Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2016
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IF 0.963
Jianquan Tan,Weiqu Liu,Zhengfang Wang
Novel pH-sensitive amphiphilic comb-shaped copolymers containing long fluorinated side chains, which combined the characteristics of pH-sensitivity from pendent tertiary amine groups, unique hydrophobic and fluorophobic characteristic from the fluorinated moieties and hydrophilicity from the poly (ethylene glycol) segments, were designed and synthesized via radical polymerizaion of 2-(Dimethylamino) ethyl methacrylate (DMAEMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA) and homemade fluorinated macromonomer (PHFBMA-GMA). The physicochemical properties of polymeric micelles prepared therefrom were investigated. The chemical structures of the copolymers were characterized by GPC, FTIR and 1H-NMR. The critical micelle concentrations (CMC) of the copolymers in different pH (5.0 and 7.4) were determined by fluorescence spectroscopy. Larger CMCs could be obtained in lower pH since the pronation of DMAEMA moieties enhanced the hydrophilicity. With increasing the amount, as well as the molecular weight, of PHFBMA-GMA, CMC decreased significantly. As pH decreased, particle size, as well as zeta potential of the polymeric micelles increased significantly, indicating significant pH-sensitivity of the polymeric micelles. Furthermore, larger polymeric micelles were obtained with larger amount, as well as higher molecular weight, of PHFBMA-GMA. Transmission electron microscopy (TEM) showed that the morphological shapes of the copolymers performed spherical micelles. The cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity. The pH-sensitive polymeric micelles prepared from the amphiphilic comb-shaped copolymers containing long fluorinated side chains could be potential candidates for nanotanks for hydrophobic or fluorophobic molecules and drug carriers and the facile preparation might fit for large scale industrialization.
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MATERIALS LETTERS
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2018
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IF 2.687
Keke Sun,Chen Xu,Tianke Hu,Caixue Lin,Yifeng Wang,Yulin Li,Ling Li,Yingxi Wang
In this work, novel core-shell γ-Fe 2 O 3 /La-MOFs@SiO 2 nanoparticles were fabricated and characterized. The feasibility for multifunctional drug carrier was investigated. The cytotoxicity proved the high biocompatibility and the drug release experiments showed the excellent pH-responsive release. The magnetic nature and strong blue fluorescence indicated the potential use for magnetic target and magnetic resonance/fluorescence dual mode imaging.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2011
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IF 3.068
Xiujuan Huang,Yan Xiao,Meidong Lang
Comicellization of a star block copolymer poly( ε -caprolactone)- block -poly(diethylamino)ethyl methacrylate (S(PCL- b -PDEAEMA)) and a linear block copolymer methoxy poly(ethylene glycol)- block -poly( ε -caprolactone) (mPEG- b -PCL) was developed to enhance the stability and lower the cytotoxicity of the micelles. The two copolymers self-assembled into the mixed micelles with a common PCL core surrounded by a mixed PDEAEMA/mPEG shell in aqueous solution. This core–shell structure was transformed to the core–shell–corona structure at high pH due to the collapse of the PDEAEMA segment. The properties of the polymeric micelles were greatly dependent on the weight ratio of the two copolymers and the external pH. As increasing the mPEG- b -PCL content, the size and the zeta potential of the mixed micelles were lowered while the pH-dependent stability and the biocompatibility were improved. Moreover, an increase in pH accelerated the release of indomethacin (IND) from the mixed micelles in vitro . These results augured that the mixed micelles could be applied as a stable pH-sensitive release system.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2019
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IF 5.107
Yongjun Sun,Kinjal J. Shah,Wenquan Sun,Huaili Zheng
Dual-function chitosan-based flocculants with chelation and flocculation capacity, carboxylated chitosan-graft-polyacrylamide (PCA), carboxylated chitosan-graft-polyacrylamide-co-sodium xanthate (PCAXC), and carboxylated chitosan-graft-poly(acrylamide-2-acrylamido-2-methylpropane sulfonic acid) (PCAAF), are designed and prepared by UV initiation method. The physicochemical characteristics of PCA, PCAXC, and PCAAF were characterized by fourier transform infrared spectroscopy, 1 H nuclear magnetic resonance, and X-ray diffraction pattern to confirm the successful syntheses. Then PCA, PCAXC, and PCAAF are applied to chelate and flocculate Cu, Cr, and Ni from water. Effects of pH, flocculants dosage, reaction time, and stirring speed were investigated systematically to detect the relationship between flocculants structural and chelation-flocculation capacity. The maximum removal rate of Cu and Cr obtained by PCAXC at are 85.1% and 76.1%, respectively, while The maximum removal rate of Ni obtained by PCAAF at is more than 75.7%%. In addition, the relationship between the initial concentration of simulated heavy metal wastewater and the flocculants dosage and the competitive chelation-flocculation properties in the mixed heavy metal solution are also detected in detail. The mechanism can be assigned to the effective interaction between function groups of the flocculants and heavy metal irons by chelation, charge neutralization, and adsorption bridging mechanism.
