CHEMISTRY-A EUROPEAN JOURNAL
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2026
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IF 3.6
Lin Zhou,Zhanghong Guo,Haining Cui,Jinxin Ma,Chan Wang,Qijun Song
Direct transformation of biomass-derived platform compound 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) represents a highly attractive route with significant environmental and economic benefits. The nanozymes with oxidase-like (OXD-like) activity hold great promise for the green oxidation of HMF to FDCA. Herein, an iridium-coated γ-Fe 2 O 3 core-shell nanozyme (γ-Fe 2 O 3 @Ir) was prepared by the reduction of Ir 3+ with glycerol on the surface of γ-Fe 2 O 3, and the structure of the γ-Fe 2 O 3 @Ir nanozyme was confirmed by XRD, HAADF-STEM image, and elemental line-scan analyses results. The magnetic property of the nanozyme not only facilitates its recovery but also effectively enhances its affinity to oxygen. By employing γ-Fe 2 O 3 @Ir nanozyme as the catalyst and atmospheric oxygen as a green oxidant, a near-quantitative conversion (98.5%) of molar level HMF to FDCA was achieved.
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PubMed
高影响因子
CELLULOSE
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2026
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IF 4.6
Li Jingzhen,Zhou Jiayi,He Jiatai,Xu Hao,Wang Peng,Lu Ming,Wang Shu,Zhang Tonghua,Xiao Hang
Multifunctional membranes have recently attracted considerable attention as promising separation materials for the purification of complex oily wastewater, owing to their capability of simultaneously removing various contaminants. However, the organic polymer substrates utilized in multifunctional membrane fabrication suffer from low biodegradability and poor environmental compatibility, and their preparation processes are often technically complex. In this study, a multifunctional membrane based on cotton fabric (CF) was fabricated through the grafting of polyethyleneimine (PEI) and the deposition of titanium dioxide nanoparticles (TiO 2 NPs) via a surface micro-dissolution technology. The prepared membrane exhibited excellent oil/water separation, as well as remarkable performance in dye removal, heavy metal ion adsorption, and antibacterial activity. Specifically, it achieved a water flux of 1189 L/(m 2 h) for oil/water mixtures while maintaining separation efficiencies above 98%. The modified CF-based membrane also exhibited removal efficiencies of 96.3% for Congo red and 67.8% for chromium ions, respectively. Furthermore, antibacterial assessment revealed that the membrane generated inhibition zones of 8 mm for Escherichia coli and 5 mm for Staphylococcus aureus after a 6 h contact period, indicating satisfactory antibacterial performance. More than 83% of the membrane’s adsorption was recovered after a facile cleaning step, indicating good regeneration performance. Moreover, the membrane demonstrated satisfactory stability under harsh conditions. This work may provide a facile approach for fabricating multifunctional fabric-based membranes for the effective removal of contaminants in complex oily wastewater. Graphical abstract
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Advanced Science
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2026
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IF 14.1
Hang Zhou,Yi Tan,Chuanwei Lu,Yanlin Li,Tianyi Tang,Zheng Yang,Ying Li,Xuehan Chen,Jianfeng Yao,Zhengchun Cai,Yuanyuan Jiang,Ping Zhao,Chengguo Liu
Developing recycling photo-curing 3D printing materials (especially using renewable biobased feedstocks) can greatly alleviate environmental burden raised by the rapid development of 3D printing industry. Currently, it is still hard to achieve both high performance and excellent recyclability for such materials. In this study, by using a typical biobased phenol (i.e., eugenol) as starting material, we design biobased photopolymers containing dynamic dissociative phenol-carbamate bonds, part of which come from the phenol itself. The obtained materials not only have relatively high biobased contents, but also demonstrate excellent thermal and mechanical properties. Subsequently, the materials are conveniently recycled by a proposed “mixed-monomer assisted recycling” strategy, and high recovery efficiencies in at least three cycles were achieved. Furthermore, the materials indicate exceptional 3D printing performance and functionalities (such as oral bacteria inhibition and shape memory) as well as low environmental impacts. Overall, the combination of rigid biobased feedstocks (especially biobased phenols) and suitable dissociative covalent bonds offers the opportunity to develop high performance, recycling photopolymers with more functionalities and better sustainability.
