CELL PROLIFERATION
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2026
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IF 7.6
Zhaosong Meng,Jiacheng Liu,Yue Zhang,Ruimeng Yang,Jingyi Zhang,Haosun Yang,Zheng Wang,Ran Wei,Zhe Li,Shuling Guo,Lizhi Hu,Lei Sui
Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell-based therapy has emerged as a promising strategy to promote bone regeneration. N-acetylcysteine (NAC), a potent antioxidant, has been shown to modulate the PI3K-AKT signalling pathway and potentially enhance osteogenesis; however, the specific downstream effectors mediating this process remain unidentified. In this study, post-extraction serum metabolomic profiling revealed that alveolar bone injury is accompanied by systemic oxidative stress and metabolic remodelling. Transcriptomic analysis of antioxidant-treated dental stem cells further identified type VI collagen A1 (COL6A1) as a key functional mediator. We subsequently investigated the role of COL6A1 in antioxidant-mediated osteogenesis through immunofluorescence and protein assays, and performed knockdown and in vivo experiments to evaluate its function in oxidative stress regulation and osteogenic differentiation. Our results demonstrated that alveolar bone injury is associated with systemic oxidative stress and global metabolic alterations. In vitro, NAC markedly promoted the osteogenic differentiation of dental follicle stem cells (DFSCs) by activating the PI3K-AKT pathway and upregulating COL6A1. COL6A1 knockdown resulted in elevated reactive oxygen species (ROS) levels, impaired mitochondrial function, and attenuated NAC-mediated osteogenesis. In vivo, NAC-treated DFSCs exhibited enhanced bone healing and extracellular matrix (ECM) deposition in a rat model of alveolar bone injury, effects that were mediated through COL6A1 upregulation. Collectively, these findings demonstrate that NAC enhances osteogenesis in DFSCs via the PI3K-AKT-COL6A1 axis, offering a promising antioxidant-based strategy for stem cell therapies in bone regeneration. Moreover, COL6A1 is essential for maintaining redox homeostasis and represents a potential therapeutic target for improving regenerative outcomes.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Yunlong Lan,Chao Deng,Qiaoping Kong,Chuanxi Yang,Bingrui Ma,Erling Zhao,Xiaoning Wang,Yongkun Wu,Liping Xiao
Nowadays, industrial wastewater contains abundant refractory organic pollutants, which seriously threaten ecological environment and human health. As an eco-friendly and efficient technology, photocatalysis is a promising approach for wastewater purification. Nevertheless, the rapid recombination of photogenerated carriers greatly limits the practical application of conventional photocatalysts. Introducing oxygen vacancies (OVs) into photocatalysts is an effective strategy to solve this problem and improve photocatalytic activity. In this study, we facilely synthesized 0D/2D BiOBr-OVs/g-C 3 N 4 heterojunction by a one-pot solvothermal method, which was composed of zero-dimensional (0D) oxygen vacancy BiOBr-OVs and two-dimensional (2D) g-C 3 N 4 components. The 0D/2D heterojunction exhibited enhanced visible-light degradation for the hazardous pollutant 1-naphthoic acid. And its removal rate by 0D/2D composites was up to 76.3% after 100 min of irradiation, which was 1.61 and 1.45 times those of 2D g-C 3 N 4 and 0D BiOBr-OVs. The noticeably increased removal efficiency of 0D/2D composites for 1-naphthoic acid was attributed to the rational utilization of oxygen vacancies to promote charge carrier separation. And the tight bonding between components also contributed to photoinduced carrier migration and exerted a synergistic effect for photocatalysis. Possible degradation pathways were proposed for the intermediates via gas chromatography-mass spectrometry (GC-MS) qualitative analysis, and their toxicity was evaluated using the Toxicity Estimation Software Tool (T.E.S.T.). This paper provides an innovative approach for one-step manufacture of 0D/2D nanojunctions with oxygen vacancies, and advances to prospective organic photodegradation applications.
