MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·596
·
IF 5.4
Wang Wenzhuo,Lu Juan,Jiang Hanyue,Han Pengfei,Ma Guangping,Li Ruixin,Mao Huiyuan,Ma Tengying,Wang Jing,Chen Ruizhan,Tian Li
A dual-mode sensing platform has been developed for ultrasensitive malathion (MAT) detection based on bifunctional rGO@ZnO/Zn-Fe 3 O 4 composites (reduced graphene oxide-supported ZnO nanorods and Zn-doped Fe 3 O 4 microspheres). The rGO@ZnO/Zn-Fe 3 O 4 nanozyme is fabricated via a one-pot hydrothermal strategy and integrates favorable electrochemiluminescence (ECL) emission and intrinsic peroxidase-mimicking activity to realize dual-signal readout. In the K 2 S 2 O 8 ECL system, Au NPs@UiO-66 serves as a coreactant booster to further magnify the ECL intensity of the composite. Meanwhile, the nanozyme catalyzes the H 2 O 2 -mediated oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to produce a colorimetric response. MAT suppresses both ECL and colorimetric responses by occupying Fe 2+ /Fe 3+ catalytic sites and scavenging of reactive radicals. The sensor achieves limits of detection as low as 2.8 × 10 –13 mol/L under ECL mode and 1.32 × 10 –6 mol/L under colorimetric mode. In practical testing of MAT-spiked vegetable samples, the sensor exhibits acceptable recoveries and low relative standard deviations, demonstrating its practicability for field food safety supervision and rapid pesticide residue screening. Graphical abstract
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Zhaoyan Ge,Fengni Liu,Ziwei Chen,Hao Liu,Jiang Yuan
A coating was constructed via LBL self-assembly to improve hemocompatibility. • The coating had an adjusted KSNO payload capacity, achieving a tunable NO release. • The coated film promoted the ECs, while suppressing the over-proliferation of SMCs. • The coated film showed antibacterial, antioxidant, and anti-inflammatory activities. • Biomacromolecular donor of NO was used as a monolayer for LBL for the first time. Nitric oxide (NO) releasing coating is promising for implantable medical devices due to the role of NO in the vascular system. In the study, a multilayered NO-releasing coating was constructed via layer-by-layer (LBL) self-assembly to improve the hemocompatibility of poly(ethylene terephthalate)(PET). A keratin-based NO donor (KSNO) was synthesized and used as a negatively-charged monolayer. Polyethyleneimine (PEI) acted as a positively-charged monolayer. The LBL coating has an adjusted KSNO payload capacity, achieving a tunable NO release in the presence of ascorbic acid (Asc). The coated PET film (n = 5) selectively promoted the proliferation of endothelial cells, while suppressing the excessive proliferation of smooth muscle cells. Furthermore, the coated film demonstrated excellent biocompatibility, along with antibacterial, antioxidant, and anti-inflammatory activities. To the best of our knowledge, it is the first time that a biomacromolecular donor of NO has been used as a monolayer for LBL self-assembly.
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Food Bioscience
·
2026
·
IF 6.2
Wenhui Fu,Xuemeng Ji,Dongze Qin,Lingda Zhao,Huan Lv,Yaozhong Hu,Ruican Wang,Wentao Gu,Dongfei Tan,Shuo Wang
Chemotherapy-induced intestinal mucositis is a common and clinically important adverse effect. However, its underlying mechanisms remain poorly understood and effective interventions are limited. This study investigated the protective effects of a cell-free L. rhamnosus -fermented cereal fraction against 5-fluorouracil (5-FU) induced CIIM in a murine model. L. rhamnosus fermentation markedly enhanced the functional value of the cereal matrix by enriching soluble fermentation-derived bioactives, including TCA-soluble peptide content, total phenolic and flavonoid content, and lactic acid. Prophylactic administration of the fermented cereal fraction attenuated 5-FU-induced mucosal injury, enhanced intestinal antioxidant capacity, improved mucosal architecture and barrier-related indices, and suppressed epithelial apoptosis. Exploratory quantitative proteomic analysis identified candidate proteins whose abundance was altered following 5-FU treatment, including proteins associated with antioxidant defense, apoptosis, cytoskeletal organization, and epithelial barrier-related processes. In contrast, fermented cereal intervention restored the expression of key endogenous antioxidant and barrier-associated proteins. Notably, the final pH-matched lactic acid control indicated that low final pH and the direct presence of lactic acid were insufficient to account for the protective effects of the fermented cereal fraction, suggesting that multiple fermentation derived components contributed to the observed bioactivity. Collectively, these findings indicate that L. rhamnosus -fermented cereal mitigates CIIM through fermentation-enhanced exogenous antioxidant delivery, support of endogenous antioxidant defenses, and attenuation of mucosal and barrier-related alterations. This study supports the potential of cereal fermentation-derived bioactives as functional dietary ingredients for managing CIIM.