CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2024
·Vol. 40
·期 4
·730-736
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IF 3.1
Hu Lin,Tong Shengrui,Xu Yanyong,Zhang Hailiang,Yu Shanshan,Chen Meifang,Ge Maofa
Unsaturated ketones are typical oxygenated volatile organic compounds (OVOCs) with high reactivity, and are important precursors in air pollution. The sources of OVOCs are complex and include direct emissions and secondary oxidation formation of VOCs in the atmosphere. 2-Cyclohexen-1-one is a widespread substance, and is derived from the industrial catalytic oxidation of cyclohexene. In this paper, we investigated the rate constants of the chemical reactions of 2-cyclohexen-1-one with NO 3 radicals, which is (7.25±0.29)×10 −15 cm 3 ·molecule −1 ·s −1 at 298 K and under 1 atm (1 atm=101325Pa). It supplemented the kinetics of NO 3 radicals database, and revealed its effects in the nighttime atmosphere. In addition, the reaction products of 2-cyclohexen-1-one with NO 3 radicals were detected by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), which revealed a series of nitrate esters in the composition of the secondary organic aerosol (SOA), which may reduce atmospheric visibility. Finally, the possible pathways for the generation of the products were developed.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Nan Hu,Meng Sun,Nan Lv,Yangyang Gao,Xiaohong Fu,Dayi Xing,Xiang Guo,Shaodong Zhai,Ruiping Zhang
Myocardial infarction (MI) is the leading cause of death worldwide. The most effective way to treat myocardial infarction is to rescue ischemic cardiomyocytes. After an ischemic event, the overproduction of reactive oxygen species (ROS) is a key driver of myocardial injury. The produced ROS affects mitochondrial function and induces apoptosis in cardiomyocytes. This was accomplished by constructing platelet-membrane-encapsulated ROS-responsive drug-releasing nanoparticles (PMN@NIC-MalNPs) to deliver malonate and niclosamide (NIC). The results revealed that PMN@NIC-MalNPs degraded and released malonate and niclosamide in a high-level ROS microenvironment, effectively reducing the oxidative stress and apoptosis rate. By enhancing basal mitochondrial oxygen consumption rate (OCR), adenosine triphosphate (ATP) production, and spare respiratory capacity (SRC) in vitro, reduced the oxidative stress levels and restored mitochondrial function. In vivo studies revealed that the PMN@NIC-MalNPs improved cardiac dysfunction, inhibited succinate dehydrogenase (SDH) activity, increased ATP production, and reduced the myocardial infarct size in myocardial infarction model mice. Further, transcriptome analysis and Western blot revealed that PMN@NIC-MalNPs prevented apoptosis by activating the expressions of the signal transducer and activator of transcription 3 (STAT3) and Bcl-2, and inhibiting the expression of Bax. Thus, this study provides a novel therapeutic solution for treating myocardial infarction and predicting the viability of an antioxidant and antiapoptotic therapeutic solution in the treatment of myocardial injury.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Duo Xu,Bowen Du,Yantian Ji,Huimin Sun,Tiecheng Wang,Xianqiang Yin
The study examined the transport behavior of the 2-aryl propionic acid (2-APA) chiral pharmaceutical enantiomers by means of a laboratory-scale saturated quartz sand column experiment. Four typical of 2-APA and their enantiomers were selected for the study under different types of chiral organic acids (COAs)-mediated effects. Differences in the transport of the 2-APA enantiomeric pairs have been identified in response to various pH, types of COAs, and enantiomeric structures of COAs. Redundancy analysis identified the factors responsible for the largest differences in transport of 2-APA enantiomeric pairs, while spectroscopic characterization and density function theory (DFT) studies elucidated the underlying mechanisms contributing to the differences in transport of enantiomeric pairs. Obvious correlations among homochirality or heterochirality between COAs and 2-APA enantiomeric pairs were observed for changes in the mobility of 2-APA. The results indicate widespread COAs significantly affect the transport behavior of chiral man-made chemicals, suggesting more attention is needed to fill the gap in the perception of the transport behavior of chiral compounds.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
·
IF 2
Xin Yin,Jing Wang,Shufeng Shen
The water-lean absorbent of dimethyl sulfoxide (DMSO)/2-(butylamino)ethanol (BAE)/H2O has recently been proposed for energy-efficient CO2 capture. The CO2/N2O analogy method can provide important fundamental data for its kinetic study. In this work, the physical solubility of N2O and CO2 in DMSO was measured in a static equilibrium cell at temperatures of (293.15–333.15) K. Solubility of N2O in BAE and the BAE/DMSO binary blends with 22.6, 34.9, and 61.8 mass % BAE was also determined. The effect of the water content on N2O solubility in the water-lean ternary blends with 61.8 mass % BAE was also discussed. The ratios of solubility of CO2 to N2O in polar solvents (i.e., DMSO and water) were found to be very close at temperatures of 323–333 K. Experimental solubility data and the ones calculated from the recommended correlation models match well with each other, with average absolute relative deviations within 0.9%.
