Molecular Catalysis
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2021
·
IF 5.062
Yuchen Zhu,Hao Wu,Zheng Fang,Xiaobing Yang,Kai Guo,Wei He
Cobalt (II)-meso-tetra(4-carboxyphenyl) porphyrin supported by deprotected lignin was synthesized through the covalent linkage between carboxy groups in the porphyrin and hydroxyl groups in the lignin. The resulting supporting catalysts were applied in the selective oxidation of 5-hydroxymethylfurfural. Through solvent optimization, 5-hydroxymethyl-2-furancarboxylic acid and 2,5-furandicarboxylic acid could be selectively obtained. Steric effect of lignin prevented unwanted aggregation-caused quenching, avoiding catalyst deactivation. Thus, supported catalysts displayed better catalytic efficiency compared free metal porphyrin catalyst. Unlike the excessive use of sodium hydroxide in the oxidation of HMF catalyzed by metal catalysts, an equivalent amount of sodium hydroxide was used in this oxidation process. Meanwhile, lower activation energy was detected when metal porphyrin supported by deprotected lignin was used. By adjusting the pH in the reaction, supported catalysts could be reused. The catalytic activity remained stable during the recycling experiments.
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Virology Journal
·
2025
·Vol. 22
·期 1
·1-14
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IF 3.8
Liu Xianglan,Hu Jiaming,Wu Jiarui,Tian Yiru,Wang Jinbo,Wu Chunyan,Chen Qingfeng,Krall Leonard,He Yanping,Lu Qun
Background Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or antiviral drug available. Consequently, the development of effective antiviral agents is of critical importance. Methods and results In this study, a series of 41 5-cyano-2-thiacetyl aromatic pyrimidinone compounds were designed and synthesized. A cell viability-based screening for anti-murine norovirus (MNV) compounds was conducted, revealing that compound 29 (hereafter used as Co-29) exhibited antiviral activity against MNV. Co-29 demonstrated effective inhibition of MNV CW3 RNA replication, exhibiting an EC 50 of 58.22 μM. An RdRp enzyme activity assay indicated that Co-29 directly inhibits RdRp activity to both MNV and HNV. Molecular docking studies suggested that Co-29 interacts with the palm region of RdRp via hydrogen bonding with specific residues, which are conserved in RdRps across MNV and HNV norovirus variants. Conclusions In conclusion, our study suggests that the newly synthesized Co-29 may serve as a potential antiviral candidate or lead compound for future studies.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2024
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IF 5.8
Yanlong Jia,Mengyan Wang,Bolun Li,Jiang Liu,Xueping Song,Min Wu,Yongjun Yin
To solve the long-term environmental pollution caused by black liquor and waste plastics, and achieve high-value utilization, the method about co-pyrolysis of black liquid solid and waste plastics (Polypropylene, Polyethylene) catalyzed by Mo-Ni/HZSM-5 to prepare high-quality bio-oil is studied. The results found that hydrocarbons increased from 14.92% to 42.03% as Polyethylene was co-pyrolyzed with BLS, and hydrocarbons increased from 14.92% to 41.75% as Polypropylene was co-pyrolyzed with BLS, adding plastics can significantly improve the hydrocarbons yield of black liquor. Mo-Ni/HZSM-5 acts as a hydro deoxidizer in the pyrolysis of black liquid and waste plastics, the total hydrocarbons of black liquid solid, black liquid solid& Polypropylene, black liquid solid & Polyethylene increased by 6%, 78%, and 45%, respectively. An appropriate increase of pyrolysis temperature can promote the co-pyrolysis of BLS with PP, and BLS with PE, and can increase the yield of hydrocarbons. Compared with black liquor’s pyrolysis, the yield of hydrocarbons can be increased by 59.65% and 24.52% as Polyethylene or Polypropylene is adapted to pyrolysis with black liquid solid, respectively, the high-quality bio-oil is obtained because of a large number of hydrocarbons and high hydrogen content.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Ting Liang,Han Liu,Lanjing Li,Ru Huan,Chunshan Gui
Human organic anion transporting polypeptide 1B3 (OATP1B3) and 1B1 are two liver-specific and highly homologous uptake transporters, whose structures consist of 12 transmembrane domains. The present study showed that OATP1B3 is more heavily N-glycosylated than OATP1B1 in extracellular loop 2 (EL2) and EL5. OATP1B3 has six N-glycosylation sites, namely N134, N145, N151, N445, N503, and N516, which is twice of that of OATP1B1. Single removal of individual N-glycans seems to have minimal influence on the surface expression and function of OATP1B3. However, simultaneous removal of all N-glycans will lead to OATP1B3's large retention in the endoplasmic reticulum and cellular degradation and thus significantly disrupts its surface expression. While N-glycosylation plays a crucial role in the surface expression of OATP1B3, it also has some effect on the transport function of OATP1B3 per se , which is not due to a decrease of substrate binding affinity but due to a reduced transporter's turnover number. Taken together, N-glycosylation is essential for normal surface expression and function of OATP1B3. Its disruption by some liver diseases such as NASH might alter the pharmacokinetic/pharmacodynamic properties of OATP1B3's substrate drugs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ying Wen,Zhen Zou,Yitong Li,Danhua Zhang,Ziru Liu,Hong Liu,Xiejia Li,Wei Wu,Liyun Zeng,Qiongyan Zou,Wenjun Yi
