Nature Communications
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2025
·
IF 15.7
Qian Zhengyi,Han Guokang,Tan Yingjun,Ye Na,Wang Shuguang,Lin Zheng,Huang Qizheng,Gu Yu,Guo Hongyu,Liu Fei,Wang Kai,Li Lu,Shang Changshuai,Luo Mingchuan,Guo Shaojun
Copper-based catalysts are the premier choice for electrochemical reduction of CO 2 (CO 2 RR) into hydrocarbons or oxygenates. However, the facilely structural reconstruction of copper sites during electrolysis poses significant challenges to the long-life electrolytic efficiency. Herein, we leverage the strong σ-π dative bonding between Cu δ+ and alkyne-based ligands to stabilize copper sites for the prolonged CO 2 RR. We demonstrate the feasibility of taming the electronic structures of copper sites through the tug of war between σ and π backbonding interactions. The optimal copper organic polymer with methoxy group functionalization (OMe-PhCu) exhibits a moderate charge density of copper sites and an intensified local asymmetric charge distribution of coordinative carbon, enhancing the selectivity of methane with a Faradaic efficiency of 68.8% and a partial current density of 324.5 mA cm −2 in acidic electrolyte. In situ spectra and density functional theory calculations reveal enhanced *CO adsorption and lowered energy barrier for CO 2 RR into methane over OMe-PhCu. Building upon such stable Cu δ+ sites, we further construct Cu δ+ /Cu 0 catalytic interfaces for the generally enhanced electrosynthesis of multi-carbons and ammonias. This synthetic chemistry paves the pathway for the design of stable catalytic active sites for renewable conversions.
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JOURNAL OF ELECTRONIC MATERIALS
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2025
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IF 2.5
Li Song,Chen Zhenyu,Chen Xingang,liu Kang,Ma Lintao,Ao Yi
To enable effective monitoring of human physiological signals, this study fabricates a piezoresistive flexible pressure sensor using a composite of Ti 3 AlC 2 (a type of MXene material) and NaKC 4 H 4 O 6 as the sensing material. The structure of Ti 3 AlC 2 before and after composite formation was observed via scanning electron microscopy, while x-ray diffraction, x-ray photoelectron spectroscopy, and energy-dispersive x-ray spectroscopy characterizations were conducted. Based on these analyses, the binding behavior between Ti 3 AlC 2 and NaKC 4 H 4 O 6 , as well as the mechanism underlying the enhanced sensing performance, were elucidated. The mechanism underlying the enhanced pressure response was further analyzed from the perspective of heterojunctions. In pressure testing, the as-fabricated pressure sensor demonstrates outstanding performance, including a high sensitivity of 2.46%/kPa within the range of 0–30 kPa and a rapid response time of 0.2 s. It has also successfully detected scenarios including wrist flexion, pulse beats, and fist clenching, thereby demonstrating promising application potential in physiological signal monitoring.
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Nature Communications
·
2025
·Vol. 16
·期 1
·11099
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IF 15.7
Zhao Chunyu,Wu Yidan,Song Dongxing,Zhang Xing,Ma Weigang
Ionic thermoelectrics (i-TEs) demonstrate immense application potential in such fields as wearables and low-grade energy harvesting. Though adequate moisture absorption is required to facilitate ion dissociation in i-TEs, the impact of moisture gradient has been overlooked. Herein, we demonstrate a moisture-gradient-enhanced ionic thermoelectric generator (MGITG) driven by both moisture and temperature gradients. The MGITG exhibits an ionic thermopower of 34.02 mV K -1 , a high open-circuit voltage of 644.19 mV, and an ultrahigh 1 h output energy density of 917.54 J m -2 . We attribute the enhanced performance to fast and selective ion transport driven by coupled heat and moisture transfer. As a proof of concept, this material enabled the development of wearables capable of monitoring motion and respiration, as well as robotic systems equipped with synchronous environmental and tactile sensing. This work holds promise in the design of high-sensitivity, multifunctional, and high-energy-density i-TEs, facilitating their applications in robotic touch and wearables.
