JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
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2017
·
IF 1.31
Yang Liu,Zhongxun Zhang,Huilin Lv,Yong Qin,Linhong Deng
Chitosan-based material has been widely used as bone substitute due to its good biocompatibility and biodegradability. However, the hydrophobic surface of chitosan film constrains the osteogenesis mineralization in the process of bone regeneration. For this reason, we develop a novel polydopamine-modified chitosan film suitable for bone tissue engineering applications by a simple and feasible route in this study. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the process of surface modification. For comparison, surface wettability, the capacity of mineralization in vitro, and biocompatibility of the chitosan film and the polydopamine-modified chitosan film were assessed. Research results indicate that the polydopamine-modified chitosan film has good hydrophilicity. It is very evident that the polydopamine treatment significantly influences the biomineralization capacity of the chitosan-based substrates, which enhance the growth rate of apatite on the modified chitosan film. Besides, MC3T3-E1 osteoblast experiments demonstrate that the cells can adhere and grow well on the polydopamine-modified chitosan film. It is anticipated that this polydopamine-modified chitosan film, which can be prepared in large quantities simply, should have potential applications in bone tissue engineering.
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Materials Science & Engineering C-Materials for Biological Applications
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2017
·
IF 4.164
Tian-Ming Liu,Jing-Jie Xu,Yun-Ren Qiu
In order to ameliorate the biocompatibility of polysulfone (PSf), sulfonated hydroxypropyl chitosan (SHPCS) was grafted from PSf membrane material by Schiff-Base reaction. The original and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), water contact angle (WCA) measurement, tensile strength test and antibacterial test in vitro, and the results indicated that the PSf modified by SHPCS (PSf-SHPCS) was synthesized successfully, the hydrophilicity of PSf-SHPCS membrane was improved to a great extent, all the membranes possessed good stability in physiological condition and the PSf-SHPCS membrane had good antibacterial property. Protein adsorption, platelet adhesion, hemolysis assay, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and whole blood clotting time were executed to evaluate the hemocompatibility of membranes decorated by SHPCS, and the results demonstrated that the modified membrane had fine hemocompatibility.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2017
·Vol. 134
·期 34
·45229
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IF 1.86
Chunyang Shang,Yanjun Chen,Chaocan Zhang,Zongyi Deng,Zhihui Wu
This article describes a new and simple method to control the release of payloads encapsulated in chitosan capsules. The capsules with the liquid core and rigid shell are performed by drop-wisely adding chitosan solution into anionic surfactant solution. The capsules can be destroyed by β-CD because β-CD binds and sequesters surfactant from the shell through the host-guest interaction. The destruction process is studied by optical microscopy and scanning electron microscopy. The capsules can swell in acid solution and shrink in alkaline solution. It is found that the destruction speed increases with increasing acidity or alkalinity of β-CD solution. Rhodamine B encapsulated in the liquid-core of chitosan capsules can be released from the capsules in β-CD solution. The release rate can be adjusted by the pH value of β-CD solution. The release speed of the capsule increases with the increase of acidity or alkalinity in β-CD solution. The above concept can provide more versatility for controlled release of a variety of payloads such as drugs, cosmetics, and so on. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45229.
