Nature Communications
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2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Zhang He-Shan,Dong Xue-Mei,Zhang Zi-Cheng,Zhang Ze-Pu,Ban Chao-Yi,Zhou Zhe,Song Cheng,Yan Shi-Qi,Xin Qian,Liu Ju-Qing,Li Yin-Xiang,Huang Wei
Neuromorphic electronics, which use artificial photosensitive synapses, can emulate biological nervous systems with in-memory sensing and computing abilities. Benefiting from multiple intra/interactions and strong light-matter coupling, two-dimensional heterostructures are promising synaptic materials for photonic synapses. Two primary strategies, including chemical vapor deposition and physical stacking, have been developed for layered heterostructures, but large-scale growth control over wet-chemical synthesis with comprehensive efficiency remains elusive. Here we demonstrate an interfacial coassembly heterobilayer films from perylene and graphene oxide (GO) precursors, which are spontaneously formed at the interface, with uniform bilayer structure of single-crystal perylene and well-stacked GO over centimeters in size. The planar heterostructure device exhibits an ultrahigh specific detectivity of 3.1 × 10 13 Jones and ultralow energy consumption of 10 −9 W as well as broadband photoperception from 365 to 1550 nm. Moreover, the device shows outstanding photonic synaptic behaviors with a paired-pulse facilitation (PPF) index of 214% in neuroplasticity, the heterosynapse array has the capability of information reinforcement learning and recognition.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Li Siwu,Zhu Haolin,Liu Yuan,Han Zhilong,Peng Linfeng,Li Shuping,Yu Chuang,Cheng Shijie,Xie Jia
Potassium metal is an appealing alternative to lithium as an alkali metal anode for future electrochemical energy storage systems. However, the use of potassium metal is hindered by the growth of unfavourable deposition (e.g., dendrites) and volume changes upon cycling. To circumvent these issues, we propose the synthesis and application of nitrogen and zinc codoped porous carbon nanofibres that act as potassium metal hosts. This carbonaceous porous material enables rapid potassium infusion (e.g., < 1 s cm −2 ) with a high potassium content (e.g., 97 wt. %) and low potassium nucleation overpotential (e.g., 15 mV at 0.5 mA cm −2 ). Experimental and theoretical measurements and analyses demonstrate that the carbon nanofibres induce uniform potassium deposition within its porous network and facilitate a dendrite-free morphology during asymmetric and symmetric cell cycling. Interestingly, when the potassium-infused carbon material is tested as an active negative electrode material in combination with a sulfur-based positive electrode and a nonaqueous electrolyte solution in the coin cell configuration, an average discharge voltage of approximately 1.6 V and a discharge capacity of approximately 470 mA h g −1 after 600 cycles at 500 mA g −1 and 25 °C are achieved.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Zhang Tianze,Chang Libo,Zhang Xiaofeng,Wan Hujie,Liu Na,Zhou Liujiang,Xiao Xu
The surface and interface chemistry are of significance on controlling the properties of two-dimensional transition metal carbides and nitrides (MXenes). Numerous efforts have been devoted to the regulation of Ti 3 C 2 T x MXene, however, tuning interlayer spacing and surface halogen termination of other MXenes (besides Ti 3 C 2 T x ) is rarely reported while demanded. Here we propose a Lewis-basic halides treatment, which is capable of simultaneously engineering the interlayer spacing and surface termination of various MXenes. Benefited from the abundant desolvated halogen anions and cations in molten state Lewis-basic halides, the -F termination was substituted by nucleophilic reaction and the interlayer spacing was enlarged. Ti 3 C 2 T x MXene treated by this method showed a high specific capacity of 229 mAh g −1 for Li + storage, which is almost 2 times higher than pristine one. Considering the universality, our method provides an approach to regulating the properties of MXenes, which may expand their potential applications in energy storage, optoelectronics and beyond.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-19
·
IF 17.694
Zhang Xianzhu,Jiang Wei,Xie Chang,Wu Xinyu,Ren Qian,Wang Fei,Shen Xilin,Hong Yi,Wu Hongwei,Liao Youguo,Zhang Yi,Liang Renjie,Sun Wei,Gu Yuqing,Zhang Tao,Chen Yishan,Wei Wei,Zhang Shufang,Zou Weiguo,Ouyang Hongwei
