ACS Applied Energy Materials
·
2022
·
IF 6.959
Xiaofei Sun,Zikang Wang,Qiongdan Hu,Xuesong Mei,Yue Zhao,Anastase Ndahimana,Tao Geng,Jianlei Cui
The abundant reserves of sodium resources and its low price make the desire to build energy storage systems on room-temperature rechargeable sodium batteries. The current challenge exists in exploring high-performance key materials, especially cathode materials. Vanadium-based phosphates have attracted extensive attention as a class of promising cathode materials for sodium batteries due to their stable structure, large capacity, and high voltage advantages. In this paper, sodium vanadium oxyfluorophosphate, Na3V2(PO4)2F3–2yO2y (0 ≤ y < 1), is exploited to improve its electrochemical performance through oxygen tuning. The effect of oxygen amount on the structure, morphology, and performance is comprehensively and comparatively investigated. It is found that the optimal electrochemical performance is achieved in Na3V2(PO4)2F2O when y = 0.5. Its specific discharge capacity at 0.1, 0.5, 1, 8, and 20 C is 125, 111, 101, 71, and 58 mA h g–1, respectively. The superior rate performance and good cyclability are ascribed to the low impurity, mixed V3+/V4+ valence state, small particle size, suitable residual carbon coating, low charge transfer resistance, fast Na+ diffusion, and particularly the regulation of charge/discharge potentials as well as polarizations due to proper oxygen tuning.
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Frontiers of Environmental Science & Engineering
·
2025
·Vol. 19
·期 12
·1-16
·
IF 6.4
Zhao Biyi,Chen Wei,Chen Geng,Zhao Feng,Xiao Yong
Electroactive microorganisms are integral to biogeochemical cycles through extracellular electron transfer and have potential applications in environmental remediation. However, their long-term competitive interactions and evolutionary dynamics with non-electroactive microorganisms remain poorly understood. In this study, we conducted a 320-day cultivation experiment in which monocultures of the electroactive Shewanella oneidensis MR-1, the non-electroactive Citrobacter freundii An1, and their cocultures were compared under three single electron acceptor conditions: anaerobic (no exogenous electron acceptor), ferrihydrite, or oxygen. After 320 d, S. oneidensis MR-1 presented the highest relative abundance of 30.94% ± 0.74% in the ferrihydrite cocultures. S. oneidensis MR-1 maintained ferrihydrite reduction capacity after cultivation under all three conditions, indicating the long-term stability of its extracellular electron transfer. Moreover, no other phenotypic evolution was observed in S. oneidensis MR-1 after ferrihydrite or anaerobic cultivation. In contrast, both monocultured and cocultured S. oneidensis MR-1 exhibited enhanced adaptation to oxygen, characterized by increased growth rates, metabolic activity, and reduced cell aggregation. Notably, substrate consumption increased in monocultures but decreased in cocultures, suggesting an optimization of metabolic efficiency in the latter. Genome sequencing revealed mutations in genes associated with cell division, adenosine triphosphate synthesis, lactate metabolism, and flagellar/pilus expression in S. oneidensis MR-1. Interestingly, the ferrihydrite-adapted groups also exhibited enhanced adaptation to oxygen. 83.96% of mutations were shared across all culture systems and enriched in environmental signal-sensing pathways, indicating that parallel genomic evolution facilitated cross-environmental adaptation. Our findings reveal the ecological evolution of electroactive microorganisms in diverse redox environments and establish a foundation for engineering electroactive communities.
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CRYSTENGCOMM
·
2024
·Vol. 26
·期 38
·5469-5478
·
IF 2.6
Shengjie Zhu,Xiaomin Zhang,Lei Dong,Yangyang Yuan,Xiuyun Ma,Yanping Chen,Lei Xu
Hierarchically structured materials are considered to be one of the important options to enhance the mass transportation efficiency in microporous zeolites. Herein, we reported a highly efficient steam-assisted crystallization strategy for the synthesis of a hierarchical TS-1 zeolite with a tunable macropore size. The amorphous SiO2–TiO2 precursor dissolved gradually and acted as both a nutrient supplier and macropore template in situ. The framework Ti content of the synthesized TS-1 zeolites could be tuned over a wide range (Ti wt% = 0.70–1.39) by varying the Ti content of the SiO2–TiO2 precursor. Moreover, the pore size of the macropores could be modulated according to the particle size of the precursor based on the investigation of the formation mechanism of the macropores in the hierarchical TS-1 zeolite. The hierarchical TS-1 zeolite exhibited better catalytic activity in the epoxidation reaction of 1-hexene and hydroxylation of phenol compared to the typical microporous zeolites. The improved performance of the hierarchical TS-1 zeolite was probably caused by the improved diffusion performance of the hierarchical structure.