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JOURNAL OF ELECTRONIC MATERIALS
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2025
·Vol. 54
·期 10
·8561-8569
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IF 2.5
Dong Tianhao,Cui Yongpeng,Wei Lianghuan,Zhu Shengjie,Si Jianxiao
CaM(M = Cu, Ag)Sb Zintl-phase compounds have ignited tremendous research activities due to their promising thermoelectric properties. In this work, a series of CaCu 1− x Ag x Sb (x = 0, 0.2, 0.4, 0.6, 0.7, 0.8, 0.9, 1) samples have been synthesized and investigated. The continuous structure transition from the hexagonal CaCuSb to the orthorhombic CaAgSb is characterized as the composition regulation on Cu/Ag ratios. Lattice bonding hardens and the electrical band structure changes as a result of this transition. The lattice thermal conductivity of CaCu 0.2 Ag 0.8 Sb, which benefitted from the structure transition, showed a minimum value of 1.05 W m −1 K −1 at 323 K. At the same time, the Seebeck coefficient was improved as a result of the rise in effective mass. The findings show that the CaMSb compounds have flexible structural tunability for thermoelectric applications if the hole concentration can be further optimized. Graphical
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JOURNAL OF APPLIED ELECTROCHEMISTRY
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2025
·Vol. 56
·期 1
·3
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IF 3
Fan Lei,Zhang Weixin,Li Zehang,Yan Shuai,Wang Kangli,Li Haomiao,Zhang Zhiqing
Liquid metal batteries (LMBs) based on liquid metal electrodes and molten salt electrolytes, are deemed as one of the most promising technologies for large-scale energy storage, due to the advantages of long-lifespan, low-cost and high-safety. Nevertheless, the issue of inadequate wettability between the collectors and the liquid electrodes in LMBs hinders the electrode reaction kinetics, resulting in a considerable polarisation voltage and, consequently, a reduction in the voltage efficiency of the cell. This work proposes a novel strategy for the construction of a self-generated Cr-C transition layer at the graphite collector/electrode interface, utilising Cr as a cathode additive with the objective of enhancing interfacial wettability. It was demonstrated that the formation of a Cr-C transition layer resulted in an increase in the contact area at the collector/cathode interface, as well as the reaction area at the electrolyte/cathode interface. This led to an acceleration in the kinetics of the electrode reaction. As a consequence, the voltage efficiency of Li||Sb-Sn cells was enhanced from 86.10% to 89.91%. In particular, the improvement in energy efficiency is more pronounced with an increase in the charge/discharge rate, and a reasonable proportion of chromium addition does not have a detrimental impact on battery performance. Graphical
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Scientific Reports
·
2025
·
IF 3.9
Xu Qiuling,Liu Zhuoxi,Wang Liyuan,Liu Guoyang,Zhao Long,Yue Hui,Liu Yong
Diabetic cardiomyopathy (DCM) requires a systematic approach for effective management. Focusing on key signaling pathways in myocardial fibrosis could offer novel therapeutic approaches for DCM. The objective of this research is to investigate new biomarker and the underlying mechanisms by which baicalin intervenes in the progression of DCM. Swiss Target Prediction databases and weighted correlation network analysis (WGCNA) were employed to collect and analyze targets of baicalin and DCM. Intersection targets were obtained through venn online website, network visualization was conducted through STRING database and Cytoscape 3.7.2 software. Molecular docking validation was completed via AutoDock Vina software. Western blotting, RT-qPCR and histology were carried out to validate the direct targets of baicalin and explore the molecular mechanism during DCM progression. In mice induced to DCM, we observed that disruptor of telomeric silencing 1-like (DOT1L) was upregulated. Baicalin (BC) reduced myocardial fibrosis in mice as indicated by the reduced expression levels of fibrosis markers COL-1 and TGF-β. The inhibitory effect of BC was reversed by overexpressed DOT1L and further enhanced by silenced DOT1L. Our results indicate that cardiomyocyte DOT1L exerts a pathogenic role in DCM and BC specifically targets DOT1L/COL-1 signaling to reduce myocardial fibrosis in DCM.