Critical-sized bone defects often lead to non-union and full-thickness defects of the calvarium specifically still present reconstructive challenges. In this study, we show that neurotrophic supplements induce robust in vitro expansion of mesenchymal stromal cells, and in situ transplantation of neurotrophic supplements-incorporated 3D-printed hydrogel grafts promote full-thickness regeneration of critical-sized bone defects. Single-cell RNA sequencing analysis reveals that a unique atlas of in situ stem/progenitor cells is generated during the calvarial bone healing in vivo. Notably, we find a local expansion of resident Msx1+ skeletal stem cells after transplantation of the in situ cell culture system. Moreover, the enhanced calvarial bone regeneration is accompanied by an increased endochondral ossification that closely correlates to the Msx1+ skeletal stem cells. Our findings illustrate the time-saving and regenerative efficacy of in situ cell culture systems targeting major cell subpopulations in vivo for rapid bone tissue regeneration.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Tan Peng,Wang Haifei,Xiao Furui,Lu Xi,Shang Wenhui,Deng Xiaobo,Song Huafeng,Xu Ziyao,Cao Junfeng,Gan Tiansheng,Wang Ben,Zhou Xuechang
Soft electronics are rising electronic technologies towards applications spanning from healthcare monitoring to medical implants. However, poor adhesion strength and significant mechanical mismatches inevitably cause the interface failure of devices. Herein we report a self-adhesive conductive polymer that possesses low modulus (56.1-401.9 kPa), high stretchability (700%), high interfacial adhesion (lap-shear strength >1.2 MPa), and high conductivity (1-37 S/cm). The self-adhesive conductive polymer is fabricated by doping the poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) composite with a supramolecular solvent (β-cyclodextrin and citric acid). We demonstrated the solution process-based fabrication of self-adhesive conductive polymer-based electrodes for various soft devices, including alternating current electroluminescent devices, electromyography monitoring, and an integrated system for the visualization of electromyography signals during muscle training with an array of alternating current electroluminescent devices. The self-adhesive conductive polymer-based electronics show promising features to further develop wearable and comfortable bioelectronic devices with the physiological electric signals of the human body readable and displayable during daily activities.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Zhang Yuan,Yang Junlong,Hou Xingyu,Li Gang,Wang Liu,Bai Ningning,Cai Minkun,Zhao Lingyu,Wang Yan,Zhang Jianming,Chen Ke,Wu Xiang,Yang Canhui,Dai Yuan,Zhang Zhengyou,Guo Chuan Fei
Electronic skins (e-skins) are devices that can respond to mechanical stimuli and enable robots to perceive their surroundings. A great challenge for existing e-skins is that they may easily fail under extreme mechanical conditions due to their multilayered architecture with mechanical mismatch and weak adhesion between the interlayers. Here we report a flexible pressure sensor with tough interfaces enabled by two strategies: quasi-homogeneous composition that ensures mechanical match of interlayers, and interlinked microconed interface that results in a high interfacial toughness of 390 J·m −2 . The tough interface endows the sensor with exceptional signal stability determined by performing 100,000 cycles of rubbing, and fixing the sensor on a car tread and driving 2.6 km on an asphalt road. The topological interlinks can be further extended to soft robot-sensor integration, enabling a seamless interface between the sensor and robot for highly stable sensing performance during manipulation tasks under complicated mechanical conditions.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-14
·
IF 17.694
Xu Zhichen,Chen Dongjuan,Li Tao,Yan Jiayu,Zhu Jiang,He Ting,Hu Rui,Li Ying,Yang Yunhuang,Liu Maili
Fast, inexpensive, and multiplexed detection of multiple nucleic acids is of great importance to human health, yet it still represents a significant challenge. Herein, we propose a nucleic acid testing platform, named MiCaR, which couples a mi crofluidic device with CRISPR- C as12a a nd multiplex r ecombinase polymerase amplification. With only one fluorescence probe, MiCaR can simultaneously test up to 30 nucleic acid targets through microfluidic space coding. The detection limit achieves 0.26 attomole, and the multiplexed assay takes only 40 min. We demonstrate the utility of MiCaR by efficiently detecting the nine HPV subtypes targeted by the 9-valent HPV vaccine, showing a sensitivity of 97.8% and specificity of 98.1% in the testing of 100 patient samples at risk for HPV infection. Additionally, we also show the generalizability of our approach by successfully testing eight of the most clinically relevant respiratory viruses. We anticipate this effective, undecorated and versatile platform to be widely used in multiplexed nucleic acid detection.