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CARBOHYDRATE POLYMERS
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2016
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IF 4.219
Dong-Yan Wu,Yu Ma,Xiao-Shuang Hou,Wen-Jie Zhang,Pei Wang,Huan Chen,Bo Li,Can Zhang,Ya Ding
Although combination delivery (co-delivery) shows much superiority in the defect compensation of single-agent therapy, the construction and application of co-delivery systems are still challenging, especially for protein-based joint systems. In this work, a series of chitosan (CS)-amino acid derivatives (Arg-CS, Lys-CS, and Phe-CS) with different degrees of substitution (DS) were synthesized to prepare CS nanocapsules (CNCs) using a simple emulsification method in the presence of linoleic acid (LA). The hydrophobic drug can be loaded in LA droplets, and a positively charged protein stabilized the optimized Arg-CS nanocapsules (Arg-CNCs) on their negative surfaces. The in vitro antitumor efficacy of Arg-CNCs co-delivering paclitaxel and recombinant human caspase-3 was evaluated in HeLa cells. The co-delivery system displayed much lower IC 50 values and a higher percentage of apoptotic cells compared with the control groups. This system provides a promising and universal strategy for co-delivery, leading to collaborative tumor treatment.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2017
·
IF 1.591
Shuang Zhang,Ting Lü,Dongming Qi,Hongting Zhao
Chitosan (CS)-based flocculants, denoted as CS-g-PAM and CS-g-PDBC, were successfully prepared via graft copolymerization of CS with acrylamide (AM) or dimethyl acryloyloxyethyl benzyl ammonium chloride (DBC). The grafting was confirmed by Fourier transform infrared spectroscopy (FTIR) and x-ray photoelectron spectroscopy (XPS). The flocculation performance of CS-g-PAM and CS-g-PDBC, as well as flocculants such as cationic polyacrylamide (CPAM), polyaluminum chloride (PAC), and CS, was evaluated and compared for treating emulsified oil wastewater. It was found that CS-g-PDBC exhibited excellent flocculation performance under both acidic and neutral conditions, while CS showed better flocculation ability under alkaline condition. The flocculation mechanism of CS and CS-g-PDBC was investigated via zeta potential measurements. Results showed that different flocculation mechanisms were involved at various pH levels. As regarding CS, the flocculation mechanism is mainly charge neutralization, patching, and sweep floc under acidic, neutral, and alkaline conditions, respectively, while for CS-g-PDBC, patching was the dominant mechanism under both acidic and neutral conditions.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2017
·Vol. 24
·期 22
·18640-18650
·
IF 2.741
Chen Yuan,Lei Xin,Dou Rongni,Chen Yuancai,Hu Yongyou,Zhang Zhiqi
A water-compatible magnetic triclosan (TCS) imprinted material (TCS-CTS-Fe 0 -MIPs) was synthesized for selective enrichment and detection of TCS in real complex water samples. The material was synthesized by using chitosan (CTS) as functional monomer, which has rich surface O- and N-containing functional groups. The TCS imprinted CTS was coated on Fe 0 surface and then cross-linked with glutaraldehyde. Scanning electron microscopy suggested that the imprinted material was covered with a layer of imprinted film, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed that the imprinted material had more functional groups (amino and hydroxyl groups) than that of non-imprinted material. The TCS imprinted and non-imprinted materials used in each adsorption experiments were 0.1 mg mL −1 . The maximum adsorption capacity of the TCS imprinted material and non-TCS imprinted material were 20.86 and 15.11 mg g −1 , respectively. The adsorption results showed that selectivity coefficient was 10.151, 1.353, and 8.271 in the presence of p-chlorophenol, 2,4,6-trichlorophenol, and bisphenol-A, respectively. The recoveries of river water and lake water samples were 92.8, 91.3, 92.4, and 81.4, 82.3, 82.1%, respectively, when the samples were spiked with 4, 6, and 8 μg L −1 of TCS with the imprinted material. The adsorption capacity of the TCS imprinted material and non-TCS imprinted material lost 5.2 and 6.2% after six times of recycling. The high selectivity and excellent adsorption capacity of the imprinted material can be attributed to the presence of sterically complementary imprinted sites and high surface, which would also made it more accessible to TCS than that of non-imprinted material. The present study would provide an environmental friendly and convenient method for the removal and the monitoring of TCS in environmental water samples.
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POLYMER TESTING
·
2017
·
IF 2.464
Xiaolan Zhang,Chuanlong Jia,Xiuying Qiao,Tianyi Liu,Kang Sun
Porous mSF/PGS and CS/PGS composite scaffolds were prepared by the combination of poly(glycerol sebacate) (PGS) with silk fibroin microfibers (mSF) and chitosan (CS) as modifiers through particulate leaching and freeze-drying techniques. Both mSF/PGS and CS/PGS scaffolds show highly interconnected and open porous structures, and the crosslink density and water absorption of PGS were obviously enhanced by the modifiers. Moreover, the silk fibroin microfiber and chitosan can slow down and control the degradation rate of PGS. The biocompatibility of these porous PGS based composite scaffolds for skin tissue engineering was evaluated by cell culture experiments, and the results indicate of the good attachment, proliferation and deep penetration of cells into these composite scaffolds.
