Food Bioscience
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2026
·
IF 5.9
Lixia Ma,Dina Chang,Jiaxin Lv,Yan Yan,Anxu Zheng,Xuehang Wang,Yue Leng,Bin Jiang,Dayong Ren,Ji Wang
Walnuts are nutrient-dense with diverse physiological functions. This study developed a walnut-milk dual-protein yogurt (WY) using Lactiplantibacillus plantarum JLAU103, investigating its refrigerated storage (4 °C) properties, microstructure, volatile profile, sensory traits, antioxidant activity, and isolating antioxidant peptides. The WY exhibited excellent storage stability over a 21-day period, maintaining an optimal and stable pH range of 4.48–4.78 and titratable acidity of 63.3–72.66 °T. Compared with the MY control, WY showed markedly reduced syneresis, enhanced water-holding capacity, and superior textural and viscosity properties, while sustaining viable L. plantarum JLAU103 populations above 10 7 CFU/mL. Rheological and microstructural analyses showed WY had higher elastic (G′)/viscous (G″) moduli and a denser protein network, enhancing gel stability. WY contained 200 volatile compounds, with higher aldehydes/furans (key for nutty/roasted aromas) and better sensory acceptability than MY. Ultrafiltration fractionated WY proteins into <3 kDa (superior antioxidant) and 3–10 kDa fractions; the <3 kDa fraction was purified to sub-fraction B1, which exhibited strong radical scavenging (ABTS + : 15.86 %, DPPH: 53.48 %, •OH: 48.21 %) and Fe 2+ chelating (98.23 %) capacities. Nano-LC-MS/MS identified 1972 peptides in B1, 10 peptides with predicted antioxidant activity via BIOPEP-UWM. Peptide GPYHFR bound Aβ 1-42 oligomers (−7.7 kcal/mol), showing potential to mitigate memory impairment. This study provides a theoretical/technical basis for high-quality functional walnut fermented dairy products and walnut bioactive peptide exploitation.
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Materials Today Bio
·
2026
·
IF 10.2
Henan Xu,Yuxin Jiang,Ruohao Zhang,Daguang Wang,Jing Feng,Hongjie Zhang
Chemotherapy and photothermal therapy (PTT) have made prominent progress in the treatment of gastric cancer. However, the poor targeting of chemotherapeutic drugs and the thermotolerance or collateral damage induced by PTT lead to suboptimal therapeutic outcomes. To address these issues, we developed a mild PTT (mPTT) nanoparticle based on mesoporous polydopamine (MPDA), loaded with oxaliplatin (OXP) and manganese dioxide (MnO 2 ), and coated with tumor cell membranes to enhance the targeting capability. On one hand, this nanoparticle disrupts glycolysis by inhibiting hypoxia-inducible factor (HIF), while suppressing heat shock proteins (HSP) to mitigate tumor "thermotolerance." On the other hand, the reactive oxygen species (ROS) generated by the MnO 2 -mediated Fenton-like reaction, OXP, and mPTT also induce immunogenic cell death (ICD) to boost adaptive immunity, as well as activate the cGAS-STING pathway through tumor DNA damage to reinforce innate immunity. The activation of both adaptive and innate immune responses triggers a potent antitumor immune reaction, which, combined with chemotherapy and enhanced mPTT, significantly suppresses tumor growth, metastasis and recurrence. This strategy not only enhances the targeting of chemotherapeutic drugs but also provides new possibilities for expanding the field of immunotherapy in gastric cancer by regulating tumor metabolism and enhancing mPTT.
