ChemElectroChem
·
2017
·Vol. 4
·期 9
·2314-2320
·
IF 4.136
Cong Zhou,Lina Lin,Yuzhu Ma,Liyan Huang,Jun Li,Zhengping Liu,Zhaoxia Dong
The amorphous mesoporous Ni(OH) 2 hollow spheres (Ni(OH) 2 -HSs) with waxberry-like morphology were fabricated by using a facile hydrothermal method with poly(styrene-acrylic acid) spheres as the template, followed by extraction of the template. In the hydrothermal process, Ni(NO 3 ) 2 ⋅6H 2 O was employed as the precursor of Ni(OH) 2 . SEM, TEM, XPS, XRD, and N 2 adsorption-desorption isotherm techniques were used to characterize the structure and morphology of Ni(OH) 2 -HSs. The obtained Ni(OH) 2 -HSs have a uniform morphology with an average diameter of 300 nm and shell thickness of about 25 nm. The mesoporous shells of the Ni(OH) 2 -HSs are composed of amorphous Ni(OH) 2 particles. When used as an electrode, the as-prepared Ni(OH) 2 -HSs exhibit pseudocapacitive behavior with a high specific capacitance of 2559 F g −1 at a scan rate of 1 mV s −1 and a good capacitance retention of 91.8% after 1000 cycles at a current density of 5 A g −1 . These results suggest promising applications of the waxberry-like amorphous Ni(OH) 2 hollow spheres in electrode materials for supercapacitors. Graphical Caps off : Amorphous mesoporous Ni-(OH) 2 hollow spheres (Ni-(OH) 2 -HSs) with a waxberry-like morphology are fabricated through a facile hydrothermal method by using poly-(styrene-acrylic acid) spheres as a template, followed by extraction of the template. When used as an electrode, the as-prepared Ni-(OH) 2 -HSs exhibit pseudocapacitive performances with a high specific capacitance and a good capacitance retention. These results suggest promising applications of the waxberry-like amorphous Ni-(OH) 2 hollow spheres in electrode materials for supercapacitors.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2019
·Vol. 2019
·期 9
·1273-1278
·
IF 2.578
Wenqiang Chen,Qun Jing,Qiaoqiao Zhang,Ming-Hsien Lee,Xuefang Lu,Ping Wei,Zhaohui Chen
Introduction transition metal with d 10 electrons and lone pair cations with large radius into phosphate systems are helpful to get new crystal structure configuration. Guided by the above method, the first lead cadmium phosphate, Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ), was synthesized. Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ) features a three-dimensional (3D) structure, in which Pb(1) 2 O 8 dimer and Pb(2)O 5 polyhedra are filled between the two-dimensional (2D) layers, which are composed of unique [Cd 6 P 8 O 30 ] groups. In the Pb II M II PO (M II = without or divalent metal ions) systems, the title compound is the first phosphate containing two different P–O groups simultaneously. The ratios of cation/phosphorus (C/P) and polymerization modes of P–O anions have a close relationship by many structural comparisons. Thermal analysis shows that Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ) melts congruently and is thermally stable. In addition, the UV/Vis-IR diffuse reflectance spectrum and infrared (IR) spectrum have been reported. The relationship between electronic structure and optical properties was clarified by first-principles studies. Graphical The crystal structure of a new cadmium-based compound Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ), containing two kinds of P–O groups, exhibits unique [Cd 6 P 8 O 30 ] ∞ layers.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2016
·Vol. 44
·期 8
·1286-1290
·
IF 0.566
Li-Hua DENG,Jin-Bo DAI,Zhen-Lin XU,Jin-Yi YANG,Hong WANG,Zhi-Li XIAO,Hong-Tao LEI,Yuan-Ming SUN,Yu-Dong SHEN
To detect furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) in fish sample, a Eu 3+ labeling time-resolved fluoroimmunoassay (TRFIA) was developed. The experimental conditions were optimized as follows: the AMOZA-OVA concentration was 0.25 μg mL −1 ; the antibody was diluted by 50000 folds, and the competitive reaction time was 50 min. Under the optimal conditions, the method showed a detection limit of 0.01 ng mL −1 , an IC 50 of 0.26 ng mL −1 and a linear range (IC 20 −IC 80 ) of 0.025−2.83 ng mL −1 . The spiked recoveries of AMOZ in fish at three spiked levels ranged from 78.0% to 86.0%, and the relative standard deviations were less than 15%. Good correlation between ic-TRFIA and high performance liquid chromatography-tandem mass spectrometry was obtained for spiked food samples. The proposed ic-TRFIA method was suitable for the determination of AMOZ residue in food samples.