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Journal of Cleaner Production
·
2024
·
IF 9.7
Jian Wu,Rongjie Yang,Qun Zheng,Jingtong Zhou,Botong Wang,Wenjuan Yan,Shaoke Meng,Yongqing Wang,Zixia Song,Dongmei Cheng,Suqing Huang,Zhixiang Zhang,Peiwen Zhang
Understanding the impact of chitosan-based nanoparticles (NPs) on ecological systems is vital for assessing their environmental behavior and safety. In this study, we investigated the effects of pyraclostrobin@chitosan-based nanoparticles (NPs.PYR) on microbial communities in a pond. NPs.PYR significantly impacted the abundance of microbial communities in the pond, compared with the commercial pesticide suspensions. We employed Chlorella sp. as a representative microorganism to explain this phenomenon and found that the NPs and NPs.PYR treatments induced a rapid decrease in the abundance of Chlorella sp. This phenomenon can be attributed to the electrostatic interaction between the NPs and microorganisms, along with the affinity of the microorganisms’ extracellular polymers to the chitosan-based NPs, resulting in the cosettlement of the microorganisms with these NPs. The NPs.PYR migrated from the overlying water to the sediment, decreasing the PYR concentration in the overlying water. The mortality of zebrafish specimens exposed to NPs.PYR was significantly lower than that of the specimens exposed to pyraclostrobin suspension concentrate. These results suggest that the prepared chitosan-based nanopesticide tends to aggregate with microorganisms, leading to cosettlement and reduced pesticide levels in the overlying water, thus enhancing the safety of nontarget animals.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1836
·
IF 4.2
Guiling Chen,Yitong Yin,Xianting Zhang,Andong Qian,Xiaoyang Pan,Fei Liu,Rui Li
To develop valuable applications for the invasive weed Palmer amaranth, we utilized it as a novel biochar source and explored its potential for methyl orange adsorption through the synthesis of chitosan-encapsulated Palmer amaranth biochar composite microspheres. Firstly, the prepared microspheres were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy and were demonstrated to have a surface area of 19.6 m2/g, a total pore volume of 0.0664 cm3/g and an average pore diameter of 10.6 nm. Then, the influences of pH, dosage and salt type and concentration on the adsorption efficiency were systematically investigated alongside the adsorption kinetics, isotherms, and thermodynamics. The results reveal that the highest adsorption capacity of methyl orange was obtained at pH 4.0. The adsorption process was well fitted by a pseudo-second-order kinetic model and the Langmuir isotherm model, and was spontaneous and endothermic. Through the Langmuir model, the maximal adsorption capacities of methyl orange were calculated as 495.0, 537.1 and 554.3 mg/g at 25.0, 35.0 and 45.0 °C, respectively. Subsequently, the adsorption mechanisms were elucidated by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy investigations. It is indicated that electrostatic interactions, hydrogen bonding, π–π interactions and hydrophobic interactions between methyl orange and the composite microspheres were pivotal for the adsorption process. Finally, the regeneration studies demonstrated that after five adsorption–desorption cycles, the microspheres still maintained 93.6% of their initial adsorption capacity for methyl orange. This work not only presents a promising method for mitigating methyl orange pollution but also offers a sustainable approach to managing Palmer amaranth invasion.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yiwen Lu,Wen Geng,Lili Li,Fang Xie,Mingchang Zhang,Huatao Xie,Jie Cai
