Cancer Communications
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2026
·
IF 28.4
Chenchen Hu,Feiming Hu,Changjian Shao,Yuanli He,Liping Su,Daimei Shi,Lingying Yu,Yuanjie Sun,Jing Wang,Xiyang Zhang,Hongtao Duan,Junqi Zhang,Yubo Sun,Dongbo Jiang,Xiaolong Yan,Shuya Yang,Kun Yang
Background: Lung cancer remains a major global health burden. RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation, and their dysregulation is frequently implicated in tumorigenesis. The present study aimed to elucidate the molecular network governed by the highly expressed RBP TIMELESS in lung adenocarcinoma (LUAD) and determine its mechanistic role in LUAD progression. Methods: The Cancer Genome Atlas-LUAD, Gene Expression Omnibus, and single-cell RNA sequencing datasets were analyzed to identify aberrantly expressed RBP genes. The RBP gene TIMELESS exhibited the most significant effect on LUAD cell death and was selected for further study. Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation sequencing and RNA sequencing were employed to identify ferroptosis-related targets directly bound by TIMELESS. Molecular mechanisms underlying the TIMELESS-mediated regulation of ferroptosis in LUAD were investigated via immunoprecipitation–mass spectrometry, glutathione S -transferase pull-down, immunofluorescence–fluorescence in situ hybridization, RNA immunoprecipitation, poly(A)-tail, and RNA stability assays. In an orthotopic lung cancer mouse model treated with erastin (a ferroptosis inducer) and programmed cell death protein 1 (PD-1) blockade, the role of TIMELESS in therapeutic response was assessed via flow cytometry and multiplex immunofluorescence (mIF). Infiltrating immune cells in LUAD were analyzed by tissue microarrays (TMAs) via mIF. Results: TIMELESS significantly affected LUAD cell proliferation and death, and TIMELESS knockdown significantly enriched RNA-binding and ferroptosis pathways. Transferrin (TF) was identified as a direct TIMELESS target governing ferroptosis. TIMELESS was revealed to bind Ccr4-Not transcription complex subunit 3 (CNOT3) to promote TF mRNA degradation. TIMELESS depletion combined with erastin and PD-1 blockade enhances efficacy, prolongs survival, increases T cell and M1 macrophage infiltration, and reduces M2 macrophage infiltration. Further, high TIMELESS expression was inversely correlated with ferroptosis marker 4-hydroxynonenal but positively correlated with programmed cell death ligand 1 (PD-L1), reduced T cell and M1 macrophage infiltration, and increased M2 macrophage infiltration. Conclusions: TIMELESS recruits CNOT3 to accelerate TF mRNA degradation, thereby suppressing ferroptosis and promoting LUAD growth. These findings suggest that the TIMELESS/TF regulatory axis may be a promising therapeutic target for LUAD.
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高影响因子
PHYTOMEDICINE
·
2026
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IF 11.3
Yutong Kang,Abudureyimu Alimujiang,Fan Zhou,Liangmian Chen,Hongzhi Wang,Wenjing Wei,Jingcheng Zhao,Ziqi Zhu,Wancheng Sun,Xuejiao Xie,Shixia Huo,Dengqiu Xu,Zhijian Li
Objective Psoriasis is a chronic, immune-mediated dermatological disorder characterized by pathological epidermal hyperplasia, aberrant keratinocyte differentiation, and dermal infiltration of inflammatory cells. Sihe Tufuling (SHTFL), a clinically established traditional Chinese medicine formula, has demonstrated therapeutic efficacy in psoriasis management. This study aimed to investigate the anti-psoriatic activity of SHTFL and its principal herb, Smilax glabra Roxb. (SGR), and to elucidate their underlying mechanisms of action. Methods Ultra-performance liquid chromatography-mass spectrometry was used to identify the major chemical constituents of SHTFL and SGR. An imiquimod (IMQ)-induced psoriasis-like mouse model was employed to assess therapeutic efficacy using the psoriasis area and severity index, spleen index, hematoxylin and eosin staining, immunohistochemistry, immunofluorescence. Transcriptomic sequencing, single-cell RNA sequencing, gene knockdown, immunofluorescence, and quantitative reverse-transcription PCR analyses were performed to investigate the molecular mechanisms involved. Results The results of the chemical component identification indicated that flavonoids constitute essential components in both the SHTFL formula and SGR. Treatment with SHTFL and SGR resulted in a significant reduction of the PASI score, skin thickness, splenic index and serum levels of inflammatory cytokines in IMQ-induced mice psoriasis mice. Moreover, both SHTFL and SGR alleviated psoriasis by inhibiting keratinocyte hyperproliferation and the inflammatory response in IMQ-induced mice. Transcriptomic analysis revealed that SHTFL and SGR mitigates keratinocyte hyperproliferation and the inflammatory response by modulating the HIF-1 signaling pathway. Furthermore, HIF-1α knockdown abolished the protective effects of SHTFL in these models. Conclusion Our results indicate that both SHTFL and SGR hinder the excessive growth of keratinocytes and reduce inflammation in psoriasis by inhibiting the HIF-1 signaling pathway. This evidence backs SHTFL as a promising therapeutic approach for psoriasis.