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Food Biophysics
·
2026
·Vol. 21
·期 1
·9
·
IF 3.2
Yu Xiaohong,Liu Yanli,Zhao Xin,Liu Jinbin,Dai Xujia,Zhao Xia,Shang Yueling
Sea buckthorn polyphenols demonstrate significant lipid-lowering potential. Although probiotic fermentation has been shown to enhance the bioactivity of food matrices, its effect on the lipid-lowering function of sea buckthorn juice—particularly regarding the cholesterol esterase inhibition mechanism—remains unclear. Optimized fermentation increased total phenolic and total flavonoid contents to 0.531 mg/g and 0.926 mg/g, respectively, while enhancing antioxidant activity (hydroxyl radical scavenging activity reached 90.13%, metal ion-chelating activity of 69.82%), and increased the inhibition rates against lipase (from 87.13% to 98.13%) and cholesterol esterase (from 94.13% to 98.13%). Among polyphenolic components, conjugated phenols exhibited the strongest inhibitory activity (84.1%). Enzyme inhibition and kinetic studies demonstrated that conjugated phenols effectively inhibit cholesterol esterase. Fermented conjugated phenols exhibited competitive inhibition, whereas unfermented conjugated phenols demonstrated mixed inhibition. Fluorescence quenching experiments confirmed that fermentation-derived conjugated phenols form more stable complexes with cholesterol esterase through dynamic quenching, indicating higher binding affinity. In summary, sequential fermentation serves as an effective bioprocessing strategy. By generating competitive inhibitors of cholesterol esterase, it enhances the lipid-lowering activity of sea buckthorn juice, providing a theoretical basis for developing fermented functional beverages to manage hyperlipidemia. Graphical
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ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Qianjun Su,Hui Duan,Qiyan Li,Mengdan Zhang,Pan Liu,Huixue Chen,Weili Li,Ping Liu,Chunlin Chen,Ruiyuan Liu,Pengfei Li
Persistent infection with high-risk HPV in women can progress to cervical intraepithelial neoplasia and even cervical cancer. This study investigated the cytotoxic and immunomodulatory effects of the TBTCN-TDG photodynamic therapy (PDT) probe in treating HPV-associated cervical lesions. The TBTCN-TDG probe was designed by integrating a donor-acceptor-π-acceptor 1 (D-A-π-A1) structure (TBTCN) with TDG, a moiety targeting Galectin-1, and its targeting ability in HPV-positive SiHa cells was confirmed. The in vitro results demonstrated that TBTCN-TDG combined with light treatment significantly inhibited SiHa cell proliferation, increased apoptosis, and activated immune responses by stimulating dendritic cells, macrophages, and NK cells, through enhanced NF-κB pathway signaling. In vivo, this targeted photosensitizer exhibited substantial therapeutic effects under laser excitation, as evidenced by TUNEL staining, which showed increased apoptosis in lesions. Immune analysis indicated that TBTCN-TDG enhanced NK cell viability and elevated the levels of pro-inflammatory cytokines under laser excitation, such as TNF-α, IFN-γ, and IL-6, confirming immune response activation. In conclusion, the combination of TBTCN-TDG and PDT effectively targets cells infected with HPV, enhances immune responses, and suppresses HPV infection. This suggests a novel therapeutic strategy for photodynamic immunotherapy in patients with cervical high-risk HPV infections.
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JOURNAL OF MOLECULAR STRUCTURE
·
2026
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IF 4.7
Renzhang Liang,Kun Hu,Xia Qiao,Chao Xu,Shue Gu,Rui Ping,Jiayue Liu,Xu Zhang,Lu Ding,Bingren Tian
β-acids, one of the primary active components in hops, possess notable antioxidant, anti‑inflammatory, and neuroprotective activities. Their encapsulation into biodegradable poly(lactic‑co‑glycolic acid) (PLGA) nanoparticles represents a promising approach for the treatment of neurological disorders. In this study, β‑acids were first loaded into PLGA to form negatively charged nanoparticles, followed by surface modification with quaternized chitosan (CSTM) to obtain composite nanoparticles (β‑acids@PLGA/PVA@CSTM). After CSTM coating, the average particle size increased to approximately 500 nm, while the zeta potential shifted to +33.5 mV. The encapsulation efficiency and loading capacity were 39.14 % and 7.09 % for β‑acids@PLGA/PVA, and 30.27 % and 8.41 % for β‑acids@PLGA/PVA@CSTM, respectively. In vitro release studies revealed a pH‑responsive release pattern, with CSTM modification further imparting a sustained‑release profile. Biosafety assessments showed no significant cytotoxicity in NCM460 or PC12 cells at concentrations ranging from 5 to 80 μg/mL. Proliferation assays demonstrated that β‑acids@PLGA/PVA@CSTM effectively promoted PC12 cells growth. Molecular docking analysis suggested that β‑acids interact with key signaling proteins involved in PC12 cells proliferation pathways, indicating a potential mechanism through modulation of protein expression. Together, these results underscore the potential of CSTM‑modified PLGA nanoparticles as a sustained‑release delivery system for β‑acids, supporting their further investigation in neuronal proliferation and related applications.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
·
IF 5.4
Yiyu Yang,Yifan Liu,Yuenan Zhang,Aiguo Wu,Changyong Gao,Yujie Zhang
Uric acid (UA) serves as a crucial biomarker, its abnormal levels can lead to various diseases, including gout and Parkinson's disease. Consequently, the rapid detection of UA in biofluids is essential for clinical diagnosis, monitoring and disease prevention. This study developed a convenient colorimetric assay for the detection of UA using gold nanorods (Au NRs) based on the reductive property of UA and using I 3 - as an oxidative etchant. At room temperature, I 3 - oxidatively etched Au NRs, prompting a blue shift in the longitudinal localized surface plasmon resonance (LSPR) absorption peak of Au NRs, altering solution color from blue to pink. As a reducing agent, UA is capable of inhibiting the etching process of Au NRs induced using I 3 - through redox reaction, thereby preserving the original color of the solution. This detection strategy displays good selectivity and anti-interference capabilities, achieving an unaided eye detection limit of 5 μM and a UV–vis absorption spectroscopy detection limit of 1.51 μM. Furthermore, it exhibits satisfactory performance when it was applied to practical samples, offering an innovative sensing approach for UA detection with significant potential for application in clinical analysis.