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PHARMACOLOGICAL RESEARCH
·
2022
·
IF 10.334
Xingda Li,Yang Zhang,Yue Zhao,Yang Zhou,Qilong Han,Ying Yang,Lingmin Zhang,Ling Shi,Xuexin Jin,Ruixin Zhang,Haiyu Gao,Genlong Xue,Desheng Li,Zhi-Ren Zhang,Yanjie Lu,Baofeng Yang,Zhenwei Pan
Pathological cardiac hypertrophy is a process characterized by significant disturbance of protein turnover. Cullin-associated and Neddylation-dissociated 1 (CAND1) acts as a coordinator to modulate substrate protein degradation by promoting the formation of specific cullin-based ubiquitin ligase 3 complex in response to substrate accumulation, which thereby facilitate the maintaining of normal protein homeostasis. Accumulation of calcineurin is critical in the pathogenesis of cardiac hypertrophy and heart failure. However, whether CAND1 titrates the degradation of hypertrophy related protein eg. calcineurin and regulates cardiac hypertrophy remains unknown. Therefore, we aim to explore the role of CAND1 in cardiac hypertrophy and heart failure and the underlying molecular mechanism. Here, we found that the protein level of CAND1 was increased in cardiac tissues from heart failure (HF) patients and TAC mice, whereas the mRNA level did not change. CAND1-KO+ /- aggravated TAC-induced cardiac hypertrophic phenotypes; in contrast, CAND1-Tg attenuated the maladaptive cardiac remodeling . At the molecular level, CAND1 overexpression downregulated, whereas CAND1-KO+ /- or knockdown upregulated calcineurin expression at both in vivo and in vitro conditions. Mechanistically, CAND1 overexpression favored the assembly of Cul1/atrogin1/calcineurin complex and rendered the ubiquitination and degradation of calcineurin. Notably, CAND1 deficiency-induced hypertrophic phenotypes were partially rescued by knockdown of calcineurin, and application of exogenous CAND1 prevented TAC-induced cardiac hypertrophy. Taken together, our findings demonstrate that CAND1 exerts a protective effect against cardiac hypertrophy and heart failure partially by inducing the degradation of calcineurin.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Kaiyuan Jiang,Fen Xiong,Yiwen Peng,Lingfei Meng,Xinran Wang,Yingruo Xu,Tian Tang,Hongchang Gao
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes with limited effective interventions. Using a streptozotocin-induced insulin-deficient, type 1 diabetes-like DCM mouse model, we show that intermittent fasting (IF) improves cardiac function and attenuates myocardial remodeling. Antibiotic-mediated microbiota depletion largely abolished these benefits, whereas fecal microbiota transplantation from IF-treated donors recapitulated cardioprotection, supporting a causal role of the gut microbiota. Metagenomic profiling identified Akkermansia muciniphila ( A. muciniphila ) as a prominent IF-responsive taxon, and A. muciniphila supplementation alleviated cardiac injury without obvious improvement in glycaemia. Integrated serum and heart metabolomics identified 1-methyl-L-histidine as a microbiota-associated metabolite reduced in diabetes but restored by IF and A. muciniphila . In vitro and ex vivo assays further supported an L-anserine-linked microbial route for 1-methyl-L-histidine generation. Importantly, oral 1-methyl-L-histidine supplementation recapitulated key cardioprotective effects, remodeled cardiac lipid homeostasis, and reduced lipid peroxidation and oxidative injury. Together, these findings support a gut microbiota–metabolite–lipid axis associated with IF-related cardioprotection in DCM and highlight microbial metabolites as tractable targets to complement dietary intervention.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Yuhan Qiao,Gang Li,Zhiwen Luo,Mengqi Lin