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DIABETOLOGIA
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2025
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IF 10.2
Yun Yue,Liu Yu-Dan,Yang Ze-Mian,Wang Yi-Qiao,Zhang Nan,Li Wen-Jing,Gao Di,Sha Lei
Aims/hypothesis While Roux-en-Y gastric bypass (RYGB) effectively treats diabetes, its underlying mechanisms remain unclear, highlighting the need to develop less-invasive alternatives. Emerging evidence suggests duodenal involvement in metabolic homeostasis and type 2 diabetes pathophysiology, yet the role of duodenal myoelectrical activity in diabetes and RYGB is poorly understood. This study aims to characterise duodenal myoelectrical changes in diabetes and RYGB, and evaluate their therapeutic potential. Methods Duodenal myoelectrical activity was recorded in male Sprague Dawley rats and high-fat diet/streptozocin (HFD/STZ)-induced diabetic rats, with or without RYGB. An antro-duodenum electrical stimulation (ADES) system was developed to mimic RYGB-associated myoelectrical hyperactivity. Its effects were examined by reducing stimulating power or chemically ablating duodenal myoelectrical activity with benzalkonium chloride, alongside pancreatic morphometric analyses. ADES was further validated in male Zucker diabetic fatty (ZDF) rats. Results RYGB induced duodenal myoelectrical hyperactivity in HFD/STZ rats, characterised by shortened migrating myoelectric complex cycles, a nearly doubled phase III duration, and a 50.9% increase in fed-state spike frequency. By replicating these specific patterns, ADES achieved glucose-lowering effects comparable with those of RYGB, decreasing fasting glucose levels, reducing the OGTT AUC by approximately 40%, and enhancing insulin secretion by 71.7% at the 30 min time point. These glycaemic improvements were attenuated by either reducing the stimulating power or through benzalkonium chloride-mediated ablation of myoelectrical activity. Furthermore, ADES promoted pancreatic beta cell recovery, increasing beta cell mass by 1.5-fold through a 65.3% enhancement in proliferation and a 39.0% reduction in apoptosis. It also preserved beta cell identity, as evidenced by upregulated expression and promoted nuclear localisation of the key transcription factors pancreatic and duodenal homeobox factor-1 (PDX1) and MAF bZIP transcription factor A (MAFA). In ZDF rats, ADES similarly improved glucose homeostasis, significantly lowering 120 min OGTT glucose, and ameliorated hyperinsulinaemia, reducing plasma insulin levels by 35.1%. Conclusions/interpretation ADES mimics RYGB-induced duodenal hyperactivity, offering comparable glucose-lowering effects. Targeting duodenal myoelectrical activity may provide a minimally invasive alternative to RYGB for diabetes treatment. Graphical
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 2
·51
·
IF 3
Hu Huixiang,Zhang Yixing,Li Yun,Xu Zhongqing,Zheng Weinan,Chen Hao,Tang Xuan
In recent years, antibiotics have been widely found in different types of water bodies, and these residues pose a serious threat to ecosystems and human health. Among the treatment methods for degrading antibiotics, advanced oxidation processes (AOPs) based on persulfate activation have received extensive attention and application due to their excellent degradation performance. In this study, the flower-like Fe 7 S 8 @Mn 3 O 4 catalyst material with agglomerated small particles attached to the surface was prepared by hydrothermal method to activate persulfate (PMS) to remove tetracycline. The results showed that the degradation rate of TC could reach 91% in 60 min when TC was 25 mg/L, catalyst dosage was 0.2 g/L and PMS was 0.3 g/L. The pH range was wide, and the degradation rate increased with the increase of temperature. HCO 3 − and H 2 PO 4− have a certain inhibitory effect on the catalytic reaction. Cl − , SO 4 2− and NO 3 − have little impact on the reaction system, and the catalytic material has strong applicability to the environment. The catalytic material has good reusability. Free radical quenching experiments showed that SO4· − , ·OH, 1 O 2 , O 2 · − all played a role. It was confirmed by EPR experiments that ·OH and SO4· − existed in the reaction system. The degradation pathways mainly include demethylation, deamidation, dehydroxylation, hydroxylation, ring-opening oxidation, etc.
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Scientific Reports
·
2025
·
IF 3.9
Shen Xiaojing,Wang Yunmei,Deng Huicui,Yang Fuman,Luo Xiaona,Jiang Weiwei
This study aimed to optimize the extraction process of total saponins from the stems and leaves of Panax zingiberensis (SLPZ) and analyze its chemical composition. This study investigated the optimal extraction conditions for total saponins from the stems and leaves of Panax zingiberensis (SLPZ) via single-factor experiments and response surface methodology (RSM) optimization, and the optimal parameters were determined as follows: cellulase-to-pectinase ratio of 1%:5%, enzymatic hydrolysis pH 4.5, ultrasound temperature 55 °C, and ultrasound time 28.88 min. Under these conditions, the total saponin extraction rate from SLPZ reached 37.12%. UHPLC-Q-TOF-MS/MS analysis identified 42 saponin compounds, including 28 dammarane-type triterpenes, 7 oleanane-type triterpenes, and 7 other saponins. Among them, triterpenes comprising the majority (51.07%) of the total compounds detected. Diterpenes, sesquiterpenes, and monoterpenes accounted for 18.26%, 17.74%, and 12.93%, respectively. This study provides a theoretical basis for the comprehensive utilization of SLPZ resources.