The combination of photodynamic therapy (PDT) and gene therapy is a viable therapeutic approach for the management of secondary hyperparathyroidism (SHPT). Nevertheless, the effective delivery of photosensitizers or nucleotide drugs remains a crucial limitation in achieving therapeutic efficacy. MiR-146b-3p directly targeted BCL2, and its overexpression enhanced the antiproliferative, proautophagic, and proapoptotic effects during 5-aminolevulinic acid (5-ALA)-mediated PDT in this study. Herein, we investigated the potential of codelivering 5-ALA and miR-146b-3p to SHPT primary cells via polyamidoamine (PAMAM) and achieving enhanced therapeutic efficacy relative to that of monotreatment. The fabrication of the PAMAM-based 5-ALA and miR-146b-3p dual-delivery system (5-ALA@PAMAM/miR) involved the use of covalent condensation reactions and electrostatic self-assembly. The nanoparticles were characterized by various analytical techniques, including transmission electron microscopy (TEM), zeta potential measurements, and size measurements. Fluorescence and confocal laser scanning microscopy demonstrated a greater degree of cellular uptake of nanoparticles. Moreover, the synthesized nanoparticles considerably enhanced the effectiveness of PDT without systemic toxicity both in vitro and in vivo. Overall, the nanocarrier-gene-photosensitizer coloaded system is a promising platform for the efficient simultaneous delivery of miR-146b-3p and 5-ALA and achieves synergistic therapeutic effects.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2025
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IF 3.9
Litian Liu,Qing Wang,Jiacheng Liu,Xiao Chen,Yingguo Li,Danfeng Jiang,Chao Yu
The efficient conversion of fructose to 5-hydroxymethylfurfural (HMF) with high yields is challenging in biorefinery processes. In this study, we synthesized nonprecious metal WO3–SO3H catalysts with various crystalline phases using a simple hydrothermal method for HMF production from fructose. The experimental results revealed that the catalytic performance of the WO3–SO3H catalysts with different crystalline phases followed the order: o-WO3–SO3H > h-WO3–SO3H > m-WO3–SO3H > t-WO3–SO3H. In a conventional batch reactor, the o-WO3–SO3H catalyst exhibited remarkable performance, achieving an HMF yield of 99.2% and nearly complete fructose conversion after 100 min of reaction at 140 °C. When used in our developed modular microreactor, the reaction time was drastically reduced, achieving the same yield as in the batch reactor in just 20 min. This research offers a new approach for the rapid and efficient synthesis of HMF.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-14
·
IF 2.4
Yao Wenjie,Chen Lei,Wang Yinzhong,Yang Gang
The composite molecular sieve catalysts with long reaction times were successfully synthesized by introducing Cu 2+ /Mn 2+ and ZSM-5 into the initial gel. The catalysts were characterized with XRD, SEM and NH 3 -TPD, and further investigated through the methanol-to-olefin reactions. The results showed that the addition of Cu 2+ caused the crystallinity of ZSM-5/SAPO-34 (Z-S) to increase significantly, but with addition of Mn 2+ , the crystallinity gradually decreased. With the increase of the Mn 2+ /Cu 2+ ratio, the desorption summits of the weak and strong acid sites gradually increased, but the weak acid centres gradually dominated, which is herein thought helped reducing formation of the coke. The designed Cu 0.05 -Mn 0.05 /Z-S samples showed beneficial catalytic performances with a lifetime of 1500 min, a 1.5-fold increase compared with the Cu 0.05 /Z-S, while their selectivities remained exceeding 89%. Graphical
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Hongke Li,Yunlei Zhang,Yiran Liu,Qinghua Xia,Maobin Wei,Wen Guan,Fang Wang,Yao Chen
Production of high value-added 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF) is a promising alternative to petroleum derivate of terephthalic acid. However, it is still challenging to construct efficient and easily available catalysts suitable for green production process of FDCA under base-free conditions. Herein, a natural clay mineral sepiolite supported AuPd bimetallic catalysts with varied bimetallic ratio were developed and employed for aerobic oxidation of HMF to produce FDCA under alkali-free hydrothermal conditions. Au 1.2 Pd 1 /sepiolite catalyst showed the best catalytic performance with 100% HMF conversion and 98.4% FDCA yield. The key to excellent catalytic performance benefited from synergistic effect between hydroxy-rich surface property of natural sepiolite support and the positive role of AuPd bimetallic sites in the tandem oxidation of aldehyde and hydroxyl groups. The localized electron transfer between AuPd nanoparticles and carriers was investigated by density functional theory calculations. The bimetal promoted the formation of electron-rich interfaces, modulated the local electron redistribution at the interface, and enhanced the adsorption and activation of O 2 , HMF, and the reacted formed intermediates. This work presents a promising strategy for green synthesis of FDCA as well as offers a facile way for the high-value usage of nanofibrous clay mineral.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Qian-Wen Lu,Qing He,Qing-Shuai Zhang,Da Sheng,Song-Hai Wu,Yong Liu,Xu Han
