Journal of Materials Chemistry B
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2026
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IF 6.2
Shengke Zhu,Wei Li,Kangan Wang,Bin Hu,Shenggang Huang,Jiahao Yang,Peng Fan,Shige Wang,Yu Sun,Chunping Zhu
Wound repair is a coordinated and sequential biological process involving multiple cells and phases, with inflammation, vascularization, re-epithelialization, collagen deposition, and remodeling being critical stages. Mesenchymal stem cells, capable of sensing the wound microenvironment and secreting cytokines to regulate the repair process, have garnered significant attention in wound repair. This study developed a self-healing polysaccharide-based hydrogel system using two widely sourced polysaccharides. The main components of the hydrogel are oxidized dextran (OD) and carboxymethyl chitosan (CMCS). This hydrogel features a simple preparation process and favorable biocompatibility, serving as a carrier for cell culture to enable three-dimensional (3D) cultivation of adipose-derived mesenchymal stem cells (ADSCs). Experiments on full-thickness skin defect repair in nude mice demonstrated that the ADSC-loaded polysaccharide hydrogel (OC-ADSCs) significantly promoted wound closure, collagen deposition, epidermal regeneration, as well as angiogenesis and vessel maturation. The OC-ADSC hydrogel can function as a novel cell delivery system, synergistically promoting wound healing and tissue regeneration by modulating the wound microenvironment, showing potential for clinical translation.
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ADVANCED MATERIALS
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2026
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IF 29.1
Wang Si-ma,Jiaming Ma,Zhengwu Yang,Kun Chen,Juncheng Hong,Haoyu Yan,Chaoping Xu,Yuming Gao,Dawei Tang,Bo Jiang
Solar-driven dry reforming of methane (DRM) offers an energy-saving and environmentally sustainable route for syngas production. Nevertheless, this technology still suffers from insufficient production rates, especially under high gas hourly space velocity (GHSV). In this work, we design an electron pump catalyst with an asymmetric light-responsive architecture, comprising Ru nanoclusters and Ni single atoms, to boost syngas production rates. Under illumination without external heating, Ru ac -Ni sa /NC achieves a remarkable syngas production of 4.70 mol·g cat −1 ·h −1 at 500°C and a GHSV of 288 000 h − 1 , outperforming state-of-the-art benchmarks by five times, and maintained excellent stability over 1500 min. Experimental and computational studies disclose that the asymmetric architecture enables directional electron transfer and suppresses electron-hole recombination, as an electron pump, creating electron-enriched Ru sites and electron-deficient Ni sites. This interfacial electron configuration furnishes favorable active sites for reactant activation and * CH 3 O formation, thereby improving DRM kinetics. This work unlocks a design strategy for catalysts in solar-driven reactions and provides a mechanistic lever for enhancing electron-transfer efficiency and reactant activation.
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POWDER TECHNOLOGY
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2026
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IF 5.5
Wenyun Zhou,Sen Huang,Xingwei Peng,Anrong Yao,Meng Zhou,Yanping He
The high volatility of eugenol severely restricts its application in long-lasting fragrances. While microencapsulation is a common solution, conventional materials face significant limitations: melamine-formaldehyde (MF) microcapsules raise safety concerns, while monolithic polymer shells often undergo swelling and rupture, leading to premature leakage. Herein, we present a novel and safe microencapsulation platform based on an in-situ core viscosification strategy. We designed double-shelled microcapsules featuring an inner sacrificial shell of poly (styrene-acrylic acid) and an outer rigid shell of cross-linked polystyrene. The pivotal innovation lies in the post-encapsulation dissolution of the inner shell by eugenol, which transforms the liquid core into a highly viscous, polymer-rich matrix. This transformation intrinsically retards fragrance diffusion, without compromising the initial capsule formation. Systematic optimization of fabrication parameters yielded microcapsules with exceptional mechanical strength, exhibiting a rupture force of 7.24 ± 0.39 mN and toughness of 2.42 ± 0.24 J/m 3 . Release kinetics and thermal analysis demonstrated a profound enhancement in sustained release, with exhibited remarkably sustained release behavior compared to conventional MF microcapsules, and a major release event shifted to a temperature over 100 °C higher. This work presents an in-situ core viscosification strategy driven by synergistic sacrificial-layer dissolution and molecular entanglement for sustained fragrance delivery, offering a high-performance, formaldehyde-free alternative for cosmetics and textiles.
