ChemistrySelect
·
2023
·Vol. 8
·期 32
·e202300507
·
IF 2.1
Yang Xu,Yingying Zhu,Yifan Zhou,Jinyuan Zhu,Chaoran Li,Geng Chen
Graphical A thin-film nanocomposite forward osmosis membrane containing APTMS-modified SiO 2 nanoparticles was prepared and evaluated herein. The modification of APTMS effectively improved the uniformly dispersion of SiO 2 due to the transitions from the original hydrophilic surface to the lipophilic. The key finding is that the APTMS-SiO 2 TFN membrane exhibited remarkble enhancements in water fluxes and improvements in CR and RhB dye rejections. Fumed silica (SiO 2 ) is often applied in the modification of thin-film composite (TFC) forward osmosis (FO) membranes due to its hydrophilicity. However, a key challenge to be solved is to improve its compatibility with organic matrices and dispersion in the material. In this study, we synthesized well-designed nanoparticles of (3-aminopropyl)trimethoxysilane-modified SiO 2 (APTMS-SiO 2 ) and applied them for the first time in the preparation of FO membranes. Furthermore, we systematically investigated the effects of different pretreated SiO 2 , SiO 2 dosages, draw solution types, and concentrations on FO membranes. The results showed that APTMS-SiO 2 thin-film nanocomposite with a silica dosage of 0.1 wt.% has the highest water permeate flux (J w ) (26.25 LMH, 370.43 % higher than the control TFC of 5.58 LMH) and the minimum specific reverse solute flux (SRSF) of 0.17 g/L with 1 M NaCl as the draw. The incorporation of APTMS effectively prevented mutual agglomeration of SiO 2 and improved its dispersion. The J w of 13.36 LMH after seven cycles and the rejection of above 96.6 % for Congo Red and 95.8 % for Rhodamine B indicated potential reusability and dye rejection. This work presents an alternative approach to prepare FO membranes with enhanced water flux and increased selectivity, and it also offers insights for the treatment of printing and dyeing wastewater using FO.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 41
·15797-15805
·
IF 4.569
Jiawei Wu,Bangfu Ding,Xin Qian,Liang Mao,Huibin Zheng,Lei Zhang,Shukai Zheng,Junying Zhang
The Bi2MoO6 nanosheets are loaded on to γ-Bi2O3 tetrahedron surfaces to form Bi2MoO6/γ-Bi2O3 heterojunctions using a simple calcination method. The photocatalytic degradation efficiencies of the lomefloxacin and the Rhodamine B using the optimum sample are 96% and 99%, respectively, much higher than that of pure phase samples. When the waters from different regions in China were used as solvents, the removal efficiencies of the lomefloxacin and the Rhodamine B are still higher than 88% and 90%, respectively, which shows excellent prospects for practical applications. The photocatalytic degradation efficiencies of these two pollutants are higher than 91% and 95% in the five cycling tests, and the crystal structure of the sample is not changed after cycling. Based on the first-principles calculation, Bi2MoO6 and γ-Bi2O3 form a Z-type energy band structure which accelerates the separation of the photogenerated charge carriers. The Bi2MoO6 valence band potential of 3.25 V and the γ-Bi2O3 conduction band potential of −0.21 V are reserved to generate ˙OH− and O2−, respectively, for the photocatalytic reaction. The degradation of the lomefloxacin is ascribed to the shedding of functional groups and bond breaking with the final products being CO2, F−, H2O, and NO3−. This research shows that Bi2MoO6/γ-Bi2O3 heterojunctions can be employed to purify domestic and textile industrial sewage.
