JOURNAL OF CATALYSIS
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2026
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IF 6
Zeyu Wang,Huijuan Shao,Ai Zhang,Ying Zhang,Chen Luo,Tao Jiang,Yating Wang
Porous organic polymers (POPs) are promising heterogeneous catalyst supports. However, their application in ethylene tetramerization for high-value 1-octene (1-C 8 ) is limited by nonuniform metal coordination and poorly controlled pore-confined reactions. Here, one-step solvent thermal polymerization was carried out by vinyl functionalized full diphosphine (PNP) ligand to synthesize POPs derived from the PNP ligand and used as a support for chromium-based catalysts. The characterization confirms that the interaction between POPs, modified methylaluminoxane (MMAO) and Cr(III) chloride tetrahydrofuran complex promotes the formation of Cr(III) active sites, and the chemical coordination environment of the support determines the concentration of these Cr(III) species. The adjustable POPs framework can selectively produce linear alpha-olefins (C 4 , C 6 and C 8 ) with different carbon numbers. Notably, POP-2, which exhibited a larger pore size, lower steric hindrance and a higher density of Cr(III) active sites, showed exceptional catalytic performance in the ethylene tetramerization reaction under 1 MPa and 45℃ conditions, achieving 51.54% of C 8 selectivity (1-C 8 accounted for 97.6%), C 6 /C 8 total selectivity of 88.11%, and high catalytic activity of 8.08 × 10 5 g(mol·Cr) −1 h −1 . Whereas the high-steric-hindrance POP-3 system is predisposed to trimerization. The calculation of density functional theory (DFT) revealed that the tetramerization pathway is energetically preferred over the trimerization pathway in the POPs/Cr(III) system. These results further clarified that product carbon number distribution is dually governed by the Gibbs free energy barriers of trimerization/tetramerization and the steric hindrance of Cr(III) active centers. Collectively, these findings highlight the remarkable application potential of POPs as tunable matrices for engineering Cr(III) sites and fabricating high-selectivity ethylene oligomerization catalysts.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
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IF 4
Haixia Han,Juanjuan Gao,Quan Sun,Dandan Tong,Jian Liu,Xiuli Yang,Jingjing Sun,Yue Cui,Juan Wang,Zuoshan Feng,Mingxi Jia
BACKGROUND Acrylamide (ACR), an environmental neurotoxicant prevalent in thermally processed foods, contributes to brain injury via oxidative stress and neuroinflammation. The cumulative effects of long-term low-dose exposure are particularly alarming. As a traditional food ingredient, the inflorescence of Coreopsis tinctoria Nutt. is rich in polyphenolic compounds that exhibit significant anti-inflammatory and antioxidant properties. This study systematically evaluated the neuroprotective potential of Coreopsis tinctoria Nutt. polyphenols (CTNP) against chronic low-dose ACR exposure in mice. RESULTS Behavioral analyses demonstrated that CTNP (0.25–1.00 g kg −1 ) significantly ameliorated ACR-induced gait abnormalities and restored voluntary activity. CTNP mitigated neuronal misalignment and loss of synaptic density in the hippocampal CA1/CA3 regions and markedly reduced serum levels of brain injury markers MBP and GFAP by 30.6% and 41.7%, respectively. Mechanistic investigations revealed that CTNP attenuated oxidative damage via activation of the Nrf2/HO-1 pathway, leading to decreased brain reactive oxygen species and malondialdehyde levels while enhancing catalase, superoxide dismutase and glutathione peroxidase activities. Furthermore, CTNP suppressed MAPK pathway-mediated neuroinflammation, reducing pro-inflammatory factors such as COX-2, TNF- α and IL-1 β . CONCLUSION These findings demonstrate that CTNP, as diet-derived bioactives, mitigate ACR neurotoxicity through coordinated modulation of Nrf2/HO-1 antioxidant and MAPK anti-inflammatory pathways, supporting their potential as a functional food component for preventing environmental toxicant-associated neural damage. © 2026 Society of Chemical Industry.