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SENSORS
·
2026
·Vol. 26
·期 7
·2126
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IF 4
Zhenqing Li,Yueqing Wang,Jing Yang,Bo Yang,Yuan Zeng,Shinichi Sekine,Yoshinori Yamaguchi
Polymerase chain reaction (PCR) is widely regarded as the gold standard for nucleic acid analysis; however, conventional thermal cycling limits its applicability in rapid and compact analytical systems. Here, we report an oscillating-flow microfluidic PCR method that enables rapid and flexible amplification by repeatedly shuttling the reaction mixture between two fixed-temperature zones. Unlike continuous-flow PCR, the proposed approach decouples PCR cycle number from microchannel geometry, allowing programmable cycling while reducing chip footprint. To enhance analytical reliability, polymer-assisted surface passivation using polyvinylpyrrolidone was employed to suppress nonspecific adsorption in polydimethylsiloxane (PDMS) microchannels, significantly improving amplification efficiency. Using Porphyromonas gingivalis and Treponema denticola as representative periodontal pathogens, 35-cycle amplification was completed within 20 min with reliable product yield. The proposed method advances oscillating-flow PCR toward a robust analytical strategy for rapid pathogen detection and related microfluidic nucleic acid analysis.
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ACS Nano
·
2026
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IF 17.3
Ningyu Wu,Hongrun Jin,Zhoudong Yang,Boya Wang,Jinchi Li,Jiazhuang Tian,Gaoyang Li,Zeyu Wang,Shixiang Ding,Xinran Li,Tengsheng Zhang,Fanxing Bu,Dongyuan Zhao,Wanhai Zhou,Dongliang Chao
Tellurium (Te)-based redox chemistries are attractive for high-energy aqueous batteries due to their multielectron transfer and high theoretical capacity, but their available capacities are hindered by the high oxidation energy barrier of Te. Here, we propose a heterochalcogen strategy by introducing electronegative Se to regulate the electronic structure of Te. Combined in situ characterizations, synchrotron spectroscopy, and theoretical simulation reveal the formation of Te2+ intermediates and the charge redistribution via Se doping, facilitating the complete six-electron K2Te4O9 ↔ K2Te conversion. As a result, the optimized Se-doped Te electrodes deliver a high reversible capacity of 1186 mAh g–1 with an exceptional Te utilization rate of 98.6%, unprecedented rate performance of 688 mAh g–1 at 6 A g–1, and stable cycling over 500 cycles. This work demonstrates the effectiveness of heterochalcogen engineering in overcoming intrinsic limitation of Te-based chemistry and highlights a promising pathway to unlock multielectron chalcogen chemistry for the development of next-generation high-energy aqueous batteries.
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Catalysis Science & Technology
·
2026
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IF 4
Kaiyang Lian,Fei Li,Lijuan Ma,Ranran Wu,Zhiguang Zhu
Glycine, the simplest amino acid with versatile physiological functions, is widely used in pharmaceuticals, animal feed, and the food industry. However, conventional production methods are limited by sustainability, safety, and environmental concerns. Here, we develop an efficient and green one-pot in vitro multi-enzyme cascade that converts oxalate into glycine under mild conditions. Upon optimization of the reaction conditions and integration of a cofactor recycling system, nearly complete conversion (100%) of oxalate to glycine was achieved in a 1-mL reaction system within 7 hours. After 4 hours of reaction in a 10 mL system, the glycine yield reached 95.7%, with a corresponding synthesis rate of 179.6 mg L-1 h-1. This work demonstrates that a C2-fixing multi-enzyme cascade circumvents the inherent challenge of C-C bond formation, achieving efficient conversion of CO2-derived oxalate to glycine, and presents a practical and conceptually innovative strategy for carbon-negative chemical synthesis.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2026
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IF 3.1
Jiayan Luo,Jinquan Huang,Jiwei Huang,Wenzhai Cao,Junying Chen
Wound healing is frequently accompanied by bacterial infections, and the ongoing antibacterial activity can impact the healing process. Therefore, it is crucial to develop a smart antibacterial material that can be utilized and halted at will. Herein, we fabricated a multifunctional hyaluronic acid-based hydrogel integrated with novel conductive polypyrrole–polydopamine (PPy/PDA) nanoparticles. The hydrogel network is crosslinked via boronate ester bonds, forming a hydrogel with a porosity of approximately 60%, and rheological experiments demonstrate its excellent self-healing ability. This composite hydrogel exhibits superior photothermal conversion efficiency and electrical conductivity, which are synergistically enhanced by the incorporation of PPy/PDA nanohybrids. Near-infrared irradiation serves as a noninvasive stimulus to trigger its antibacterial activity, achieving 99% bactericidal efficacy against both Escherichia coli and Staphylococcus aureus upon NIR exposure. Electrical characterization reveals a conductivity range of 10 −4 to 10 −3 S/cm, enabling its application as a sensitive strain sensor for real-time monitoring of joint flexion and other biomechanical movements. Furthermore, the hydrogel demonstrates robust tissue adhesion properties and favorable biocompatibility profiles. These findings highlight the potential of this multifunctional hydrogel as an intelligent wound dressing for integrated wound monitoring and on-demand infection control.
