ACS Nano
·
2024
·
IF 15.8
Peilei Wang,Jingwen Wu,Xiaolin Xiao,Yujiang Fan,Xianglong Han,Yong Sun
The application of enzyme-like molybdenum disulfide (MoS2) in tissue repair was confronted with stable dispersion, solubilization, and biotoxicity. Here, the injectable self-healing hydrogel was successfully designed using a step-by-step coassembly of chitosan and MoS2. Polyphenolic chitosan as a “structural stabilizer” of MoS2 nanosheets reconstructed well-dispersed MoS2@CSH nanosheets, which improved the biocompatibility of traditional MoS2, and strengthened its photothermal conversion and enzyme-like activities, guaranteeing highly efficient radical scavenging and antimicrobial properties. Furthermore, the polyphenol chitosan was employed again as a “molecular cross-linking agent” to form the injectable NIR-responsive MoS2@CSH hydrogel by accelerating hydrogen-bond interaction among chitosan and the multicross-linking reaction among polyphenols. The rapid self-healing ability was conducive to wound closure and dynamic adaptability. An experimental study on infected wound healing demonstrated that MoS2@CSH hydrogel could substantially eradicate bacteria and accelerate the angiogenesis of infected wounds. The photothermal-driven coassembly of MoS2 and polycation provided an alternative strategy for infected wound healing.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Lirong Liao,Zhijun Ke,Shuchun Li,Sijie Wang,Xinyang Wang,Xiaoping Rao
This study focuses on enhancing the antibacterial and self-cleaning properties of bio-based food packaging films. We developed a zwitterionic rosin sulfonated betaine (MPA-BN + SO 3 − ) and co-grafted it with rosin quaternary ammonium salt onto chitosan, which was then combined with gelatin to create the films. Characterization was done using FTIR and 1 H NMR. The films exhibited a minimum inhibitory concentration (MIC) of 200 μg/mL for Staphylococcus aureus and 400 μg/mL for Escherichia coli , with a 19 mm antibacterial zone for 30% CS-B-S in Staphylococcus aureus . The modification improved water solubility, tensile strength (10.22 MPa, a 20% increase), elongation at break (87%), and antioxidant properties (48.2%). Preservation tests on fresh fruits and biological safety assessments through cytotoxicity tests and a 30-day gastric lavage experiment in mice confirmed the effectiveness and safety of films. Outdoor degradation tests showed strong biodegradability and minimal environmental impact. These results suggest that the CS-B-S/gelatin film is a promising food packaging material with excellent antibacterial, antifouling, and biodegradable properties.
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Food Biophysics
·
2024
·
IF 2.8
Weng Shuni,Su Huanhuan,McClements David Julian,Wang Yuting,Li Teng,Fu Yuying
Curcumin (CUR) is found to exhibit a broad spectrum of potentially beneficial biological activities, which make it suitable as a nutraceutical ingredient in functional foods and supplements. But its application for this purpose is often limited by its low water-solubility, chemical stability, and bioavailability. In this study, acid-treated soybean protein isolate (SPI) and chitosan quaternary ammonium salt (CQAS) were used to assemble colloidal carriers for CUR to form soybean protein isolate-curcumin-chitosan quaternary ammonium salt nanoparticles (SPI-CUR-CQAS NPs). The nanoparticles formed were relatively small (< 400 nm), approximately spherical, and strongly positively charged (> 45 mV). Fluorescence spectroscopy demonstrated that the dominant interaction between CUR and SPI was hydrophobic attraction, while the dominant interaction between CQAS and SPI was electrostatic attraction. The encapsulation efficiency (95.4%) and loading capacity (14%) of the SPI-CUR-CQAS NPs (pH 1.5) were relatively high. The vitro digestion experiments showed that the CUR was progressively released from the nanoparticles under stomach, small intestine, and colon conditions. Moreover, the final bioavailability of the encapsulated CUR (63%) was much higher than for free CUR (18.5%). The SPI-CQAS NPs developed in this study can therefore be used as an effective delivery system for CUR in functional foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yuxin Li,Ziqi Hua,Yangjing Li,Tao Chen,Abdulhakeem S. Alamri,Yu Xu,Wei Gong,Yiyang Hou,Majid Alhomrani,Jiangning Hu