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 7
·196
·
IF 2.5
Cai Chang,Li Jinhong,Li Rongwu,Zhao Nan,Zhang Yue,Fan Qiuyu,Zhang Jianguo,Chen Lidong
This study addresses the limitations of conventional industrial methods for acetophenone (AP) production by developing a modified TS-1 zeolite catalyst with a predominantly interparticle micro-mesoporous architecture for the selective oxidation of ethylbenzene (EB) under mild and environmentally benign conditions. To overcome the intrinsic pore constraints of TS-1 zeolite that restrict substrate accessibility and mass transfer, a specific sequential acid-then-alkali post-treatment strategy followed by cobalt oxide impregnation was employed. This treatment sequence leads to surface enrichment of framework-like Ti species and the creation of interparticle mesoporosity, resulting in a coexisting micro-mesoporous architecture while preserving the MFI framework. Under optimized reaction conditions, the catalyst achieved 76.2% EB conversion and 74.8% AP selectivity to AP. Systematic evaluation in the EB/H 2 O 2 oxidation system under acidic reaction conditions revealed a synergistic effect between framework titanium active sites and cobalt oxide active species. The developed catalyst offers distinct advantages, including straightforward synthesis procedure, high catalytic activity, and facile recoverability. Graphical This study constructs a micro-mesoporous TS-1 via specific sequential acid-then-alkali modification and loads optimal Co 3 O 4 to create dual active centers. This architecture reduces mass transfer resistance and optimizes active sites, enabling efficient ethylbenzene oxidation to acetophenone under mild conditions. The catalyst is easily recoverable, regenerable, and stable. The alternative text for this image may have been generated using AI.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Yanqing Yang,Yuchen Yang,Zhixian Du,Weike Zhang,Jin Liu
A Z-scheme BiOBr/COF-1 heterojunction was synthesized via a solvothermal method. • The catalyst exhibited enhanced visible-light absorption and charge separation. • A mechanism for the simultaneous removal of RhB and Cr(VI) was revealed. The construction of heterojunctions is commonly employed to boost the separation efficiency of photogenerated charge carriers and the overall photocatalytic performance. In this study, a novel Z -scheme BiOBr/COF-1 heterojunction photocatalyst was synthesized via a facile solvothermal method. Comprehensive characterization confirmed the effective formation of the heterojunction, which exhibited enhanced visible-light absorption and improved separation efficiency of photogenerated charge carriers. Compared with pristine COF-1 and BiOBr, the optimized BiOBr/COF-1 composite (BC-1) demonstrated superior photocatalytic activity for both rhodamine B (RhB) degradation and Cr(VI) reduction. Notably, the reduction efficiency of Cr(VI) was significantly enhanced in a coexisting system of RhB and Cr(VI). In addition, BiOBr/COF-1 exhibited good structural stability over multiple reaction cycles. This work provides an effective strategy for designing Z -scheme photocatalysts to treat complex wastewater containing organic and heavy metal pollutants. Download: Download high-res image (339KB) Download: Download full-size image
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GREEN CHEMISTRY
·
2026
·
IF 10.6
Huilin Li,Xuechong Ding,Teng Zhou
