JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Hailan Wang,Rui Wang,Ruobin Dai,Zhiwei Wang
Reverse osmosis (RO) is a leading technology for wastewater/water treatment and resource recovery. The formation of Si–Al complex scale significantly impairs the performance of RO systems. Due to the diverse forms of silica and aluminum species, the scaling process involves both homogeneous and heterogeneous mechanisms, presenting substantial challenges in understanding Si–Al scale formation. Herein, we investigated the scaling mechanism of Si–Al complexes in RO systems under acidic, neutral, and alkaline conditions, focusing on Si–Al interactions in solution and their deposition behavior on membrane surfaces. We found that Si–Al interactions in solution did not directly determine their fouling behavior on RO membranes. In acidic conditions, silicic acid and aluminum species (i.e., Al 3+ ) remained stable in solution but underwent heterogenous polymerization on the membrane surface. The electrostatic shielding and the bridging effects of Al 3+ facilitated the formation of a dense and thick Si–Al complex layer. Under neutral and alkaline conditions, the Si–Al complex primarily underwent homogenous polymerization before depositing on the membrane surface, due to the adsorption of silicic acid by polymeric aluminum hydroxide. The electrostatic repulsion between the Si–Al complex and the membrane resulted in minimal scaling. This work offers comprehensive insights into the pH-dependent scaling behavior of Si–Al complexes in RO processes, providing a theoretical foundation for developing effective scaling control strategies.
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FOOD HYDROCOLLOIDS
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2025
·
IF 12.4
Chang Liu,Ning Li,Linjie Luo,Xu Li,Zhiming Liu
A dual-layer pH-responsive fluorescent film was developed using hydroxypropyl methylcellulose (HPMC), zinc alginate (ZA), fluorescein isothiocyanate (FITC), and dragon fruit peel extract (DE) for real-time food freshness monitoring. The outer protective layer served as a hydrophobic barrier to reduce moisture interference, while the inner indicator layer acted as a pH-sensitive interface, integrating FITC's fluorescence and DE's visible color change for dual-mode sensing. The film exhibited good thermal stability, antimicrobial activity, and improved hydrophobicity. Optical responses were evaluated across a wide pH range (2.0–12.0), showing stable visible color under ambient light and enhanced fluorescence under 365 nm UV. Upon exposure to ammonia vapor, fluorescence intensity increased linearly from 0 to 1000 ppm (R 2 = 0.9895; LOD = 6.73 ppm), while visible color changes became evident at 500–5000 ppm, with R/B and R/G ratios exhibiting strong linearity (R 2 = 0.96176 and 0.96747; LODs = 1126 ppm and 958 ppm, respectively). Application trials with pork revealed distinct color changes after 4 days at 25 °C or 2 days at 5 °C. These results confirm the film's effectiveness for dual-mode, non-destructive, and real-time monitoring of pork freshness.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yu Wang,Jingru Shi,Mengyao Wang,Lingjiao Zhang,Rui Wang,Junjie Zhang,Huiling Qing,Jinyou Duan,Xiaoli Zhang,Guojuan Pu
Drug-resistant bacterial infection and biofilm formation are the key inhibitors of wound healing, and new strategies are urgently needed to address these issues. In this study, we designed a pH-responsive co-assembled peptide hydrogel to inhibit Methicillin-resistant Staphylococcus aureus (MRSA) infection and promote wound healing. We synthesized a cationic short peptide (Nap-FFKKK) and a co-assembled hydrogel with curcumin at pH ∼ 7.8. The loaded curcumin was continuously released in a weak acid environment (pH ∼ 5.5). The lysine-rich cationic peptide inhibited biofilm formation in MRSA via electrostatic interaction with the negatively charged bacterial cell surface and, thus, provided a reinforcing antibacterial effect with curcumin. In vitro antibacterial experiments showed that the co-assembled system considerably reduced the minimum inhibitory concentration of curcumin against MRSA by 10-fold and promoted wound healing in a mouse model of MRSA-infected wounds. This study provides a simple and promising strategy to treat drug-resistant bacterial infections in wounds.
