SCIENCE
·
2026
·Vol. 391
·期 6792
·
IF 47.3
Liping Cai,Qing Zhang,Tianxiong Yao,Xiaoxiao Zou,Lei Xie,Siyu Yang,Yanyuan Xiao,Fei Huang,Zhiwei Peng,Jiawen Yang,Jianzhen Huang,Qiqi Jing,Ziqi Ling,Min Zheng,Chuanmin Qiao,Jinyuan Wu,Jiaqi Chen,Tao Jiang,Qin Liu,Min Liu,Zhe Chen,Jingquan Li,Hui Jiang,Haoyun Jiang,Zuoquan Chen,Yaya Liao,Yizhong Huang,Longyun Li,Yunyan Zhou,Zhou Zhang,Chao Yin,Yu Ye,Hui Yang,Biao Chen,Zhong Wang,Huanfa Gong,Dong Chen,Cong Huang,Xinkai Tong,Zhimin Zhou,Hao Fu,Yingchun Sun,Xiao Sun,Min Yan,Lin Wu,Shuqi Xiong,Yaxiang Wang,Xinke Xie,Mengqing Zhou,Xiaodong Liu,Xianhua Xie,Fusheng Wu,Zifeng Liu,Mei Ge,Sanya Xiong,Chenyu Li,Tao Shen,Yuxin Liu,Xi Tang,Xiaolong Chang,Siyi Liu,Chuangang Yu,Naixiang Yu,Zikang Hu,Dengshuai Cui,Jiahong Zhong,Sha Liu,Jianchao Hu,Yang Wen,Weiwei Zhou,Guanyue Wei,Shiyao Lin,Yiwen Xiahou,Liqing Chen,Jianjun Li,Ruirong Liu,Xiaoyun Chen,Yujie Shu,Feng Chen,Chao Wei,Xiaofen Hu,Yong Li,Yong Hou,Qingjie Zeng,Jun Gao,Ying Su,Jing Li,Junwu Ma,Yuanmei Guo,Congying Chen,Shijun Xiao,Huashui Ai,Zhiyan Zhang,Weiwei Liu,Qiang Yang,Yuyun Xing,Lin Rao,Bin Yang,Lusheng Huang
Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also deciphered that l -leucine transport insufficiency in the trophoblast causes fetal growth restriction by reducing a muscle type II myofiber subcluster. Our “all-from-one” strategy enabled the identification of tissue cell type–specific transcription factors and provided insights into pregnancy heart adaptation and fetal growth restriction.
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iScience
·
2026
·
IF 4.5
Bo Pang,Siyuan Chen,Yikai Bai,Yan Zhang,Zhida Wang
Diabetic peripheral neuropathy (DPN) is a prevalent complication characterized by Schwann cell dysfunction. The role of the nuclear receptor subfamily 4 group member 3 (NR4A3) in DPN remains unclear. We found that NR4A3 expression is upregulated in the sciatic nerves of streptozotocin (STZ)-induced DPN mice. Overexpression of NR4A3 via AAV9-Mpz-NR4A3 lumbar intrathecal injection improved motor and sensory nerve function and mitigated sciatic nerve pathology. NR4A3 overexpression also reduced oxidative stress and enhanced mitochondrial function. In the high glucose (HG)-induced Schwann cell injury model, NR4A3 overexpression inhibited apoptosis, mitochondrial dysfunction, and dedifferentiation. Integrated ChIP-seq and mRNA-seq profiling identified glutaminase 2 (GLS2) as a direct transcriptional target of NR4A3. NR4A3 bound to the GLS2 promoter and promotes its transcriptional activation, and suppression of GLS2 abrogated the functional protection conferred by NR4A3 in Schwann cells. Together, NR4A3 represents a promising therapeutic target for DPN.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·303
·
IF 38.5
Zhu Huang,Wang Ting,Gao Shihuan,Geng Wei,Ma Tian,Cheng Liang,Han Xianglong,Deng Jiuhong,Gao Shanshan,Cheng Chong
The phage-inspired de novo design of the artificial peroxidase (IrNC@TiO 2 ) features robust subnanometer cluster sites and a sea-urchin-like topography.
The potent enzymatic activity of Ir clusterzymes and the topological advantages of the spiky substrate endow IrNC@TiO 2 with the ability to effectively capture and eradicate planktonic Streptococcus mutans while inhibiting biofilm formation.
