COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
·
IF 5.4
Rutong Song,Yurong Wu,Fei Zhong,Chunlin Chen,Zhikui Huang,Yaqi Ren,Wei Li,Jie Cao,Yichao Ding
Cu-doped PDA and PA were grafted onto GO to form a P-N-rich barrier (GPCu/PA). • Co-Fe/B nanosheets were grown on GPCu/PA to construct a hierarchical structure. • Multi-metal (Cu, Co, Fe) and boron synergistically enhance char formation and stability. • The hierarchical filler provides physical barrier, radical quenching, and catalytic charring. Water-based intumescent epoxy coatings for steel structures face challenges in simultaneously achieving high-efficiency flame retardancy, smoke suppression, thermal insulation, and long-term environmental durability. In this study, a hierarchical GPCu/PA/Co-Fe/B hybrid flame retardant was developed by sequentially grafting Cu 2+ -chelated polydopamine (PDA) and phytic acid (PA) onto graphene oxide (GO), followed by the in situ growth of Co-Fe/B nanosheets. This ingeniously designed structure integrates the layered barrier effect of GO, the catalytic charring capability of PDA and transition metal species, the phosphorus-promoted expansion effect of PA, and the protective effect of boron-containing compounds. Through these synergistic effects, the hybrid system facilitates the formation of a dense and stable char layer, thereby effectively suppressing heat conduction, oxygen diffusion, and the release of flammable volatiles during combustion. When incorporated into water-based epoxy coatings, just 2 wt% of GPCu/PA/Co-Fe/B significantly improves flame-retardant performance by reducing the back-surface temperature by 36.3%, increasing the char layer expansion height by 244.9%, and enhancing smoke suppression capabilities. The cone calorimeter test further confirmed the reduced heat release, smoke generation, and toxic gas emissions achieved by this coating, demonstrating its outstanding fire safety performance. Additionally, water immersion and UV-accelerated aging tests showed that even after environmental exposure, the coating maintained low water absorption, structural integrity, and flame-retardant properties, indicating excellent durability and weather resistance. This study provides a highly promising strategy for developing multifunctional, tiered flame-retardant systems for durable water-based intumescent coatings designed for fire protection of steel structures. Download: Download high-res image (370KB) Download: Download full-size image
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JOURNAL OF MEDICINAL CHEMISTRY
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2026
·
IF 7.3
Hongwei Li,Huiying Zhuang,Dianxi Zhang,Tingting Qiu,Lu Liu,Ziyi Sunyang,Yuqiang Han,Rilei Yu,Guanzhao Wu,Ruijuan Yin,Tao Jiang
Mitogen-activated protein kinase-interacting kinase (MNK), a pivotal kinase downstream of MAPK signaling, is currently the only enzyme reported to be capable of phosphorylating eIF4E. This study first confirmed that MNK silencing in LPS-stimulated macrophages inhibits eIF4E phosphorylation, inflammatory polarization, and cytokine release. Based on the prior discovery that the imidazo[2,1-b][1,3,4]thiadiazole skeleton can effectively inhibit the MNK kinases, this study further designed and synthesized a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives modified with sulfonyl or phosphoryl groups. Among these derivatives, compound 13 potently and selectively inhibited MNK1/2 (IC50 = 10.84/12.81 nM), exerted dose-dependent anti-inflammatory effects in LPS-induced RAW 264.7 cells, and alleviated kidney and spleen damage in the mouse model of LPS-induced inflammation. Mechanistically, 13 suppressed eIF4E phosphorylation, NF-κB signaling, and macrophage polarization, thereby reducing pro-inflammatory cytokines and oxidative stress. These results suggest that MNK inhibition is a promising strategy for treating inflammatory diseases by targeting both inflammation and oxidative stress.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Zichen Zhuang,Xiaoyu Zhang,Ting Chen,Zuzhi Huang,Guozhu Zheng,Baoshui Wu,Guangjun Zhang,Xiaofeng Ye,Lang Xu,Shaorong Wang
Co/Sr-based perovskite oxides are extensively utilized as cathodes for both solid oxide fuel cells (SOFCs) and protonic ceramic fuel cells (PCFCs), mainly because of their excellent oxygen reduction reaction (ORR) activity and superior electrical conductivity. However, the high cost and intrinsically unstable nature of Co, coupled with Sr segregation tendency, severely degrade the long-term durability of these cathode materials. In this study, a Co/Sr-free perovskite oxide, Ba 0.95 La 0.05 Fe 0.95 Zr 0.05 O 3-δ (BLFZ), was designed and synthesized via rational doping of 5% high-valent Zr 4+ cation at the B-site of Ba 0.95 La 0.05 FeO 3-δ (BLF) as a bifunctional mixed-conducting cathode material. Systematic measurements coupled with density functional theory (DFT) calculations revealed that Zr incorporation effectively enhances the hydration capacity, CO 2 tolerance, oxygen-vacancy concentration, and ORR activity. As a result, excellent electrochemical performance was obtained with BLFZ-based composite cathodes on microtubular PCFCs and SOFCs, achieving peak power densities of 968 mW cm −2 at 700°C and 877 mW cm −2 at 800°C, respectively. The cells also showed favorable long-term stability for over 200 h. Collectively, these results highlight BLFZ as a robust and versatile cathode candidate for dual application in PCFCs and SOFCs.