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PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Xia Lei,Jie Meng,Tianyu Gao,Mengxue Zhang,Zhanlin Zhang,Shuang Xie,Yupeng Su,Xiaohong Li
Pyroelectrodynamic therapy (PEDT) integrates photothermal ablation and catalytic generation of reactive oxygen species (ROS), yet tumor-specific PEDT remains unexplored. Herein, pyroelectric tetragonal BaTiO 3 (tBT) nanoparticles (NPs) were capped with polyaniline (PANI) via a Pickering emulsion-masking method, followed by in situ deposition of MnO 2 nanodots on PANI caps to synthesize Janus tBT@PANI-MnO 2 NPs. PANI emeraldine salts (PANI-ES) at pH 6.5 display strong near-infrared II (NIR-II) absorption and 4.67-fold higher photothermal conversion efficiency than that of PANI emeraldine base at pH 7.4. MnO 2 nanodots exhibit self-propagating glucose oxidase (GOx), peroxidase (POD), and catalase (CAT) catalytic activities, remodeling the tumor microenvironment and enhancing PTT and PEDT efficacy. Heterojunction formation with PANI-ES generates 1.63-fold higher pyroelectric potentials compared to pristine tBT NPs. The pyroelectric field selectively alters tumor cell membrane potential and, along with the self-propelled motion by asymmetrical thermophoresis from the Janus structure, promotes cellular uptake of NPs. Tumor accumulation of NPs increases 3.2 folds with broad intratumoral distributions of NPs and ROS. Synergistic toxicities to tumor cells arise from PANI-mediated photothermal effect, ROS generation from tBT-PANI heterojunctions, and MnO 2 nanozymes-catalyzed glucose depletion. Integration of PEDT, mild PTT and MnO 2 -catalyzed starvation therapy completely inhibits tumor growth, extends animal survival, elevated intratumoral O 2 levels, and suppressed adenosine triphosphate productions. Thus, this Janus NP design represents the first attempt to develop pH-responsive heterojunctions and enables tumor-specific PTT, PEDT and nanozyme-catalyzed starvation therapy. Statement of Significance Although phototherapy achieves light localization for tumor suppression, inevitable toxicities usually occur when light penetrates healthy tissues with accumulation of photoactive agents. Extensive efforts have been dedicated to exploring tumor microenvironment-responsive drug delivery systems, aiming to enhance tumor-targeting efficiency and treatment selectivity of anticancer agents. However, to date, no efforts have been made to develop a method that can achieve tumor-specific temperature elevation and pyroelectrodynamic therapy while simultaneously minimizing exposure to normal tissues. To address these challenges, a concise strategy is proposed to generate pyroelectric heterojunctions in response to the slightly acidic tumor microenvironment, taking advantages of reversible protonation and deprotonation properties of polyaniline. The tumor-specific conversion into polyaniline emeraldine salts triggers strong NIR-II absorptions and pyroelectric effect, and the self-propagated catalytic reactions of MnO 2 nanozymes reinforce photothermal, pyroelectrodynamic and starvation therapies of tumors.