Water-lean solvents are promising alternatives to aqueous amines for post-combustion CO2 capture due to their lower regeneration energy. However, the majority of state-of-the-art water-lean solvents rely on 1-methyl-2-pyrrolidone (NMP) as the organic cosolvent, whose reproductive toxicity poses a serious barrier to large-scale deployment. This study proposes a systematic strategy to identify green, low-toxicity replacements for NMP in water-lean solvents. Based on COSMO-RS σ-profile similarity calculation, 20 high-potential candidates were first identified from 2562 organic solvents. Subsequent environmental, health, and safety (EHS) evaluations, combined with physicochemical property filtering, narrowed the selection to two green cosolvents: methylaminoacetaldehyde dimethyl acetal (MAADMA) and 3-methoxy-1-butanol (MOB). These two candidates and NMP were then experimentally validated in combination with three representative amines (EMEA, DMEDA, and DMPDA) at 5 wt% water content. Among all tested systems, the EM-A-5H solvent (30% EMEA/65% MAADMA/5% H2O) showed the best performance, with a remarkable cyclic capacity of 0.86 mol CO2 per mol amine and a regeneration efficiency of 93.6%. Importantly, EM-A-5H achieved a total regeneration energy of 2.20 GJ per t CO2, 41% lower than conventional 30 wt% MEA and 15% lower than the NMP-based counterpart solvent. It also exhibited an excellent stability and satisfactory viscosity over seven absorption–desorption cycles without performance degradation. This work offers a systematic and practical approach for the rational design of eco-friendly, high-performance water-lean solvents for CO2 capture.
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ACS Applied Engineering Materials
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2026
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IF 3.5
Zehui Yao,Xinhai Zhang,Yi Wang,Xiaozu Wang,Zhaohui Wang,Zhaoliang Cui
Polyimide (PI) membranes face a trade-off between permeability and selectivity, limiting their gas separation applications. To address this, we synthesized 6FDA-DAM/DABA(DAM:DABA = 3:2) PI and two-dimensional COF-1 nanofillers, fabricating hollow fiber mixed matrix membranes (MMMs) via dry-jet wet-spinning. Under optimized conditions (25 cm air gap, 50 °C spinneret temperature, 30 °C NMP coagulation bath), the 10 wt % COF-1 incorporated membranes achieved optimal performance: tensile strength of 15.34 MPa; H2 and CO2 permeances of 79.3 GPU and 54.3 GPU, and ideal selectivities of 187.9 for H2/CH4 and 128.7 for CO2/CH4, respectively. The results demonstrate that the incorporation of COF-1 modifies solvent exchange during spinning, necessitating targeted optimization of spinning parameters to coordinate membrane structure and performance.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2026
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IF 3.6
Congcong Zhao,Zhiqiang Yu,Mengyun Wang,Yingfen Ying,Yunbing Tang,Huitao Li,Ren-shan Ge,Junbo Liang
Per - and polyfluorinated substances (PFAS) are synthetic, long-lasting contaminants that persist in the environment. However, it is still unknown whether these chemicals can inhibit the activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in humans and rats to disrupt glucocorticoid metabolism. Eighteen PFAS (11 carboxylic acids and 7 sulfonic acids) were used to analyze their inhibition on human and rat 11β-HSD1 activity. Eight of the eleven PFAS carboxylic acids (from C7 to C14) gradually inhibited human 11β-HSD1 with the increase of carbon-chain length (inhibitory potency was C4-C6 < C7 < C8 < C9 < C10 < C11 < C12 < C13 < C14). The IC 50 values of perfluoroheptanoic acid (C7) and perfluorotetradecanoic acid (C14) were 100.4 and 10.33 μM, respectively. Perfluorooctanesulfonic acid (PFOS, C8) from 7 sulfonic acids can significantly inhibit human 11β-HSD1. The carbon-chain length, carbon atom number, fluorine atom number, molecular weight, rotatable bonds, boiling point, and melting point, pKa, apolar desolvation, and polar desolvation, and LogP were negatively correlated with IC 50 values to inhibit human 11β-HSD1 (the higher the number, the lower the IC 50 value, thus, stronger inhibition). On the contrary, LogS, Gibbs free energy, and lowest binding energy were positively correlated with IC 50 values. All these chemicals bind to steroid binding site of human 11β-HSD1 as competitive or mixed inhibitors. Only perfluorononanoic acid (C9, IC 50 = 128.2 μM) and perfluorodecanoic acid (C10, 68.21 μM) markedly inhibited rat 11β-HSD1. In conclusion, PFAS show structure-dependent inhibition on human 11β-HSD1 and they increase inhibitory potency with the increase in carbon-chain length, and rat enzyme is less sensitive to the inhibition of these chemicals.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·464
·
IF 15
Wang Xueqing,Li Kai,Xu Wenyan,Wang Danyang,Wang Ying,Feng Junkun,Chen Yi,Liu Xiaoyi,Xu Zishan,Liu Xiaojia,Ge Shaohua,Liu Hong,Li Jianhua