Incorporating polysaccharide-based composite films with nanobiotechnology offers a new strategy for food preservation. This study initially focuses on the preparation of tea polyphenol nanoparticles (TPNP), novel and derived from natural antibacterial agents, which serve to improve stability. Afterwards chitosan-based composite films loaded with TPNP (CTN film) were developed using solution casting method. The incorporation of TPNP significantly improved the UV/water/oxygen barrier properties, mechanical properties and thermal stability, alongside notable physical properties including water contact angle (93.65 ± 0.04°), low water vapor permeability (33.72 ± 3.32 g/m 2 h) and oxygen permeability (0.11 ± 0.02 g/m 2 h), tensile strength (61.83 ± 0.70 %), and elongation at break (31.60 ± 6.12 %). The CTN film not only exhibited exceptional biodegradability and nontoxicity, but also demonstrated remarkable antimicrobial efficacy against Escherichia coli and Bacillus subtilis . Additionally, it showcased potent antioxidant activity, boasting DPPH and ABTS radical scavenging rates up to 89.25 ± 0.18 % and 93.84 ± 0.42 %. The CTN film was successfully formed on the surface of strawberries through dip-coating process and their shelf life was extended from 4 to 6 days at 20 °C without side-effect on the weight loss, harness, pH and total soluble solids, illustrating its potential for enhancing food preservation.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Wenting Gao,Bin Mu,Fangfang Yang,Yalong Li,Aiqin Wang
Multifunctional biodegradable packaging films with antibacterial and antioxidant properties are highly desirable for food preservation. In this study, multifunctional bioactive chitosan-based composite films were fabricated for loquat preservation after incorporation of licorice flavonoids/ZnO/attapulgite (LF/ZnO/APT) nanocomposites, which were prepared by anchoring ZnO nanoparticles on the surface of attapulgite followed by mechanochemical-assisted loading of licorice flavonoids. The structure and physicochemical properties of composite films were characterized using Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray powder diffraction, etc., while the effects of the added amount of LF/ZnO/APT nanocomposites on the mechanical, antibacterial and antioxidant performances of composite films were investigated. The results indicated that introduction of LF/ZnO/APT nanocomposites obviously enhanced the mechanical properties and antibacterial ratios against Escherichia coli (97.04 ± 2.08%) and Staphylococcus aureus (98.68 ± 1.10%) of composite films. Moreover, the composite films also exhibited excellent scavenging capacities against 2,2-diphenyl-1-picrylhydrazyl and hydroxyl radicals. Therefore, the as-prepared composite films significantly extended the shelf life of loquats, and it is feasible to be served as promising active food packaging materials based on component synergistic effect of composite films.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Yanke Li,Huilin Liu,Runda Nie,Yue Li,Qinglin Li,Yunfeng Lei,Mingming Guo,Yichuan Zhang
Graphene oxide nanosheets (GONs) treatment of anionic dyeing wastewater has been characterized by low removal efficiency due to its electronegativity. However, further modification and enhancement of graphene oxide make it difficult to balance cost and efficiency. Herein, we report an economical, practical, and environmentally friendly composite aerogel of GONs and chitosan (CS) in anionic dye adsorption. The abundant oxygen-containing functional groups on the surface of GONs may form hydrogen bonds with dye molecules. Meanwhile, the amino-positive active sites on the chain segments of CS molecules may anchor anionic dyes. The adsorption capacities of composite aerogel for methyl orange (MO) and bromophenol blue (BPB) anionic dyes by electrostatic attraction, hydrogen bonds, and π-π conjugate interactions are 3.7 and 1.8 times than that of pure CS aerogel from the adsorption results, respectively. Moreover, the maximum adsorption capacities of composite aerogel for MO and BPB are 179.21 and 236.42 mg g −1 at room temperature and in a neutral environment. Therefore, this simple and cost-effective graphene aerogel anionic dye adsorbent may be used for the protection of the water environment.