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PubMed
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Advanced Sustainable Systems
·
2022
·Vol. 6
·期 5
·2100436
·
IF 6.737
Xiaolin Ren,Yuchen Tian,Firdoz Shaik,Jine Yang,Rong Liu,Kaiming Guo,Bin Jiang
Iron group metal phosphides (IMPs) are one of the most promising substitutes for non-noble electrocatalysts in overall water splitting. In this work, an electrocatalyst system consisting of different vertically aligned heteroatom-doped graphene arrays (X-rGO, X = N, P, B, O, S) integrated with FeCoNiP nanoparticles (FeCoNiP@X-rGO, X = N, P, B, O, S) is prepared for overall water splitting. The unique vertical structure and the synergistic effect between the P in P-rGO and the P in FeCoNiP leads to the excellent electrocatalytic performance of FeCoNiP@P-rGO by exhibiting low overpotentials (121 and 216 mV) at a current density of 10 mA cm −2 for hydrogen evolution reaction in 1 m KOH and 0.5 m H 2 SO 4 , respectively. As well as a low overpotential (354 mV) at a current density of 10 mA cm −2 for the oxygen evolution reaction in 1.0 m KOH. The FeCoNiP@P-rGO electrocatalyst exhibits an outstanding durability toward overall water splitting in alkaline electrolytes, and excellent Faraday efficiency (about 92%) as well. This work provides an insight in proper tuning and the development of appropriate substrates for IMPs and other transition metal compounds toward cost-effective and high efficiency electrocatalysts for water splitting reactions.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Chenhui Yin,Meng Wu,Ting Liu,Lixing Fu,Qijun Sun,Ligang Chen,Na Niu
A sensitive and effective strategy for the screening of α-glucosidase and its inhibitors was established based on carbon quantum dots (CQDs) and vanadium oxide nanoribbons. B,S,N co-doped CQDs (BSN-CQDs) were prepared by one-step microwave hydrothermal method using o-phenylenediamine, boric acid, and thiourea as raw materials. The prepared CQDs emitted yellow fluorescence (λ em = 565 nm) under excitation of 410 nm, and the quantum yield was 15.3%. The fluorescence of CQDs was firstly quenched by the vanadium oxide nanoribbons via inner filter effect. Then, 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA2G) was introduced as a substrate of α-glucosidase to produce ascorbic acid (AA). Vanadium oxide nanoribbons could be converted to V 4+ by AA, which led to fluorescence recovery. After adding inhibitors (anti-diabetic drugs), the α-glucosidase activity was inhibited and the degree of fluorescence recovery was reduced. The established nanoprobe showed a response linearity to α-glucosidase in the range of 0.01–5 U mL −1 , with a low detection limit of 0.003 U mL −1 . This platform was applied for the screening of acarbose, with a detection limit of 0.02 μM. The constructed sensing strategy had the advantages of high selectivity, sensitivity, and was successfully used for α-glucosidase detection in serum samples and anti-diabetic drugs screening.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2020
·
IF 6.205
Liqing Hu,Lijun Li,Qi Chang,Songsen Fu,Jia Qin,Zhuo Chen,Xiaohui Li,Qinglian Liu,Gaoyun Hu,Qianbin Li
Current pulmonary arterial hypertension (PAH) therapeutic strategies mainly focus on vascular relaxation with less emphasis on vascular remodeling, which results in poor prognosis. Hence, dual pathway regulators with vasodilation effect via soluble guanylate cyclase (sGC) stimulation and vascular remodeling regulation effect by AMP-activated protein kinase (AMPK) inhibition provide more advantages and potentialities. Herein, we designed and synthesized a series of novel pyrazolo[3,4-b] pyridine derivatives based on sGC stimulator and AMPK inhibitor scaffolds. In vitro, 2 exhibited moderate vasodilation activity and higher proliferation and migration suppressive effects compared to riociguat. In vivo, 2 significantly decreased right ventricular systolic pressure (RVSP), attenuated pulmonary artery medial thickness (PAMT), and right ventricular hypertrophy (RVH) in hypoxia-induced PAH rat models (i.g.). Given the unique advantages of significant vascular remodeling inhibition and moderate vascular relaxation based on the dual pathway regulation, we proposed 2 as a promising lead for anti-PAH drug discovery.
