npj Science of Food
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2024
·Vol. 8
·期 1
·1-10
·
IF 6.3
Li Hang,Xu Hui,Yao Shuo,Wei Shengnan,Liu Yi,Shi Xuening,Zhao Wei,Zhao Chao
Pathogens detection is a crucial measure in the prevention of foodborne diseases. This study developed a novel multicolor colorimetric assay to visually detect Salmonella Typhimurium ( S. Typhimurium ), by utilizing the etching process of gold nanorods (AuNRs) with TMB 2+ . The strategy involved the construction of nanozyme by assembling magnetic covalent organic framework (MCOF) with aptamer-conjugated AuNPs (Apt-AuNPs), exhibiting remarkable peroxidase-like activity to catalyze the oxidation of TMB/H 2 O 2 and inducing the etching of AuNRs. The presence of S. Typhimurium could inhibit this process, resulting in the generation of vivid colors. The multicolor colorimetric assay could specifically determine S. Typhimurium from 10 2 to 10 8 CFU mL −1 in 60 min with visual detection limit of 10 2 CFU mL −1 , and instrumental detection limit of 2.3 CFU mL −1 . Moreover, detecting S. Typhimurium in chicken, milk, pork and lettuce samples has shown promise in practical applications.
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MOLECULAR BIOLOGY REPORTS
·
2024
·Vol. 51
·期 1
·1-10
·
IF 2.6
Li Zhipeng,Jiao Yang,Wu Zhisong,Liu Haoge,Li Yang,Cai Yaodong,Wei Wan,Cao Fang
Background Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by a constant incidence rate. Unfortunately, effective pharmacological treatments for this condition are lacking and the identification of novel therapeutic approaches and underlying pathological mechanisms are required. This study investigated the potential of quercetin in alleviating pulmonary fibrosis by promoting autophagy and activation of the SIRT1/AMPK pathway. Methods Mouse models of IPF were divided into four treatment groups: control, bleomycin (BLM), quercetin (Q), and quercetin + EX-527 (Q + E) treatment. Pulmonary fibrosis was induced in the mouse models through intratracheal instillation of BLM. Various indexes were identified through histological staining, Western blotting analysis, enzyme-linked immunosorbent assay, immunohistochemistry, and transmission electron microscopy. Results Quercetin treatment ameliorated the pathology of BLM-induced pulmonary fibrosis of mice by reducing α-smooth muscle actin (α-SMA), collagen I (Col I), and collagen III (Col III) levels, and also improved the level of E-cadherin in lung tissue. Furthermore, Quercetin significantly enhanced LC3II/LC3I levels, decreased P62 expression, and increased the number of autophagosomes in lung tissue. These effects were accompanied by the activation of the SIRT1/AMPK pathway. Treatment with EX-527, an inhibitor for SIRT1, reversed all effects induced by quercetin. Conclusion This study showed that quercetin could alleviate pulmonary fibrosis and improve epithelial-mesenchymal transition by acting on the SIRT1/AMPK signaling pathway, which may be achieved by regulating the level of autophagy.