Although thermocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-formylfuran (DFF) by O2 is an important reaction, achieving a high yield of DFF is still challenging. In this study, a series of MoxCuy/NH2-SBA-15 are prepared, and Mo3Cu1/NH2-SBA-15 exhibits the desirable catalytic reactivity with a complete conversion of HMF and high selectivity of 94.4% toward DFF. XPS and EPR analyses indicate that the abundant oxygen vacancies (Ov) and Cu(I) are the reactive sites for O2 activation. Quenching experiments and various characterizations reveal that superoxo (≡Cu(II)/Ov-OO•) on the surface of catalyst, instead of •OH and O2•–, are the primary oxidizing species to abstract H from HMF to RCH2-O•, accompanied by the formation of ≡Cu(II)/Ov-OOH peroxo. Meanwhile, the doped Mo(V/VI) further activates ≡Cu(II)/Ov-OOH peroxo to form ≡Mo-(η2-O2) peroxo, which significantly promotes the oxidation selectivity of RCH2-O• toward DFF via the H-abstraction pathway. This study provides new insight on selective thermal-oxidation of biomass-derived compounds to high-value-added chemicals via regulating reactive oxidizing species on the surface of catalysts.
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Scientific Reports
·
2017
·Vol. 7
·期 1
·1-9
·
IF 4.259
Wang Chao,Zhang Liming,Zhou Tian,Chen Jiachuan,Xu Feng
5-hydroxymethylfurfural (HMF) is an important platform molecule in the synthesis of various chemicals and materials. Herein, we reported a simple and effective dehydration of glucose-based carbohydrates to HMF in a biphasic system containing cyclopentyl methyl ether as the organic phase and AlCl 3 with minute amounts of HCl as co-catalysts. The results showed that the mixed catalysts had a positive synergistic catalytic effect on glucose conversion to HMF compared with single AlCl 3 or HCl catalyst. For glucose, the highest HMF yield of 54.5% was achieved at 175 °C for 20 min. More importantly, the optimal catalytic system was so efficient that it achieved one of the highest reported yields of HMF (30.5%) directly from corncob acid hydrolysis residues. Thus, the catalytic system can become a promising route for effective utilization of biomass in future biorefineries.
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MATERIALS RESEARCH BULLETIN
·
2022
·
IF 5.6
Huazhen Liao,Song Ye,Jingxin Ding,Jianzhong Yu,Xinling Xv,Ling Pan,Peixuan Lin,Deping Wang
Enabling the drug delivery systems with drug release monitoring function is of essential importance to enhance therapeutic effectiveness. Herein, we took a ship-in-a-bottle synthesis strategy to construct the upconversion nanocrystal and zeolite compounded drug delivery system with real-time monitoring function, by using desilicated ZSM-5 zeolite as drug carrier and NaYF 4 : Yb 3+ /Tm 3+ nanocrystal as luminescent probe. Benefiting from the enlarged mesoporous in desilicated ZSM-5, the NaYF 4 : Yb 3+ /Tm 3+ nanocrystals can be successfully loaded inside and the upconversion emission intensity of Tm 3+ under 980 nm excitation was one order of magnitude enhanced after mild heat treatment. The drug release monitoring function were studied by using doxorubicin as model drug, the experimental results indicated that the upconversion emission intensity ratio of I 802nm /I 475nm can accurately evaluate drug release percentage. Further in vitro cytotoxicity evaluation suggested the doxorubicin-loaded [email protected] /DS/HT has excellent biocompatibility and is able to inhibit tumor cells effectively.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Xiaoxue Zhang,Shuman Xu,Jing Hao,Xiaojin Xie,Fengqiu Chen,Dang guo Cheng
Single-crystalline hierarchical ZSM-5 zeolites with different particle sizes (namely 100, 140, and 200 nm) were successfully prepared by adjusting the amount of tetrapropylammonium hydroxide (TPAOH), and investigated in n -heptane catalytic cracking reaction. Diffusional measurements by zero-length column (ZLC) method showed that the apparent diffusivities of n -heptane decreased with the reduction of particle size, indicating the existence of surface barriers. Moreover, with the decrease of particle size, the additional diffusion path length increased, which meant the influence of surface barriers became more apparent. Despite the change of surface barriers, the intracrystalline diffusion still dominated the overall diffusion. Catalytic performance showed that the zeolite with smaller particle size had better stability.
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