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JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Wang Chunlai,Li Xinbo,Zang Wanyue,Zhu Zhejiaji,Liu Zhuoqi,Ma Aijing,Lv Li
An efficient synthesis method for the NbOFFIVE-1-Ni/calcium alginate aerogel composite was reported in this study. The composite material exhibited the combined beneficial properties of both aerogels and MOFs. Calcium alginate, as the carrier of NbOFFIVE-1-Ni, endowed the aerogel with excellent mechanical strength and a synergized macroporous structure with the microporous structure of NbOFFIVE-1-Ni, resulting in a significant synergistic effect. Moreover, the composites exhibited excellent structural properties, including favorable morphology and structure, intact crystal structure, superior thermal stability, mechanical strength, and good cycling stability. The CO 2 adsorption capacity of the aerogel reached 1 mmol/g at a CO 2 concentration of 3000 ppm and a temperature of 298 K. After ten cycles of adsorption and desorption, the efficiency remained stable, indicating the significant potential of the composite for fast uptake of low-concentration CO 2 .
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INTERNATIONAL UROLOGY AND NEPHROLOGY
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2026
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IF 2.2
Chen Huihui,Zhang Guolei,Jin Jingjing,Cheng Mei Juan,Zhang Dongxue,Niu Zhezhe,Zhu Rongfang,Qian Yuetong,Liang Xiangnan,He Lei,Zhou Wei,Zhang Shenglei,Bai Yaling,Xu Jin Sheng
Purpose Vascular calcification (VC) is highly prevalent and a significant cardiovascular risk factor in patients with chronic kidney disease (CKD). Secreted frizzled-related protein 1 (SFRP1) is a secreted glycoprotein closely associated with the Wnt/β-catenin pathway which plays a crucial role in bone formation, but its function and mechanism in VC remain unknown. Methods Serum and radial artery tissues were collected from CKD patients with or without VC. The cellular model of VSMCs’ calcification was established under high-phosphate conditions in vitro. Western blot, qRT-PCR, and immunofluorescence were used to detect SFRP1 expression. The function of SFRP1 was identified by transfection with sh-SFRP1 and pCMV3-SFRP1 plasmid. Results Initially, bioinformatics analysis showed that SFRP1 expression was significantly elevated in high-phosphate-stimulated rat VSMCs. Subsequently, we discovered that the expression of SFRP1 was dramatically increased in the calcified arteries of CKD patients. Functionally, when SFRP1 was knocked down, the calcification process and the expression of Runx2 were attenuated. In contrast, SFRP1 overexpression exacerbated the β-GP-induced VSMCs’ calcification. Mechanistically, we confirmed the activation of Wnt/β-catenin signaling in the in vitro calcification model and this activation was inhibited by SFRP1 knockdown. Furthermore, when the Wnt/β-catenin signaling was enhanced with LiCl, the suppressing effect of SFRP1 knockdown on β-GP-induced osteogenic transdifferentiation of VSMCs was reversed, and calcification was promoted. Conclusion We identified that SFRP1 promoted vascular calcification in CKD partly by regulating the Wnt/β-catenin/Runx2 axis, suggesting that SFRP1 may be a potential biomarker and therapeutic target for VC in CKD.
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高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 7
·196
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IF 2.5
Cai Chang,Li Jinhong,Li Rongwu,Zhao Nan,Zhang Yue,Fan Qiuyu,Zhang Jianguo,Chen Lidong
This study addresses the limitations of conventional industrial methods for acetophenone (AP) production by developing a modified TS-1 zeolite catalyst with a predominantly interparticle micro-mesoporous architecture for the selective oxidation of ethylbenzene (EB) under mild and environmentally benign conditions. To overcome the intrinsic pore constraints of TS-1 zeolite that restrict substrate accessibility and mass transfer, a specific sequential acid-then-alkali post-treatment strategy followed by cobalt oxide impregnation was employed. This treatment sequence leads to surface enrichment of framework-like Ti species and the creation of interparticle mesoporosity, resulting in a coexisting micro-mesoporous architecture while preserving the MFI framework. Under optimized reaction conditions, the catalyst achieved 76.2% EB conversion and 74.8% AP selectivity to AP. Systematic evaluation in the EB/H 2 O 2 oxidation system under acidic reaction conditions revealed a synergistic effect between framework titanium active sites and cobalt oxide active species. The developed catalyst offers distinct advantages, including straightforward synthesis procedure, high catalytic activity, and facile recoverability. Graphical This study constructs a micro-mesoporous TS-1 via specific sequential acid-then-alkali modification and loads optimal Co 3 O 4 to create dual active centers. This architecture reduces mass transfer resistance and optimizes active sites, enabling efficient ethylbenzene oxidation to acetophenone under mild conditions. The catalyst is easily recoverable, regenerable, and stable. The alternative text for this image may have been generated using AI.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Yanqing Yang,Yuchen Yang,Zhixian Du,Weike Zhang,Jin Liu