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PubMed
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
·
2017
·
IF 2.454
Zhipei Sang,Keren Wang,Huifang Wang,Lintao Yu,Huijuan Wang,Qianwen Ma,Mengyao Ye,Xue Han,Wenmin Liu
A series of novel phthalimide-alkylamine derivatives were synthesized and evaluated as multi-functions inhibitors for the treatment of Alzheimer’s disease (AD). The results showed that compound TM - 9 could be regarded as a balanced multi-targets active molecule. It exhibited potent and balanced inhibitory activities against ChE and MAO-B ( hu AChE , hu BuChE , and hu MAO-B with IC 50 values of 1.2 μM, 3.8 μM and 2.6 μM, respectively) with low selectivity. Both kinetic analysis of AChE inhibition and molecular modeling study suggested that TM - 9 binds simultaneously to the catalytic active site and peripheral anionic site of AChE. Interestingly, compound TM - 9 abided by Lipinski’s rule of five. Furthermore, our investigation proved that TM - 9 indicated weak cytotoxicity, and it could cross the blood-brain barrier (BBB) in vitro . The results suggest that compound TM - 9 , an interesting multi-targeted active molecule, offers an attractive starting point for further lead optimization in the drug-discovery process against Alzheimer’s disease.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yuehao Shen,Yuxin Xiao,Hongjie Zhang,Hongjie Fan,Yao Li,Zhongli Yan,Wen-Hui Zhang
Treating the wastes generated from pulp and paper mills, such as black liquor and Fenton sludge is challenging. In this study, the biochar-supported Fe-Cu bimetallic catalysts were synthesized by a one-step pyrolysis method using Fenton sludge as iron source, acid-precipitated black liquor (APBL) as carbon source and copper nitrate as copper source. The catalysts were used to remove rhodamine B (RhB) dye from aqueous solution by Fenton-like reaction. The optimal catalyst (FeCu@BC 600-2 ) was pyrolyzed at 600 °C with an Fe/Cu mixing ratio of 2 and consisted of mesoporous biochar supported nanoscale Fe 3 O 4 and Cu 0 . It had a specific surface area of 104.6 m 2 ·g −1 and a saturation magnetization of 33.3 emu·g −1 . In the FeCu@BC 600-2 /H 2 O 2 system, RhB dye (10 mg·L -1 ) was completely removed within 60 min at acidic pH (initial pH 3, 0.2 g·L -1 catalyst, 1 mM H 2 O 2 ) or 6 h at neutral pH (initial pH 7, 0.25 g·L -1 catalyst, 25 mM H 2 O 2 ) at 30 °C. Moreover, the FeCu@BC 600-2 exhibited good magnetic separation ability, low metal leaching, excellent reusability and broad applicability to other synthetic dyes. The dye removal mechanism involved the synergistic effect of adsorption and catalytic oxidation (especially heterogeneous catalytic oxidation). At acidic pH, RhB degradation was due to •OH radical, which was generated from the activation of H 2 O 2 by ≡Cu(I) or Cu(I) oxidized from Cu 0 and ≡Fe(II) in Fe 3 O 4 . At neutral pH, RhB degradation was mainly due to •OH and 1 O 2 with the former being produced by ≡Cu(I) and ≡Fe(II). Furthermore, Cu(I) oxidized from Cu 0 and the active functional groups (such as sp 2 C = C) in the biochar facilitated the reduction of Fe(III) to Fe(II), resulting in a high catalytic oxidation efficiency.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Jinling Xie,Liu Chen,Xuan Luo,Li Huang,Siyu Li,Xiaobo Gong
Peroxymonosulfate (PMS) based advanced oxidation process has been proved to be an efficient method for Antibiotic treatment. B, N co-doped carbon porous material was derived from metal-organic frameworks. B-NC catalysts showed excellent efficiency for removal of tetracycline hydrochloride. Nitrogen doping essentially changed the degradation pathway of tetracycline hydrochloride, while boron doping provided more active sites. through more defect sites, which is closely related to the adsorption and catalytic performance of the catalyst. The major active species of B-NC/PMS system was singlet oxygen ( 1 O 2 ) through quenching experiments and electron paramagnetic resonance (EPR) studies. Electron transfer was another non-radical oxidation pathway of B-NC/PMS system. This provides a new idea for the selective oxidation of antibiotics by metal-free activated PMS.