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Bei Zhang,Xin-Xin Chen,Xin-Ping Wang,Xiao-Rui Ge,Jia-Ying Chen,Si-Min Zheng,Guan-Hui Liu,Jie Tu,Dong-Yang Zhang,Xiao-Hui Yao,Wei-Guo Zhao
BC synergistic anti-dialysis strategy was used to prepare anti-swelling hydrogels. • The BP-RD hydrogel exhibits high water content and excellent mechanical properties. • The dense network structure endows the potential for underwater applications. • This method can be used to prepare biomimetic double-layer hydrogels. Hydrogels, a typical solid–liquid hybrid material, have shown great potential in wearable electronics, tissue engineering, and other fields; however, their underwater applications have long been limited by the ‘swelling–weakening ‘effect. To address this challenge, this study proposes a ‘bacterial cellulose (BC) synergistic reverse -dialysis-induced confined dense network ‘strategy to construct a BP-RD hydrogel with high water content and excellent mechanical–functional properties through a one-step approach. The design innovatively uses the reverse dialysis process to drive dual dynamic assembly. First, polyethylene glycol-mediated water extraction compresses the BC network to form a rigid confined space. Then, polyvinyl alcohol molecules move and crystallize in the BC framework, creating a dense interpenetrating network. At 75% moisture content, the material achieved 22 MPa fracture strength, 145 MJ m −3 toughness, and 1.58 S m −1 conductivity owing to the confinement effect. Additionally, it showed outstanding antiswelling characteristics (the tensile strength increased by 14% after 7 days). This method can also be applied to combine existing hydrogels in one step, creating a double-layer hydrogel structure with improved mechanical properties and swelling performance. This approach solves the key problems of the failure of traditional hydrogels to expand, the cumbersome preparation process, and the difficulty in meeting the performance requirements of multiple scenarios.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Hu Ruiling,Zhang Yujie,Gao Chengzhi,Wei Hang,Hong Xianjian,Wei Xiaodan,Qiang Tinghui,Guo Zhongshang,Huang Li,Lei Xiaoyun,Zhao Caibin,Ji Xiaohui,Han Hao,Guo Shaobo
The treatment of wounds caused by drug-resistant bacteria is a significant challenge in clinical medicine. Silver (Ag) nanoparticles have attracted considerable attention due to their ability to inhibit drug-resistant bacteria. Nevertheless, the propensity of Ag nanoparticles to aggregate as well as their elevated toxicity have restricted their practical application. To address this issue, this study involved the design of a core–shell-type ZnO@ZIF-8/Ag nanocomposite material that combines high antibacterial activity with excellent biocompatibility. The mean diameter of the Ag nanoparticles in this material was approximately 2.4 nm, and they were highly dispersed. Within the wound microenvironment, antibacterial factors, such as hydroxyl radicals ( · OH), singlet oxygen ( 1 O 2 ), Zn 2+ , and Ag + , were generated. The material induced bacterial death by altering the structure of the cell wall of drug-resistant bacteria, thereby inhibiting respiration, lysing phospholipid layers, and causing cellular content leakage. The introduction of zinc oxide (ZnO) significantly reduced the toxicity of the Ag nanoparticles and regulated macrophage polarization, which inhibited the secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by M1-type macrophages (M1) while concomitantly promoting the secretion of interleukin-10 (IL-10) and vascular endothelial growth factor by M2-type macrophages (M2). The expression of platelet-endothelial cell adhesion molecule-1 (CD31), type I collagen/fibronectin (COL-I/FN), and proliferating cell nuclear antigen (PCNA) was significantly promoted, which significantly enhanced wound healing in infected wounds. This study thus offers a strategy for developing therapies against drug-resistant bacterial infections with the potential for clinical application.