A Z-scheme BiOBr/COF-1 heterojunction was synthesized via a solvothermal method. • The catalyst exhibited enhanced visible-light absorption and charge separation. • A mechanism for the simultaneous removal of RhB and Cr(VI) was revealed. The construction of heterojunctions is commonly employed to boost the separation efficiency of photogenerated charge carriers and the overall photocatalytic performance. In this study, a novel Z -scheme BiOBr/COF-1 heterojunction photocatalyst was synthesized via a facile solvothermal method. Comprehensive characterization confirmed the effective formation of the heterojunction, which exhibited enhanced visible-light absorption and improved separation efficiency of photogenerated charge carriers. Compared with pristine COF-1 and BiOBr, the optimized BiOBr/COF-1 composite (BC-1) demonstrated superior photocatalytic activity for both rhodamine B (RhB) degradation and Cr(VI) reduction. Notably, the reduction efficiency of Cr(VI) was significantly enhanced in a coexisting system of RhB and Cr(VI). In addition, BiOBr/COF-1 exhibited good structural stability over multiple reaction cycles. This work provides an effective strategy for designing Z -scheme photocatalysts to treat complex wastewater containing organic and heavy metal pollutants. Download: Download high-res image (339KB) Download: Download full-size image
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GREEN CHEMISTRY
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2026
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IF 10.6
Huilin Li,Xuechong Ding,Teng Zhou
Water-lean solvents are promising alternatives to aqueous amines for post-combustion CO2 capture due to their lower regeneration energy. However, the majority of state-of-the-art water-lean solvents rely on 1-methyl-2-pyrrolidone (NMP) as the organic cosolvent, whose reproductive toxicity poses a serious barrier to large-scale deployment. This study proposes a systematic strategy to identify green, low-toxicity replacements for NMP in water-lean solvents. Based on COSMO-RS σ-profile similarity calculation, 20 high-potential candidates were first identified from 2562 organic solvents. Subsequent environmental, health, and safety (EHS) evaluations, combined with physicochemical property filtering, narrowed the selection to two green cosolvents: methylaminoacetaldehyde dimethyl acetal (MAADMA) and 3-methoxy-1-butanol (MOB). These two candidates and NMP were then experimentally validated in combination with three representative amines (EMEA, DMEDA, and DMPDA) at 5 wt% water content. Among all tested systems, the EM-A-5H solvent (30% EMEA/65% MAADMA/5% H2O) showed the best performance, with a remarkable cyclic capacity of 0.86 mol CO2 per mol amine and a regeneration efficiency of 93.6%. Importantly, EM-A-5H achieved a total regeneration energy of 2.20 GJ per t CO2, 41% lower than conventional 30 wt% MEA and 15% lower than the NMP-based counterpart solvent. It also exhibited an excellent stability and satisfactory viscosity over seven absorption–desorption cycles without performance degradation. This work offers a systematic and practical approach for the rational design of eco-friendly, high-performance water-lean solvents for CO2 capture.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
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IF 4
Haixia Han,Juanjuan Gao,Quan Sun,Dandan Tong,Jian Liu,Xiuli Yang,Jingjing Sun,Yue Cui,Juan Wang,Zuoshan Feng,Mingxi Jia
BACKGROUND Acrylamide (ACR), an environmental neurotoxicant prevalent in thermally processed foods, contributes to brain injury via oxidative stress and neuroinflammation. The cumulative effects of long-term low-dose exposure are particularly alarming. As a traditional food ingredient, the inflorescence of Coreopsis tinctoria Nutt. is rich in polyphenolic compounds that exhibit significant anti-inflammatory and antioxidant properties. This study systematically evaluated the neuroprotective potential of Coreopsis tinctoria Nutt. polyphenols (CTNP) against chronic low-dose ACR exposure in mice. RESULTS Behavioral analyses demonstrated that CTNP (0.25–1.00 g kg −1 ) significantly ameliorated ACR-induced gait abnormalities and restored voluntary activity. CTNP mitigated neuronal misalignment and loss of synaptic density in the hippocampal CA1/CA3 regions and markedly reduced serum levels of brain injury markers MBP and GFAP by 30.6% and 41.7%, respectively. Mechanistic investigations revealed that CTNP attenuated oxidative damage via activation of the Nrf2/HO-1 pathway, leading to decreased brain reactive oxygen species and malondialdehyde levels while enhancing catalase, superoxide dismutase and glutathione peroxidase activities. Furthermore, CTNP suppressed MAPK pathway-mediated neuroinflammation, reducing pro-inflammatory factors such as COX-2, TNF- α and IL-1 β . CONCLUSION These findings demonstrate that CTNP, as diet-derived bioactives, mitigate ACR neurotoxicity through coordinated modulation of Nrf2/HO-1 antioxidant and MAPK anti-inflammatory pathways, supporting their potential as a functional food component for preventing environmental toxicant-associated neural damage. © 2026 Society of Chemical Industry.