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高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Wenhui Liu,Fan Nie,Haojing Jiang,Yinan Zhao,Yan Zhang,Zheng Zhang,Jie Zhang,Jing Xu,Yuanqiang Guo
Hydrophobic chemotherapy drugs face significant challenges in cancer treatment, including low bioavailability, unavoidable toxic side effects, and the development of drug resistance. To address these issues, a multifunctional nanoplatform was developed for cancer therapy, aimed at achieving effective drug delivery and enhancing antitumor efficacy. Poria cocos polysaccharide (PCP), a natural polymer known for its immunomodulatory properties, was utilized as an immunoreactive vector for drug delivery after being cross-linked with 1,4-phenylenebisboronic acid (BDBA). Subsequently, a small-molecule chemotherapy drug, esculetin (EL), was confirmed through density functional theory (DFT) simulations to be encapsulated within the PCP-BDBA nanoparticles via weak interactions. The results demonstrated that the synthesized nanoparticles were spherical, with an average particle size of 162.0 nm. In addition to exhibiting excellent stability, the nanoparticles also displayed pH-responsive drug release properties. In vivo experiments indicated that EL@PCP-BDBA NPs exhibited antitumor effects. Furthermore, EL@PCP-BDBA NPs showed superior in vitro antitumor activity compared to EL at the cellular level. Additionally, EL@PCP-BDBA NPs were found to increase intracellular reactive oxygen species (ROS) levels, induce cell apoptosis, and suppress cell migration to combat cancer. Meanwhile, EL@PCP-BDBA NPs enhanced immune function in vivo. In summary, this study developed a nano-pharmaceutical that combined chemotherapy and immunotherapy functions, which was considered a promising tool for cancer therapy.
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高影响因子
Gels
·
2025
·Vol. 11
·期 9
·700
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IF 5.3
Shuhan Feng,Patrick Laurén,Jacopo Zini,Zahra Gounani,Jinfeng Bi,Jianyong Yi,Timo Laaksonen
Cellulose nanofibers and pectin are promising candidates for polysaccharide-based gel carriers. However, their integration into a structurally modified hybrid gel system has not been extensively investigated. In this study, hybrid cryogels with a pH-responsive release profile favoring small intestinal delivery were prepared by freeze-drying various ratios of anionic nanofibrillar cellulose (aNFC) and amidated pectin (AP). Under acidic conditions, carboxylate protonation reduced intermolecular electrostatic repulsion, promoting the formation of the aNFC/AP hybrid gel network. Increasing the AP content enhanced the mechanical strength of the hydrogels and resulted in larger pore sizes after freeze-drying. The hybrid cryogels prolonged the release of a model drug for up to 20–30 min at pH 3.0, while exhibiting rapid release within 1–2 min when the pH exceeded 6.5, due to gel network collapse. The release behavior was governed by both the porous morphology and the crosslinking density of the cryogel scaffolds. These findings demonstrate that aNFC/AP hybrid cryogels possess a well-defined pH-responsive functional window (pH 6.5–7.0) and hold strong potential as oral drug delivery systems targeting the small intestine.
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Materials Today Advances
·
2025
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IF 8
Lina Huang,Chao Lin,Hanyi Hua,Zehao Chen,Yong Xu,Kezhen Zhou,Xiaoming Liu,Yifan Li,Jiangming Yu,Xiaojian Ye,Xiaoxiao Li,Shuai Jiang
In osteoporotic bone defects, bone marrow mesenchymal stem cells (BMSCs) play a pivotal role in tissue regeneration by orchestrating the local microenvironment through both differentiation and paracrine signaling. However, persistent pathological stimuli such as oxidative stress significantly impair their functionality, while limited cell survival and homing efficiency at the defect site remain major obstacles hindering therapeutic efficacy. To overcome these issues, we designed a stem cell delivery system using microfluidic techniques, in which microspheres were modified with resveratrol. This system leveraged a sustained-release liposomal formulation of resveratrol to enhance the antioxidant resilience of BMSCs. Simultaneously, the platform created a three-dimensional porous microenvironment using pH-responsive microspheres, which supported the maintenance of paracrine activity and promoted osteogenic differentiation of transplanted cells, thereby accelerating bone regeneration. In vitro experiments demonstrated that this system significantly enhanced mineralized nodule formation, accompanied by marked upregulation of osteogenesis-related genes and proteins including RUNX2, COL-1, and SP7. Furthermore, BMSCs exhibited increased secretion of key paracrine factors such as VEGFA, thereby improving proangiogenic support to endothelial cells. In vivo study, we employed an osteoporotic rat model with femoral bone defects, micro-CT imaging and multimodal histological analyses confirmed that the proposed platform markedly facilitated new bone formation and structural tissue reconstruction. Collectively, this study proposes a synergistic strategy for osteoporotic bone repair, providing a new approach to cell therapy design.