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高影响因子
PHYTOMEDICINE
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2026
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IF 11.3
Chunge Zhang,Shuai Huang,Wenxin Zhang,Hongbo Teng,Yuna Shao,Yihua Zhang,Shihang Ren,Qi Wu,Yan Zhao,Zhaowei Yan
Background Acanthopanax sessiliflorus ( A. sessiliflorus ) extract has been used in various traditional Chinese medicines and compound preparations for the treatment of arrhythmia. Our preliminary studies have demonstrated that A. sessiliflorus extract exerts significant protective effects against arrhythmia induced by barium chloride. The present study aims to elucidate the bioactive components of A. sessiliflorus and to investigate the underlying mechanisms by which it mitigates barium chloride-induced arrhythmia. Methods Network pharmacology was employed to predict the pharmacological profiles of chemical constituents from A. sessiliflorus, followed by a systematic screening of their biological activities. Subsequently, a barium chloride-induced arrhythmia model was established, and the potential therapeutic mechanisms were analyzed using transcriptomics. Functional and histopathological analyses of the rat hearts were performed. Western blot was used to detect the expression levels of the Nrf2/HO-1 axis, connexins, ion channels, and autophagy-related proteins in myocardial tissue and NRVMs. Subsequently, PCR, immunofluorescence, co-immunoprecipitation, and molecular docking were employed to verify the involvement of the targets in the intervention of arrhythmia. Results The results showed that after treatment with divaroside, the arrhythmia and redox system imbalance induced by BaCl₂ in rats were significantly restored. Divaroside can inhibit calcium overload by regulating the expression levels of RyR2 and SERCA2a in the sarcoplasmic reticulum, serving as a means to alleviate arrhythmia. In addition, we have confirmed that autophagy plays a crucial role in arrhythmia, and divaroside can activate autophagy, thereby protecting cardiomyocytes from BaCl₂-induced damage. Finally, it was confirmed that divaroside can weaken the interaction between the Keap1-Nrf2 complex and promote the nuclear translocation of Nrf2, activating the Nrf2/HO-1 axis and regulating the aforementioned pathways to counteract arrhythmia. Conclusion This study suggests that divaroside prevents the occurrence of arrhythmia by activating autophagy and reducing abnormal calcium ion homeostasis through the Nrf2/HO-1 axis.
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PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Yue Hu,Tiancong Liu,Yahan Zhang,Mengmeng Ding,Guang Shi,Haiying Su,Jian Guan,Xinyu Fan
L-type amino acid transporter 1 (LAT1) is essential for the transport of large neutral amino acids (AA) across the blood–brain barrier (BBB), which plays a crucial role and is widely employed in brain drug delivery. Thus, in this study, tryptophan (Trp), leucine (Leu) and tyrosine (Tyr) were selected and various amino acid grafted chitosan (CTS) was first synthesized and characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) spectrum. Furthermore, oxytocin (OT) loaded polyelectrolyte complex (PEC) based on various amino acid grafted chitosan and chondroitin sulfate (CS) as well as OT loaded chitosan-chondroitin sulfate PEC was fabricated and optimized by particle size, zeta potential and encapsulation efficiency (EE%). The morphologies and OT conformation stability of different PEC formulations were investigated by transmission electron microscopy (TEM) and circular dichroism (CD) spectroscopy respectively. Moreover, to further reveal the superiority of amino acid grafted chitosan PECs on mucosal permeation and brain targeting via LAT1 transporter, the ex vivo permeation study, in vivo pharmacokinetics behavior as well as brain distribution of OT in different PECs were also carried out by intranasal administration. It was found that both chitosan-chondroitin sulfate and amino acid grafted chitosan-chondroitin sulfate PECs exhibited comparable particle size ranging from 180 to 210 nm with a positive charge. The PEC formulation presented a sustained release behavior compared to the OT solution and better nasal mucosal permeation was observed for amino acid grafted chitosan-chondroitin sulfate PECs. Both pharmacokinetics behavior and brain distribution results demonstrated that amino acid grafted chitsaon could significantly improve the OT absorption and brain accumulation in the order of Trp > Tyr > Leu, compared to naked chitosan-chondroitin sulfate PECs and OT solution. The behavioral and immunofluorescence results also revealed that amino acid grafted chitosan-chondroitin sulfate PECs exhibited a superior inhibitory effect on oxycodone (Oxy) addiction. In conclusion, amino acid grafted chitosan-chondroitin sulfate PECs could significantly promote brain drug transportation and could be a potential vehicle for protein or peptide delivery via nasal to brain pathway.