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LANGMUIR
·
2025
·
IF 3.9
Dandan Liu,Hui Zhang,Jinfeng Mei,Xudong Zheng,Jian Rong,Zhongyu Li
A three-dimensional porous aerogel was synthesized by combining soft chitosan oligosaccharide to hard multi-walled carbon nanotubes (MWCNTs) under mild conditions. Owing to the support of MWCNTs, mesopores can be detected on the inner surfaces of the aerogel. The cross-linking by tetraethylenepentamine forms a macropore structure after freeze drying, using water as the template. The hydrogel can bear 30% recoverable compression with the aid of hydrogen bonds between the amide groups. The aerogel exhibits excellent adsorption capabilities for Cr(VI) in water. The adsorption capacity can reach 367.6 mg/g within 100 min. Notably, the aerogel demonstrated an extremely high efficiency in removal for trace Cr(VI). Soluble Cr(VI) of 1 mg/L can be completely removed by the aerogel at a dosage of 0.2 g/L. This work provides a new strategy to synthesize adsorbents with hierarchical pores that exhibit high porosity and a fast mass transfer rate.
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iScience
·
2024
·
IF 4.6
Mengxi Gu,Xuan Zhou,Jienan Shen,Ruibin Xie,Yuhan Su,Junxue Gao,Binzhe Zhao,Jie Li,Yingjie Duan,Zhixun Wang,Yougen Hu,Guoqiang Gu,Lei Wang,Lei Wei,Chunlei Yang,Ming Chen
It is still a great challenge for the flexible piezoresistive pressure sensors to simultaneously achieve wide linearity and high sensitivity. Herein, we propose a high-performance textile pressure sensor based on chitosan (CTS)/MXene fiber. The hierarchical “point to line” architecture enables the pressure sensor with high sensitivity of 1.16 kPa −1 over an ultrawide linear range of 1.5 MPa. Furthermore, the CTS/MXene pressure sensor possesses a low fatigue over 1000 loading/unloading cycles under 1.5 MPa pressure load, attributed to the strong chemical bonding between CTS fiber and MXene and excellent mechanical stability. Besides, the proposed sensor shows good antibacterial effect benefiting from the strong interaction between polycationic structure of CTS/MXene and the predominantly anionic components of bacteria surface. The sensor is also applied to detect real-time human action, an overall classification accuracy of 98.61% based on deep neural network-convolutional neural network (CNN) for six human actions is realized.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Meng Yu,Renyan Huang,Jiahui Hua,Min Ru,Renchuan You,Ying Huang,Shuqin Yan,Qiang Zhang
Hydrogel has attracted tremendous attentions due to its excellent biocompatibility and adaptability in biomedical field. However, it is challenging by the conflicts between inadequate mechanical properties and service requirements. Herein, a rapid and robust hydrogel was developed by interpenetrating networks between chitosan and silk fibroin macromolecules. Thanks to these unique networks, the chitosan-based hydrogel exhibited superior mechanical performances. The maximum breaking strength, Young's modulus and swelling ratio of the hydrogel were 1187.8 kPa, 383.1 MPa and 4.5 % respectively. The hydrogel also supported the proliferation of human umbilical vein endothelial cells for 7 days. Notably, the hydrogel was easily molded into bone screw, and demonstrated compressive strengths of 45.7 MPa, Young's modulus of 675.6 MPa, respectively. After 49-day biodegradation, the residual rate of the screw in collagenase I solution was up to 89.6 % of the initial weight. In vitro , the screws not only had high resistance to biodegradation, but also had outstanding biocompatibility of osteoblast. This study provided a promising physical-chemical double crosslinking strategy to build orthopedic materials, holding a great potential in biomedical devices.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xiaochen Zhang,Jiahong Jian,Zisheng Luo,Guo Li,Yifeng Huang,Yue Wu,Dong Li,Li Li