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高影响因子
Polymers
·
2018
·Vol. 10
·期 3
·326
·
IF 2.935
Feng Ji,Hong Sun,Zhihui Qin,Ershuai Zhang,Jing Cui,Jinmei Wang,Shuofeng Li,Fanglian Yao
Multifunctional drug carriers have great applications in biomedical field. In this study, we introduced both polydopamine (PDA) and zwitterionic polymer of poly(3-(3-methacrylamidopropyl-(dimethyl)-ammonio)propane-1-sulfonate) (PSPP) onto the surface of mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle (MSNs@PDA-PSPP), which was employed as a new kind of drug carrier for the delivery of doxorubicin (DOX). The PDA coating, as a gatekeeper, could endow the drug carrier with pH-sensitive drug release performance. The outermost PSPP layer would make the drug carrier possess protein resistance performance. The chemical structure and properties were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA). MSNs@PDA-PSPP could keep good colloidal stability within 72 h in phosphate buffered saline (PBS) and protein solutions. Meanwhile, MSNs@PDA-PSPP exhibited a high drug loading for DOX. In vitro drug release experiments suggested MSNs-DOX@PDA-PSPP exhibited pH-dependent drug release behaviors. Besides, MSNs@PDA-PSPP had no cytotoxicity to human hepatocellular carcinoma cells (HepG2 cells) even at a concentration of 125 µg/mL. More importantly, cellular uptake and in vitro anticancer activity tests suggested that MSNs-DOX@PDA-PSPP could be taken up by HepG2 cells and DOX could be successfully released and delivered into the cell nuclei. Taken together, MSNs@PDA-PSPP have great potential in the biomedical field.
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MACROMOLECULAR CHEMISTRY AND PHYSICS
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2014
·Vol. 216
·期 2
·164-171
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IF 2.451
Pengyan Wang,Yinyu Zhang,Lu Cheng,Wenguang Liu
Conventionally, biodegradable hydrogels end up with quick disintegration and consequently fail to bear external loading after degradation. Here, a biocleavable high-strength hydrogel prepared by copolymerization of 2-vinyl-4,6-diamino-1,3,5-triazine (alkali active H-bonding monomer), 3-acrylamidophenylboronic acid (acid active H-bonding monomer), oligo(ethylene glycol) methacrylate, and crosslinker N,N ′-bis(acryloyl)cystamine is reported. The hydrogel is shown to be degraded after the disulfide bonds in the chemical crosslinkers are broken down in a reducible medium. Remarkably, the degraded hydrogel evolves into supramolecular network, which is strengthened by diaminotriazine–diaminotriazine and phenylboronic acid–phenylboronic acid dual H-bonded physical crosslinks despite the loss of chemical crosslinking. It is demonstrated that over a broad pH range, the degraded hydrogels are able to retain macroscopic integrity and withstand high external loading due to the existence of at least one kind of hydrogen bonding crosslinking. This biodegradable double hydrogen bonding strengthened hydrogel may push forward the research on a new type of high-strength hydrogels.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Jianfeng Hu,Huiya Cheng
A challenge in metal protection is developing anti-corrosion materials that possess both high adsorption capacity and intelligent responsiveness. To overcome the limitations of traditional corrosion inhibitors, a novel pH-responsive corrosion inhibitor (PDT@ZIF-90) was developed through a multi-step strategy. Specifically, the catechol-modified polymer–TiO2 hybrid (PDT) was synthesized through Schiff base reactions, which demonstrated dense adsorption on Q235 carbon steel through Fe–N/O coordination. Subsequent ZIF-90-mediated in situ encapsulation enabled precise payload integration of the PDT corrosion inhibitor. UV-vis characterization confirmed that the PDT@ZIF-90 composite system enables pH-triggered intelligent release of the active corrosion inhibitor component under acidic conditions (pH < 6). Electrochemical tests revealed a 95.2% inhibition efficiency for 200 ppm PDT@ZIF-90 in 3.5 wt% NaCl. This dual-functional strategy offers a scalable paradigm for self-adaptive anticorrosion materials suitable for Q235 carbon steel in marine and energy infrastructure applications.