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高影响因子
ACS Applied Polymer Materials
·
2026
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IF 5.2
Kavya Adot Veetil,Senthil Kannan,Eun Kyu Sun,Md. Homayun Kabir,Ook Choi,Tae-Hyun Kim
Integrating nanomaterials with tunable surface functionalities into polymer matrices offers a promising route for developing high-performance mixed matrix membranes (MMMs). Among these, graphitic carbon nitride (g-C3N4) facilitates gas transport and enhances membrane permeability due to its intrinsic nanopores. However, while improving the CO2 permeability, pristine g-C3N4 often compromises the CO2/CH4 selectivity. To address this trade-off, iron-doped g-C3N4 (Fe-g-C3N4) was incorporated into a polymer of intrinsic microporosity (PIM-1), possessing a high free volume and excellent gas diffusion characteristics. Iron doping served to increase the CO2-philicity of g-C3N4 and strengthen its interaction with the CO2 molecules, thereby improving both permeability and selectivity. The resulting Fe-g-C3N4/PIM-1 MMMs demonstrated enhanced CO2 permeability and CO2/CH4 selectivity, indicating their potential for use in CO2 separation applications. Incorporating 0.5 wt % Fe-doped g-C3N4 into the PIM-1 matrix led to a 38.5% increase in CO2 permeability compared to pristine PIM-1 and a 12.7% improvement over the undoped g-C3N4-based MMM. While undoped g-C3N4 reduced the CO2/CH4 selectivity, Fe doping had the reverse effect, enhancing the selectivity by 7.2% relative to the undoped system. Notably, the Fe-g-C3N4/PIM-1 MMMs approach the 2008 Robeson upper bound for the CO2/CH4 separation. In addition, the membrane exhibited improved mechanical strength and antiaging and antiplasticization characteristics, collectively outperforming pristine PIM-1.
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高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2026
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IF 5.2
Lubin Xie,Chuhang Chi,Chengshuang Pan,Nianci Chen,Yunbing Tang,Shaowei Wang,Ren-shan Ge,Qianjin Fei
Halogenated disinfectants are widely used in medical, household, and industrial settings, but their inhibitory effects on 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1), a key enzyme catalyzing estrone-to-estradiol (E 2 ) conversion, remain unclear. We evaluated nine compounds for inhibition of human placental and rat ovarian 17β-HSD1 using enzymatic assays, kinetic analysis, BeWo cell E 2 production assays, 3D quantitative structure-activity relationship (3D-QSAR), molecular docking, molecular dynamics simulations (MDS), absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction, and network toxicology. Six compounds inhibited human 17β-HSD1, with half-maximal inhibitory concentration (IC 50 ) values of 0.78-14.90 μM; potency followed hexachlorophene > bithionol > bromochlorophene > fenticlor > dichlorophene > chlorophene. Rat 17β-HSD1 was inhibited by these six compounds and by triclosan, with IC 50 values of 6.13-54.77 μM. Kinetic analysis indicated mainly mixed/noncompetitive inhibition. In BeWo cells, fenticlor decreased E 2 production at ≥ 1 μM, dichlorophene at 10 and 20 μM, and bromochlorophene and hexachlorophene at 20 μM, whereas chlorophene and bithionol were inactive up to 20 μM. The 3D-QSAR model and descriptor analysis suggested associations of inhibition with hydrophobicity, aromatic features, molecular size and halogenation. Docking and 100-ns MDS supported stable binding of active compounds near the nicotinamide adenine dinucleotide phosphate (NADPH)-binding region, particularly for hexachlorophene. Network toxicology placed HSD17B1, which encodes 17β-HSD1, within preeclampsia-related estrogen and steroidogenic pathways. These findings indicate that halogenated disinfectants may disrupt estrogen homeostasis through direct 17β-HSD1 inhibition and warrant further evaluation for reproductive and placental endocrine toxicity.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Jiaozhong Cai,Jiacheng Li,Jiushuai Deng,Bozeng Wu,Ni Xiao,Junnan Chen,Wei Weng,Xiaopeng Chi,Wen Tan,Guangsheng Zeng,Shuiping Zhong
Selective depression of chalcopyrite while preserving molybdenite floatability remains challenging. Conventional sulfur-containing depressants may oxidize readily, require high dosages, or depend on strong alkalinity, prompting the development of new selective reagents. Sodium 3-mercapto-1-propanesulfonate (MPS), containing thiol and sulfonate groups, was introduced as a selective chalcopyrite depressant. At pH 7 and 1.5 × 10 −5 mol L −1 MPS, the maximum recovery difference in single-mineral flotation reached 87.6 percentage points. In artificial mixed-mineral flotation, Cu recovery decreased to 7.28%, whereas Mo recovery remained at 91.16%, increasing the separation index from 1.28 to 11.49. Contact angle, SEM–EDS, and FTIR analyses indicated preferential retention of MPS-related species on chalcopyrite, together with interaction