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高影响因子
Journal of Water Process Engineering
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2026
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IF 6.6
Li Zeng,Hanbin Wu,Yiyang Xu,J. Paul Chen,Yiqiao Xie,Yang Yu
The efficient treatment of dye-containing wastewater remains a critical environmental issue, primarily due to its biological toxicity to aquatic microorganisms and high chromaticity. In this work, two types of Co₃O₄-functionalized ceramic hollow fiber membranes were designed to activate peroxymonosulfate (PMS) for the efficient removal of dyes from water. Compared to the static-deposited membrane (SCHFM), the dynamic-deposited membrane (DCHFM) demonstrated a higher loading capacity and more uniform distribution of Co 3 O 4 on both the surface and internal pores, leading to a significant enhancement in catalytic performance. Under optimal operating parameters, the DCHFM achieved over 98% removal of rhodamine B (RhB) during the filtration. Radical quenching and electron paramagnetic resonance (EPR) confirmed the involvement of multiple reactive oxygen species, including singlet oxygen ( 1 O 2 ), hydroxyl radical (HO•), sulfate radical (SO 4 •− ) and superoxide radical (•O 2 − ), with 1 O₂ identified as the predominant reactive species. Furthermore, the functionalized membrane exhibited outstanding operational stability and reusability with negligible cobalt leaching. The findings of this study provide a high-performance catalytic membrane system for the advanced purification of industrial wastewater.
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Advanced Science
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2026
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IF 14.1
Haoming Zou,Zhi-Xiong Fei,Zhao Yang,Ke-Ke Yang,Dong-Xu Yang,Ling-Ying Shi
The rapid progress of soft robotics and flexible electronics has sparked tremendous demand for elastomers that unite high mechanical strength with intrinsic softness, thereby mimicking the mechanical performance of natural skin. Herein, we report a class of dynamically crosslinked supramolecular polyurethanes that combine skin-comparable low modulus with high strength and room-temperature self-healing, achieved through a segmental molecular engineering strategy. The design leverages entropy-driven soft elasticity together with enthalpy-governed strain-stiffening and energy dissipation, dictated by polymer segment topology. Using a prototypical supramolecular elastomer, we demonstrate that incorporating an isophorone diisocyanate (IPDI) chain extender, whose steric configuration matches that of ureidopyimidinone (UPy), reinforces hydrogen bonding interaction and suppresses premature crystallization. The optimized elastomer exhibits an ultralow initial modulus (<3 MPa) yet undergoes pronounced strain-stiffening, yielding exceptional tensile strength (>50 MPa) and high fracture toughness (∼2×10 5 J m −2 ), outperforming state-of-the-art room-temperature self-healing elastomers. Moreover, the elastomer features hydrophobicity, ensuring stability in underwater applications. These results underscore the promise of segment-level molecular engineering for constructing dynamic polyurethanes with thermoplastic processability, skin-like softness, and unprecedented mechanical robustness.
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高影响因子
Advanced Science
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2026
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IF 14.1
Yan Xu,Weitao Yang,Yanjing Yun,Hui Wang,Zhuoyao Wu,Youyi Yu,Bingbo Zhang
Non-invasive visualization of glucose metabolism in living organisms remains a major challenge, as existing techniques cannot specifically detect glucose molecules with deep-tissue penetration and without ionizing radiation. To overcome this, we developed an enzyme-activated magnetic resonance imaging strategy (eaMRI) using a biodegradable nanoprobe, CrGOx@Lip, that integrates endogenous Cr 3+ ions with glucose oxidase for glucose-responsive imaging. Our approach leverages GOx not only as a catalytic engine to specifically oxidize glucose but also as a structural template to guide the in-situ synthesis of a potent MRI reporter (paramagnetic chromium gluconate). This design enables direct, specific amplification of MRI signals in proportion to local glucose concentration, achieving an 8.28-fold relaxivity increase. We validated this method for sensitive glucose mapping in vivo, including delineating Warburg-effect-driven tumors and quantifying pathological glucose accumulation in metabolic dysfunction-associated fatty liver disease (ΔSNR% = 18.51 ± 3.72 vs. 1.14 ± 1.39 in controls; p <0.001), and further demonstrated its utility in monitoring therapeutic efficacy via glucose-responsive signal changes. By synergizing enzymatic precision with nanomaterial engineering, our CrGOx@Lip-mediated eaMRI platform provides a glucose-specific, radiation-free, and non-invasive strategy for sensitive metabolic diagnostics in precision medicine.