The one-pot synthesis of 1,2-pentanediol from 1-pentene is a route featuring environmental benignity, cost-effectiveness, and high atom economy. In this study, a bifunctional zirconium sulfate-loaded titanosilicate molecular sieve (ZS/Ti-MWW) catalyst was prepared via the impregnation method and used in the one-pot synthesis of 1,2-pentanediol. The effects of reaction conditions, zirconium sulfate loading, and calcination temperature on the catalytic performance for the oxidative hydration of 1-pentene were systematically investigated. On the basis of the NH3-TPD characterization results, the acid amounts of different catalysts were quantitatively analyzed. The results confirmed that zirconium sulfate could introduce abundant acidic sites into the catalyst, and the acid amount varied with the loading amount of zirconium sulfate and the calcination temperature. With the increase in acid sites in the ZS/Ti-MWW catalyst, its catalytic activity in epoxide hydration was markedly improved. Thus, the 1-pentene epoxidation and epoxide hydration were efficiently carried out in one system without additional separation. Under the optimal reaction conditions, the conversion rate of 1-pentene, the selectivity, and the yield of 1,2-pentanediol reached 95.65%, 80.72%, and 77.21%, respectively. This work offers new insights into the design and preparation of bifunctional titanosilicate molecular sieve catalysts as well as the efficient and green synthesis of 1,2-diols from olefins.
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AICHE JOURNAL
·
2026
·
IF 4.4
Qi Liu,Shanlei Han,Dong Xiong,Yuming Li,Qingxin Yang,Dan Zhao,Yuhang Zhong,Shihao Wang,Zhentao Chen,Dmitry E. Doronkin,Laiyong Zhang,Chunming Xu,Guiyuan Jiang
Tuning hydroxyl defects and constructing active sites at the molecular level is critical for rational design of propane dehydrogenation (PDH) catalysts and understanding the structure–activity relationship. For practical application, enhancing catalysts anti-coking performance is equally important. Herein, the simultaneous regulation of hydroxyl nests content and b -axis thickness was achieved by adjusting the urea/SiO 2 ratio during the preparation of Silicalite-1. The propylene formation rate of the catalysts prepared by introducing Zn species showed a linear positive correlation with the hydroxyl nests content, and the coking behavior was governed by the b -axis thickness of the support. The optimized ZnO x /Silicalite-1 exhibited a high propylene space time yield of 2.2 kg h −1 kg cat −1 with propane conversion of 31% at 550°C. This work provides novel insights into PDH catalyst design from both chemistry and chemical engineering views.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Zhan Wang,Cheng Zheng,Wenzhen Li,Kaung Myat Kyaw,Yunmin Zhu,Yihan Lin,Zhen Lin,Di Wu,Zhiqi Hu,Yang Sun,Kaitao Li
Introduction Androgenetic alopecia (AGA), the most common form of hair loss, lacks ideal therapies due to the limitations of current drugs. Natural compounds with low toxicity and good biocompatibility present promising alternatives. Ginkgolide B (GB), a bioactive component of Ginkgo biloba , possesses multiple biological activities, yet its efficacy and mechanism against AGA remain unexplored. Objectives This study aimed to investigate the hair growth-promoting effect of GB in a dihydrotestosterone (DHT)-induced hair loss model and to elucidate the underlying molecular mechanism. Additionally, a novel detachable microneedle delivery system was developed and evaluated to overcome GB's poor transdermal permeability, thereby enhancing its therapeutic efficacy. Methods The AGA microenvironment was first simulated using DHT-stimulated human dermal papilla cells (HDPCs) in vitro. The molecular mechanism by which GB improves the secretory function of HDPCs was investigated through network pharmacology, western blot, transmission electron microscopy, and immunofluorescence. Subsequently, a detachable microneedle system was designed, in which GB was encapsulated in poly (lactic-co-glycolic acid) (PLGA) microspheres and integrated with the sulfobutylether-β-cyclodextrin (SCD)-based matrix (GB@MS-MN). The therapeutic efficacy of this system was evaluated in a DHT-induced hair loss model. Results GB rescued DHT-induced dysfunction in HDPCs, reversing the aberrant secretion of hepatocyte growth factor (HGF) and dickkopf-1 (DKK1). Mechanistically, GB alleviated DHT-induced endoplasmic reticulum stress (ERS) in HDPCs by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. And GB promoted hair growth in DHT-induced hair loss mice. The GB@MS-MN system demonstrated excellent mechanical properties and targeted follicular delivery and showed superior hair growth promotion compared to free GB and minoxidil. It effectively suppressed follicular ERS, with no observed systemic toxicity. Conclusion In summary, this study confirms that GB protects HDPCs function by suppressing DHT-induced ERS through activation of the Nrf2/HO-1 pathway. Furthermore, a detachable microneedle delivery system based on a PLGA-SCD composite effectively overcomes the transdermal barrier of GB and demonstrates superior hair-promoting efficacy.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2026