IrNC@TiO 2 can significantly inhibit tooth-surface biofilm development, prevent enamel demineralization, and reduce caries incidence in anticaries experiments
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DYES AND PIGMENTS
·
2026
·
IF 3.9
Zekuo Lv,Leipeng Zhang,Wenchao Liu,Yike Zhang,Lei Xu,Yuqiang Wang,Qiumei Jiang,Miaomiao Zhao,Rui Yang,Xingcan Han,Dongqi Liu,Jiupeng Zhao,Yao Li
Viologen-based materials are among the most promising organic electrochromic systems due to their high optical contrast, fast redox response, and molecular tunability. However, their practical deployment is fundamentally constrained by the dimerization and irreversible side reactions of viologen radical cations (V +• ), which lead to rapid performance degradation and limited cycling stability. Here, we propose an asymmetric molecular design strategy that synergistically integrates electron-withdrawing inductive effects with moderate steric hindrance to fundamentally suppress radical cation dimerization. Using site-selective functionalization of 4,4′-bipyridine, a novel asymmetric viologen derivative, 4-( p -cyanobenzyl)-4′-( p -fluorobenzyl)-4,4′-bipyridinium (FCBV), is rationally designed and synthesized.The combined effects of dual electronegative substituents and benzyl-induced steric hindrance not only inhibit V +• aggregation but also promote directional electron transfer, resulting in simultaneously enhanced stability and kinetics. Electrochromic devices based on FCBV deliver a high optical contrast exceeding 60 % in the 500–700 nm range, an exceptional coloration efficiency of 155.8 cm 2 ·C -1 , and outstanding durability, retaining 98.9 % of their initial optical modulation after 20,000 switching cycles. The devices are further demonstrated in smart windows with effective light–thermal regulation and in adaptive anti-glare rearview mirrors, confirming their practical applicability in building and automotive optoelectronic systems.
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PHYTOTHERAPY RESEARCH
·
2026
·
IF 8.1
Bingyu Chen,Ke Liu,Yaya Guo,Jingwei Zhao,Yanhua Wang
The global incidence of ulcerative colitis (UC), a chronic inflammatory bowel disease, is rising. Epi-berberine (EPI), an alkaloid from Coptidis Rhizoma , shows potential for UC treatment. This study aimed to assess EPI's effect on UC and explore the mechanism underlying its UC-alleviating effect. The therapeutic effects of EPI on UC were validated in dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide (LPS)-induced Caco-2 inflammatory models and further investigated the underlying mechanism. In vivo, high-dose EPI (200 mg/kg) attenuated weight loss, reduced disease activity index, increased colon length, lowered colon macroscopic/histological scores, restored intestinal mucosal barrier and inhibited colonic inflammation. EPI (25/50 μM) had similar in vitro effects. mRNA-seq identified EPI-regulated genes in UC mice, revealing six gene clusters with analogous expression patterns. The largest cluster contained genes upregulated by DSS but downregulated by EPI, potentially involved in the MAPK pathway. Key DEGs were enriched in PI3K-Akt and MAPK pathways, verified in vivo and in vitro. Literature retrieval and molecular docking predicted glutaminyl-peptide cyclotransferase (QPCT) as EPI's potential UC therapeutic target. EPI inhibited DSS/LPS-induced QPCT upregulation in vivo and in vitro; QPCT knockdown suppressed inflammation and preserved Caco-2 monolayer barrier function, while QPCT overexpression reversed EPI's therapeutic effects. QPCT mediates PI3K-Akt/MAPK activation, and its overexpression abrogated EPI's inhibitory effects. EPI alleviates murine UC by protecting the intestinal mucosal barrier and inhibiting inflammation, likely via regulating the QPCT-PI3K-Akt/MAPK pathway. It provides a preclinical basis for developing prophylactic strategies for inflammatory bowel disease.