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Nature Communications
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2022
·Vol. 13
·期 1
·1-15
·
IF 17.694
Hou Yun Nan,Cai Yang,Li Wan Hua,He Wei Ming,Zhao Zhi Ying,Zhu Wen Jie,Wang Qiang,Mai Xinyi,Liu Jun,Lee Hon Cheung,Stjepanovic Goran,Zhang Hongmin,Zhao Yong Juan
Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during axonal injury. Its activation mechanism is not fully understood. Here, we generate a nanobody, Nb-C6, that specifically recognizes NMN-activated SARM1. Nb-C6 stains only the activated SARM1 in cells stimulated with CZ-48, a permeant mimetic of NMN, and partially activates SARM1 in vitro and in cells. Cryo-EM of NMN/SARM1/Nb-C6 complex shows an octameric structure with ARM domains bending significantly inward and swinging out together with TIR domains. Nb-C6 binds to SAM domain of the activated SARM1 and stabilized its ARM domain. Mass spectrometry analyses indicate that the activated SARM1 in solution is highly dynamic and that the neighboring TIRs form transient dimers via the surface close to one BB loop. We show that Nb-C6 is a valuable tool for studies of SARM1 activation.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Tong Linjing,Huang Siming,Shen Yujian,Liu Suya,Ma Xiaomin,Zhu Fang,Chen Guosheng,Ouyang Gangfeng
Crystallization of biomacromolecules-metal-organic frameworks (BMOFs) allows for orderly assemble of symbiotic hybrids with desirable biological and chemical functions in one voxel. The structure-activity relationship of this symbiotic crystal, however, is still blurred. Here, we directly identify the atomic-level structure of BMOFs, using the integrated differential phase contrast-scanning transmission electron microscopy, cryo-electron microscopy and x-ray absorption fine structure techniques. We discover an obvious difference in the nanoarchitecture of BMOFs under different crystallization pathways that was previously not seen. In addition, we find the nanoarchitecture significantly affects the bioactivity of the BMOFs. This work gives an important insight into the structure-activity relationship of BMOFs synthesized in different scenarios, and may act as a guide to engineer next-generation materials with excellent biological and chemical functions.
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NATURE CELL BIOLOGY
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2024
·
IF 17.3
Son Sung Min,Park So Jung,Breusegem Sophia Y.,Larrieu Delphine,Rubinsztein David C.
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus–cytoplasmic shuttling of p300/EP300 regulates mTORC1 activity in response to amino acid or glucose levels. Depletion of these nutrients causes cytoplasm-to-nucleus relocalization of p300 that decreases acetylation of the mTORC1 component raptor, thereby reducing mTORC1 activity and activating autophagy. This is mediated by AMP-activated protein kinase-dependent phosphorylation of p300 at serine 89. Nutrient addition to starved cells results in protein phosphatase 2A-dependent dephosphorylation of nuclear p300, enabling its CRM1-dependent export to the cytoplasm to mediate mTORC1 reactivation. p300 shuttling regulates mTORC1 in most cell types and occurs in response to altered nutrients in diverse mouse tissues. Interestingly, p300 cytoplasm–nucleus shuttling is altered in cells from patients with Hutchinson–Gilford progeria syndrome. p300 mislocalization by the disease-causing protein, progerin, activates mTORC1 and inhibits autophagy, phenotypes that are normalized by modulating p300 shuttling. These results reveal how nutrients regulate mTORC1, a cytoplasmic complex, by shuttling its positive regulator p300 in and out of the nucleus, and how this pathway is misregulated in Hutchinson–Gilford progeria syndrome, causing mTORC1 hyperactivation and defective autophagy.