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Waste and Biomass Valorization
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2024
·
IF 2.6
Wang Xin,Yu Shenglong,Li Yuan,Fang Yue,Wang Yifan,Yalikun Nuerbiya
This paper investigates the recovery of waste PE (mulch film) from Xinjiang by solvent recovery method. Under the guidance of solubility parameter theory, combined by HSPiP (version 4.1.07) experiment and HSPs library screening, xylene was selected as the most suitable solvent for recovery of PE. Subsequently, the solid–liquid method was used to graft MAH (maleic anhydride) to PE, and the optimal process conditions were obtained through orthogonal experiments, and the successful grafting of MAH to PE was verified by infrared spectroscopy. Then through XRD(X-ray diffraction) and other checks to analyze the PE before and after grafting, MAH did not change the crystal arrangement of PE, nor did it alteration the crystal type, the introduction of MAH enhanced the surface energy of PE and reduced the regularity of the PE structure. The results of DSC(Differential scanning calorimeter) showed that after MAH grafting, the nucleation site on the surface of PE increased, which could make the modified PE crystallize rapidly, so that the cold crystallization peak disappeared, and the stability was enhanced, which is of great significance for subsequent asphalt modification. Graphical Abstract
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 4
·1-15
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IF 3
Lin Ze,Liu Shaokui,Wang Jiankai,Wang Jie,Hu Shaohua,Liu Jie,Wang Xuecheng,Feng Wendong,Zhou Qingzhi
Uranium mining and the processing of nuclear materials generate significant quantities of low-level radioactive wastewater, which, if untreated, pose environmental and health risks. This study addresses the challenge of removing uranium from such wastewater by comparing the uranium ion removal performance and mechanisms of iron hydroxide colloids and powders. Iron hydroxide colloids were synthesized under alkaline conditions via an environmentally friendly oxidation process using ferrous sulfate and hydrogen peroxide. The colloids and powders were characterized using scanning electron microscopy (SEM), particle size analysis, and zeta potential measurements. The results showed that the colloid’s average particle size (17.61 nm) was significantly smaller than that of the powder (164.18 nm), resulting in a higher specific surface area, more uniform particle distribution, and increased adsorption site density. Zeta potential analysis indicated that the colloid reduced the solution potential from -22.13 mV to -15.46 mV, promoting uranium flocculation through double-layer compression, whereas the powder maintained a potential of -23.43 mV, preventing effective flocculation. Response surface methodology (RSM) was employed to optimize process parameters, identifying the optimal conditions as a pH of 8.82, a dosing concentration of 424.80 mg/L, and a settling time of 2.2 h. Under these conditions, the uranium removal rate achieved 98.38%, closely aligning with the predicted rate of 98.81%. This method outperforms conventional ferric salt flocculation by avoiding the introduction of additional impurity ions, with the only by-products being oxygen and water. Moreover, this study demonstrates for the first time how the adjustment of iron hydroxide colloids can enhance uranium removal efficiency, offering a promising and eco-friendly approach to treating radioactive wastewater.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-15
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IF 14.7
Jiang Jun,Yang Lili,Xie Qianqian,Liu Xi,Jiang Jie,Zhang Jie,Zhang Shuping,Zheng Huizhen,Li Wenjie,Cai Xiaoming,Liu Sijin,Li Ruibin
Ferroptosis is a promising strategy for cancer therapy, with numerous inhibitors of its braking axes under investigation as potential drugs. However, few studies have explored the potential of activating the driving axes to induce ferroptosis. Herein, phosphatidylcholine peroxide decorating liposomes (LIP PCPO ) are synthesized to induce ferroptosis by targeting divalent metal transporter 1 (DMT1). LIP PCPO is found to boost lysosomal Fe 2+ efflux by inducing cysteinylation of lysosomal DMT1, resulting in glutathione peroxidase 4 (GPX4) suppression, glutathione depletion and ferroptosis in breast cancer cells and xenografts. Importantly, LIP PCPO induced ferroptotic cell death is independent of acquired resistance to radiation, chemotherapy, or targeted agents in 11 cancer cell lines. Furthermore, a strong synergistic ferroptosis effect is observed between LIP PCPO and an FDA-approved drug, artesunate, as well as X rays. The formula of LIP PCPO encapsulating artesunate significantly inhibits tumor growth and metastasis and improves the survival rate of breast cancer-bearing female mice. These findings provide a distinct strategy for inducing ferroptosis and highlight the potential of LIP PCPO as a vector to synergize the therapeutic effects of conventional ferroptosis inducers.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2024
·
IF 4.7
Duan Guangyu,Zhou Chunjie,Li Xiaoya,Cao Zhanfang,Jiao Feipeng,Zhong Hong,Ma Xin,Wang Shuai