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CANCER SCIENCE
·
2026
·
IF 4.9
Xinyu Xu,Jiayuan Wang,Meng Jiang,Ling Ouyang
Ovarian cancer is one of the most prevalent gynecologic malignancies worldwide. Dysregulated cell proliferation and angiogenesis are well-recognized to be involved in the pathogenesis of ovarian cancer. Nucleolar Protein 7 (NOL7), a novel RNA-binding protein, has been identified as a tumor suppressor and a key anti-angiogenetic factor. However, the function of NOL7 and its underlying molecular mechanisms in ovarian cancer remain unclear. In this study, we demonstrated that NOL7 expression was down-regulated in ovarian cancer tissues, and low NOL7 expression was associated with poorer prognosis in patients with ovarian cancer. Overexpression of NOL7 decreased cell viability, inhibited cell cycle entry and proliferation, and promoted apoptosis in OVCAR-3 and SKOV-3 cells. Additionally, NOL7 overexpression decreased VEGF-A level, increased TSP-1, and suppressed angiogenesis of human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of NOL7 in ovarian cancer cells enhanced cell proliferation and angiogenesis, while reducing apoptosis. In vivo experiments further confirmed that NOL7 overexpression inhibited tumor growth and angiogenesis. Mechanistic studies revealed that NOL7 could bind to the 3′UTR of growth arrest and DNA damage inducible alpha (GADD45A), and overexpression of NOL7 up-regulated GADD45A expression by stabilizing GADD45A mRNA in ovarian cancer cells. The anti-cancer effects of the NOL7/GADD45A were mediated by inhibiting the phosphorylation of STAT3 at Ser727. Collectively, our findings indicate that NOL7 functions as a tumor suppressor in ovarian cancer and provide a novel therapeutic target for the treatment of ovarian cancer.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
·
IF 5.4
Lingling Mao,Jiashuo Wang,Zekai Wu,Zibo Di,Dixiong Zou,Rongjun Wei,Mingqiao Fang,Yuechao Huang
Wearable thermal management materials that can simultaneously regulate temperature and suppress bacterial growth remain challenging due to the difficulty of integrating active heating, thermal buffering, and antibacterial functionality within flexible fibrous systems. Here, we report an asymmetric phase change fabric that couples latent heat storage with light-to-thermal and electric-to-thermal conversion through organic-inorganic interfacial engineering. The fabric is constructed from paraffin wax@polyvinylidene fluoride core-shell fibers with a latent heat capacity of 108.8 J/g, which decreases to 50.1 J/g after combining with a polyaniline@silver interlayer and a MXene-based conductive coating. Owing to its asymmetric architecture, the composite exhibits direction-dependent optical absorption, enabling enhanced light-to-thermal conversion with temperatures reaching 83.4 °C within 30 s. The MXene network provides high electrical conductivity up to 2359 S/m, allowing stable Joule heating to 61.5 °C under low voltages of 1.5 V. Additionally, benefiting from combined thermal effects and antibacterial components, the fabric shows strong antibacterial activity, particularly under light irradiation. This work offers a promising strategy for multifunctional thermal management textiles.
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Dongxin Wang,Jinglei An,Xinwei Chang,Yan Xu,Junxiu Zhao,Linying Gao,Ping Zhang,Xiangjun Li,Jisheng Nie,Hong Cui
Fluctuations in neurotransmitters and essential metabolites are closely linked to the development and progression of multiple diseases. Accurate monitoring of these biomolecules provides critical information for early diagnosis, disease evaluation, and timely clinical intervention. However, their coexisting electrochemical detection remains impeded by signal overlap due to similar redox potentials, such as uric acid (UA), dopamine (DA) and ascorbic acid (AA). This work reports a universal in-situ synthesis strategy to construct Zr-based metal-organic frameworks (MOFs) (UiO-66)/graphene oxide (GO) complexes, wherein the GO dosage critically regulates the crystallinity and pore architecture of UiO-66. Subsequent integration with protonated polyaniline (PANI) yields ternary composites (UiO-66/GO/PANI) as an electrochemical sensing platform for the simultaneous detection of UA, DA, and AA. Significantly, the partial autogenous reduction of GO during solvothermal synthesis eliminates the need for dedicated reduction steps and toxic reductants while enhances conductivity. The UiO-66/GO/PANI-modified glassy carbon electrode exhibits well-separated oxidation peaks for UA (0.32 V), DA (0.19 V), and AA (0.007 V). The sensor achieves low detection limits of 2.12 μM for UA, 1.68 μM for DA, and 18.49 μM for AA, together with excellent selectivity and practical applicability in complex samples. This work establishes a green synthesis paradigm for MOF/GO hybrids and provides a universal biosensing strategy for neurotransmitter and metabolite, with potential extensibility to complex biomarker panels in neurological diagnostics.