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PHYTOMEDICINE
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2026
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IF 11.3
Chunge Zhang,Shuai Huang,Wenxin Zhang,Hongbo Teng,Yuna Shao,Yihua Zhang,Shihang Ren,Qi Wu,Yan Zhao,Zhaowei Yan
Background Acanthopanax sessiliflorus ( A. sessiliflorus ) extract has been used in various traditional Chinese medicines and compound preparations for the treatment of arrhythmia. Our preliminary studies have demonstrated that A. sessiliflorus extract exerts significant protective effects against arrhythmia induced by barium chloride. The present study aims to elucidate the bioactive components of A. sessiliflorus and to investigate the underlying mechanisms by which it mitigates barium chloride-induced arrhythmia. Methods Network pharmacology was employed to predict the pharmacological profiles of chemical constituents from A. sessiliflorus, followed by a systematic screening of their biological activities. Subsequently, a barium chloride-induced arrhythmia model was established, and the potential therapeutic mechanisms were analyzed using transcriptomics. Functional and histopathological analyses of the rat hearts were performed. Western blot was used to detect the expression levels of the Nrf2/HO-1 axis, connexins, ion channels, and autophagy-related proteins in myocardial tissue and NRVMs. Subsequently, PCR, immunofluorescence, co-immunoprecipitation, and molecular docking were employed to verify the involvement of the targets in the intervention of arrhythmia. Results The results showed that after treatment with divaroside, the arrhythmia and redox system imbalance induced by BaCl₂ in rats were significantly restored. Divaroside can inhibit calcium overload by regulating the expression levels of RyR2 and SERCA2a in the sarcoplasmic reticulum, serving as a means to alleviate arrhythmia. In addition, we have confirmed that autophagy plays a crucial role in arrhythmia, and divaroside can activate autophagy, thereby protecting cardiomyocytes from BaCl₂-induced damage. Finally, it was confirmed that divaroside can weaken the interaction between the Keap1-Nrf2 complex and promote the nuclear translocation of Nrf2, activating the Nrf2/HO-1 axis and regulating the aforementioned pathways to counteract arrhythmia. Conclusion This study suggests that divaroside prevents the occurrence of arrhythmia by activating autophagy and reducing abnormal calcium ion homeostasis through the Nrf2/HO-1 axis.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Yue Hu,Tiancong Liu,Yahan Zhang,Mengmeng Ding,Guang Shi,Haiying Su,Jian Guan,Xinyu Fan
L-type amino acid transporter 1 (LAT1) is essential for the transport of large neutral amino acids (AA) across the blood–brain barrier (BBB), which plays a crucial role and is widely employed in brain drug delivery. Thus, in this study, tryptophan (Trp), leucine (Leu) and tyrosine (Tyr) were selected and various amino acid grafted chitosan (CTS) was first synthesized and characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) spectrum. Furthermore, oxytocin (OT) loaded polyelectrolyte complex (PEC) based on various amino acid grafted chitosan and chondroitin sulfate (CS) as well as OT loaded chitosan-chondroitin sulfate PEC was fabricated and optimized by particle size, zeta potential and encapsulation efficiency (EE%). The morphologies and OT conformation stability of different PEC formulations were investigated by transmission electron microscopy (TEM) and circular dichroism (CD) spectroscopy respectively. Moreover, to further reveal the superiority of amino acid grafted chitosan PECs on mucosal permeation and brain targeting via LAT1 transporter, the ex vivo permeation study, in vivo pharmacokinetics behavior as well as brain distribution of OT in different PECs were also carried out by intranasal administration. It was found that both chitosan-chondroitin sulfate and amino acid grafted chitosan-chondroitin sulfate PECs exhibited comparable particle size ranging from 180 to 210 nm with a positive charge. The PEC formulation presented a sustained release behavior compared to the OT solution and better nasal mucosal permeation was observed for amino acid grafted chitosan-chondroitin sulfate PECs. Both pharmacokinetics behavior and brain distribution results demonstrated that amino acid grafted chitsaon could significantly improve the OT absorption and brain accumulation in the order of Trp > Tyr > Leu, compared to naked chitosan-chondroitin sulfate PECs and OT solution. The behavioral and immunofluorescence results also revealed that amino acid grafted chitosan-chondroitin sulfate PECs exhibited a superior inhibitory effect on oxycodone (Oxy) addiction. In conclusion, amino acid grafted chitosan-chondroitin sulfate PECs could significantly promote brain drug transportation and could be a potential vehicle for protein or peptide delivery via nasal to brain pathway.