Typically, traditional rare earth element (REE) extraction processes generate industrial effluents rich in REEs, resulting in significant resource waste and environmental pollution. Hence, there are important practical applications for the preparation of adsorbents with high adsorption efficiency and superior stability for the recovery of REEs. In this work, a poly(6-(N-acetyl-acryloylamino) hexyl hydroxamic acid) (PAAHA) chelating resin was successfully prepared by grafting 6-acetyl amino hexyl hydroxamic acid onto polyacrylic resin (D113). The PAAHA chelating resin was utilized for the removal of La³⁺, Ce³⁺, and Y³⁺, and the maximum uptake capacities determined from the batch adsorption experiments were 2.10, 2.38, and 3.98 mmol/g, respectively, which were 3.09, 3.05, and 9.05 times greater than those of the D113 resin. The results demonstrated that the adsorption process was consistent with the pseudo-second-order kinetic and Langmuir isotherm models, suggesting that monolayer chemisorption was the dominant process. Concurrently, five successive adsorption‒desorption cycles revealed that the PAAHA chelating resin displayed remarkable reproducibility and stability. Notably, the –CONHOH group exhibited a marked affinity for REEs, resulting in the formation of stable five-membered rings via mechanism characterization. In summary, this resin represents a novel strategy for designing adsorbents and shows considerable promise for the remediation of mining tailings containing REEs. Graphical
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Scientific Reports
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2024
·Vol. 14
·期 1
·1-11
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IF 3.8
Ren Jia,Cai Haopeng,Zhao Gaiqing,Xu Zhuang,Wang Xiaobo
The effects of shear degradation on the microstructures and properties of grease were investigated using a planetary ball mill to simulate a bearing shear zone on grease. The microstructure, cone penetration, colloidal stability, rheological properties noise properties, water washout characteristics and low-temperature torque of lithium grease were characterized. The microstructure of the initial lithium grease is a three-dimensional network structure formed by the uniform fibers. The entanglement level is high. As the ball milling shear time increases, the network structure of lithium grease is destroyed and the fibers are sheared to become short. Eventually all of them become short fibers. The performance test of lithium grease reveal that the cone penetration increases, colloidal stability, structural strength, noise properties, water washout characteristics of lithium grease gradually decreased with the increase of ball milling shear time. Additionally, the low-temperature starting torque and running torque of the grease gradually decrease. This phenomenon occurs due to changes in the microstructure of lithium grease. The shear degradation of lithium grease was mainly divided into two stages: the rapid stage was the destruction of the thickener network structure and the fibers being shortened by shearing. The slow stage was the process in which short fibers were sheared into shorter fibers.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 27
·1-11
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IF 2.8
Wu Keyue,Cui Jingbiao
Cr 3+ doped ZnMgTiO 4 phosphors were successfully prepared with a high-temperature solid-state reaction method. The Cr 3+ doped ZnMgTiO 4 phosphor exhibits a near-infrared emission around 620–870 nm with a peak at 720 nm under UV 325 nm excitation. The emission peak at around 720 nm is related to the 2 E → 4 A 2 transition of Cr 3+ , which matches the absorption spectra of phytochrome P FR . The structure and crystal field environment were studied and discussed. The Cr concentration and temperature dependent photoluminescence properties of ZnMgTiO 4 : Cr 3+ were also investigated. This study indicates that ZnMgTiO 4 : Cr 3+ phosphor has a promising potential for plant cultivation.
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Journal of Coatings Technology and Research
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2024
·
IF 2.3
Huang Zhichao,Wang Lin,Wu Hongfu,Zhang Junfeng,Wang Zhuo,Sun Fu,Duan Huimin,Qi Dongming
Herein, a simple and efficient inorganic particle surface modification strategy was developed to improve the flame retardancy of flammable polyurethane (PU) materials while avoiding the serious degradation of their mechanical properties due to the incorporation of inorganic particles. Novel organic–inorganic hybrid hydroxylation ammonium polyphosphate (OHAPP) was fabricated via an ion-exchange reaction between APP and diethanolamine, and a PU/OHAPP film was prepared by crosslinking OHAPP with reactive PU via in situ polymerization. The curing properties, flame retardancy, and mechanical properties of materials were evaluated. Results showed that the addition of 15 wt% OHAPP in PU increased the tensile strength of the sample by 16% compared to PU alone. The peak heat release rate, total heat released, and total smoke produced from the materials measured via the conical calorimetric method were 337.2 kW/m 2 , 78.1 MJ/m 2 , and 8.9 m 2 , respectively, which were 63.8%, 43.6%, and 15.2% lower than those of PU. Additionally, the flame-retardant mode of action of the PU/OHAPP film was verified. This study is a useful reference for further studies on flame-retardant materials.
