ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2024
·Vol. 31
·期 18
·27388-27402
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IF 0
Lan Jinghao,Yan Hengwei,Liu Zhanwei,Ma Wenhui
In aluminum electrolysis, the iron-rich cover material is formed on the cover material and the steel rod connecting the carbon anode. Due to the high iron content in the iron-rich cover material, it differs from traditional cover material and thus requires harmless recycling and treatment. A process was proposed and used in this study to recovery F, Al, and Fe elements from the iron-rich cover material. This process involved aluminum sulfate solution leaching for fluorine recovery and alkali-acid synergistic leaching for α-Al 2 O 3 and Fe 2 O 3 recovery were obtained. The optimal leaching rates for F, Na, Ca, Fe, and Si were 93.92, 96.25, 94.53, 4.48, and 28.87%, respectively. The leaching solution and leaching residue were obtained. The leaching solution was neutralized to obtain the aluminum hydroxide fluoride hydrate (AHFH, AlF 1.5 (OH) 1.5 ·(H 2 O) 0.375 ). AHFH was calcined to form a mixture of AlF 3 and Al 2 O 3 with a purity of 96.14%. The overall recovery rate of F in the entire process was 92.36%. Additionally, the leaching residue was sequentially leached with alkali and acid to obtain the acid leach residue α-Al 2 O 3 . The pH of the acid-leached solution was adjusted to produce a black-brown precipitate, which was converted to Fe 2 O 3 under a high-temperature calcination, and the recovery rate of Fe in the whole process was 94.54%. Therefore, this study provides a new method for recovering F, Al, and Fe in iron-rich cover material, enabling the utilization of aluminum hazardous waste sources.
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Advanced Fiber Materials
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2024
·
IF 17.2
Wang Peng,Li Xiaodan,Sun Guifen,Wang Guoqing,Han Qing,Meng Chuizhou,Wei Zhonghe,Li Yang
Wearable sensors have been rapidly developed for application in various human monitoring systems. However, the wearing comfort and thermal properties of these devices have been largely ignored, and these characteristics urgently need to be studied. Herein, we develop a wearable and breathable nanofiber-based sensor with excellent thermal management functionality based on passive heat preservation and active Joule heating effects. The multifunctional device consists of a micropatterned carbon nanotube (CNT)/thermoplastic polyurethane (TPU) nanofiber electrode, a microporous ionic aerogel electrolyte and a microstructured Ag/TPU nanofiber electrode. Due to the presence of a supercapacitive sensing mechanism and the application of microstructuration, the sensor shows excellent sensing performance, with a sensitivity of 24.62 kPa −1 . Moreover, due to the overall porous structure and hydrophobicity of TPU, the sensor shows good breathability (62 mm/s) and water repellency, with a water contact angle of 151.2°. In addition, effective passive heat preservation is achieved by combining CNTs with high solar absorption rates (85%) as the top layer facing the outside, aerogel with a low thermal conductivity (0.063 W m −1 k −1 ) as the middle layer for thermal insulation, and Ag with a high infrared reflectance rate as the bottom layer facing the skin. During warming, this material yields a higher temperature than cotton. Furthermore, the active Joule heating effect is realized by applying current through the bottom resistive electrode, which can quickly increase the temperature to supply controlled warming on demand. The proposed wearable and breathable sensor with tunable thermal properties is promising for monitoring and heat therapy applications in cold environments. Graphical Abstract We reported a wearable and breathable nanofiber-based sensor with excellent thermal management functionality based on passive heat preservation and active Joule heating effects.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2024
·
IF 3.1
Wang Guanghui,Cheng Jianxiang,Yao Meizhen,Li Jing,Chen Ting,Zhang Jia,Du Wensheng,Chen Youguo
Ovarian cancer stands as the foremost cause of mortality among gynaecological diseases globally, characterized by high morbidity and mortality. Pinocembrin, a flavonoid from natural plant sources, exhibits diverse pharmacological properties. Despite its known pharmacological activities, its specific role in ovarian cancer treatment remains scarcely reported, and its precise molecular mechanism remains elusive. This study integrates network pharmacology and molecular docking techniques to explore pinocembrin’s potential mechanism in ovarian cancer treatment. The targets of pinocembrin were compiled from the several online databases. Ovarian cancer targets were identified using the GeneCards database, with common target genes determined by data aggregation. Protein–protein interactions were analysed using the STRING platform. Subsequent Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed. Molecular docking assessed the binding affinity between potential targets and active compounds. Finally, target validity was verified through in vitro experiments. We identified 163 potential pinocembrin targets for ovarian cancer treatment. GO and KEGG analyses revealed pinocembrin’s involvement in protein kinase activity, protein phosphorylation, protein kinase complexes and cancer pathways in ovarian cancer treatment. Molecular docking demonstrated strong binding affinity between pinocembrin and most potential target active sites. In vitro experiments suggested pinocembrin’s potential to induce apoptosis in ovarian cancer cells through the AKT1-mTOR signalling pathway. This study comprehensively elucidates pinocembrin’s potential targets and mechanisms against ovarian cancer, aiming to provide promising candidates for developing novel and effective alternative and/or complementary nutritional supplements for the clinical treatment of ovarian cancer.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2024