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JOURNAL OF COORDINATION CHEMISTRY
·
2016
·
IF 1.756
Lei Qi,Qian Li,Xiao Hong,Li Liu,Xin-Xin Zhong,Qiao Chen,Fa-Bao Li,Qian Liu,Hai-Mei Qin,Wai-Yeung Wong
Highly emissive three-coordinate copper halide complexes with a bidentate phosphine ligand have attracted attention. Here, a series of three-coordinate mono- and dinuclear copper halide complexes, [CuI(dpbp)2] (1) and [CuX(dpbp)]2 (dpbp = 2-(diphenylphosphino)biphenyl, X = Br (2), Cl (3)), were synthesized, and their molecular structures and photophysical properties were investigated. In the solid state, these complexes exhibit green photoluminescence with microsecond lifetimes (λmax = 515–538 nm; τ = 11.8–19.1 μs) at 298 K. The emission of the complexes originates from the (σ + X) → π* transition. All three complexes displayed good thermal stability.
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Chemistry-An Asian Journal
·
2021
·Vol. 16
·期 19
·2973-2977
·
IF 4.568
Jun Zhou,Sha Yang,Yesen Tan,Huaisheng Cheng,Jinsong Chai,Manzhou Zhu
The change in the valence state of nanocluster can induce remarkable changes in the properties and structure. However, achieving the valence state changes in nanoclusters is still a challenge. In this work, we use Cu 2+ as dopant to “oxidize” [Ag 62 S 12 (SBu t ) 32 ] 2+ (4 free electrons) to obtain the new nanocluster: [Ag 62−x Cu x S 12 (SBu t ) 32 ] 4+ with 2 free electrons. As revealed by its structure, the [Ag 62−x Cu x S 12 (SBu t ) 32 ] 4+ (x=10∼21) has a similar structure to that of [Ag 62 S 12 (SBu t ) 32 ] 2+ precursor and all the Cu atoms occupy the surface site of nanocluster. It′s worth noting that with the Cu atoms doping, the [Ag 62−x Cu x S 12 (SBu t ) 32 ] 4+ nanocluster is more stable than [Ag 62 S 12 (SBu t ) 32 ] 2+ at higher temperature and in electrochemical cycle. This result has laid a foundation for the subsequent application and exploration. Overall, this work reveals crystals structure of a new Ag−Cu nanocluster and offers a new insight into the electron reduction/oxidation of nanocluster.
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ELECTROCHIMICA ACTA
·
2012
·
IF 3.832
Yao Huang,Baoyang Lu,Jingkun Xu,Ge Zhang,Leiqiang Qin,Shuai Chen,Fangfang Kong
Anionic ring-open polymerization of ethylene oxide (EO) functionalized 1-hydroxy-2-methoxybenzene (HMOB) monomer 1-(2,3-epoxypropyl)-2-methoxybenzene (EPMOB) led to the formation of the precursor polymer oligo(1-(2,3-epoxypropyl)-2-methoxybenzene) (OEPMOB). Poly(OEPMOB- co -1-hydroxy-2-methoxybenzene) films P1 , P2 , P3 , and P4 were successfully achieved by secondary electrochemical copolymerization of the monomer mixtures OEPMOB/HMOB with different mass ratios of 3:1, 2:1, 1:1, and 1:2, respectively. The possibility of inter- and intramolecular polymerization resulted in a cross-linking conjugated network microstructure. A series of experiments were carried out to investigate the influence of monomer mass ratios on the electrochemical copolymerization and other properties of copolymer films. UV–vis, FT-IR, and 1 H NMR were used to characterize the structure of copolymers. Fluorescence spectroscopic studies revealed that the copolymers partly dissolved in DMSO were all good blue light-emitters, with strong emissions at 392 nm in the doped state. Since EO and HMOB units were introduced into the skeletal backbone, thermal stability of copolymers was improved in comparison with their corresponding homopolymers.
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POLYMER
·
2013
·Vol. 54
·期 18
·4902-4908
·
IF 3.379
Peng Liu,Wang Tang,Hailiang Zhang
A series of water-soluble thermoresponsive copolymers , i.e., poly[( N -isopropylacrylamide- co -bis( N -hydroxyisopropyl pyrrolidone) 2-vinylterephthalate] [P(NIPAm- co -HIPPVTA)], with well-defined comonomer content have been synthesized via conventional free-radical copolymerization at low conversion. The liquid crystalline behavior of the copolymers was investigated using polarized light microscope and differential scanning calorimetry . The results revealed that the P(NIPAm- co -HIPPVTA) exhibit liquid crystallinity when the NIPAm content is lower than 52.2 mol%, which was obviously different from that of previous papers. In addition, thermo-responsive behaviors of copolymer also demonstrated by dynamic light scattering . The cloud points of these copolymers can be tuned over a broad range (i.e., 9.9–81.2 °C) by simply altering the molar content of the HIPPVTA. It is noted that the cloud point of the copolymers showed unexpected trend (i.e., parabolicaly other than linearly or exponentially) with the increasing of HIPPVTA content. That is, with an increase of HIPPVTA molar content, the cloud point of copolymer decreases at first and then increases.