Multidrug-resistant (MDR) bacterial infections pose a severe threat to global public health and present significant challenges in the treatment of bacterial keratitis. The escalation of antimicrobial resistance (AMR) underscores the urgent need for alternative therapeutic strategies. In this study, we report the homogeneous synthesis of quaternized ultra-highly deacetylated chitosan (QUDCS) using a sequential acid-base combination approach. The optimized QUDCS-2 exhibits broad-spectrum antibacterial activity through a membrane-disruption mechanism driven by electrostatic, hydrogen bonding, and hydrophobic interactions, while maintaining low cytotoxicity and high selectivity. Compared to less deacetylated counterparts, QUDCS-2 demonstrates superior stability in enzyme-rich environments and effectively inhibits and eradicates mature biofilms of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa . Furthermore, QUDCS-2 exhibits a remarkable ability to prevent the development of antimicrobial resistance. In a mouse keratitis model, QUDCS-2 shows excellent biocompatibility and significant antibacterial efficacy, providing strong support for its potential as a long-term, effective antimicrobial agent.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Jingxuan Lu,Juan Li,Shiyan Fu,Huanhuan Tan,Yuhui Hao
The combined chemotoxicity and radiotoxicity associated with uranium, utilized in nuclear industry and military applications, poses significant threats to human health. Among uranium pollutants, uranyl is particularly concerning due to its high absorptivity and potent nephrotoxicity in its + 6 valence state. Here, we have serendipitously found Na 2 SeO 3 facilitates the conversion of U(VI) to U(IV) precipitates. A novel approach involving nano-chitosan loaded internally with melatonin and externally modified with selenite (NPs Cs-Se/MEL) was introduced. This modification not only enhances the conversion of U(VI) to U(IV) but also preserves the spherical nanostructure and specific surface area, leading to increased adsorption of U(VI) compared to unmodified samples. Selenite modification improves lysosomal delivery in HEK-293 T cells and kidney distribution of the nanoparticles. Furthermore, NPs Cs-Se/MEL demonstrated a heightened uranium concentration in urine and exhibited remarkable efficiency in uranium removal, resulting in a reduction of uranium deposition in serum, kidneys, and femurs by up to 52.02 %, 46.79 %, and 71.04 %, respectively. Importantly, NPs Cs-Se/MEL can be excreted directly from the kidneys into urine when carrying uranium. The results presented a novel mechanism for uranium adsorption, making selenium-containing nano-materials attractive for uranium sequestration and detoxification.
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Toxics
·
2024
·Vol. 12
·期 3
·230
·
IF 3.9
Lingli Min,Yahui Ma,Bi Zhang,Dulan He,Jinhua Chen,Xuerong Li,Shuhua Wang,Yulang Chi
Efficient removal of extremely mobile and toxic As(III) from water is a challenging but critical task. Herein, we developed a functionalized sorbent of chitosan nanofiber with iron–manganese (Fe-Mn@CS NF) using a one-step hybrid electrospinning approach to remove trace As(III) from water. Batch adsorption studies were performed to determine the adsorption efficiency under a variety of conditions, including contact time, starting concentration of As(III), ionic strength, and the presence of competing anions. The experimental results demonstrated that the concentration of As(III) dropped from 550 to less than 1.2 µg/L when using 0.5 g/L Fe-Mn@CS NF. This demonstrates the exceptional adsorption efficiency (99.8%) of Fe-Mn@CS NF for removing As(III) at pH 6.5. The kinetic tests revealed that the adsorption equilibrium was reached in 2.6 h, indicating a quick uptake of As(III). The ionic strength effect analysis showed that the adsorbed As(III) formed inner-sphere surface complexes with Fe-Mn@CS NF. The presence of SO42−or F−had a negligible impact on As(III) uptake, while the presence of PO43−impeded As(III) absorption by competing for adsorption sites. The exhausted sorbent could be effectively regenerated with a dilute NaOH solution. Even after 10 cycles of regenerating Fe-Mn@CS NF, the adsorption efficiency of As(III) in natural groundwater was maintained over 65%. XPS and FTIR analyses show that the presence of M–OH and C–O groups on the sorbent surface is essential for removing As(III) from water. Overall, our study highlights the significant potential of Fe-Mn@CS NF for the efficient and quick elimination of As(III) from water.
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