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Cancer Management and Research
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2025
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IF 2.6
Mengzhu Chen,Jian Li,Shaodan Hu,Yuhan Wang,Keju Wang,Tan Wang
Background Lung cancer has high incidence and mortality rates. In consideration of the high toxicity and side effects of traditional chemical drugs and drug resistance, researchers have substituted some natural products for anti-lung cancer drugs. Ziziphi spinosae semen (ZSS) is a famous traditional Chinese herb, and ZSS-based formulas have been used against lung cancer in clinic, such as Xiaoyi Sanjie Formula. Jujuboside B (JUB) is one of the main bioactive components in ZSS; however, JUB’s roles in the treatment of lung cancer, and the mechanism have not been well reported.Objective This study intends to evaluate the effects of JUB on the proliferation and migration of non-small cell lung cancer H1299 cells (NC-1299 cells), as well as the potential related regulatory mechanism.Methods The viability, migration and invasive ability of NC-1299 cells were analyzed by CCK8, wound-healing, transwell invasion, and the expression of proteins was analyzed through Western blotting experiments.Results It showed that 160 and 320 μmol/L JUB significantly inhibited the proliferation of NC-1299 cells, reduced the cell migration in the wound healing test, and decreased the cell number of clonal assay (P < 0.05). JUB also significantly inhibited the expression of Vimentin, MMP2, and MMP9 proteins related to the migration and invasion of tumor cells, as well as inhibited the PI3K/AKT and Wnt/β-catenin pathways.Conclusion The results indicate JUB has a significant inhibitory effect on NC-1299 cells, and such inhibitory effect is associated with inhibiting the expression of migration and invasive proteins such as MMP2, as well as inhibiting the PI3K/AKT and Wnt/β-catenin pathways. The findings provide some references for the application of JUB in the substitution of anti-lung cancer drugs.
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ChemistrySelect
·
2025
·Vol. 10
·期 22
·e01437
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IF 2
Xinge Sun,Shiwei Xue,Shuhan Zhu,Shuan Tang,Bingbing Fan,Mingliang Li,Gang Shao,Hailong Wang,Hongliang Xu,Hongxia Lu
Graphical A hybrid Mn 2+ -based metal halide (HMMH) was synthesized by high-energy ball milling (HEBM) for 25 minutes. A- and B-site co-doping of Cs 3 MnBr 5 are designed to form a more stable luminescent center and a hydrogen-bonding system. Poor luminescence intensity of Mn 2+ metal halides produced by HEBM and poor thermal stability of HMMHs were solved. Mn 2+ -based metal halides are important materials in the study of lead-free metal halides because of their high luminous efficiency, extensive availability of raw materials, and nontoxicity. At present, the synthesis of Cs₃MnBr₅ is impeded by the presence of intricate processes and environmental pollution, and the formation of crystals exhibits poor stability and low photoluminescence (PL) intensity. In this paper, an Mn 2+ -based hybrid metal halide was synthesized by co-doping Cs 3 MnBr 5 at the A and B sites. This synthesis was conducted under high-energy ball milling conditions for 25 min, resulting in a material with high photoluminescence intensity and temperature stability. In the new system, a hydrogen bond system and a [MnBr z (H 2 O) 4- z ] 2- z structure with high-binding energy are constructed. PL intensity of [Cs 0.85 (C 7 H 17 N 2 ) 0.15 ] 3 Mn 0.8 Mg 0.2 Br 5 · (6H 2 O) 0.2 is 302% of the initial value of Cs 3 MnBr 5 . The high-temperature thermal stability test of the samples was conducted using a platform constructed in our laboratory. The results demonstrated that the PL intensity after three rounds of thermal cycling is 374% of the initial value of Cs 3 MnBr 5 , which only decreases by 2.9% compared with the maximum. The solid-phase synthesis of Mn 2+ -based hybrid metal halides with excellent high-temperature luminescence stability has been realized, which shows a potential application prospect in the field of display.