·
IF 3.8
Qiao Yinuo,Wang Xiaoyan,Fan Zhenlin,Song Yuzhu,Zhang Jinyang,Han Qinqin
Tuberculosis is a highly infectious disease caused by the bacterium Mycobacterium tuberculosis , and the spread of this agent has caused serious health problems worldwide. The rapid and accurate detection of M. tuberculosis is essential for controlling the spread of infection and for preventing the emergence of multidrug-resistant strains. In this study, the powerful trans-cleavage ability of CRISPR-Cas12a for ssDNA was combined with a surface-enhanced Raman spectroscopy (SERS)–based strategy to establish a CRISPR-SERS sensor for the hypersensitive detection of M. tuberculosis DNA. We observed a linear relationship between the concentration of M. tuberculosis DNA and the output signal over the range of 5 to 100 pM. The equation describing the standard curve was y = 24.10 x + 1594, with R 2 = 0.9914. The limit of detection was as low as 4.42 pM for genomic DNA, and a plasmid containing an M. tuberculosis –specific sequence was detected at 5 copy/μL. A detection accuracy of 100% was achieved in the analysis of DNA isolated from the sputum of hospitalized patients with tuberculosis. The entire detection process is simple to deploy and only takes 50 min and results in the sensitive and specific detection of M. tuberculosis DNA. This study provides a new method for the detection of tuberculosis. The tool is stable and can be utilized on-site, and it thus broadens the diagnostic application of CRISPR-Cas12a-based sensor technology.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2024
·
IF 1.5
Gao Kai,Shi Yunfeng,An Kexin,Tan Jun,Zhang Yanna,Dong Jiajie,Yu Weiyue,Lin Haipeng
A hydrothermal method which can convert free cesium ions into stable pollucite at low temperatures was established in this work, avoiding any evaporation pollution during the disposal of cesium containing waste. Meanwhile, rapid synthesis under hydrothermal conditions was achieved using seed guidance, which shorten the growth time of pollucite crystals to 8 h, and making the treatment and disposal of cesium containing wastewater faster. Standard leaching test results show that the leaching rate of Cs was very low (< 3.5 × 10 −7 g·m 2 ·d), it still has good thermal stability at a temperature of 1300 °C, when the cesium content in pollucite reaches 20%.
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Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1-19
·
IF 7.5
Hu Songliu,Zhan Ning,Li Jian,Wang Liqun,Liu Yiyan,Jin Ke,Wang Yixuan,Zhang Juxuan,Chen Yiyang,Bai Yang,Wang Yichong,Qi Lishuang,Liu Shilong
Background Radiotherapy is commonly used for locoregionally advanced NSCLC, but radioresistance is a clinical challenge. The long non-coding RNA CBR3-AS1 mediates radioresistance in NSCLC, yet the underlying molecular mechanism is unclear. This study aims to explore whether and how N6-methyladenosine (m6A) modification regulates CBR3-AS1 expression and promotes NSCLC radioresistance. Methods Integrative bioinformatics analyses were used to investigate the m6A methyltransferases that were associated with CBR3-AS1 expression and radioresistance of patients using data from The Cancer Genome Atlas of lung adenocarcinoma and squamous cell carcinoma. Clinical samples of 133 patients with NSCLC was collected to validate the correlation of the methyltransferase with radioresistance. The functional role and molecular mechanism of the methyltransferase in radioresistance was investigated through a series of in vitro experiments including m6A MeRIP-PCR, lentivirus transfection, RNA immunoprecipitation, Luciferase reporter, Colony formation, Transwell invasion, Flow cytometry, ELISA and TUNEL assay and in vivo experiments. Results The methyltransferase RNA binding motif protein 15 (RBM15) was identified as it was significantly positively correlated with CBR3-AS1 expression and overall survival of NSCLC patients receiving radiotherapy. The clinical samples demonstrated that the high protein expression of RBM15 was significantly enriched in patients with radioresistance as well as associated with poor prognosis of patients receiving radiotherapy. In vitro, RBM15 silencing enhanced the effects of radiation on the growth and invasion inhibition, and apoptosis induction of NSCLC cells; RBM15 overexpression had the opposite effects. Mechanistically, RBM15 induced CBR3-AS1 upregulation via an m6A-IGF2BP3-dependent mechanism, inducing CXCL1 expression by sponging miR-409-3p to recruit myeloid-derived suppressor cells (MDSCs) and inhibit T cell activity. In vivo, RBM15 silencing suppressed MDSC invasiveness and enhanced CD8 + and CD4 + T cell infiltration, causing NSCLC cells to overcome radioresistance. Conclusion Our study identifies methyltransferase RBM15 as a potential therapeutic target for NSCLC radioresistance whose inhibition reverses resistance through limiting MDSC recruitment via the m6A-IGF2BP3-CBR3-AS1/miR-409-3p/CXCL1 axis. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-22