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ACTA MATERIALIA
·
2023
·
IF 9.4
Weijia Guo,Yutian Lu,Zhiyu Ma,Haitao Wu,Zhenxing Yue
Dielectric ceramics with low dielectric loss in the microwave bands are key materials used in fifth/sixth-generation (5G/6G) telecommunication. Exploring the defect behavior and the broadband dielectric response of ceramics is helpful to understand the loss mechanism and develop novel low-loss microwave dielectric ceramics. In this work, Al/Nb was co-substituted for Ti 4+ in Na 1/2 Sm 1/2 TiO 3 (NST) ceramics with a perovskite structure, and the low frequency, microwave and terahertz (THz) dielectric responses were investigated. In different frequency bands, the variations of dielectric loss with substitution amount are inconsistent. The Al/Nb-substitution increases the dielectric loss in the low frequency and microwave bands, while the dielectric loss in the THz band decreases. The changes in dielectric loss are closely related to the lattice defects in Na 1/2 Sm 1/2 Ti 1– z (Al 1/2 Nb 1/2 ) z O 3 (NST- z AN, 0 ≤ z ≤ 0.1) ceramics, which are studied by thermally stimulated depolarization current (TSDC) technique. The dielectric relaxation of the defects including oxygen vacancies ( V O · · ) and defect dipoles leads to the dielectric loss in the low-frequency and microwave bands. The dielectric loss in the THz band is mainly affected by the damping of lattice vibration , which is associate with the defect concentration. This work might provide a considerable reference for the development of low-loss dielectric materials.
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CHEMICO-BIOLOGICAL INTERACTIONS
·
2019
·
IF 3.407
Wen-Jing Wu,Wei-Feng Tang,Ming-Hui Xiang,Jianshe Yan,Xiumei Cao,Chang-Hui Zhou,Yan Chang,Jing Xi,Yi-Yi Cao,Yang Luan,Xin-Yu Zhang
1-Chloro-2-hydroxy-3-butene (CHB) is a possible metabolite of 1,3-butadiene, a carcinogenic air pollutant . To demonstrate its formation in vivo, it is desirable to develop a practical biomarker and the corresponding analysis method. CHB can undergo alcohol dehydrogenase- and cytochromes P450 enzymes (P450)-mediated oxidation to yield 1-chloro-3-buten-2-one (CBO), which readily forms glutathione conjugates. We hypothesized that CBO-derived mercapturic acids , which are the expected biotransformed products of CBO-glutathione conjugates, could be used as CHB biomarkers. Thus, in the present study, we investigated the in vivo biotransformation of CHB into CBO-derived mercapturic acids. Because the reaction of CBO with N -acetyl- l -cysteine yields two products, 1,4- bis ( N -acetyl- S -cysteinyl)-2-butanone (NC1) and 1-chloro-4-( N -acetyl- S -cysteinyl)-2-butanone (NC2), we first developed an isotope dilution LC/ESI − -MS-MS method to quantitate urinary NC1 and NC2, and then determined their concentrations in urine of C57BL/6 mice and Sprague-Dawley rats administered CHB. Since no NC2 was detected in samples, the LC/ESI − -MS-MS method was optimized specifically for NC1. NC1 was enriched through solid phase extraction with the recovery being 75–82%. The limits of detection and quantitation were 6.8 and 34 fmol/0.1 mL for mouse urine, and 4.5 and 7.1 fmol/0.1 mL for rat urine, respectively. In urine of animals before CHB administration, no NC1 was detected; in mice administered CHB at 10 and 30 mg/kg, and rats at 5 and 15 mg/kg, NC1 was detected and its concentrations in urine from animals given higher doses were 3–6 fold higher than those given lower doses. Moreover, the NC1 concentrations in urine during 0–8 h were 4–6 fold and 10–11 fold higher than those during 8–24 h for mice and rats, respectively. The results demonstrated that CHB could be in vivo biotransformed into NC1, which could be used as a practical CHB biomarker.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Bin Ou,Xiaofang Li,Lemei Huang,Yujiang Ke,Chaohui Che,Xiaobing Liu,Yajun Li,Kui Wu