·
IF 6.6
Chuanlong Huang,Mengqi Hao,Shurun Yao,Lirong Wang,Gang Liu,Zhuo Wei
Bioreduction of Cr(VI) by Shewanella through extracellular electron transmission (EET) attracts increasing interest due to cytochrome c (cyts c ) system especially conductive flagella (“nanowire”) structure. The responses of bioreduction efficiency, “nanowire” growth, cyts c synthesis, and e (electron) transmission intensity through CymA→MtrA→MtrB→MtrC→OmcA (Route 1) and CymA→NapA→NapB (Route 2) to iron ion (Fe 3 + ) and nitrate (NO 3 - ) were evaluated. Results showed that Fe 3+ and NO 3 - of 1–1.5 mM significantly ( p < 0.01) enhanced bioreduction of Cr(VI) from 67% to 82% and 79%, respectively with promoted cyts c -mediated c onductivity (C p ). Both Fe 3+ and NO 3 - stimulated the growth of “nanowire” and synthesis of cyts c participating in EET with Fe 3+ showing stronger stimulation on Routes 1 while NO 3 - on Routes 2. The genes expression of cyts c on inner membrane (CymA), periplasmic space (NapA/NapB), and “nanowire” (MtrA/MtrB/MtrC, OmcA) show synchronous responses to Fe 3+ and NO 3 - . However, contents of mobile cyts c in extracellular polymeric substances (EPS) and structural cyts c in cell membrane showed inconsistent responses to Fe 3+ and NO 3 - . Overall, this study illustrated the regulation mechanism of e acceptors on cyts c- electron transmission system of Shewanella , which help improving the electrochemical efficiency on Shewanella and provide novel idea in chromium remediation strategy .
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高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2026
·
IF 4
Malik Jan,Kashif Hayat,Israr Khan,Aadil Ahmed Memon,Ibrar Khan
The new metabolite 3-hydroxyphenazine 1-carboxylic acid (3-OH-PCA) was obtained by Aspergillus sclerotiorum ASJ82 whole-cell biocatalysis of phenazine 1-carboxylic acid. Despite the biotechnological perspective, the lack of favorable methods for 3-OH-PCA separation and purification from complex biotransformation media has considerably hampered further experimental studies for large-scale industrial applications because of insufficient amounts of purified compounds. In this context, the present work aimed to develop a simple and proficient technique for the separation and purification of 3-OH-PCA from the crude extraction and culture medium of A. sclerotiorum ASJ82. The static adsorption and desorption characteristics of five macroporous resins were evaluated, namely, HP-20, HZ-818, HZ-801, D001, and D155. Remarkably, compared with the other resins, the HZ-818 resins exhibited notable advantages in the adsorption and desorption of 3-OH-PCA. Additionally, the equilibrium adsorption data of the HZ-818 resins were assessed via the Langmuir and Freundlich isotherm models. The analysis revealed that the experimental data exhibited a favorable fit with the Langmuir isotherm model, providing valuable insights into the adsorption behavior of 3-OH-PCA on the HZ-818 resins. Furthermore, a chromatographic column packed with HZ-818 resins was employed, and dynamic adsorption and desorption experiments were conducted. These tests aimed to establish and optimize the operational parameters required to effectively separate and purify 3-OH-PCA. Under the optimized separation and purification conditions, the average adsorption capacity and desorption ratio of 3-OH-PCA were 21.1 ± 1.2 mg/g dry resin and 88 ± 1.2 %, respectively. After treatment with HZ-818 resin, the 3-OH-PCA content considerably increased. These findings revealed that the purity of 3-OH-PCA was 96.5 ± 2.1 %, whereas the recovery rate was 85.32 ± 1.2 %. The results indicate that the HZ-818 resin has significant potential as an adsorbent for effectively separating and purifying 3-OH-PCA from complex media. Overall, this methodology demonstrates great promise for achieving high yields in the separation and purification of 3-OH-PCA and could be utilized in the large-scale production of 3-OH-PCA purification from A. sclerotiorum ASJ82 extracts in industry, presenting an avenue for further investigation and application.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2026