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FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
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2023
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IF 2.3
Yongzheng Yin,Huanhuan Lu,Weijun Song,Xiaofeng Hu,Chunyan Sun
In this study, carbon quantum dots (CQDs) and rhodamine B (RhB) were physically mixed to construct a highly selective and sensitive ratiometric fluorescent sensor (CQDs@RhB) for the quantitative and visual detection of Hg2+. After adding Hg2+, the emission peak of CQDs at 445 nm was quenched and the peak of RhB at 575 nm remained unchanged; the ratio of the two emission peaks had a linear relationship with the Hg2+ concentration. The CQDs@RhB had a detection range of 0–15 µM and the limit of detection (LOD) is 65.93 nM and a color change from blue to pink was visible to the naked eye under ultraviolet light. The study revealed a static quenching mechanism of CQDs@RhB. The established method was successfully applied to the detection of Hg2+ in real water and rice samples with satisfactory results. In addition, a portable fluorescent paper-based sensor platform was developed using computer software assistance. The relationship with Hg2+ concentration was constructed by converting the pictures obtained under ultraviolet light to RGB color mode for visualization and quantitative detection of Hg2+. This study provides a valuable strategy for constructing a rapid detection system for Hg2+ in the field.
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FOOD CHEMISTRY
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2026
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IF 10.4
Qijun He,Wei Hu,Zhihao Yi,Bin Du,Yuan He,Jianjie Xu
Early and portable detection of foodborne pathogens is a key challenge for food safety, as conventional methods suffer from insufficient sensitivity and cumbersome operation. Herein, inspired by cellular compartmentalization, we designed the composite nanozyme MIL-88(Fe)@Pt@COF-B(OH) 2 (MPC-B(OH) 2 ) and constructed a dual-mode biosensing platform with Escherichia coli ( E. coli ) as the model. In this design, a catalytic MIL-88(Fe)@Pt core was encapsulated by a boronic acid-functionalized COF shell, which mimicked a cell membrane to provide specific recognition while optimizing the local microenvironment to enhance peroxidase-like activity, as clarified by density functional theory calculations. Meanwhile, its porous COF layer improved electrochemical performance. This sensor achieved detection limits of 2 and 3 CFU/mL for colorimetric/electrochemical modes, and 7 CFU/mL for on-site detection via a smartphone platform. With excellent selectivity, stability and reliability in real samples, this work provided a new strategy for biomimetic nanozyme design and a practical platform for on-site food safety monitoring.
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NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 9
·4277-4287
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IF 3.3
Jiaxin Mou,Yunlan Xu,Dengjie Zhong,Haixing Chang,Jun Li,Chunzi Xu,Hui Wang,Hongyu Shen
To expand the optical absorption range and charge transfer efficiency of photoanode, the ZnIn2S4/PANI/TiO2/Ti photoanode was developed using a coating method and applied in a photocatalytic fuel cell (PFC) system for the removal of organic pollutants and chemical energy recovery. The prepared photoanode obtained a maximum photocurrent density of 4.19 mA cm−2 (1.2 V vs. SCE). The rhodamine B (RhB) removal efficiency, maximum power density (Pmax) and short-circuit current density (Jsc) of PFC constructed with the ZnIn2S4/PANI/TiO2/Ti composite photoanode and Cu cathode were 93.80% (1 h), 18.83 μW cm−2 and 0.26 mA cm−2, respectively. The improved photocatalytic activity of PFC was due to the outstanding photoelectric properties of the ZnIn2S4/PANI hybrid material, in which PANI, as a photosensitizer, promoted the absorption of visible light by the photoanode. The photoexcited electrons of ZnIn2S4 and PANI tend to be directly transferred to the CB of TiO2, while holes accumulate in the VB of PANI to participate in the oxidation reaction. The synergistic effect accelerates the separation of photogenerated electron–hole pairs and improves the photoelectric conversion efficiency of PFC.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2022
·
IF 4.644
Muhammad Khalid Hussain,N.R. Khalid,M.B. Tahir,Muhammad Tanveer,Tahir Iqbal,Maira Liaqat
A novel ternary ZnO/CuO/MoO 3 (ZnO/CuO/M) heterojunction photocatalysts with the nanorods morphology was synthesized by facile hydrothermal treatment . The surface morphology as nanorods, optical properties , photogenerated separation/transfer of charge carriers and photocatalytic properties were characterized for all developed photocatalysts. The photodegradation of organic pollutants including rhodamine B (RhB) and alizarin yellow (AY) dyes was studied under the visible light irradiance. The ternary ZnO/CuO/M nanorods revealed improved photocatalytic performance than pristine ZnO, CuO, MoO 3 and binary CuO/M composite. Amongst all ternary ZnO/CuO/M photocatalysts displayed the best photocatalytic activity for RhB (97%) and AY (79%) dyes within 120 min, which is 57 times and 64 times higher than that of pristine MoO 3 . Reactive trapping experiments were also executed qualitatively to perceive the characters of different active species for both dyes degradation. The improved photocatalytic presentation could be credited to the development of the ZnO/CuO/M heterojunction photocatalysts, which is advantageous for efficient fast transfer and separation of the photoexcited charge carriers.