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BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Chunxia Chen,Shujie Duan,Jianing Ji,Mengli Wu,Zhan Yang,Mengyang Cai,Menghan Xue,Lanju Wang,Rui Chen,Sima Yaron,Keying Guo,Sergio Benardini,Zhizeng Wang,Yang Luo
Conventional point-of-care lateral flow immunoassays are characterized by an antibody-tagged probe irregular coupling that can limit sensitivity and require a long assay’s time. We synthesized polyethylene glycol-modified selenium nanoparticles (PEG-SeNPs) by template method and developed a strategy to set antibody probes targeted and orderly by using PEG-SeNPs. Synthesized PEG-SeNPs with high stability could immobilize antibodies in the “stand-up” orientation, resulting in a faster detection time of less than 1 min by direct observer visualization without instruments or equipment. Results showed that SARS-CoV-2 antibody could be systematically structured on the chip, resulting in a detection limit of 10 pg/mL, significantly higher than conventional chips. The new device has been validated on 192 clinical samples and we found 100% negative coincidence, 93.94% positive coincidence, and 95.83% overall coincidence with reverse transcriptional PCR test. The orderly arrayed probe’s stability allowed to detect throat swabs, saliva, serum, fingertip blood samples, and mutant strains without cross-reactivity with common respiratory viruses or pathogenic strains, demonstrating promising potential for a universal colorimetric platform for ultrafast field-deployable diagnostics.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ruihong Dong,Yuting Wang,David Julian McClements,Qiang Yu,Jianhua Xie,Huijie Zhang,Lizhi Huang,Bin Li,Jinlong Tian,Yi Chen
This study investigated intestinal absorption and cellular antioxidant efficacy of anthocyanin (ACN)-loaded ovalbumin (OVA)-carrageenans (ι-, λC)/dextran sulfate (DS) nanocomplexes. Utilizing Caco-2 cells, we assessed endocytic pathways, intracellular trafficking, and delivery efficacy of ternary nanocomplexes. ACN-loaded nanocomplexes could be internalized by cells in a time-, dose-, energy-dependent manner, with macropinocytosis, lipid raft/caveolae, and actin co-mediated endocytosis routes playing pivotal roles. Nanocomplexes inhibited P-glycoprotein efflux of Rhodamine-123, enhancing the apparent permeability of ACN into cells, especially for OVA-ιC-ACN. Transport pathways of ACN-loaded nanocomplexes through Caco-2 monolayers involved different organelles including microtubules, Golgi complexes, endoplasmic reticulum, and lysosomes. Compared to free ACN, nanocomplexes exhibited more efficiency in recovering cellular viability and endogenous antioxidant enzyme activities under oxidative stress. Our findings provide a more comprehensive understanding of internalization, transport mechanisms of protein-polysaccharide-anthocyanin nanocomplexes across epithelial cell monolayers, and provide valuable insights for designing efficient ACN-loaded nanocomplex systems with high transportation efficiency and intestinal absorption.
