Bin Zhang,Ye Ma,Minggang Zhao,Ruiqi Xu,Hongzhi Cui
Glutathione (GSH) is an essential antioxidant in the human body, but its detection is difficult due to the interference of complex components in serum. Herein, hollow double-layer Pt@CeO 2 nanospheres were developed as oxidase mimetics, and the light-assisted oxidase mimetics effects were found. The oxidase activity was enhanced significantly by utilizing the synergistic effect of Schottky junction and the localized surface plasmon resonance (LSPR) of Pt under UV light . A novel GSH colorimetric-fluorescent-SERS sensing platform was established, with the sensing performance notably boosted by using the light-assisted oxidase mimetics effects. This platform boasts an exceptionally low detection limit (LOD) of 0.084 μM, while the detection time was shortened from 10 min to just 2 min. The anti-interference detection with high recovery rate (96.84%–107.4 %) in real serum made it be promising for practical application.
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Food Chemistry-X
·
2025
·
IF 8.2
Xiaoyu Yang,Dan Zhou,Xin Yang,Bo Wu,Jiaxin Xie,Runzi Zhang,Yao Liu,Yi He
Diacetyl is a flavoring agent commonly used to enhance food aroma. However, excessive levels can pose health risks, making rapid and sensitive detection crucial for food safety. In this study, multifunctional cobalt oxide tetraoxide@silver nanoflowers (Co 3 O 4 @Ag NFs) were synthesized to enhance the photocatalytic coloration of diacetyl, enabling a simple and highly sensitive colorimetric/SERS dual-channel sensor. Co 3 O 4 @Ag NFs serve three key functions: First, Co 3 O 4 acts as a photocatalyst, improving catalytic efficiency and detection sensitivity. Second, Ag nanoparticles enhance light scattering and reflection, prolonging light interaction with diacetyl molecules and accelerating the reaction. Third, the strong electromagnetic field generated by Co 3 O 4 @Ag NFs creates numerous hotspots, making it an effective and highly sensitive SERS substrate. The sensor achieves detection limits of 10 × 10 −6 mol/L for colorimetric detection and 3.0 × 10 −12 mol/L for SERS, providing a simple, rapid, sensitive, and accurate way for diacetyl detection and offering potential for future food safety analysis.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xingkang Diao,GuoHua Qi,Xinli Li,Yu Tian,Jing Li,Yongdong Jin
Cell cycle analysis is crucial for disease diagnosis and treatment, especially for investigating cell heterogeneity and regulating cell behaviors. Exosomes are highly appealing as noninvasive biomarkers for monitoring real-time changes in the cell cycle due to their abundant molecular information inherited from their metrocyte cells and reflecting the state of these cells to some extent. However, to our knowledge, the relationship between exosomes and the cell cycle has not been reported. Herein, we successfully monitored the variation of exosomal surface-enhanced Raman spectroscopy (SERS) spectra to discriminate different cell cycle stages (G0/G1, S, and G2/M phases) based on label-free surface-enhanced Raman spectroscopy (SERS) combined with the machine learning method of linear discriminant analysis (LDA). An average accuracy of 85% based on the trained SERS spectra of exosomes from different cell cycle stages confirmed the high reliability of the support vector machine (SVM) algorithm for analyzing dynamic changes in the cell cycle at different time points. Importantly, the related molecular mechanisms among mitotic processes (prometaphase, metaphase, and anaphase/telophase) and unique biomolecular events between cancerous (HeLa) and normal (H8) cells were also revealed by the present label-free SERS detection platform. Based on SERS analysis, the content of phenylalanine (Phe) within HeLa cells increased, and some structures of proteins containing Phe and tryptophan (Trp) residues may be transformed during the mitotic process. Notably, the α-helix and β-sheet of proteins coexisted in HeLa cells; meanwhile, the α-helix of the proteins was more dominant in H8 cells than in HeLa cells. The strategy is effective for discriminating cell cycle stages and elucidating the associated molecular events during the cell mitotic process and will provide potential application value for guiding the cell cycle treatment strategies of cancer in the future.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xinyuan Zhao,Hui Pan,Wenwen Chen,Wei Zhang,Chuanxi Liu,Mengjie Wang,Ming Shang,Cuijuan Wang