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ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Yong Chen,Huiping Zeng,Jiaxin Xu,Sibo Fu,Yuliang Zhu,Fanxu Zeng,Luyao Teng,Jiahao Wu,Fanhao Meng,Dong Li,Jie Zhang
This work simplified the structure of waste iron-containing sludge from groundwater treatment plants to explore its mechanism of activating periodate(PI) for degrading organic pollutants in water. The pH during preparation was used to regulate the crystallinity and the doping of transition metal Mn in the precursor solution to prepare catalysts similar to the waste iron-containing sludge. Sulfadiazine (SDZ) was selected as the model contaminant, and it was found that the efficiency of the prepared catalyst to remove the contaminants was 100% in 10min by activating PI. Combining electrochemical and performance experiment results, it was found that the amorphous part of the material can optimize the electronic structure and enhance the electron transfer ability. However, Mn doping can also reduce the electron transfer resistance, and the synergistic effect of Fe-Mn bimetal occupied a more important part in the entire catalytic system. According to the results of Electron paramagnetic resonance (EPR) and quenching experiments, it was found that although a variety of free radicals were produced, the active substances that contributed the most were IO 3 • and 1 O 2 . The materials showed certain environmental adaptability in the subsequent experiments. This study provides theoretical support for removing organic pollutants from waste iron-containing sludge and provides some basic insights for bimetal synergistic activation of PI.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Wen Luo,Yana Ma,Weijia Zhu,Ruican Nie,Yue Wu,Dongqiu Shan,Shijun Xu,Ho-Young Song,Hongtao Hu
Liver cancer remains a major global public health threat, with high mortality. Lenvatinib is a tyrosine kinase inhibitor that has been used for the treatment of advanced liver cancer. However, its therapeutic efficacy is often limited by severe adverse effects and drug resistance. To overcome these challenge, we developed a biomimetic versatile nanoplatform based on Mn-doped polydopamine (PML@CM). Owing to their homologous tumor-targeting ability and pH-responsive drug release properties, PML@CM nanoparticles effectively improved the biocompatibility of lenvatinib and enhanced its tumor accumulation. Upon exposure to the tumor microenvironment, the released Mn2+ not only triggered chemodynamic therapy through Fenton-like reactions but also enabled magnetic resonance imaging (MRI). In addition, PML@CM nanoparticles exhibited an efficient photothermal conversion performance for tumor photothermal therapy. In conclusion, this nanoplatform provides a promising therapeutic strategy for MRI-enabled synergistic therapy against liver cancer.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Guitao Tan,Huaqiang Luo,Yuxin Wang,Haonan Hu,Bingtian Tu,Huan He,Jing Tu
Bacterial infections at wound sites impede healing and pose a serious threat to human health. Conventional antibiotic therapies, however, tend to trigger resistance. Consequently, copper (Cu)-based materials have recently emerged as highly promising alternatives that synergistically kill bacteria and thereby accelerate wound healing. Herein, we developed a core–satellite nanomedicine (PZH) composed of a degradable Cu-doped phosphate-based glass (PBG) core and multiple ZIF-8/hyaluronic acid (HA) satellites. PZH shows pH-triggered behavior: at physiological pH its structure remains intact and Cu2+ release is minimal, whereas the acidic microenvironment of infected wounds triggers disassembly, releasing Cu2+ and generating •OH radicals through peroxidase-like (POD-like) activity. This dual-functional ionic-catalytic mechanism achieves potent bactericidal effects against both Gram-positive and Gram-negative bacteria. At 6 μg/mL, PZH eliminates >99% of Staphylococcus aureus. In vitro assays further confirm that PZH is cytocompatible and accelerates cell migration. To overcome the application limitations of conventional Cu nanoparticle suspensions, PZH was loaded into a thermosensitive F127 hydrogel to yield PZHF, which preserves the POD-like activity and enables minimally invasive, injectable delivery to irregular wound geometries. In vivo tests further demonstrated that the biocompatible PZHF hydrogel displayed good antibacterial properties and promoted wound healing. As a smart, clinically translatable Cu-based nanomedicine, this system provides a precision therapeutic strategy for treating bacterially infected wounds.
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DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 3.6
Mengling Hou,Shaofei Song,Dali Gan,Sengpeng Wong,Tingting Zhao,Yanxin Zhang,Min Huang,Weiwei Zeng,Yiming Jiang
Sedum sarmentosum Bunge extract (SSBE) is widely used in clinical practice to treat various liver diseases. Cyclosporine A (CsA) is a potent immunosuppressant known to cause hepatotoxicity. However, it is unclear whether combining SSBE and CsA is effective or increases the risk of adverse reactions. This study explored the potential herb-drug interaction between SSBE and CsA. Male rats were given an oral dose of CsA (2.5 mg/kg) one hour after a single dose of SSBE (600 mg/kg) or vehicle. Blood CsA concentrations measured by UHPLC-MS/MS revealed that SSBE dramatically increased the CsA exposure; the C max and AUC 0→48h values were significantly increased by 150% and 220% (from 222.89 to 567.06 ng/mL and from 2,089.37 to 6,615.08 ng/mL∙h), respectively. In parallel, the exposure of the CsA metabolite AM1 was significantly reduced, with Cmax and AUC 0→48h decreased by 68% and 70%, respectively. In vitro study demonstrated that SSBE and its active constituents inhibited CYP3A activity and suppressed CsA metabolism to AM1. In conclusion, SSBE significantly increased the systemic exposure of CsA, and the effect might be related to inhibition of CYP3A activity. Additional caution should be exercised when treating CsA and SSBE together, as it may cause unexpected potential herb-drug interaction.
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