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Advanced Healthcare Materials
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2026
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IF 11
Jinling Zheng,Yingying Ke,Dandan Meng,Marie Helene Delville,Shiwen Yu,Yiteng Huang,Xiaoyu Xu,Xu Zhang,Shayibai Shabiti,Na Liang,Yujue Wang,Fangjie Li,Hongfei Chen,Wenjun Li
Sono-photodynamic therapy (SPDT) offers a non-invasive, spatiotemporally precise approach to cancer treatment, but its effectiveness is still limited by poor tumor specificity and penetration. To address this, we developed a cascade-targeted type I/II sensitizer, Ce6-TPP-Phe-Tyr (CTPT), which integrates chlorin e6 (Ce6), triphenylphosphonium (TPP), and a phospho-peptide motif for precise tumor targeting and potent SPDT. Upon dephosphorylation by tumor-overexpressed alkaline phosphatase (ALP), CTPT undergoes enzyme-instructed self-assembly (EISA) into nanoparticles (CTPT NPs), promoting their accumulation and retention in tumors. The TPP cations then guide these nanoparticles to mitochondria, concentrating the therapeutic payload at this critical organelle for cellular energy metabolism. Subsequent ultrasound/laser irradiation further enhances tissue permeability and triggers the generation of both type I and type II reactive oxygen species (ROS), leading to potent oxidative damage. This integrated strategy of EISA and mitochondria-targeted SPDT achieved approximately 86% tumor regression in ALP-overexpressing xenografts. This strategy minimizes systemic toxicity and achieves potent tumor regression by cascade delivery of the therapeutic agent, thereby significantly enhancing the precision and efficacy of SPDT.
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CHEMISTRY-A EUROPEAN JOURNAL
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2026
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IF 3.6
Jiyong Wu,Jing Nie,Huina Wu,Dongbo Wang,Yamei Li,Minyan Liang,Huimei Qian,Yong Wang
Platinum-based chemotherapeutics remain clinically indispensable for treating various malignancies despite causing severe side effects, with ototoxicity being particularly limiting. This study reports the synthesis and evaluation of platinum(IV) prodrugs incorporating the hearing-protective ligand RG108. Among the synthesized mono- and di-substituted cisplatin and oxaliplatin derivatives, compound 4 exhibited exceptional antitumor activity with an IC 50 value of 0.07 ± 0.08 µM in FaDu cells. Mechanistic investigations revealed that the enhanced anti-tumor effect was primarily mediated via the EZH2/SLC47A2 regulatory axis. These prodrugs significantly mitigated ototoxicity, preserving cochlear hair cell viability, stabilizing auditory brainstem response thresholds, and maintaining cochlear basement membrane morphology. Our findings establish a framework for designing dual-functional platinum agents that synergize antitumor efficacy with organoprotective properties, addressing critical hearing loss limitations of conventional platinum chemotherapy while maintaining robust therapeutic outcomes. Graphical
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高影响因子
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
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2026
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IF 4.2
Pengrui Zhang,Haiyang Zhang,Xinyu Yang,Yuanli Wu,Shanshan Dai,Yanqin Ding,Shanshan Sun
Bacteria play an important role in the biodegradation of polycyclic aromatic hydrocarbons (PAHs), especially the more recalcitrant high-molecular-weight compounds like pyrene. In this study, we isolated and characterized a novel pyrene-degrading bacterium, Glutamicibacter soli ENR6, from petroleum-contaminated soil. Strain ENR6 was able to utilize various PAHs as sole carbon sources and degrade 88.8% of 50 mg L−1 pyrene and 76.8% of 100 mg L−1 pyrene within 15 days. During pyrene degradation, eight metabolites were detected, with 2,2′-diphenic acid emerging as the predominant intermediate. By day 7, 40.6% of the degraded pyrene had accumulated in the form of 2,2′-diphenic acid, which was subsequently metabolized via the phthalate pathway. To our knowledge, this is the first report identifying 2,2′-diphenic acid as an intermediate in pyrene degradation. Integrated genomic and transcriptomic analyses revealed four gene clusters (clusters I–IV) involved in pyrene degradation in strain ENR6. Reverse transcription-quantitative PCR (RT-qPCR) analysis demonstrated that these clusters were specifically induced by pyrene and its intermediates, with genes chr_3400-chr_3404 in cluster I strongly associated with 2,2′-diphenic acid degradation. Based on these findings, we propose a distinct 2,2′-diphenic acid-centered pathway for pyrene degradation in strain ENR6. This study not only broadens the bacterial repertoire available for PAH bioremediation but also provides new insights into the metabolic diversity of PAH-degrading microorganisms.