·
IF 12.6
Fu Xianhua,Zhang Yongkang,Chen Guojie,Mao Guangyao,Tang Jiajia,Xu Jin,Han Yuhan,Chen Honglin,Ding Lianshu
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytokines and chemokines and creating a vicious “ROS-neuroinflammation” cycle, making it essential to break this cycle for effective TBI treatment. In this study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified antioxidant nanoparticles (C-PPS/C) for co-delivery of curcumin (Cur) to modulate oxidative and neuroinflammatory disturbances after TBI. In TBI mice, C-PPS/C nanoparticles accumulated in injured brain regions, where poly (propylene sulfide) 120 scavenged ROS, reducing oxidative stress, while Cur release further suppressed ROS and inflammation. C-PPS/C nanoparticles broke the “ROS-neuroinflammation” cycle, protecting the blood-brain barrier (BBB), reducing acute brain edema, and promoting long-term neurological recovery. Further investigation showed that C-PPS/C nanoparticles inhibited the NF-κB pathway, reducing pro-inflammatory gene expression and mitigating inflammation, suggesting a promising approach for TBI treatment.
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ANALYTICAL SCIENCES
·
2024
·
IF 1.8
Zhou Zhihua,Lin Jiajia,Yue Daoping,Chen Huaiyu,Chen Sheng
The level of interleukin-8 (IL-8) in the body is an effective factor for the early diagnosis of acute tubular necrosis and oral tumor. In this work, a novel sandwich-like voltametric immunosensor (SVS) of IL-8 was constructed by preparing β-cyclodextrin/carbon nanotube (CD/CNT) to immobilize primary antibody (PAb) of IL-8 and UIO-66-NH 2 MOFs structure to immobilize second antibody (SAb) and methylene blue (Mb) probe. In this designed SVS, the prepared CD/CNT nanohybrid with large surface area and conductivity can immobilize PAb via simple host–guest recognition, and UIO-66-NH 2 provided an ideal platform to accommodate SAb and a large number of Mb molecules as signal-amplifier. In the existence of target IL-8, the current peak of Mb from the SVS assay increases with the increasement of IL-8 level. Through optimizing and adjusting various factors, a wide linearity (0.001–2.5 ng mL −1 ) and low analytical limit (0.2 pg mL −1 ) of IL-8 were realized, so it’s expected the developed SVS strategy has significant applications for the detection of IL-8. Graphical abstract
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高影响因子
ANALYTICAL SCIENCES
·
2024
·
IF 1.8
Sha Ou,Wu Yunfan,Dai Xincheng,Li Huiwen,Xu Yuan,Wang Ziwen,Zhang Pu
In this study, a reliable method for determining eugenol content in environmental water samples was established by combining magnetic solid-phase extraction with high-performance liquid chromatography. Magnetic molecular imprinted polymers MGO@MIPs were prepared through surface molecular imprinting technique with eugenol as the template molecule. The material displayed good superparamagnetic properties and magnetic responsiveness in favor of rapid separation. The adsorption properties of MGO@MIPs for eugenol were evaluated through adsorption kinetics and selectivity experiments. MGO@MIPs were found to have favorable reusability and obvious selectivity for eugenol. In addition, adsorption and elution conditions were investigated. Under optimal conditions, a linear relationship was obtained between the concentration of eugenol and its peak area in the range of 0.02–5 mg/L ( R 2 = 0.9998) and the limit of detection was 4.0 × 10 –6 mg/mL. The performance of the established method was assessed with the average recovery of 96.59–102.20% and the relative standard deviation (RSD) below 3.5%. The application of this method provides a new perspective for the separation, enrichment and detection of eugenol in water environment. Graphical abstract Preparation of the molecularly imprinted polymers
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Nature Catalysis
·
2024
·Vol. 7
·期 6
·666-677
·
IF 42.8
Dou Xiaomeng,Yan Tao,Qian Lixiang,Hou Huaming,Lopez-Haro Miguel,Marini Carlo,Agostini Giovanni,Meira Debora M.,Zhang Xiangjie,Zhang Liang,Cao Zhi,Liu Lichen
Achieving the regioselective hydroformylation of linear α-olefins to linear aldehydes using solid catalysts with regioselectivities comparable to the corresponding homogeneous process is a great challenge in the chemical industry. Despite the tremendous efforts devoted to this research topic, most of the reported heterogeneous metal catalysts still give considerably lower regioselectivities than well-established homogeneous metal catalysts. Here we show the design of efficient Rh-zeolite catalysts, in which subnanometre Rh clusters are selectively confined in the sinusoidal ten-membered-ring channels of MFI zeolite, for the hydroformylation of long-chain linear α-olefins (C 6 –C 12 ) into linear aldehydes with very high linear-to-branched aldehyde ratios (up to 400). The exceptional catalytic performances result from the involvement of the MFI zeolite framework as a rigid solid ligand that accommodates subnanometre Rh clusters in the sinusoidal channels of the MFI zeolite.