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ANALYTICAL CHEMISTRY
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2026
·
IF 7.3
Bei Xu,Yun-Dong Yin,Lei Yang,Rui Shi,Xi-Tong Song,Zhi-Yuan Gu
The host–guest nanopore analysis method provided an avenue for hydrophobic analytes detection. However, the fixed cavity of conventional rigid hosts restricted the size range of detectable analytes, thereby partly limiting their further development. Herein, an organic clip (OC) was used as a flexible host to enhance the host–guest nanopore method in sensing hydrophobic drugs with various sizes. With the help of OC-assisted WT α-HL nanopores, differently sized hydrophobic drugs were detected and displayed distinguishable Level 2 signals, offering an effective approach to accomplish “one for more” analysis for hydrophobic analytes with various sizes. To explore the resolution of this method, the OC-assisted nanopore method was further used to simultaneously identify structurally similar antibiotics, including enoxacin, enrofloxacin, and moxifloxacin. Assisted by a machine learning algorithm, the validation accuracy for these three antibiotics reached up to 96.1%. Furthermore, the calibration curve for moxifloxacin was built based on the nanopore event frequency, through which moxifloxacin in commercial pharmaceuticals was accurately quantified. The OC-assisted nanopore method displayed the capability to extend the detection range across analyte sizes and demonstrated good resolution in distinguishing antibiotics with similar structures.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhi-Guo Wang,Xi Liao,Yong-Jie Dan,Yu-Wei Liu,Yan-Hua Niu,Rui Hong,Ming Cai,Ju-Xiang Gou,Jia-Zhuang Xu,Zhong-Ming Li,Ka Li
Hydration-assisted aqueous lubrication exhibits foreseeable promise in promoting the intubation/implantation of invasive medical devices. However, it remains a challenge to settle a hydration layer on various and complex polymer surfaces. Herein, we develop a surface chemistry-topology coupled strategy to engineer an earthworm-inspired hydrogel coating by copolymerizing methacryloxyethyl sulfobetaine and acrylamide monomers. The sulfonic-amino zwitterionic pairs and acylaminos of our hydrogel coating absorb water molecules and form a hydration layer due to the strong hydrophilic interaction. Our hydrogel coating is embodied by coarse-grained microgels, which resemble the microripple skin of an earthworm. This elaborate surface topology facilitates the spreading of water droplets and locks water molecules to form a highly stable hydration layer, significantly improving the hydrophilicity and wet lubricity. Our hydrogel coating has an arbitrarily shaped adaptability for diverse polymer surfaces, and exhibits exceptional durability and the anti-biofouling property. As a proof of concept, the earthworm-inspired hydrogel coating is applied on the nasogastric tube and effectively migrates intubation-related complications, such as invasive stimuli, mucosal damage, and inflammation. This notion of bioinspired design offers a promising prototype to endow invasive biomedical devices with lubricative interfaces.