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Nature Photonics
·
2024
·
IF 32.3
Shan Xuchen,Ding Lei,Wang Dajing,Wen Shihui,Shi Jinlong,Chen Chaohao,Wang Yang,Zhu Hongyan,Huang Zhaocun,Wang Shen S. J.,Zhong Xiaolan,Liu Baolei,Reece Peter John,Ren Wei,Hao Weichang,Lu Xunyu,Lu Jie,Su Qian Peter,Chang Lingqian,Sun Lingdong,Jin Dayong,Jiang Lei,Wang Fan
Precise force measurement is critical to probe biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect, as well as the detection of gravitational waves. Yet, despite extensive technological developments, the three-dimensional nanoscale measurement of weak forces in aqueous solutions still faces major challenges. Techniques that rely on optically trapped nanoprobes are of significant potential but are beset with limitations, including probe heating induced by high trapping power, undetectable scattering signals and localization errors. Here we report the measurement of the long-distance interaction force in aqueous solutions with a minimum detected force value of 108.2 ± 510.0 attonewton. To achieve this, we develop a super-resolved photonic force microscope based on optically trapped lanthanide-doped nanoparticles coupled with nanoscale three-dimensional tracking-based force sensing. The tracking method leverages neural-network-empowered super-resolution localization, where the position of the force probe is extracted from the optical-astigmatism-modified point spread function. We achieve a force sensitivity down to 1.8 fN Hz –1/2 , which approaches the nanoscale thermal limit. We experimentally measure electrophoresis forces acting on single nanoparticles as well as the surface-induced interaction force on a single nanoparticle. This work opens the avenue of nanoscale thermally limited force sensing and offers new opportunities for detecting sub-femtonewton forces over long distances and biomechanical forces at the single-molecule level.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-18
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IF 12.6
Lei Rui,Wang Wenjun,Li Guan,Yu Qian,Fang Haowei,Xu Jinghong,Zhang Kunxi,Ye Yinghai
Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α -lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. The bioadhesives are fabricated from the aggregation of LA, MXene and Ag + through their supramolecular interactions, which can be rapidly formed in mild environments, showing strong interface adhesion without adhesive failure caused by depolymerization, while exhibiting mechanical self-reinforcing. To further improve the adhesive strength, the formation of MXene/Ag + /LA interactions was integrated into poly(2-hydroxyethyl methacrylate) (pHEMA) electrospinning to manufacture electrospun film with the adhesion strength as high as 2 MPa. The bioadhesives are sensitive to alkaline environments and can lead to deprotonation of LA. The released H + can instantly adjust the pH of weakly alkaline seawater-immersed wounds to normal pH, while deprotonated LA is released into wounds to exert anti-inflammatory functions. Together with antibacterial property, bioadhesives applied to seawater-immersed wounds provide stable barrier protection and correct adverse microenvironment, promoting wound healing.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 12
·1-13
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IF 2.8
Wang Leilei,Ji Xiaohui,Xiao Kefeng
A series of red-luminescence bismuthate phosphors of double perovskite BaBiNaTeO 6 doped with trivalent europium (Eu 3+ ) were prepared by the solid-state diffusion method. The crystal structure and phase purity of the phosphors were analyzed. The photoluminescence (PL) properties of BaBiNaTeO 6 :Eu 3+ were studied in detail. Upon blue light (466 nm) excitation, the powders showed brilliant red light at around 619 nm, and it was attributed to the electric dipole (ED) 5 D 0 → 7 F 2 transition of Eu 3+ . The optimal dopant concentration ( x ) of the as-prepared phosphor was x = 0.60 mol and the concentration quenching mechanism was evaluated as the electric quadrupole–quadrupole interaction. The BaBiNaTeO 6 :Eu 3+ exhibited good thermal stability and the corresponding activation energy ( E a ) was obtained to be 0.27 eV. The chromaticity points of phosphors were near the edge of the red region of the Commission Internationale De L’Eclairage (CIE) 1931 chromaticity diagram. As-prepared white LED based on the GaN blue chip exhibited relatively low correlated color temperature (CCT) of 5042.5 K and high color rendering index (CRI) of 91.6. All characterizations suggest that these double perovskite BaBiNaTeO 6 :Eu 3+ red-emitting phosphors have promising applications in illumination and display field based on blue LEDs.
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