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高影响因子
TALANTA
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2025
·
IF 6.1
Yuhui Wang,Haoxu Wu,Xinhui Lou,Yaping Li
A pH-responsive magnetic nanocomposite (Fe 3 O 4 @SiO 2 @PGMA- b -PDEAEMA) was designed for organic solvent-free and rapid extraction of tetracyclines (TCs) from water samples via microwave-assisted magnetic solid-phase extraction (MSPE) coupled with high performance liquid chromatography (HPLC) analysis. The pH-modulated extraction was realized through changes in the conformation of PDEAEMA chains and ionization states of TCs for reversible adsorption without using organic solvents. Three representative TCs-oxytetracycline, tetracycline and doxycycline-were selected as the model compounds. The successful fabrication of the nanomaterial was confirmed by 1 H nuclear magnetic resonance, transmission electronic microscopy, Fourier transform infrared spectroscopy, elemental analysis and vibrating sample magnetometry. The key parameters affecting the extraction efficiency were comprehensively investigated and the adsorption mechanism was carefully studied. Under the optimal conditions, the developed microwave-assisted MSPE-HPLC-UV method presented good analytical performance with short extraction time (90 s), limits of detection between 3.10 and 9.38 μg/L, relative recoveries ranging from 84.0 to 114 % and the relative standard deviations less than 9.4 %, confirming that this sustainable and rapid sample preparation method provided great potential for determination of TCs in environmental water. Lastly, the proposed method's greenness and practicality were evaluated using the Sample Preparation Metric of Sustainability and Blue Applicability Grade Index.
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 6
·1316-1325
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IF 5.344
Danping Ling,Haihong Li,Wensong Xi,Zhuo Wang,Artur Bednarkiewicz,Solomon T. Dibaba,Liyi Shi,Lining Sun
Developing multifunctional nanocomposites for a pH-responsive controlled dual-drug delivery is still a huge challenge. Herein, we report a gentle and simple method for growing metal–organic frameworks (MOFs) that can load two anticancer drugs, namely DOX and 5-FU (doxorubicin and 5-fluorouracil), on the surface of upconversion nanoparticles (UCNPs) by the reactions of Schiff bases and electrostatic adsorption. The resulting pH-responsive UCMOFs@D@5 nanosystem showed effective dual-drug release by the cleavage of chemical bonds and the disruption of the MOF structure under acidic conditions. Moreover, the final nanosystem UCMOFs@D@5 showed much higher cytotoxicity in comparison with UCMOFs@D and UCMOFs@5, which loaded only one kind of drug, respectively, after being incubated with human cervical cancer (HeLa) cells, indicating that Dox and 5-FU released from the final nanosystem had synergistic effects on cytotoxicity. Cellular uptake studies showed that UCMOFs@D@5 was well uptaken by HeLa cells and has potential for bioimaging applications in intracellular fluorescence imaging with high-contrast, and is beneficial for the intracellular localization of anti-cancer drugs. In addition, the nanosystem can be successfully applied in T1-weighted magnetic resonance imaging. Therefore, we developed a visualized tracking agent combined with MOFs to load two anticancer drugs to form a nanosystem for diagnosis and synergistic treatment, thus achieving the bioimaging and stimulation-responsive dual-drug release.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2026
·Vol. 37
·期 1
·42
·
IF 4.7
Xiaomei Ye,Shuzhen Lu,Hao Peng,Zhirong Huang,Chunyu Pan,Yayan Huang,Kangrui Yuan,Youfa Qin
Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as the organic linker, was successfully synthesized via a surfactant-assisted solvothermal method. Surface characterization revealed that MOF-2 exhibited high surface area (1325 m 2 /g), pore volume (0.273 cm 3 /g), and average pore diameter (5.69 nm). UV-Vis analysis showed that MOF-2 demonstrated improved drug loading (18% w/w), encapsulation efficiency (86%), and cumulative release (96%), along with both pH-responsive degradation and drug release properties. Furthermore, cisplatin-loaded MOF-2 exhibited potent antitumor activity against A549 cells and effectively inhibited cell migration and invasion, while maintaining minimal cytotoxicity toward LO2 normal hepatic cells. These findings suggest MOF-2 as a promising nanocarrier for pH-responsive anticancer drug delivery.