between thiol S and surface Cu sites and enhanced surface hydrophilicity associated with the sulfonate group. Under the electrochemical test conditions, MPS attenuated the anodic response and reduced the corrosion current density of chalcopyrite by approximately 40%, with little effect on molybdenite. DFT calculations further identified the Cu site on chalcopyrite (112) as more favorable for MPS adsorption than the Fe site (−100.96 versus −86.02 kJ mol −1 ), whereas the modelled adsorption configuration on molybdenite (001) was energetically unfavorable (+47.61 kJ mol −1 ). This study elucidates a selective depression mechanism involving preferential adsorption, increased surface hydrophilicity, and altered chalcopyrite redox behavior, while demonstrating the potential of MPS for near-neutral Cu Mo flotation separation. Download: Download high-res image (142KB) Download: Download full-size image
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 6
·384
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IF 5.4
Xu Ziyu,Cao Jinru,Wang Ying,Chen Tingsha,Wang Yue,Xu Huaqiu,Zeng Huihui,Huang Wenyi,Cheng Hao,Kong Hongxing,Lu Yao,Feng Jun
Human carboxylesterase 1 (hCE1) is a serine hydrolase that is distributed widely in the human liver, intestines, and various tumour tissues. It has now become a biomarker associated with diseases such as cancer. Consequently, the measurement of hCE1 levels in human serum is of significant importance for the diagnosis and assessment of these diseases. The present study involved the preparation of Ag/CQDs/ZIF-8 nanocomposites, which incorporated silver nanoparticles (Ag NPs) and carbon quantum dots (CQDs) into the ZIF-8 framework. The combination of this composite with an enzyme-linked immunosorbent assay (ELISA) and the utilisation of benzidine as the signal molecule resulted in the development of a fluorescence (FL)/surface-enhanced Raman scattering (SERS) dual-mode sensor, which was employed for the sensitive detection of hCE1 in serum. This dual-mode sensor combines the advantages of both FL and SERS technologies, demonstrating excellent selectivity and stability, and enhancing the accuracy and reliability of quantitative measurements. The limits of detection (LOD) for the FL mode and SERS mode were determined to be 0.1 and 0.072 ng·mL − 1 , respectively, with the recoveries ranging from 92.44% to 117.47%. The satisfactory outcomes obtained from testing on real sample confirm the sensor’s excellent suitability for use in complex biological matrices. Consequently, this dual-mode sensor shows considerable promise for the detection of biomolecules in clinical samples, thereby demonstrating significant potential for clinical applications. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
CELL PROLIFERATION
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2026
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IF 7.6
Zhaosong Meng,Jiacheng Liu,Yue Zhang,Ruimeng Yang,Jingyi Zhang,Haosun Yang,Zheng Wang,Ran Wei,Zhe Li,Shuling Guo,Lizhi Hu,Lei Sui
Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell-based therapy has emerged as a promising strategy to promote bone regeneration. N-acetylcysteine (NAC), a potent antioxidant, has been shown to modulate the PI3K-AKT signalling pathway and potentially enhance osteogenesis; however, the specific downstream effectors mediating this process remain unidentified. In this study, post-extraction serum metabolomic profiling revealed that alveolar bone injury is accompanied by systemic oxidative stress and metabolic remodelling. Transcriptomic analysis of antioxidant-treated dental stem cells further identified type VI collagen A1 (COL6A1) as a key functional mediator. We subsequently investigated the role of COL6A1 in antioxidant-mediated osteogenesis through immunofluorescence and protein assays, and performed knockdown and in vivo experiments to evaluate its function in oxidative stress regulation and osteogenic differentiation. Our results demonstrated that alveolar bone injury is associated with systemic oxidative stress and global metabolic alterations. In vitro, NAC markedly promoted the osteogenic differentiation of dental follicle stem cells (DFSCs) by activating the PI3K-AKT pathway and upregulating COL6A1. COL6A1 knockdown resulted in elevated reactive oxygen species (ROS) levels, impaired mitochondrial function, and attenuated NAC-mediated osteogenesis. In vivo, NAC-treated DFSCs exhibited enhanced bone healing and extracellular matrix (ECM) deposition in a rat model of alveolar bone injury, effects that were mediated through COL6A1 upregulation. Collectively, these findings demonstrate that NAC enhances osteogenesis in DFSCs via the PI3K-AKT-COL6A1 axis, offering a promising antioxidant-based strategy for stem cell therapies in bone regeneration. Moreover, COL6A1 is essential for maintaining redox homeostasis and represents a potential therapeutic target for improving regenerative outcomes.