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MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Huifang Zhao,Jie Wang,Huayu Zhao,Yulong Liu,Yanqiu Li,Ruiping Zhang
It is of significance to analyze various small molecules with high efficiency using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). In this work, we synthesized N and B dual-doped 3D carbon (N, B-C) nanofiber as a promising MALDI matrix through a facile impregnation and thermal pyrolysis process. Compared to the control C nanofiber, the N and B codoping could enhance surface area, functional groups, defective and active sites, which was conducive to adsorb the laser and enrich the desorption/ionization of analytes. For the first time, the N, B-C nanofiber was utilized as a novel matrix for MALDI-TOF MS analysis of various small molecules both in the positive-ion and negative-ion modes. This matrix showed high signal to noise (S/N) ratio, excellent salt-tolerance, and homogeneous ion distribution for the analysis of amino acids, saccharides, polymers and surfactant, which was obviously superior to the traditional α-cyano-4-hydroxycinnamic acid (CHCA) and the control C nanofiber matrix. Noticeably, the wide linear ranges (0.05–5 mM) of glucose was achieved by MALDI-TOF MS with N, B-C nanofiber matrix. Meanwhile, the MALDI-TOF MS imaging could observe the change of different content glucose based on the ion peak of [M + Na] + . Furthermore, N, B-C nanofiber-assisted LDI-TOF MS has also been applied to identify and analyze the saccharides in the natural honey.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Ruishuang Yuan,Yuhuan Xu,Yuan Wang,Fuheng You,Wei Chen,Caifeng Ding,Ding Jiang,Kun Wang
Developing non-precious metal catalysts with superior activity and stability for the oxygen reduction reaction (ORR) remains challenging for application of full cells. In this work, three-dimensional boron and nitrogen co-doped graphene aerogels loaded with cobalt oxides (3D BNG Co) catalysts were designed and prepared by a one-pot hydrothermal method . In this 3D nanoarchitecture, CoO x nanoparticles were evenly spread over the BNG surface without aggregation. As a non-precious metal cathode electrocatalyst , the 3D BNG-Co catalyst favors a direct 4e − pathway and exhibits excellent activity towards ORR, as well as superior long-term durability. In 0.1 M KOH solution, its onset potential, half-wave potential and limiting current density for the ORR reach −0.02 V (vs. Ag/AgCl), −0.3 V (vs. Ag/AgCl) and 5.6 mA cm −2 , which are comparable to those of commercial 20 wt% Pt/C catalyst. The good electrochemical activities of the as-fabricated catalyst could be attributed to the 3D network foam, unique electronic structure, and the synergy effect of pyridinic N together with BC 3 phases. The present work sheds insights into the effects of diatomic doping of the 3D graphene-based nanostructures in the field of ORR and and can be extended to other catalytic systems.