Osteomyelitis is a refractory bacterial infection of bone, presenting significant clinical management challenges due to its limited therapeutic outcome. Here, we developed heterojunction-structured sub-1 nm copper oxide-decorated strontium titanate nanosheets (Cu-STO NSs), which integrate piezocatalytic reactive oxygen species (ROS) generation with augmented copper-induced bacterial death for synergistic osteomyelitis treatment. Under ultrasound (US) irradiation, the oxygen vacancies and heterojunction structure of Cu-STO NSs facilitate the separation of piezo-generated electron–hole pairs while reducing energy barriers, thereby enhancing ROS generation. This process is augmented by the US-accelerated Cu 2+ /Cu + redox cycling, which enables sustained hydroxyl radicals supply via Fenton-like reactions. The US-driven piezocatalytic action simultaneously enhances bacterial membrane permeability, facilitating intracellular copper overload and thereby triggering copper-induced metabolic toxicity in Staphylococcus aureus ( S. aureus ). Subsequent release of bioactive Cu and Sr ions from Cu-STO NSs significantly upregulates osteogenic differentiation of bone marrow stromal cells. In rat osteomyelitis, Cu-STO NSs achieve efficient bacterial eradication while stimulating on-demand bone regeneration. This work thus presents a non-invasive, spatiotemporal controlled copper-induced bacterial death strategy that concurrently addresses antibacterial and osteogenic challenges in infected bone regeneration. Graphical The alternative text for this image may have been generated using AI.
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npj Science of Food
·
2026
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IF 9.7
Shen Linyuan,Ma Jianfeng,Liang Shuang,Yang Yiting,Liao Tianci,Lei Yuhang,Chen Lei,Wang Yan,Zhao Ye,Niu Lili,Gan Mailin,Zhu Li
Diet derived extracellular vesicles (EV) can be absorbed and influence physiological processes. Herein, this study investigates the potential health impacts of extracellular vesicles in meat products. Experimental results showed the extracellular vesicles derived from cooked red meat (RM-EV) and white meat (WM-EV) were successfully isolated via ultra-high speed centrifugation. The median particle size of RM-EV is 137.5 nm and that of WM-EV is 116.1 nm. RM-EV and WM-EV are added to the drinking water of mice for ten weeks. The mice developed insulin resistance and abnormal lipid metabolism in the liver. The influences of RM-EV are more pronounced for mice than WM-EV. High-throughput sequencing indicated that ssc-miR-1 (52.05%) and scc-miR-133a-3p (14.21%) are the most abundant microRNA in RM-EV. However, the highest content of microRNA is gga-miR-133a-3p (44.16%) in WM-EV, followed by gga-miR-1 (21.58%). Therefore, the most abundant ssc-miR-1 in red meat EV (RM-EV-miR-1) was selected for in vitro studies. In vitro experiments revealed that RM-EV-miR-1 inhibited cell proliferation by targeting IGF1 in NCTC1469 liver cell. Besides, RM-EV-miR-1 exacerbates insulin resistance in NCTC1469 insulin resistance cell model by targeting PI3K/AKT signaling pathway. Our findings show that the differential health impacts of red and white meat may be partially attributed to the presence of EV. These results provide novel insights into dietary health from the perspective of EV.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Weikang Sun,Renjie Luo,Qingwei Qu,Jie Yang,Guang Yang,Lihua Song,Peng Cao,Erguang Li
Plant-based phenolic components and their metabolites, such as ellagic acid (EA) and urolithin A (UA), possess a variety of biological activities. Here, we investigated the antiviral effect of EA and UA against HSV-1 infection, a virus that causes peripheral infection as well as brain inflammation. Both compounds demonstrated potent antiviral activity. Network pharmacology and molecular docking analyses identified protein kinase CK2 as a common target for their action. We showed that both EA and UA were direct CK2 inhibitors using an enzymatic assay, an observation substantiated in cell culture studies. The effect of EA and UA on HSV-1 infection through CK2 was confirmed in CK2 (CSNK2B) knockout cells. Finally, we demonstrated an antiviral effect using a murine model of herpetic stromal keratitis. EA or UA treatment reduced HSV-1 shedding and prevented viral neuroinvasion. CK2 is a critical enzyme involved in cell proliferation and the proinflammatory response. In addition to identifying CK2 as a putative target of EA and UA antiviral activities, this study also demonstrates that EA and its metabolite UA have the potential to reduce infection-associated neurodegenerative inflammation.