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PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Fuxin Li,Jingxian Ye,Jianjun Hao,Zexiao Liu,Dongyin Yi,Gaoming Zhang,Xinyu Luo,Yang Bi
BACKGROUND Prochloraz (Pro) is a broad-spectrum fungicide that is effective against various plant pathogens, including Colletotrichum fructicola , the causal agent of strawberry anthracnose. However, its limited absorption restricts its effectiveness. In this study, zeolitic imidazolate framework-8 (ZIF-8) was utilized as a nanocarrier and combined with the fungicide prochloraz (Pro) to develop an effective delivery system (Pro@ZIF-8), improving the fungicidal activity of prochloraz. RESULTS Characterization confirmed that Pro@ZIF-8 possesses a distinct dodecahedral crystal structure with an average particle size of 139.6 nm. The system exhibited pH-sensitive release, with 89.8% of the prochloraz released within 24 h at pH 5.0, while remaining stable at pH 7.4. Antifungal assays demonstrated that Pro@ZIF-8 had an EC 50 of 0.0150 mg L −1 against C. fructicola , which was significantly lower than that of free prochloraz (0.0429 mg L −1 ). Pro@ZIF-8 effectively delayed disease lesion development on strawberry leaves and fruits inoculated with C. fructicola . Under storage conditions, Pro@ZIF-8 prevented pathogen infection and kept the fruit fresh for an extended period. Additionally, by tracking fluorescein isothiocyanate (FITC)-labeled ZIF-8 after foliar and root applications, it was confirmed that it was systemically transported within strawberry plants. CONCLUSION These findings highlight the potential of Pro@ZIF-8 as a smart fungicide delivery system, offering a promising strategy for improving disease management in strawberries. © 2026 Society of Chemical Industry.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Li He,Cuiqing Yu,Qiuyu Feng,Aimin Wu,Yunchun Li,Xianxiang Wang
Developing intelligent antibacterial platforms that dynamically modulate therapeutic activities in response to microenvironmental cues is essential to overcome the self-limiting nature and collateral oxidative damage of conventional chemodynamic therapy (CDT). Herein, a multifunctional and self-adaptive nanozyme platform, denoted as CuPDA@CaO 2 @Qu, is developed. It rationally integrates a copper-based metal-organic gel (CuPDA) for pH-dependent enzyme-mimetic switching, calcium peroxide (CaO 2 ) for endogenous hydrogen peroxide (H 2 O 2 ) self-supply, and the natural flavonoid quercetin (Qu) to reinforce anti-inflammatory and antioxidant functions, collectively enabling synergistic and stage-programmed therapy of infected wounds. Specifically, in acidic infected microenvironments, the peroxidase-mimic CuPDA catalyzes CaO 2 -derived H 2 O 2 into highly toxic hydroxyl radical (·OH), effectively disrupting biofilms and eradicating multidrug-resistant (MDR) bacteria, with enhanced efficacy through glutathione depletion. After bacterial clearance, CuPDA self-switches to antioxidant mode, exhibiting superoxide dismutase-glutathione peroxidase mimetic activities that synergize with Qu to scavenge excess reactive oxygen species (ROS), resolve inflammation, and promote M2 macrophage polarization. Moreover, the nanocomposite is capable of promoting cellular migration, collagen deposition, and neovascularization, significantly accelerating tissue healing. This self-adaptive platform demonstrates potent efficacy in MDR bacterial-infected wounds and offers a promising strategy for intelligent nanomedicine design.
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高影响因子
危险品化学品经营许可证（带存储）