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JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Ye Shenyi,Cai Jingrui,Ding Ruyu,Zhu Hang,Xiao Jiecheng,Liu Tianhui,Zhao Chengfei
In this study, nitrogen-doped carbon quantum dots (N-CQDs) are synthesized from citric acid and tetraethylenepentamine via a one-step melting method. Leveraging the fluorescence quenching of N-CQDs by Fe 3+ through a combined static quenching and inner filter effect mechanism, an “on–off–on” fluorescent sensing platform was constructed for the detection of captopril (CAP). The method relies on the competitive chelation of Fe 3+ by the thiol and carboxyl groups of CAP, which displaces the metal ions from the N-CQD surface and restores the quenched fluorescence. Under optimized conditions, the sensor exhibited a detection limit of 0.0620 mmol/L and a linear response spanning 0.1–1 mmol/L. The method was successfully applied to the determination of CAP in commercial tablet formulations, with recoveries meeting the acceptance criteria of the Chinese Pharmacopoeia (2020 Edition). The proposed approach offers a simple, rapid, and sensitive strategy for the quantitative analysis of CAP in pharmaceutical products.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
·
IF 6.7
Shuhao Sun,Beibei Cai,Rui Tian,Junjie Xu,Dongying Wang,Lei Zhang,Fei He
Visible-light-driven photocatalysis offers a sustainable strategy to eliminate indoor volatile organic compounds (VOCs) like acetaldehyde (AA), thereby improving indoor air quality. Although heterojunctions based on MoS 2 quantum dots (MQDs) attract attention for oxidation reactions, MQDs/WO 3 composites for VOC removal remain largely underexplored. In this study, MQDs/WO 3 heterojunctions were constructed by coupling MQDs with monoclinic (m-WO 3 ) and hexagonal (h-WO 3 ) phases to systematically investigate phase-dependent charge transfer, reactive oxygen species (ROS) generation, and AA degradation pathways. Comprehensive characterizations indicated that MQDs incorporation increased oxygen vacancies, promoted ROS generation, and enhanced visible-light absorption. Furthermore, PL and in situ DRIFTS analyses revealed that MQDs/m-WO 3 exhibited superior electron-hole separation and stronger surface reactivity than the h-WO 3 system. DFT calculations confirmed MQDs as the primary adsorption sites for indoor VOCs, with MQDs/m-WO 3 exhibiting stronger AA adsorption. Consequently, the optimized 0.5MQDs/m-WO 3 demonstrated enhanced AA degradation and mineralization under visible light, exhibiting excellent stability under indoor-relevant operating conditions. This work provides profound insights into interface-regulated charge transfer and offers a promising material design strategy for advanced indoor air purification.
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ACS Nano
·
2026
·
IF 17.3
Guanmeng Zhang,Ludan Zhang,Zuhao Shi,Zihan Wang,Ji Shen,Daping He,Dingsheng Wang,Yuguang Wang
Oral squamous cell carcinoma (OSCC) lacks effective low-toxicity treatments. Chemodynamic therapy (CDT) offers a tumor-specific approach by converting hydrogen peroxide into toxic radicals. However, its efficacy is limited by insufficient H2O2, high glutathione (GSH) levels that neutralize the radicals, and reliance on a single cell death pathway. Herein, we report a precisely programmable catalytic platform consisting of Ru single atoms anchored on a CuTi layered double hydroxide (Ru CuTi-LDH) nanozyme. The Ru sites not endow the nanozyme with superoxide dismutase (SOD)-like activity and enable precise control over its catalytic functions, which also include peroxidase (POD), catalase (CAT), and glutathione peroxidase (GPx). Together, these features orchestrate a precise cascade reaction to amplify therapeutic efficacy for OSCC. Light-triggered superoxide radicals (•O2–) are converted to H2O2 by Ru sites, fueling Fenton-like reactions at Cu centers that generate cytotoxic hydroxyl radicals (•OH). Meanwhile, Ru CuTi-LDH depletes GSH and generates O2 to alleviate tumor hypoxia. This chemical reprogramming amplifies oxidative damage and sensitizes tumor cells to cuproptosis. Additionally, endoplasmic reticulum (ER) stress triggered by the cascade activates paraptosis, establishing three distinct cell death pathways simultaneously. This approach achieved 84.7% tumor inhibition and prolonged survival in an orthotopic OSCC model. This work presents a chemical strategy that addresses fundamental CDT limitations through cascade catalysis with atomic-level tunability.
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PubMed
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Dayang Wang,Pengbao Shi,Jiashuo Ye,Ziyan Wang,Hailin Cong,Bing Yu
Melanoma is one of the most lethal cancers in the clinic; cationic peptides have shown great potential in the treatment of melanoma. The large pore volume and high specific surface area of mesoporous silica nanoparticles (MSNs) allow for efficient loading of drugs, while surface-functionalized MSNs can further improve drug stability and carrier targeting. Polydopamine (PDA) coating is an effective surface modification method that provides an additional protective layer to prevent premature drug release during delivery and can prolong the treatment time. Hyaluronic acid (HA) is a commonly used tumor-targeting molecule that binds to HA receptors on the surface of tumor cells, thereby facilitating drug internalization and enhancing the therapeutic effect of the drug. In this paper, the cationic short peptide RKIIIRW, which can effectively inhibit B16F10 cells, was successfully screened by solid-phase synthesis combined with MTT assay and cell membrane chromatography. By combining the cationic short peptide RKIIIRW with MSNs and further surface modification with PDA coating and HA targeting molecules, a nanodrug delivery system with targeted and controllable release characteristics was prepared. This drug-delivery system enhances the efficacy of cationic short peptides while minimizing side effects, offering a more effective therapeutic strategy for melanoma.