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JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Yanming Xia,Lixin Hu,Yuhan Hu,Shihao Wang,Qingqing Xiong,Xiaohu Wang,Yiqun Li,Lifang Yin,Jian Wang,Suxin Li
The stimulator of interferon genes (STING) has emerged as a promising target for cancer immunotherapy. However, STING agonists alone have demonstrated limited clinical success. Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated as a key resistance mechanism that undermines the antitumor effects of STING activation, yet the cell-type-specific roles and the combined impact of STING and IDO1 on tumor immune orchestration remain poorly understood. In this study, we report that a co-delivery nanosystem of STING agonists and IDO1 inhibitors, rather than their simple combination, yields synergistic antitumor responses. This nanomedicine exhibits tropism toward myeloid cell populations in vivo , particularly dendritic cells (DCs), and facilitates pH-responsive cytosolic delivery of both agents. As a result, it enhances antigen cross-presentation, DC maturation, and cytokine secretion, driving effective priming of cytotoxic T lymphocytes. Compared to monotherapies or physical nanoparticle combinations of STING agonists and IDO1 inhibitors, this two-in-one nanomedicine significantly suppresses tumor growth and confers a survival benefit. Depletion of STING in the host ( Tmem173 −/− mice) or deficiency in type I conventional DCs (cDC1s, Batf3 −/− mice) abolishes therapeutic efficacy, whereas depletion of STING in tumor cells exerts minimal impact. A bone marrow chimera experiment further supports the STING-cDC1 dependence. Its capability to overcome tumor resistance and the underlying mechanism were further investigated in a well-established tumor model. Our findings highlight the cooperative role of STING activation and IDO1 blockade within cDC1s and introduce an integrated drug delivery system to combat immune tolerance in cancer therapy.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Jiarui Tong,Xiangrong Zhu,Xiumei Chen,Nengguo Tao
Chinese bayberry is a highly fragile and perishable fruit that requires protective and functional packaging to maintain its postharvest quality. In this study, a novel bio-based aerogel was developed using a gelatin/dialdehyde starch matrix reinforced with cellulose nanofibrils (CNF) via Schiff-base crosslinking and freeze-drying. The as-prepared aerogel exhibited superior compressibility, elasticity, and biodegradability. This aerogel was further functionalized by loading trans-2-hexenal (E2H) and combined with 1-methylcyclopropene (1-MCP) treatment, thereby constructing a postharvest preservation system for Chinese bayberry with the triple functionality of ethylene inhibition, antifungal activity, and cushioning performance. The optimal aerogel formulation (30% CNF content) demonstrated robust mechanical performance and sustained E2H release behavior, which followed first-order kinetics. In vitro and in vivo assays confirmed its significant inhibitory effect against Penicillium citrinum , the primary postharvest pathogen of bayberry. Storage experiments at 4 °C revealed that the synergistic effect of E2H-loaded aerogel pads and 1-MCP treatment effectively reduced decay, preserved firmness and nutritional quality, and extended the shelf life of bayberries to 18 d, significantly surpassing the control group which lost commercial value after 8 d. Furthermore, the aerogel completely degraded in soil within two weeks, confirming its potential as an eco-friendly packaging material. This work, integrating both protective and active preservation functionalities, provides a sustainable and efficient packaging approach for fragile fruit.
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