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Lipids in Health and Disease
·
2024
·Vol. 23
·期 1
·1-12
·
IF 3.9
Fan Yibao,Zhang Wei,Iqbal Zoya,Li Xinxin,Lin Zhiyin,Wu Zhuolin,Li Qianyou,Dong Hongxia,Zhang Xianbin,Gong Peng,Liu Peng
Background Bufalin (BA) is a potent traditional Chinese medicine derived from toad venom. It has shown significant antitumor activity, but its use is limited by cardiotoxicity, which necessitates innovative delivery methods, such as rod-shaped mesoporous silica nanoparticles (rMSNs). rMSNs have been extensively employed for reducing drug toxicity and for controlled or targeted drug delivery in tumor therapy. However, their potential in delivering BA has not been completely elucidated. Therefore, in this study, BA-loaded rMSNs (BA-rMSNs) were developed to investigate their potential and mechanism in impairing colon cancer cells.Methods rMSNs were developed via the sol‒gel method. Drug encapsulation efficiency and loading capacity were determined to investigate the advantages of the rMSN in loading BA. The antiproliferative activities of the BA-rMSNs were investigated via 5-ethynyl-2’-deoxyuridine and CCK-8. To evaluate cell death, Annexin V-APC/PI apoptotic and calcein-AM/PI double staining were performed. Western blotting, oil red O staining, and Nile red solution were employed to determine the ability of BA-rMSNs to regulate lipophagy.Results The diameter of the BA-rMSNs was approximately 60 nm. In vitro studies demonstrated that BA-rMSNs markedly inhibited HCT 116 and HT-29 cell proliferation and induced cell death. In vivo studies revealed that BA-rMSNs reduced BA-mediated cardiotoxicity and enhanced BA tumor targeting. Mechanistic studies revealed that BA-rMSNs blocked lipophagy.Conclusion srMSNs reduced BA-mediated cardiotoxicity and impaired the growth of colon cancer cells. Mechanistically, antitumor activity depends on lipophagy.
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FIBERS AND POLYMERS
·
2024
·
IF 2.2
Wang Xiaoyan,Fu Jiangpeng,Gu Fuyang,Du Jinmei,Xiao Guowei,Jiang Yang,Shao Dongyan,Xu Changhai
The industrial bleaching of cotton fabric is often carried out in an aqueous solution of hydrogen peroxide (H 2 O 2 ) with the addition of sodium hydroxide (NaOH) at a boiling temperature. To overcome the higher energy consumption problem of the traditional bleaching system, activated peroxide systems are proposed by adding bleach activators to the bleaching system. The bleach activators react with H 2 O 2 to generate more kinetically active bleaching components, which enable the cotton fabric to be bleached at lower temperatures. However, different bleaching components have different electronic properties. In this study, the electrostatic interactions between cotton fabrics and bleaching components were investigated, as well as the charge-regulation behavior of electrolytes and surfactants in the bleaching system. The research results showed that electrostatic interactions played an important role in bleaching by affecting the adsorption of bleach activators onto cotton fabric. Electrolytes and surfactants in the bleaching system could work as charge-regulation agent by effecting the adsorption of bleach activators onto cotton fabric by increasing or reducing the adsorption of bleach activators onto cotton fabric. This work proved the existence of electrostatic interactions between bleaching components and cotton fabric and also presented the charge-regulation behaviors during bleaching. It provides further understanding that the performance of the peroxide systems for bleaching depends not only on the chemical activities of the bleaching components but also on the electrostatic interactions between the bleaching components and cotton fabric.
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