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Advanced Fiber Materials
·
2024
·Vol. 6
·期 2
·501-511
·
IF 17.2
Xie Maowen,Yao Guang,Gan Xingyi,Zhang Chunhong,Zhang Tianyao,Wang Qian,Li Xinqin,Zhou Chenzheng,Zhao Kangning,Gao Min,Pan Taisong,Lin Yuan
Flexible electrochemical biosensors enable the in-situ monitoring and quantification of human biochemical constituents in molecular scale, spearheading and thriving the field toward precision medicine. However, specific biorecognition elements for multiplexed biomarkers detection, temperature stability and versatility need to be improved for higher adaption. Here, we propose a bioactive sensor patch comprising a non-enzyme Co 3 O 4 /carbon fiber-based biorecognition element and a temperature calibration unit. The optimized serpentine configuration renders the sensor intimate and seamless attachment with skin, operating robustly even subjected to 40% tensile strain. The fiber-based sensor could selectively monitor dopamine and lactic acid contents based on cyclic voltammetry and amperometry, respectively. The bioanalytical results at room temperature indicate that the electrochemical biosensor has a wide detection range (0.001–1.100 mM for dopamine and 2–35 mM for lactic acid), excellent selectivity and reproducibility (maximum error 3.2% for dopamine and 5.6% for lactic acid). In addition, temperature calibration contour maps of these two biomarkers are established in an ambient temperature range from 25 to 45 ℃. The continuously collected data could be aggregated and wirelessly transmitted to portable devices using an electrochemical signal transducer and an acquisition module, promising personalized and preventative health care in various scenarios. Graphical Abstract This work proposes a bioactive fiber-based sensor patch comprising a non-enzyme Co 3 O 4 /carbon fiber-based biorecognition element and a temperature calibration unit. The sole fiber-based sensor could selectively monitor dopamine and lactic acid contents based on cyclic voltammetry and amperometry, exhibiting a wide detection range, excellent selectivity and reproducibility with temperature calibration in an ambient temperature range from 25 to 45 ℃, promising personalized and preventative health care in various scenarios
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Advanced Fiber Materials
·
2024
·Vol. 6
·期 4
·1188-1211
·
IF 17.2
Yu Weikang,Guo Xu,Li Qingrui,Li Xuefeng,Wei Yingxin,Shao Changxuan,Zhang Licong,Wang Jiajun,Shan Anshan
Incorporating enzyme-resistant peptide sequences into self-assembled nanosystems is a promising strategy to enhance the stability and versatility of peptide-based antibacterial drugs, aiming to replace ineffective antibiotics. By combining newly designed enzymatic-resistant sequences with synthetically derived compounds bearing single, double, triple, or quadruple aromatic rings. A series of nanoscale antimicrobial self-assembled short peptides for the purpose of combating bacterial infections are generated. Nap* (Nap– D Nal–Nal–Dab–Dab–NH 2 , where Nap represents the 1-naphthylacetyl group) possesses the greatest clinical potential (GM SI = 23.96) among the peptides in this series. At high concentrations in an aqueous environment, Nap* spontaneously generates nanofibers to capture bacteria and prevent their evasion, exhibiting broad-spectrum antimicrobial effects and exceptional biocompatibility. In the presence of physiological salt ions and serum, the antimicrobial agent exhibits strong effectiveness and retains impressive resistance even when exposed to high levels of proteases (trypsin, chymotrypsin, pepsin). Nap* exhibits negligible in vivo toxicity and effectively alleviates systemic bacterial infections in mice. Mechanistically, Nap* initially captures bacteria and induces bacterial cell death primarily through membrane dissolution, achieved by multiple synergistic mechanisms. In summary, these advances have the potential to greatly expedite the clinical evolution of nanomaterials based on short peptides combined with naphthyl groups and foster the development of peptides integrated with self-assembled systems in this domain. Graphical Abstract
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危险品化学品经营许可证（带存储）