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Advanced Sustainable Systems
·
2022
·Vol. 6
·期 5
·2100436
·
IF 6.737
Xiaolin Ren,Yuchen Tian,Firdoz Shaik,Jine Yang,Rong Liu,Kaiming Guo,Bin Jiang
Iron group metal phosphides (IMPs) are one of the most promising substitutes for non-noble electrocatalysts in overall water splitting. In this work, an electrocatalyst system consisting of different vertically aligned heteroatom-doped graphene arrays (X-rGO, X = N, P, B, O, S) integrated with FeCoNiP nanoparticles (FeCoNiP@X-rGO, X = N, P, B, O, S) is prepared for overall water splitting. The unique vertical structure and the synergistic effect between the P in P-rGO and the P in FeCoNiP leads to the excellent electrocatalytic performance of FeCoNiP@P-rGO by exhibiting low overpotentials (121 and 216 mV) at a current density of 10 mA cm −2 for hydrogen evolution reaction in 1 m KOH and 0.5 m H 2 SO 4 , respectively. As well as a low overpotential (354 mV) at a current density of 10 mA cm −2 for the oxygen evolution reaction in 1.0 m KOH. The FeCoNiP@P-rGO electrocatalyst exhibits an outstanding durability toward overall water splitting in alkaline electrolytes, and excellent Faraday efficiency (about 92%) as well. This work provides an insight in proper tuning and the development of appropriate substrates for IMPs and other transition metal compounds toward cost-effective and high efficiency electrocatalysts for water splitting reactions.
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MICROCHEMICAL JOURNAL
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2022
·
IF 5.304
Chenhui Yin,Meng Wu,Ting Liu,Lixing Fu,Qijun Sun,Ligang Chen,Na Niu
A sensitive and effective strategy for the screening of α-glucosidase and its inhibitors was established based on carbon quantum dots (CQDs) and vanadium oxide nanoribbons. B,S,N co-doped CQDs (BSN-CQDs) were prepared by one-step microwave hydrothermal method using o-phenylenediamine, boric acid, and thiourea as raw materials. The prepared CQDs emitted yellow fluorescence (λ em = 565 nm) under excitation of 410 nm, and the quantum yield was 15.3%. The fluorescence of CQDs was firstly quenched by the vanadium oxide nanoribbons via inner filter effect. Then, 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA2G) was introduced as a substrate of α-glucosidase to produce ascorbic acid (AA). Vanadium oxide nanoribbons could be converted to V 4+ by AA, which led to fluorescence recovery. After adding inhibitors (anti-diabetic drugs), the α-glucosidase activity was inhibited and the degree of fluorescence recovery was reduced. The established nanoprobe showed a response linearity to α-glucosidase in the range of 0.01–5 U mL −1 , with a low detection limit of 0.003 U mL −1 . This platform was applied for the screening of acarbose, with a detection limit of 0.02 μM. The constructed sensing strategy had the advantages of high selectivity, sensitivity, and was successfully used for α-glucosidase detection in serum samples and anti-diabetic drugs screening.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 41
·15797-15805
·
IF 4.569
Jiawei Wu,Bangfu Ding,Xin Qian,Liang Mao,Huibin Zheng,Lei Zhang,Shukai Zheng,Junying Zhang
The Bi2MoO6 nanosheets are loaded on to γ-Bi2O3 tetrahedron surfaces to form Bi2MoO6/γ-Bi2O3 heterojunctions using a simple calcination method. The photocatalytic degradation efficiencies of the lomefloxacin and the Rhodamine B using the optimum sample are 96% and 99%, respectively, much higher than that of pure phase samples. When the waters from different regions in China were used as solvents, the removal efficiencies of the lomefloxacin and the Rhodamine B are still higher than 88% and 90%, respectively, which shows excellent prospects for practical applications. The photocatalytic degradation efficiencies of these two pollutants are higher than 91% and 95% in the five cycling tests, and the crystal structure of the sample is not changed after cycling. Based on the first-principles calculation, Bi2MoO6 and γ-Bi2O3 form a Z-type energy band structure which accelerates the separation of the photogenerated charge carriers. The Bi2MoO6 valence band potential of 3.25 V and the γ-Bi2O3 conduction band potential of −0.21 V are reserved to generate ˙OH− and O2−, respectively, for the photocatalytic reaction. The degradation of the lomefloxacin is ascribed to the shedding of functional groups and bond breaking with the final products being CO2, F−, H2O, and NO3−. This research shows that Bi2MoO6/γ-Bi2O3 heterojunctions can be employed to purify domestic and textile industrial sewage.
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