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International Journal of Nanomedicine
·
2026
·
IF 8.7
Tianding Shen,Xiaowei Xu,Zhenhe Guo,Wangmei Zhou,Xiuyun Xiao,Shunxin Liao,Jiejun Huang,Xiaoyan Liu,Zhexiang Fan
Introduction Chronic diabetic wounds suffer from persistent oxidative stress, unresolved inflammation, and impaired neovascularization, with limited effective therapies.Methods We developed a biomimetic nanocomposite (PEG-HS/TiO2) combining antioxidant TiO2 with sustained-release honeysuckle. In vitro, we evaluated ROS scavenging, cellular senescence, VEGF expression, and macrophage polarization. In vivo, we assessed wound closure, neovascularization, collagen remodeling, and inflammatory markers in a diabetic mouse model.Results PEG-HS/TiO2 achieved sustained HS release over 72 hours. It scavenged superoxide and H2O2, reduced endothelial ROS by approximately 89%, suppressed senescence markers, and restored VEGF expression (>7-fold increase vs. H2O2 control). The nanocomposite shifted macrophages from M1 to M2 phenotype, increasing the CD206/CD86 ratio. In vivo, PEG-HS/TiO2 accelerated wound closure (76% wound area reduction by day 7 vs. 18% in Sham), enhanced CD31+ vessels (6.3-fold vs. Sham), improved collagen organization, reduced M1 macrophages by 85% and IL-1β by 73%, increased IL-10 by 3.1-fold, and lowered systemic CRP and PCT.Discussion PEG-HS/TiO2 breaks the diabetic wound pathology cycle through ROS neutralization, anti-senescence, and macrophage immunometabolic reprogramming, representing a promising strategy for diabetic wound management.
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MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Wei Mingli,Chu Chenxiao,Ding Huaiwei,Zhao Jiansong,Ji Muse,Liang Xinxin,Bi Xiaoshuang,Zhao Jiaqi,Gou Jingxin,Yin Tian,He Haibing,Tang Xing,Zhang Yan,Zhang Yu
Cabazitaxel (CTX) exhibits potent antineoplastic activity
and is
demonstrated to promote antitumor immunity by triggering immunogenic
cell death (ICD). This is commonly used in the clinical treatment
of advanced and metastatic triple-negative breast cancer (TNBC). However,
the therapeutic index of commercial CTX injections is severely restricted
by their definite systemic toxicity and low tolerability. Herein,
we developed biomimetic low-density lipoprotein nanoparticles (CTX 2 TK&VP@LDL NPs) by integrating ROS-responsive CTX dimeric
prodrugs (CTX 2 TK) and the photosensitizer verteporfin (VP)
into LDL NPs to selectively target tumors and achieve synergistic
chemophotodynamic therapy and immunotherapy for TNBC with improved
biosafety. CTX 2 TK&VP@LDL NPs were able to enhance the
accumulation and cellular uptake in 4T1 tumors overexpressing LDL
receptor, improving the targeted codelivery efficiency. When CTX 2 TK&VP@LDL NPs were deposited at the tumor sites, localized 1 O 2 was generated upon irradiation for triggering
ultrafast CTX release with low premature CTX leakage in the off-target
tissue. Additionally, the generated 1 O 2 can
further synergistically reinforce ICD and elicit robust antitumor
immune activation. The combination treatment with CTX 2 TK&VP@LDL
NPs and PD-L1 blockade notably inhibited abscopal tumor growth and
lung metastasis. Taken together, the biomimetic CTX 2 TK&VP@LDL
NPs exploit endogenous LDL functionality to enable receptor-mediated
tumor targeting and synergistic chemophotodynamic immune activation,
providing an effective and safe therapeutic strategy for TNBC.
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ACS Biomaterials Science & Engineering
·
2026
·
IF 6
Tan Guohongfang,Chen Jialuo,Xing Teiling,Kundu Subhas C.,Lu Shenzhou
Minimally invasive microneedle devices have emerged as highly promising platforms for localized interstitial fluid (ISF) sensing and biomarker detection. In this study, we present a bilayer silk fibroin microneedle system that leverages material structure regulation to achieve optimal mechanical strength, controlled swelling, and limited dissolution. Our dual-layer architecture spatially separates skin penetration and local interstitial-fluid access from the sensing region, improving reagent retention and enabling clear, localized colorimetric readouts. Furthermore, the incorporation of 2-hydroxypropyl-β-cyclodextrin stabilizes chromogenic substrates within the hydrophilic silk matrix, delivering robust responses both in vitro and in vivo. The optimized microneedles exhibit uniform morphology and sufficient compressive strength for reliable transdermal insertion, successfully producing visually distinguishable outputs in animal models. Ultimately, this material-guided, device-integrated platform highlights the tremendous potential of combining biomaterial engineering with microscale design for next-generation minimally invasive biosensors.
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危险品化学品经营许可证（带存储）