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ELECTROCHIMICA ACTA
·
2025
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IF 5.6
Tao Huang,Yongwei Chen,Xiangzhen Zheng,Ying Pan,Maoxiang Wu
Layered lithium-rich oxides(LRO) materials have garnered significant attention due to their high reversible capacity and broad operating voltage range. However, the practical application of LRO materials is still restricted by the serious interfacial instability and surface structure reconstruction during long-term cyclic test. In this study, we use 2-(Trimethoxysilyl)ethyl methacrylate (TSM) as a multifunctional electrolyte additive to enhance the electrochemical performance of the Li/LRO cell. The capacity retention of the Li/LRO cell improves significantly from 67.2 % to 85.8 % after 100 cycles at 0.5C (1C = 300 mAh g -1 ) between 2.0 and 4.8 V with the addition of 2 % TSM. Under harsh conditions (with the addition of 1000 ppm H 2 O to the electrolytes), Li/LRO cell with TSM additives maintains the capacity retention of 82.5 % after 100 cycles, which is significantly higher than the cell without additives (38.0 %). Both theoretical calculations and experiments results demonstrate that TSM exhibits higher oxidation activity than the solvents, forming a uniform cathode electrolyte interphase (CEI) on the LRO surface. The TSM-derived CEI layer effectively mitigates the interfacial parasitic reactions and prevents structural degradation of LRO. Furthermore, theoretical calculations and nuclear magnetic resonance (NMR) results confirm that TSM effectively eliminates water (H 2 O) and hydrofluoric acid (HF), mitigating their adverse effects.
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MATERIALS & DESIGN
·
2024
·
IF 7.6
Shuai Guo,Shun Yao,Huanchun Xing,Wenbin Cao,Jianyu Wang,Xinran Zhao,Yajing Wei,Ruizhi Lin,Xin Sui,Yuan Luo,Jun Deng,Jun Yang,Yongan Wang
Sulfur mustard (2,2′-dichloroethylsulfide; SM) is a bifunctional alkylating agent that can easily penetrate skin and cause persistent pain and damage. Effective biological dressings are required to treat wounds caused or poisoned by SM. Though the use of SM is regulated under the Chemical Weapons Convention, it is still a threat during wars and terrorist attacks. Herein, we present a photothermal-enhanced detoxification microneedles array (MNA) encapsulated with ZnIn 2 S 4 @UiO-66-NH 2 (ZnInS/UIO) catalysts for the treatment of 2-chloroethyl ethyl sulfide (CEES, SM analog)-poisoned wounds under simulated sunlight (SSL) irradiation. Due to the excellent photothermal detoxification capability possessed by ZnInS/UIO, the conversion rate of CEES can be significantly increased under SSL exposure. When encased in a polyvinyl alcohol (PVA) MNA and piercing into the skin, ZnInS/UIO catalysts can be released quickly from MNA for detoxification. After applying the resultant ZnInS/UIO-MNA to the CEES-poisoned wound bed, acceleration of the wound healing process and a reduced inflammatory response can be confirmed. In conclusion, ZnInS/UIO-MNA has encouraging potential as a first-aid dressing for CEES-poisoned wound healing in battlefields and injuries related to acts of terrorism.
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ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 32
·期 4
·2106341
·
IF 18.808
Chao Chen,Wu Bin Ying,Jiayi Li,Zhengyang Kong,Fenglong Li,Han Hu,Ying Tian,Do Hwan Kim,Ruoyu Zhang,Jin Zhu
Ionic skin (I-Skin) has the advantage of feasible compatibility with biological systems. Nevertheless, developing a stable and durable ionic skin is challenging. Here, an ionic polyurethane (i-PU) is synthesized, which is capable of self-healing and able to lock the ionic liquids (ILs). In detail, an ionic chain extender containing an ammonium cationic group is synthesized, followed by the polymerization to obtain the target i-PU. Through electrostatic interaction and chain diffusion, the i-PU can be fully self-healed at room temperature within 400 min. Afterward, low contact angle (37°) of the i-PU against IL and the density functional theory (DFT) calculation prove their good compatibility and strong interaction, originating from the electrostatic interaction. The Raman intensity map shows the reversible process of the enrichment and restoration of ionic concentration on the i-PU/IL surface when external pressure is applied or released, proving stable binding of ions by ionic polymer chains. Lastly, the self-healing I-Skin based on the i-PU/IL is fabricated with a wide range of pressures (0–120 kPa), fast response time (32 ms), excellent antifatigue property (2% attenuation after 1000 cycles), and remarkable sensitivity (52.4 kPa –1 ).