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 12
·471
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IF 2.8
Luo Shajie,Wang Yuan,Zhang Shuai,Zhou Jun,Wang Jiale,Wang Xiaohan,Jiang Lishi
Two kinds of novel poly(arylene ether nitrile) copolymers (P-HFD and P-PFD) containing pendant aliphatic rings and fluorene groups were synthesized by 4, 4’-cyclohexane-1, 1’-diyldiphenol (CHDP) or 4, 4’-cyclopentane-1, 1’-diyldiphenol (CPDP), 4, 4’-(9-fluorenylidene) diphenol and 2, 6-dichlorobenzonitrile (DCBN) in this work. The inherent viscosities of these two copolymers were 0.455 and 0.576 dL/g. The copolymers P-HFD and P-PFD exhibited good thermal property, the glass transition temperatures (T g ) were 202.2–214.9 °C, and the weight-loss temperatures (T 5% ) were 421.3–433.5 °C. The polymers’ films had good tensile strengths of 27.3–38.6 MPa. The result of dissolution experiment showed that the copolymers could be dissolved in some solutions at room temperature, such as NMP, DMF and CH 2 Cl 2 , implying they had good solubility, they can be processed by the solution method. Additionally, the optical transmittances of these two copolymers were 68.3–76.3% at 450 nm, indicating that they have the potential to be applied as the heat-resistant optical films.
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npj Science of Food
·
2025
·
IF 7.8
Zheng Anru,Dong Minghua,Zhang Zhendong,Fang Jiaxin,Pan Yu,Jiang Lele,Tian Caiyun,Tan Jiayao,Deng Siwei,Zhang Cheng,Wang Zhong,Zhou Chengzhe,Guo Yuqiong
Oolong tea flavor is shaped by metabolite variations induced by season, processing, and cultivar. This study investigated the metabolic basis of sensory characteristics in Yongchun Foshou (YCFS) tea by integrating HS-SPME/GC-MS, HPLC, quantitative descriptive analysis (QDA), and chemometrics. Orthogonal partial least squares discriminant analysis (OPLS-DA) pinpointed key differential compounds between spring (YCFS-S) and autumn (YCFS-A) teas. Two-way ANOVA with effect size analysis confirmed that season was the dominant factor influencing most metabolites, although grade was the primary driver for free amino acids. YCFS-S contained significantly higher levels of taste-related phytochemical compounds, whereas YCFS-A exhibited elevated tea polyphenols. Statistical sensory analysis further identified a subset of key aroma compounds as drivers of seasonal and grade-based aroma differences. Correlation network analysis pinpointed 27 key sensory drivers: 12 aroma compounds defining a complex aroma profile dominated by floral and herbal notes, and 15 phytochemical compounds responsible for the umami, overall richness, and balanced bitterness. These findings were synthesized to construct the first dedicated flavor wheel for YCFS, elucidating how seasonality and grade collectively shape its flavor profile and providing a scientific basis for quality control and standardized production.
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Communications Biology
·
2025
·
IF 5.1
Wang Shanshan,Wu Zankai,Song Wenqin,Zhang Hui,Bu Xueshan,Gao Wenwei,Wu Kefan,Xia Zhongyuan,Zhao Bo,Wang Wei
Activation of the cGAS-STING pathway has been proposed as a potential pathogenic mechanism underlying postoperative cognitive dysfuncton (POCD). Analysis of public transcriptomic data from the hippocampus of male mice suggests upregulation of Rbm47 in an experimental POCD model. In vitro, knockdown (KD) of Rbm47 in BV2 cells reduces levels of cGAS, STING, TNF-α, IL-6, and IFN-β under isoflurane and lipopolysaccharide (Iso + LPS) conditions. HT22 cells exposed to culture medium from Rbm47 -KD BV2 cells treated with Iso + LPS show increased levels of MEF2C, GPX4, GSH, and SOD, and reduced levels of MDA and iron. Microglial Rbm47 overexpression amplifies cGAS-STING signaling and aggravates neuronal ferroptosis, which is reversed by the cGAS inhibitor RU.521. Rbm47 KD combined with RU.521 treatment synergistically ameliorates POCD in male mice. Mechanistically, the RRM2 domain of RBM47 interacts with the 3’UTR of cGAS mRNA, enhancing its stability. RUNX1 directly binds to the Rbm47 promoter and facilitates its transcription. RUNX1 overexpression activates the RBM47-cGAS-STING axis and exacerbates neuronal ferroptosis. Conversely, RUNX1 ablation ameliorates POCD, dampens the cGAS-STING signaling, and inhibits ferroptosis, which is abolished by RBM47 depletion. Our findings suggest that repression of RUNX1/RBM47 may represent a promising therapeutic strategy for POCD.
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