·
IF 6.8
Fu-Yi Shi,Chun Li,Xi-Yang Zhang,Li-Lan Ou,Gui-Sheng Wu,Huai-Rong Luo
Ethnopharmacological relevance Corylin is a natural flavonoid isolated from the seeds of Psoralea corylifolia L., a traditional medicinal herb historically used to treat bone-related disorders such as osteoporosis. However, its role in organismal aging and the underlying molecular mechanisms remain largely unexplored. Aim of the study This study aimed to evaluate the anti-aging efficacy of corylin and elucidate the molecular basis of its action. Materials and methods Using Caenorhabditis elegans ( C. elegans ) as a model organism, we systematically assessed the impact of corylin on lifespan and multiple aging-associated phenotypes, including locomotor capacity, muscle integrity, lipofuscin accumulation, and resistance to thermal, pathogenic, and oxidative stress. Neuroprotective potential was evaluated using transgenic models of Parkinson's and Huntington's diseases. To uncover the mechanisms involved, we analyzed the DAF-16/SKN-1 signaling axis and autophagy-related processes using transgenic reporter strains, RNA interference, and RT-qPCR. Results Corylin treatment significantly extended lifespan, improved locomotor performance, and reduced lipofuscin accumulation. Furthermore, it enhanced resistance to environmental stresses and conferred neuroprotection in models of neurodegeneration. Mechanistically, corylin promoted nuclear translocation of DAF-16 and upregulated the expression of DAF-16/SKN-1 target genes. This transcriptional activation was associated with enhanced autophagic flux and improved mitochondrial quality. Crucially, the beneficial effects of corylin were abolished in daf-16 and skn-1 mutants, as well as under autophagy-deficient conditions. Conclusion Corylin exerts multifaceted anti-aging effects in C. elegans by coordinately activating the DAF-16/SKN-1 signaling axis, thereby enhancing autophagic flux and maintaining mitochondrial homeostasis. These findings identify corylin as a promising natural candidate for aging intervention.
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高影响因子
ACS Nano
·
2026
·
IF 17.3
Guangyu Ma,Yuting Li,Xiang Li,Dehong Yu,Minghao Chao,Jiale Li,Jintao Guo,Ke Wang,Zhao Liu,Rongrong Sun,Fenglei Gao
Intracellular ion homeostasis is essential for cellular function; tumor cells remodel ion networks to sustain malignant proliferation. Targeting ion homeostasis represents a promising anticancer strategy. Cuproptosis and ferroptosis, emerging programmed cell death modalities, exploit tumor-specific ionic vulnerabilities but are constrained by mechanisms including ATPase copper transporter (ATP7A)-mediated Cu2+ efflux and the solute carrier family 7, member 11 (SLC7A11/xCT)-driven antioxidant axis. We developed an ion-mediated immunotherapeutic nanoplatform (CCZSM) that disrupts Cu2+ and Fe2+ metabolism while activating antitumor immunity. Zn2+ enhances zinc transporter 1 (ZNT1) expression to increase Cu2+ influx; concurrent ATP7A silencing inhibits Cu2+ efflux, inducing cuproptosis. Mitochondrial Fe2+ release combined with Co2+-induced free Fe2+ generates an “Fe2+ storm” that, alongside Cu2+-mediated disruption of cysteine (Cys) metabolism, compromises antioxidant defenses and triggers ferroptosis. This ionic dysregulation induces tumor cell death and promotes release of damage-associated molecular patterns (DAMPs) and mitochondrial DNA (mtDNA), activating immunogenic cell death (ICD) and the cGAS-STING pathway. Resultant dendritic cell (DC) maturation and T-cell activation link ion metabolic interference to systemic immune responses. This study establishes a multi-ion metabolic intervention strategy, advancing tumor immunotherapy paradigms.
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高影响因子
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