The solubility of 2-chlorocinnamic acid in 16 pure organic solvents, including alcohols, esters, ketones, toluene, and acetonitrile, was determined by the gravimetric method at 272.15–321.55 K under 101.3 kPa. Results showed that solubility of 2-chlorocinnamic acid increased with temperature in all solvents. To correlate the experimental data, five thermodynamic models, i.e., the modified Apelblat, Buchowski–Ksiazaczak λh, NRTL, Wilson, and Yaws equations, were employed. Model accuracy was evaluated using average relative deviation (ARD) and root-mean-square deviation (RMSD), and all models provided satisfactory correlations. In addition, electrostatic potential energy surface analysis was carried out to preliminarily assess possible solute–solvent interactions, while density functional theory (DFT) calculations were used to further examine molecular interactions during dissolution. The Kamlet–Abboud–Taft linear solvation energy relationship (KAT-LSER) model was applied to analyze solvent effects. Thermodynamic functions, including enthalpy, entropy, and Gibbs free energy of mixing, were calculated using the Wilson model. The results revealed that the dissolution of 2-chlorocinnamic acid in the studied solvents is an endothermic, entropy-driven, and spontaneous process, indicating favorable solute–solvent interactions and enhanced solubility at higher temperatures.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Jue Wang,Peixian Chen,Yonghua Li,Rui Wang,Wenxin Ding,Ruizhi Yu,Qingqing Qin,Runzhu Wu,Wei Wei,Jinxin Shi,Hongbin Yuan,Chunlin Zhuang,Yi Sun
Type 2 diabetes-associated cognitive dysfunction (TDACD) is a debilitating complication characterized by neuroinflammation and oxidative stress, yet its underlying molecular mechanisms remain incompletely understood. The signal transducer and activator of transcription 3 (STAT3) pathway is increasingly implicated in neurodegeneration, but its specific role in TDACD and its interplay with the Nrf2 antioxidant defense system have not been fully elucidated. This study investigated the therapeutic potential of targeting STAT3 in TDACD using both pharmacological inhibition with niclosamide and specific genetic silencing strategies. In a high-fat diet (HFD) plus streptozotocin (STZ)-induced TDACD mouse model, STAT3 inhibition significantly ameliorated cognitive deficits and reduced neuronal pathology, including amyloid-β and phosphorylated Tau accumulation. Mechanistically, inhibition of STAT3 signaling suppressed neuroinflammation and reactive astrogliosis while simultaneously promoting the nuclear translocation of Nrf2 and the expression of downstream antioxidant enzymes. These effects were also reproduced in vitro using primary astrocytes exposed to high glucose. Specific STAT3 knockdown reversed the pro-inflammatory A1 phenotype and restored redox balance in these cells. Crucially, silencing Nrf2 eliminated the protective effects of STAT3 inhibition, suggesting a functional regulatory axis between STAT3 and Nrf2. Collectively, our findings support that STAT3 inhibition ameliorates cognitive dysfunction by disinhibiting the Nrf2 pathway to restore redox homeostasis and shift astrocytes towards a neuroprotective phenotype, highlighting the STAT3-Nrf2 axis as a promising therapeutic target for TDACD.
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PubMed
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Nature Communications
·
2026
·
IF 18.1
Mao Congyang,Jin Wanyu,Dou Limeng,Guo Tong,Huang Jin,Wang Yi,Liu Xiangmei,Wu Shuilin,Qiao Wei,Xiang Yiming,Zhu Yizhou,Wu Jun,Yeung Kelvin Wai Kwok
The pandemic-scale progression of type 2 diabetes mellitus (T2DM) necessitates innovative interventions targeting the pathogenic triad of insulin resistance, dysregulation of lipid metabolism, and gut microbiome dysbiosis. Here, we report a synthetically bioengineered probiotic consortium (REcN-F/Ca) developed through directed metabolic adaptations of Escherichia coli Nissle 1917 (EcN) under iterative hydrogen peroxide selection, subsequently functionalized with fructooligosaccharide-calcium carbonate composites. REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability. In high-fat diet-induced obese male mice, REcN-F/Ca restores gut microbiota diversity, enriches butyrogenic taxa (Lachnospiraceae and Blautia ), and rescues short-chain fatty acids depletion. Transcriptomic profiling reveals PPAR signaling activation, driving lipid metabolism and suppressing adipose inflammation. These effects translate to systemic metabolic improvements with attenuated weight gain (−25.4%), restored glucose homeostasis, and reduced insulin resistance (HOMA-IR: −73.2%) in the obesity and T2DM murine model. Our findings establish REcN-F/Ca as a synthetically engineered probiotic that simultaneously corrects intestinal ecological perturbations and reverses host metabolic dysfunction, proposing a paradigm for metabolic syndrome management.
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