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高影响因子
Small
·
2026
·
IF 11.8
Min Mu,Bo Chen,Hui Li,Chenqian Feng,Susu Xiao,Rangrang Fan,Aiping Tong,Nianyong Chen,Gang Guo
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with limited efficacy of conventional therapies due to immunosuppressive tumor microenvironments and high recurrence. While bispecific T-cell engagers (BiTEs) show promise by engaging T cells against tumors, their clinical translation is hindered by poor stability, on-target off-tumor effect, and systemic toxicity. Herein, we develop a tumor-targeted nanozyme (MnO 2 -dsDNA@BiTE/APT) that co-delivers hydrolytically stable double-strand DNA (dsDNA: a STING agonist) and PD-L1/CD3 BiTE to overcome these limitations. The nanozyme leverages MnO 2 as a carrier for dsDNA, surface-loaded with BiTE via polyphenol-protein coordination, and functionalized with an aptamer (APT) for active targeting. Upon systemic administration, the nanozyme accumulates in tumors, releasing dsDNA, Mn 2+ , and BiTE. The synergistically activates the STING pathway to remodel the immunosuppressive microenvironment and enhances T cell-mediated cytotoxicity. This strategy represents a promising approach for potentiating immunotherapy in CRC by integrating innate immune activation with adaptive T cell engagement.
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高影响因子
POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Hafiza Aroosa Aslam Khan,Naveed Ramzan,Asif Jamil,Ghulam Rasool,Muneerah Alomar,Muhammad Sarfraz
Decarbonization is essential to address climatic variations caused by greenhouse effects. Membrane-based separation processes present an energy-efficient and scalable pathway for flue gas purification. Permeability-selectivity trade-off of polymeric membranes can be mitigated through combined impregnation of bi-fillers within polymer matrix coupled with applying ultrathin secondary polymer coating to fabricate efficacious dual-layer composite membrane. Microporous activated MOF-5 nanocrystals with high surface area and CO 2 affinity, combined with graphene nanoplatelets possessing exceptional CO 2 uptake, were synergistically embedded into flexible polysulfone matrix. Biodegradable poly(vinyl alcohol) coating layer was uniformly deposited onto doped polysulfone substrate, yielding novel class of anisotropic dual-layer mixed matrix composite membranes, rendering drastically improved CO 2 /N 2 selectivity of 70 and upgraded CO 2 permeability of 92 Barrer as compared to bare polysulfone membrane. Advanced characterizations verified uniform nanofiller dispersion, strong interfacial bonding, and enhanced thermal stability. Five percent PVA coating boosted thermal stability and improved mechanical robustness by 84%, markedly strengthening membrane structural and thermal resilience. An effective strategy is introduced to produce dual-layer membranes with remarkable CO 2 capture performance via optimized bi-filler loading and PVA based surface modification. Highlights Solvothermal synthesis of highly microporous activated MOF-5 nanocrystals. Preparation of Zn-BDC MOF- and graphene nanoplates-embedded composite membranes. Enhanced nanofiller-polymer interfacial compatibility furnishing uniform filler dispersal. Constructing a dual-layer composite membrane by depositing an ultrathin poly(vinyl alcohol) layer. Marked improvement in decarbonization performance of prepared multilayered membranes.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Xiaoqiang Zhang,Quanlei Wang,Junli Ren,Huixiang Li,Da-Ming Gao
The selective ring-opening of biomass-derived furanic molecules offers an attractive route for the synthesis of industrially relevant linear ketones. Herein, the ring-opening reaction of 2,5-dimethylfuran (2,5-DMF) was systematically investigated over a series of oxide catalysts. Anatase TiO2 (TiO2-A) exhibits superior catalytic performance for the conversion of 2,5-DMF to 2,5-hexanedione (2,5-HD), delivering high selectivity under mild reaction conditions. Structure-activity correlation studies reveal that surface hydroxyl groups on TiO2-A play a decisive role in promoting the ring-opening reaction through strong interfacial interactions with the furan ring. Spectroscopic analyses indicate that these hydroxyls serve as the primary surface sites involved in the activation and subsequent cleavage of the furan C-O bond. Nevertheless, catalyst deactivation occurs during prolonged operation, which is mainly attributed to the strong and irreversible adsorption of 2,5-HD on surface hydroxyl groups, leading to progressive site blockage and loss of activity.
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危险品化学品经营许可证（带存储）