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Nature Communications
·
2026
·
IF 15.7
Zhang Xinyi,Wang Liangjie,Wei Jian,Guo Zhuang,Liu Xinyao,Duan Lijie,Zhao Huazhang,Song Yonghui
Oxygen vacancies (O v ) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully achieves in-situ real-time regeneration of O v on CuO surfaces through simple alkali etching without interrupting the contaminant removal process. The surface hydroxyl groups introduced by alkali treatment significantly reduce the formation energy of O v on CuO surfaces from 1.60 eV to 0.38 eV. Both experimental results and density functional theory calculations reveal that the high activity of CuO relies on the synergy of surface hydroxyl groups and O v . This synergy increases the antibonding states below the Fermi level and the electron spin density of Cu near O v , thereby promoting electron transfer from CuO to PMS. As a result, by just adding an equimolar amount of alkali relative to PMS in CuO/PMS system, the degradation rate constant of sulfamethoxazole (SMX) greatly increases by 42 times. The primary reactive oxygen species in this system are sulfate radicals and hydroxyl radicals. Furthermore, OH - /CuO/PMS system exhibits a long-term stability (> 300 h) for SMX removal in a real water matrix. This work provides a highly executable method to in-situ real-time regenerate O v on CuO surfaces, representing significant progress in the critical yet underappreciated field of catalyst regeneration.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Xinge Ju,Guantong Liu,Xin Sun,Haiyang Lv,Zhanye Yang,Shutong Zhang,Yuan Tian,Bing Zhao
This work developed a dual-mode sensor based on aptamer regulation of silver core-cuprous oxide shell (Ag@Cu 2 O) nanozyme activity for kanamycin detection. The synthesized Ag@Cu 2 O nanoparticles served as both a surface-enhanced Raman scattering activity (SERS) substrate and a peroxidase-like catalytic activity. The aptamer adsorbed on the Ag@Cu 2 O surface enhanced the nanozyme activity through electrostatic interactions with positively charged 3,3′,5,5′-tetramethylbenzidine (TMB). This promoted the oxidation of TMB to blue oxidized 3,3′,5,5′-tetramethylbenzidine (ox-TMB) by hydrogen peroxide (H 2 O 2 ). Upon kanamycin binding, the colorimetric absorbance and SERS intensity decreased. The SERS mode achieved a linear range of 0.01–1 μM and the limit of detection (LOD) of 1.78 nM. The colorimetric mode provided a linear range of 0.1–1 μM and a LOD of 47.7 nM. Good recoveries (92.48–102.57%) and low relative standard deviations (RSD < 5.0%) were achieved in spiked honey and mutton samples. This dual-mode design offered potential for food safety monitoring of kanamycin residues.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Dong Cheng,Lin-Song Li,Xue-Jie Zhao,Bang-Bang Liu,Wen-Qi Zhu,Peng-Wei Chen,Bin Ren,Mei-Xia Zhao
Delivering chemotherapeutic agents precisely to tumors and modifying the tumor microenvironment (TME) remain major challenges in cancer therapy. Here, we developed an intelligent nanoplatform based on hepatocellular carcinoma (HCC)-targeting peptide (9R-P201)-modified hollow manganese dioxide (HMnO 2 )-coated copper sulfide (CuS) nanoparticles (CuS@HMnO 2 @9R-P201 NPs) for enhanced HCC treatment. The HMnO 2 structure enabled high loading of doxorubicin (DOX) and indocyanine green (ICG). Upon exposure to 808 nm laser irradiation, the HMnO 2 shells interacted with hydrogen peroxide (H 2 O 2 ) and protons (H + ) in TME to generate Mn 2+ and oxygen (O 2 ), alleviating hypoxia and triggering the release of ICG, DOX, and CuS. CuS enhanced the photothermal effect, while DOX allowed imaging-guided therapy. This nanoplatform demonstrates precise targeting and multimodal therapeutic potential, supporting its clinical translation.