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高影响因子
Molecular Catalysis
·
2021
·
IF 5.062
Chao Xu,Hongbo Suo,Yu Xue,Jing Qin,Hongyue Chen,Yi Hu
Four types of amino acid ionic liquids (AAILs) with chiral structure were used to modify Candida antarctica lipase B (CALB). The results showed that the catalytic activity at different temperatures and pH, thermostability, and tolerance to organic solvents of all modified lipases were improved. The composition and configuration of modifiers have great influence on the catalytic performance of the modified lipases. AAILs composed of l -proline exhibited better modification effect than those containing d -proline. The use of [N-AC- l -Pro] [Cl] led to the highest modification degree (47.92 %) of the lipase, which exhibited the highest hydrolytic activity (430.67 U/g), as well as enhanced thermal stability and tolerance to organic solvents. The structure of CALB was characterized by circular dichroism (CD) and fluorescence spectroscopy. It was found that the introduction of a modifier changes the secondary structure of CALB to a certain extent, and the microenvironment around the fluorescent group changed slightly. The structural stability of CALB modified with [N-AC- l -Pro] [Cl] and the mechanism of reaction were studied by molecular dynamics simulations. The molecular dynamics simulations of the native and modified CALB were performed for 20 ns at 300 and 328 K. The simulation results showed that the root mean square deviation (RMSD) and total energy of modified CALB were less than those of native CALB, indicating a more stable structure for the modified CALB. The root mean square fluctuation (RMSF) calculations showed that the rigidity of the modified CALB and the flexibility of the active center region were both enhanced. The solvent accessibility area (SASA) calculations showed that both hydrophilicity and hydrophobicity of the modified enzyme-protein were improved. The increase in radial distribution function (RDF) of water molecules confirmed that the number of water molecules around the active sites was also increased. Thus, the modified CALB has enhanced structural stability and higher hydrolytic activity towards the triglyceride substrates.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2021
·
IF 4.36
Yang Wang,Shi-Yang Shen,Lei Liu,Xiao-Dong Zhang,Dan-Yang Liu,Na Liu,Bing-Hua Liu,Lei Shen
Ethnopharmacological relevance The diterpenoids extracted from Euphorbia kansui S.L. Liou ex S.B.Ho, Euphorbia fischeriana Steud. have good antitumor effects. Jolkinolide B has anti-breast cancer effect, but it is unclear whether it has different therapeutic effects between luminal A subtype and luminal B subtype breast cancer. Aim of the study This study investigated the Jolkinolide B has different therapeutic, important targets and pathways effects between luminal A subtype and luminal B subtype breast cancer. Materials and methods We used bioinformatics to predict the biological process and molecular mechanism of Jolkinolide B in treating two types of breast cancer. Then, in vitro, cultured MCF-7 cells and BT-474 cells were divided into control group, PI3K inhibitor + control group, Jolkinolide B group and PI3K inhibitor + Jolkinolide B group. The CCK-8 assay, Flow cytometric analysis and Transwell cell migration assay was used to detect the cell proliferation, apoptosis, and migration in each group, respectively. ELISA was used to measure the content of Akt and phosphorylated Akt (p-Akt) in cell lysis buffer. Results Compared to luminal A breast cancer, Jolkinolide B had more targets, proliferation, migration processes and KEGG pathways when treating luminal B subtype breast cancer. Jolkinolide B significantly prolonged the survival time of luminal B subtype breast cancer patients. Compared to the control group, the cell proliferation absorbance value (A value) and migration number of the two kinds of breast cancer cells in the Jolkinolide B group were decreased ( P < 0.01, n = 6), and the number of apoptotic cells was increased ( P < 0.01, n = 6). Compared to the Jolkinolide B group, the A value and migration number of the two types of breast cancer cells were significantly decreased in the PI3K inhibitor + Jolkinolide B group ( P < 0.01, n = 6), and the number of apoptotic cells was significantly increased ( P < 0.01, n = 6). In addition, compared to MCF-7 cells, the A value and migration number of BT-474 cells stimulated with Jolkinolide B were significantly decreased ( P < 0.01, n = 6), and the number of apoptotic cells was significantly increased ( P < 0.01, n = 6). Akt and p-Akt protein levels in the two breast cancer cell lines in the Jolkinolide B group were all decreased ( P < 0.01, n = 6), especially in BT-474 cells stimulated by Jolkinolide B. Conclusion Jolkinolide B regulates the luminal A and luminal B subtypes of breast cancer through PI3K-Akt, EGFR and other pathways. Jolkinolide B has more significant therapeutic effect on luminal B subtype breast cancer. In vitro, experiments verified that Jolkinolide B significantly inhibited the proliferation and migration activity of BT-474 breast cancer cells by downregulating the PI3K-Akt pathway.
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高影响因子
危险品化学品经营许可证（带存储）