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高影响因子
NEUROCHEMISTRY INTERNATIONAL
·
2026
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IF 5.5
Zhipeng Lu,Yang Long,Xiang Li,Le Zhang,Jie Bai
The clinical utility of morphine is limited by the development of tolerance and addiction. These processes are linked to neuroinflammation involved microglial responses. Thioredoxin-1 (Trx-1) is a crucial endogenous antioxidant with neuroprotective properties, and our previous work has shown that Trx-1 overexpression blocks morphine-induced conditioned place preference (CPP). However, the role of Trx-1 in morphine-induced microglial inflammatory responses remains unclear. Here, we investigated the effects and underlying mechanisms of Trx-1 overexpression on morphine-induced microglial pro-inflammatory shifts, both in the microglial cell line BV-2 and in the ventral tegmental area (VTA) of mice. In vitro, morphine treatment increased intracellular reactive oxygen species (ROS) in BV-2 cells, upregulated markers associated with microglial reactivity (IBA-1 and MHC-II), activated the NF-κB pathway (evidenced by increased p -IκBα and nuclear p65 translocation), and elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) while reducing the anti-inflammatory cytokine IL-10. Overexpression of Trx-1 via adenoviral transduction reversed all these morphine-induced effects. In vivo, using a CPP paradigm, we confirmed that morphine CPP was blocked in Trx-1 transgenic (TG) mice. Biochemical analysis of the VTA from these mice revealed that Trx-1 overexpression similarly attenuated morphine-induced upregulation of IBA-1, MHC-II, and pro-inflammatory cytokines, consistent with in vitro results. Mechanistically, co-immunoprecipitation assays demonstrated an endogenous interaction between Trx-1 and the mu-opioid receptor (MOR). Overexpression of Trx-1 significantly enhanced this interaction and was associated with increased MOR expression. These results reveal that overexpression of Trx-1 suppresses morphine-induced neuroinflammation by binding MOR and reducing ROS-driven NF-κB activation in microglia. This mechanism positions Trx-1 as a potential therapeutic target for improving the clinical safety and efficacy of opioid addiction.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Ronggang Jiang,Hongyu Chen,Jian Ouyang,Hao Xu,Kuofei Wang,Xingchang Ou,Yun Peng,Jinhua Chen,Zhonghua Liu,Jianan Huang
Baojing Huangjincha 1 green tea (HJC) is characterized by a fresh floral aroma with a distinctive milky note, setting it apart from both conventional and other novel green tea varieties. However, the key odorants contributing to this unique profile have not yet been fully identified. In this study, 109 common volatile compounds were detected from 22 HJC samples using comprehensive two-dimensional gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC × GC-QTOFMS). Headspace solid-phase microextraction combined with gas chromatography-olfactometry (HS-SPME-GC-O) and aroma extract dilution analysis (AEDA) were employed to identify 28 aroma-active compounds (FD ≥ 8), 18 (OAV ≥ 1) of which were quantified in the tea infusion. The accuracy of these results was validated by an aroma recombination model that closely replicated the original aromatic profile of HJC. Omission and addition experiments further revealed six critical odorants as pivotal contributors to the overall aroma, including geraniol, linalool, heptanal, 2-methylbutyraldehyde, hexanal, and phenylethyl alcohol. Moreover, molecular docking analysis indicated that phenethyl alcohol, linalool, and geraniol form stable conformations with olfactory receptors OR1A1 and OR5M3, facilitated by van der Waals forces, hydrogen bonds, and hydrophobic interactions. These findings provide a foundational theoretical framework for optimizing green tea processing techniques and enhancing quality control standards.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·321
·
IF 5.4
Liu Shicong,Zhang Yuanyuan,Zhao Hongyang,Liu Junqiu,Hou Chunxi
A “turn-on” fluorescence sensor was developed for cholesterol detection on the basis of fluorescence resonance energy transfer (FRET) between the organic fluorophore 1-(4-(1,2,2-triphenylvinyl)phenyl)pyrene (TPE-Py) and a gold nanoparticle-β-cyclodextrin conjugate (AuNPs-β-CD). Mechanistically, the AuNPs-β-CD, an energy acceptor, was synthesized via Au–S bonding, and TPE-Py transferred energy to the AuNPs via FRET, resulting in fluorescence quenching of TPE-Py. In the presence of cholesterol, which has a stronger binding affinity for the β-CD cavity, TPE-Py was competitively displaced, enabling the recovery of the fluorescence signal. This sensor has high sensitivity for cholesterol, with a low detection limit of 66 nM and a linear range of 0.5–30 µM. Furthermore, the sensor was successfully used to determine the cholesterol content in food samples with satisfactory recoveries, revealing its potential for food analysis.
Section
Graphical abstract
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高影响因子
危险品化学品经营许可证（带存储）