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Clinical Respiratory Journal
·
2026
·Vol. 20
·期 1
·e70145
·
IF 2.3
Xiaowen Chen,Shangzhi Wu,Zhenwei Liu,Zhanhang Huang,Jiaxing Xu,Zhongji Wu,Hui Li,Hongwei Li,Dehui Chen
This study demonstrates that antineutrophil cytoplasmic antibodies (ANCA) induce neutrophil extracellular traps (NETs) in children with bronchiolitis obliterans (BO). NETs promote airway epithelial inflammation and cytokine release, contributing to chronic airway injury. These findings reveal a novel mechanism by which ANCA may drive inflammatory pathology in BO.
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Advanced Healthcare Materials
·
2026
·
IF 9.6
Manqing Liu,Junmei Song,Deqian Tang,Tianyou Wang,Junbin Wei,Junda Li,Jiayun Xu,Yuming Xu,Qianmin Ou,Chunyu Zhang,Zhipeng Gu,Jinming Wang
Implant failure is primarily caused by infection and dysregulated immune responses, highlighting the need to develop implants with tissue-friendly properties. This study introduces a novel one-step strategy for applying a polyphenol–aminoglycoside (PA) coating on various implant substrates, including titanium, in a simple and efficient manner. The multifunctional PA coating can reduce implant failure through its strong antibacterial, immunomodulatory, and osteoinductive activities. By eliminating bacterial infection, promoting the M2 macrophage phenotype, and restoring oxidative balance, PA-coated implants create a favorable osteoimmune microenvironment that supports the osteogenic differentiation of bone marrow mesenchymal stem cells. Furthermore, the PA-coated implants exhibit potent osseointegration in vivo. Collectively, these findings indicate that surface modification with a PA coating represents a promising strategy to meet the clinical requirements of next-generation dental and orthopedic implants in complex clinical environments.
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Advanced Healthcare Materials
·
2026
·
IF 9.6
Meichan Wu,Puze Li,Xin Xin,Cheng Song,Xiangliang Yang,Qingxia Xu,Yan Liu,Yong Shen,Guoping Wang,Jun Hu
The activation and infiltration of cytotoxic T lymphocytes (CTLs) are the key of tumor immunotherapy. However, the suppressive tumor immune microenvironment usually inhibits the function of CTLs. Tumor-associated macrophages (TAMs) play an important role in remodeling the tumor immune microenvironment. In this work, probiotic Escherichia coli Nissle 1917 (EcN) is used as a bioreactor to achieve intracellular synthesis of copper selenide nanoparticles (Cu 2-x Se NPs), giving Cu 2-x Se@EcN, which effectively repolarize macrophages from pro-tumor M2 phenotype to anti-tumor M1 phenotype mainly through activating MAPK signaling pathway. The synthesized Cu 2-x Se NPs exhibited excellent photothermal performance, inducing hyperthermia-sensitized Fenton-like reaction to catalyze the generation of hydroxyl radical from H 2 O 2 , then resulted in immunogenic death effect of tumor cells and the repolarization of M2 macrophages. Combined with surface-expressed pathogen-associated molecular patterns (PAMPs) of bacteria, Cu 2-x Se@EcN synergistically promoted DCs maturation and TAMs reprogramming, eventually promoting the infiltration and activation of T cells. Therefore, the bacteria-inorganic hybrid nanomaterials showed satisfied effect in inhibiting tumor growth and recurrence.
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