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Journal of Materials Chemistry A
·
2026
·
IF 9.5
Jiani Qin,Minna Duan,Jianping Zhang,Wen Chen,Tingjiang Yan,Chuanyi Wang,Bao Pan
The persistent presence of tetracycline (TC) in aquatic environments demands advanced oxidation processes capable of efficiently degrading this micropollutant. Although peroxymonosulfate (PMS)-based catalysis shows promise in this regard, its practical efficiency is limited by sluggish activation kinetics and rapid charge recombination, necessitating the development of high-performance catalysts. Herein, we present a strategically engineered cobalt-doped tubular carbon nitride (Co-TCN) that integrates morphological control with atomic-level doping to achieve enhanced photocatalytic PMS activation. The unique tubular architecture of TCN improves light harvesting and facilitates mass transfer, while atomically dispersed cobalt species, confirmed by XAS and XPS, act as efficient electron traps and active sites for PMS activation. This synergistic design yields a catalyst with an increased specific surface area, significantly suppressed charge recombination, and accelerated electron transfer. Under visible light, the optimized 1.1%Co-TCN/PMS system achieved a TC degradation rate constant of 15.87 × 10−2 (mg L−1)−1·min−1, which was 15.6-fold higher than that of PMS alone and demonstrates remarkable performance across various antibiotics. Mechanistic investigations reveal a catalytic cycle involving Co2+/Co3+ redox pairs, generating both radical species (SO4˙−, ˙OH, ˙O2−) and non-radical species (1O2). Furthermore, toxicity assessment confirmed the effective detoxification of TC during the degradation process. This work establishes a novel strategy for designing cost-effective, non-precious-metal–based photocatalysts through concurrent structural and electronic modulation, offering a promising approach for sustainable water treatment.
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INORGANIC CHEMISTRY
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2026
·
IF 4.6
Ze-Jia Shen,Lin Cheng,Xin Hao,Yi-Ming Zhao,Shuaihua Wang,Kai-Yao Wang
The efficient removal of Ni2+ from radioactive wastewater is crucial for environmental protection and nuclear safety, yet current ion exchangers often exhibit limited stability and selectivity. Herein, we report an open-framework gallium–antimony sulfide, K3.6[NH4]0.1[CH3NH3]0.3Ga4SbS9SH·0.9H2O (GaSbS-2K), constructed from supertetrahedral T2-{Ga4S9SH} clusters and asymmetric Sb bridges. Its three-dimensional framework features intersecting chiral channels and tetrahedral voids that facilitate ion diffusion and exchange. GaSbS-2K exhibits rapid Ni2+ adsorption, achieving 67.66% uptake within 2 min and 97.54% removal at equilibrium, with a pseudo-second-order rate constant of 0.318 g mg–1 min–1. The material shows a maximum adsorption capacity of 90.78 ± 2.74 mg g–1 under neutral conditions and remains stable across a wide pH range (3–12). It retains strong selectivity for Ni2+ in the presence of competing ions, maintaining >72% removal even in seawater. The rapid adsorption kinetics enable continuous-flow applications in both fixed-bed columns and composite membranes, achieving >99% removal of Ni2+. Notably, the GaSbS-2K/PTFE membrane with an 80 μm active layer completely removes Ni2+ from 1000 mL of solution at a flux of 1.91 mL min–1 cm–2 with only 0.25 s of contact time. Combined with its facile synthesis, radiation stability, and regenerability, GaSbS-2K represents a promising adsorbent for radionuclide-contaminated wastewater treatment.
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ACS Catalysis
·
2026
·
IF 13.6
Zhe Zhang,Yan Zhang,Zhen Du,Xiaomin Zheng,Hongrui Xu,Yanxia Lin,Peng Kong,Hong Li,Jianchun Cao,Cheng Zhang,Shan Li,Yong Xu,Lei Zhang
7α, 24R-Dihydroxy-5α-cholestan-3-one serves as a key intermediate in the synthesis of squalamine. In this study, a simple and efficient three-step chemo-enzymatic method was developed with a total yield of 61% by utilizing an engineered ketoreductase from Novosphingobium aromaticivorans (NaKRED). NaKRED was a NADH-dependent short-chain alcohol dehydrogenase, and the mutant variant (Y199A/N149L) exhibited a 94.3% conversion rate of substrate 1a and 99.8% diastereoselectivity. At the optimized reaction system, the substrate concentration at 10 mM afforded a product yield of 51.2% and a titer of 2.153 g/L while maintaining stereoselectivity above 99.8%. Crystal structures of the NAD+-free and NAD+-bound wild-type and Y199A/N149L mutant revealed that the intrinsically Ser-Tyr-Lys catalytic triad machinery formed a prominent and flexible ammonium cation hole into which the NADH molecule was buried. NADH featured two different conformations in tetrameric and octameric ketoreductases, and mediated the catalytic activity by undergoing a conformational change to form a productive substrate binding conformation (A-form) based on the crystal structure and molecular dynamics simulation. Our research presented not only an effective strategy to produce the key squalamine intermediate but also revealed a previously unrecognized NADH-regulated mechanism in KRED-catalyzed ketone reduction.
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