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Chemical Engineering Journal Advances
·
2025
·
IF 7.1
Tianhong Wang,Jiahui Xu,Anhong Cai,Jibo Xiao,Peng Wang,Min Zhao,Xianfeng Huang
Organic phosphonates detected frequently in water bodies pose severely environmental risks, and the cleavage of their C-P bonds to converse orthophosphate (PO 4 3- ) serves as a prerequisite step for achieving deep phosphorus elimination. Although the in situ generation of Cu(III) via Cu(II)/oxidant system for selective phosphonates degradation has been studied, the oxidation efficiency is constrained by sluggish Cu(II)/Cu(I) reduction, especially under acidic conditions. In this study, the introduction of UV irradiation accelerated the Cu(I)/Cu(II)/Cu(III) cycle in Cu(II)/peroxymonosulfate (PMS) process, enabling efficient and selective oxidation of 1,1-diphosphonic acid (HEDP, a typical phosphonate) into PO 4 3- across a wide pH range. UV-driven trace Cu(II)/PMS system can convert 90% of HEDP into PO 4 3- within 10 min at the pH range of 4-10, which was significantly higher than the conversion efficiency of HEDP by UV/PMS, Cu(II)/PMS and UV/Cu(II)/H 2 O 2 processes. The decomposition of HEDP was enhanced with increasing Cu(II) and PMS concentrations. Notably, mechanistic investigation revealed that Cu(III)-induced intramolecular electron transfer was the key contributor during the UV/Cu(II)/PMS-driven decomposition of HEDP into PO 4 3- . The experimental results of competitive ligands clearly suggested that the high selectivity of HEDP oxidation by UV/Cu(II)/PMS was closely related to the complexation of Cu(II) with HEDP. Additionally, although natural organic matter and inorganic anions to some extent affected HEDP degradation, UV-driven trace Cu(II)/PMS system still exhibited satisfactory results in treating HEDP in actual wastewater. This study proposes a strategy for efficient phosphonate removal under varying pH conditions, which provides new insights for practical wastewater treatment applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Huabin Liao,Feina Gu,Ya Wen,Weichun Pan,Fuge Niu
Oral administration of polysaccharide-iron complexes (UCP-Fe(III)) is limited by their degradation in the gastric environment, which reduces bioavailability. We developed core–shell sodium alginate/chitosan hydrogel microsphere for pH-responsive UCP-Fe(III) delivery. High sodium alginate (SA) concentrations increased viscosity and storage modulus, enhancing mechanical stability. The encapsulation efficiency of UCP-Fe(III) reached 94.41% using 2.0% SA. Noncovalent interactions between UCP-Fe(III) and SA contributed to enhanced hardness and chewiness of the microspheres, while higher SA concentrations promoted a denser cross-linked network. The hydrogel microspheres showed low swelling in simulated gastric fluid (SGF, pH 2.0; swelling ratio: 467.33–588.50%) but rapid swelling in simulated intestinal fluid (SIF, pH 7.4; swelling ratio: 800–962.17%), indicating significant pH responsiveness. They effectively prevented premature release (only 12.14–23.48% in SGF after 2 h) while enabling sustained release (87.60–95.16% in SIF after 6 h). This study provides a new strategy for developing oral iron supplements with pH-responsive sustained-release properties.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jingjing Tian,Yuanke Zhang,Lvyao Yang,Lijuan Wang,Guixia Ling,Peng Zhang
Once the skin was damaged, it lost the ability to prevent harmful bacteria from infiltrating into the tissues, leading to wound infection and even serious tissue damage. Although conventional therapies were effective in eradicating pathogenic bacteria, they could not promote the healing of damaged skin, which was easily affected by tissue adhesion and lacked the ability to maintain a moist wound environment. In this study, according to the principle of green chemistry, Chlorella extracellular polysaccharide–selenium nanoparticles (EPS-SeNPs) with high biological activity, high stability, and low toxicity were synthesized for the first time, which could be used to kill wound pathogens and relieve inflammation. EPS-SeNPs were combined with a wound dressing hydrogel, and the hydrogel was cross-linked by a Schiff base reaction between the biocompatible oxidized sodium alginate (OSA) and gelatin (Gel) to promote wound healing. At the same time, the pH fluctuation of the wound could be monitored by adding the acid–base indicator litmus to it by the solvent replacement method, thus indirectly predicting the healing process of the wound. The results of in vitro experiments showed that the composite hydrogel had strong antibacterial and anti-inflammatory abilities, which could inhibit the growth and reproduction of common pathogens. The experimental results showed that the antibacterial rate of the composite hydrogel could reach 99%, the ability to clear ABTS free radicals was 93.13%, and the ability to clear DPPH free radicals was 82.36%. In the in vivo experiment, SD rats were used to construct an infected wound model, and then wound healing experiments were conducted. The experimental results showed that the composite hydrogel could significantly accelerate the wound healing process, promote new epidermis formation and hair follicle growth, and reduce inflammatory response. This work may open up a way for the clinical management of infected wounds and the simultaneous monitoring of wound healing.