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AICHE JOURNAL
·
2025
·
IF 4
Yulin Li,Qian Liu,Ke Wang,Kunchi Xie,Xiangyi Kong,Zhen Song,Zhiwen Qi,Hongye Cheng
Efficient separation of high water-content azeotropes such as 1-methoxy-2-propanol (PGME) and water is crucial but challenging. Herein, a green and low-energy hybrid extraction-distillation process was developed using dibutyl oxalate (DBO) as the extractant. Experimental evaluations revealed the superior performance of DBO with high selectivity and minimal solvent loss at various PGME concentrations. Mechanistic studies via molecular simulations and FT-IR analyses demonstrated that hydrogen bonding between the carbonyl group of DBO and the hydroxyl group of PGME drives the selective extraction. Process simulation indicated a 37.0% reduction in solvent circulation, 52.6% in energy consumption, and 57.9% in carbon footprint compared to conventional benzene-based azeotropic distillation. Life cycle assessment further confirmed the environmental benefits of DBO, highlighting its low toxicity, biodegradability, and renewable synthesis potential. This work presents a sustainable and cost-effective strategy not only for PGME-water separation but also for other high water-content azeotropes separation.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Dawei Lu,Wen Meng,Xiaowei Wen,Feng Li,Taohai Li
Herein, an Ag/Ni(dmgH) 2 photocatalyst was constructed through a controllable silver modification strategy. The combination of the local surface plasmon resonance (LSPR) effect of Ag nanoparticles and the synergistic catalytic effect of Schottky junctions significantly enhanced photogenerated carrier separation. Under optimized conditions, the Ag/Ni(dmgH) 2 system achieved a remarkable hydrogen evolution rate of 922.2 μmol/g/h under visible light, approximately 16.7 times higher than the unmodified system. Furthermore, the Ag/Ni(dmgH) 2 film fabricated via screen-printing technology effectively utilized enhanced light absorption from LSPR and efficient interfacial electron transport from Schottky junctions, achieving degradation rates of 98.9 % for Rhodamine B and 86.9 % for Quinoline Blue. The film retained 86.9 % of its activity after four cycles, demonstrating excellent recyclability. This work highlights the dual application potential of Ni(dmgH) 2 materials for photocatalytic energy conversion and environmental remediation.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Mintong Tian,Huan Gao,Purui Yu,Mingming Li,Zehua Li,Qipeng Yuan
Sulforaphane (SFA), an isothiocyanate compound derived from cruciferous plants, has garnered significant attention owing to its cancer-preventive, anti-inflammatory, and antibacterial properties. However, the presence of complex impurities, including hydrolysis by-products of glucosinolates, structural analogues of SFA, and 5-vinyl-2-thioxazolidinone (VOT), in plant extracts significantly hinders both the efficiency of purification and the safety of application. In this study, 14 compounds were successfully isolated and identified from broccoli seed extracts using preparative high-performance liquid chromatography. Additionally, an efficient separation method was developed for removing the crucial impurity VOT based on the temperature-responsive properties of β-cyclodextrin (β-CD). The results demonstrated that the selective binding of β-CD to SFA at elevated temperatures achieved a VOT removal efficiency exceeding 97% following low-temperature precipitation. Additionally, the purity of SFA was enhanced from 55.8% to 90.1%. The separation mechanism at the molecular level was validated through density functional theory calculations. The binding energy of β-CD-SFA (-81.2 kJ/mol) was significantly higher than that of β-CD-VOT (-25.6 kJ/mol). The scanning electron microscopy and energy dispersive spectroscopy results confirmed the homogeneous distribution of SFA within the complexes. This study provides an innovative approach for the large-scale preparation of high-purity SFA and ensures its safe application in functional foods.
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