The fabrication of multi-component film with colloidal particles could be inconvenient. A novel “swell-permeate” (SP) strategy was proposed to form homogeneous multi-component films. The SP strategy allows colloidal particles to fit into the polymer network by stretching the polymer chains assisted by water. We demonstrated the strategy by creating films with polysaccharide substrates as β-cyclodextrin grafted chitosan (CS) with nanocellulose. The addition of nanocellulose significantly increased the mechanical properties and the barrier performance of the films. The size of nanocellulose particles in affecting mechanical properties was investigated by applying different length of cellulose nanocrystal (CNC), the longer of which, due to denser physical entanglements, showed a better increase to the film in the elastic modulus and tensile strength to 4.54-fold and 5.71-fold, respectively. The films were also loaded with ethyl- p -coumarate (EpCA) and had an enhanced performance in anti-microbial for Altenaria alternata , Salmonella typhi , and Escherichia coli . The anti-oxidative property was increased as well, and both effects were valid both in vitro and in ready-to-eat apples. The strategy provides a practical and convenient method for fabricating colloidal particle containing films, and the novel idea of “swell-permeate” is potentially regarded as a new solution to the challenge of ready-to-eat food quality maintenance.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Dibakar Pandaya,Ming-Xiao Zhang,Zhen-Liang Xu,Tehreem Ayaz,Mahesh Kumar Joshi,Yan Zheng,Tian-Xiang Ren,Liang Cheng,Jundi Wang
Electrospun nanofiber membranes are promising support for forward osmosis (FO) composite membranes due to their high porosity and low tortuosity. However, achieving a defect-free selective layer is challenging due to the large interconnected pores of nanofiber support. In this study, the potential of polyurethane (PU)/chitosan (CS) blend nanofibrous membrane as substrate for high-performance FO membrane was investigated. PUCS blend solutions were electrospun at optimized compositions to fabricate smooth and bead free nanofibrous membranes. The resulting PUCS nanofibrous membranes exhibited superior mechanical strength compared to pristine PU due to strong interaction between PU and CS at molecular level and their spider-net-like morphology. Thermal pressing enhanced the compactness of the membrane, significantly reducing the surface roughness and thickness of the support layer. Subsequently, a polydopamine (PDA)/Fe 3 + -tannic acid (TA) interlayer was introduced to facilitate the deposition of a defect-free polyamide (PA) selective layer through the interfacial polymerization (IP) process, thereby developing a thin film composite (TFC) FO membrane. The modified PUCS-TFC membrane had water flux (J w ) rates of 35.16 LMH and 44.61 LMH with a 1 M NaCl draw solution (DS) and DI water as feed solution (FS), respectively. At the same time, it had a low reverse salt flux (J s ) of 3.364 gMH and 1.605 gMH under FO and PRO modes, respectively. The J s /J w ratio of 0.095 g/L for 1 M NaCl draw solution indicated efficient performance. The FO membrane also demonstrated an anti-fouling property when tested with humic acid. Therefore, the PUCS-TFC membrane demonstrates great potential for applications in desalination.
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Biomedical Materials
·
2024
·Vol. 19
·期 2
·025002
·
IF 3.9
Liu Wenxiu,Han Guojiang,Qin Liying,Dong Wenli,Han Baoqin,Jin Liming,Yang Yan
This study aimed to synthesize bioactive glass (BG) and phosphorylated chitosan (PCS), and fabricate a BG/PCS composite scaffold. The physical properties (mechanical strength, swelling degree, and degradation rate) of the BG/PCS scaffold were tested. The in vitro mineralization properties of composite scaffolds in simulated body fluid were investigated. MC3T3-E1 cell responses with the BG/PCS scaffold were investigated using live/dead cell staining, actin staining, alkaline phosphatase (ALP) activity, and Alizarin red staining. Our results showed that the scaffold had an inner porous structure, good swelling properties, and good degradation rate. After immersion in SBF, the scaffolds demonstrated high properties in inducing mineralization. Leaching solutions of the composite scaffolds exhibited good cytocompatibility. MC3T3-E1 cells adhered, spread, and proliferated on the scaffold. The BG/PCS composite scaffold showed osteo-inductive activity by increasing ALP activity and calcium deposition. Our results indicated that the BG/PCS scaffold had potential applications as a bone-defect repair biomaterial.
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