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Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2016
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IF 0.963
Jianquan Tan,Weiqu Liu,Zhengfang Wang
Novel pH-sensitive amphiphilic comb-shaped copolymers containing long fluorinated side chains, which combined the characteristics of pH-sensitivity from pendent tertiary amine groups, unique hydrophobic and fluorophobic characteristic from the fluorinated moieties and hydrophilicity from the poly (ethylene glycol) segments, were designed and synthesized via radical polymerizaion of 2-(Dimethylamino) ethyl methacrylate (DMAEMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA) and homemade fluorinated macromonomer (PHFBMA-GMA). The physicochemical properties of polymeric micelles prepared therefrom were investigated. The chemical structures of the copolymers were characterized by GPC, FTIR and 1H-NMR. The critical micelle concentrations (CMC) of the copolymers in different pH (5.0 and 7.4) were determined by fluorescence spectroscopy. Larger CMCs could be obtained in lower pH since the pronation of DMAEMA moieties enhanced the hydrophilicity. With increasing the amount, as well as the molecular weight, of PHFBMA-GMA, CMC decreased significantly. As pH decreased, particle size, as well as zeta potential of the polymeric micelles increased significantly, indicating significant pH-sensitivity of the polymeric micelles. Furthermore, larger polymeric micelles were obtained with larger amount, as well as higher molecular weight, of PHFBMA-GMA. Transmission electron microscopy (TEM) showed that the morphological shapes of the copolymers performed spherical micelles. The cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity. The pH-sensitive polymeric micelles prepared from the amphiphilic comb-shaped copolymers containing long fluorinated side chains could be potential candidates for nanotanks for hydrophobic or fluorophobic molecules and drug carriers and the facile preparation might fit for large scale industrialization.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2011
·
IF 3.068
Xiujuan Huang,Yan Xiao,Meidong Lang
Comicellization of a star block copolymer poly( ε -caprolactone)- block -poly(diethylamino)ethyl methacrylate (S(PCL- b -PDEAEMA)) and a linear block copolymer methoxy poly(ethylene glycol)- block -poly( ε -caprolactone) (mPEG- b -PCL) was developed to enhance the stability and lower the cytotoxicity of the micelles. The two copolymers self-assembled into the mixed micelles with a common PCL core surrounded by a mixed PDEAEMA/mPEG shell in aqueous solution. This core–shell structure was transformed to the core–shell–corona structure at high pH due to the collapse of the PDEAEMA segment. The properties of the polymeric micelles were greatly dependent on the weight ratio of the two copolymers and the external pH. As increasing the mPEG- b -PCL content, the size and the zeta potential of the mixed micelles were lowered while the pH-dependent stability and the biocompatibility were improved. Moreover, an increase in pH accelerated the release of indomethacin (IND) from the mixed micelles in vitro . These results augured that the mixed micelles could be applied as a stable pH-sensitive release system.
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