High index facets of Au TOHs/ZIF-67/PTFE enables good sensitivity. • Supports air sampling and testing suitable for on-site settings. • Applicable to both airborne and aqueous samples for versatile monitoring. • Rapid detection (<5 min) for practical use. Monitoring of pesticides in air and water is essential for assessing occupational exposure and ensuring environmental safety. In this study, an integrated point-of-use (POU) surface-enhanced Raman scattering (SERS) platform based on a high-index Au trisoctahedrons (Au TOHs)/zeolitic imidazolate framework-67 (ZIF-67)-decorated polytetrafluoroethylene (PTFE) membrane was developed for the rapid sampling and in situ detection of carbaryl (CBR), diquat (DQ), and paraquat (PQ) in air and water. The high-index facets of Au TOHs generate abundant plasmonic “hot spots”, thereby enhancing the sensitivity of SERS, while the porous PTFE film and ZIF-67 provide efficient analyte enrichment. The entire detection process was completed within 5 min. The bifunctional SERS-active substrate exhibited good thermal stability, spatial uniformity, reproducibility, and long-term stability. Strong linear relationships between SERS intensity of characteristic peaks and logarithmic analyte concentrations were obtained for CBR, DQ, and PQ in airborne and aqueous environments, with detection limits of 0.0044–0.94 ppb. In addition, the platform demonstrated good selectivity against interfering pesticides and satisfactory recovery rates. The results were consistent with conventional analytical methods, confirming the reliability of the proposed approach. This work provides a promising strategy for rapid on-site monitoring of pesticide contaminants in environmental media. Download: Download high-res image (620KB) Download: Download full-size image
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Food Bioscience
·
2026
·
IF 6.2
Xifan Zhan,Xinying Wang,Md Mehedi Hassan,Fangling Jiang,Jiaying Xu,Yuan Zhang,Shanghua Li,Sha Zou,Hongfa Liu,Yi Xu,Quansheng Chen
Pesticide residues in tea pose significant health risks to consumers. This research focuses on developing a surface-enhanced Raman scattering (SERS) sensor using a solid-phase substrate made of Au@Ag@PVP nanoparticles (NPs), combined with machine learning chemometric techniques, for the rapid detection of trichlorfon, carbendazim, and clothianidin in tea. Au@Ag@PVP NPs were immobilized onto anodic aluminum oxide (AAO) filter membranes via vacuum filtration, yielding densely packed NPs that generate strong electromagnetic hot spots, thereby increasing SERS sensitivity. Raman spectra of tea infusions containing different concentrations of pesticides were acquired and analyzed using three machine-learning algorithms. Among these models, competitive adaptive reweighted sampling-partial least squares (CARS-PLS) demonstrated superior predictive performance, with Rc = 0.9950, Rp = 0.9942, and RPD = 9.2893 for trichlorfon; Rc = 0.9955, Rp = 0.9942, and RPD = 9.1010 for carbendazim; and Rc = 0.9981, Rp = 0.9957, and RPD = 9.7523 for clothianidin. This approach enables the rapid, quantitative detection of pesticide residues with minimal sample preparation and high sensitivity, representing a practical method for monitoring tea safety.
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TALANTA
·
2026
·
IF 6.7
Yasheng Dai,Jie Yao,Shiyuan Wang,Changgan Lai,Jie Gong,Chenjie Gu,Tao Jiang,Kerong Wu
Exosomes are regarded as cancer-associated biomarkers for early diagnosis and prognosis in clinical bioassays. Nevertheless, it remains a challenge to develop an approach that can achieve ultra-sensitive and quantitative detection of exosomes. Herein, an innovative dual-mode immunoassay dependent on surface-enhanced Raman scattering (SERS) and upconversion luminescence (UCL) was developed to detect prostate cancer-derived exosomes. A novel SERS-active immunosubstrate was constructed by combining black phosphorus (BP) with Ag nanoparticles, which exhibited an enhancement factor (EF) of about 3.69 × 10 9 , due to the synergistic electromagnetic and chemical effects. Meanwhile, an immunoprobe with stable and visually distinguishable UCL was developed based on Yb/Er co-doped NaGdF 4 nanoparticles with an intrinsic two-photon process. The specific capture of exosomes was achieved through antigen-antibody binding within the sandwich immunostructure, achieving limits of detection (LOD) as low as 93 and 172 particles/mL based on the dual-modal detection, respectively. Furthermore, the recognition of different derived exosomes was simply realized by visually observing the green fluorescence with different intensities, which paves the way for efficient preliminary identification of prostate cancer. Finally, the validation with clinical serum samples proved that the proposed approach holds significant promise for rapid cancer screening and diagnosis.
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