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高影响因子
ACS Applied Polymer Materials
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2026
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IF 5.2
Kavya Adot Veetil,Senthil Kannan,Eun Kyu Sun,Md. Homayun Kabir,Ook Choi,Tae-Hyun Kim
Integrating nanomaterials with tunable surface functionalities into polymer matrices offers a promising route for developing high-performance mixed matrix membranes (MMMs). Among these, graphitic carbon nitride (g-C3N4) facilitates gas transport and enhances membrane permeability due to its intrinsic nanopores. However, while improving the CO2 permeability, pristine g-C3N4 often compromises the CO2/CH4 selectivity. To address this trade-off, iron-doped g-C3N4 (Fe-g-C3N4) was incorporated into a polymer of intrinsic microporosity (PIM-1), possessing a high free volume and excellent gas diffusion characteristics. Iron doping served to increase the CO2-philicity of g-C3N4 and strengthen its interaction with the CO2 molecules, thereby improving both permeability and selectivity. The resulting Fe-g-C3N4/PIM-1 MMMs demonstrated enhanced CO2 permeability and CO2/CH4 selectivity, indicating their potential for use in CO2 separation applications. Incorporating 0.5 wt % Fe-doped g-C3N4 into the PIM-1 matrix led to a 38.5% increase in CO2 permeability compared to pristine PIM-1 and a 12.7% improvement over the undoped g-C3N4-based MMM. While undoped g-C3N4 reduced the CO2/CH4 selectivity, Fe doping had the reverse effect, enhancing the selectivity by 7.2% relative to the undoped system. Notably, the Fe-g-C3N4/PIM-1 MMMs approach the 2008 Robeson upper bound for the CO2/CH4 separation. In addition, the membrane exhibited improved mechanical strength and antiaging and antiplasticization characteristics, collectively outperforming pristine PIM-1.
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高影响因子
npj Science of Food
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2026
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IF 9.7
Shen Linyuan,Ma Jianfeng,Liang Shuang,Yang Yiting,Liao Tianci,Lei Yuhang,Chen Lei,Wang Yan,Zhao Ye,Niu Lili,Gan Mailin,Zhu Li
Diet derived extracellular vesicles (EV) can be absorbed and influence physiological processes. Herein, this study investigates the potential health impacts of extracellular vesicles in meat products. Experimental results showed the extracellular vesicles derived from cooked red meat (RM-EV) and white meat (WM-EV) were successfully isolated via ultra-high speed centrifugation. The median particle size of RM-EV is 137.5 nm and that of WM-EV is 116.1 nm. RM-EV and WM-EV are added to the drinking water of mice for ten weeks. The mice developed insulin resistance and abnormal lipid metabolism in the liver. The influences of RM-EV are more pronounced for mice than WM-EV. High-throughput sequencing indicated that ssc-miR-1 (52.05%) and scc-miR-133a-3p (14.21%) are the most abundant microRNA in RM-EV. However, the highest content of microRNA is gga-miR-133a-3p (44.16%) in WM-EV, followed by gga-miR-1 (21.58%). Therefore, the most abundant ssc-miR-1 in red meat EV (RM-EV-miR-1) was selected for in vitro studies. In vitro experiments revealed that RM-EV-miR-1 inhibited cell proliferation by targeting IGF1 in NCTC1469 liver cell. Besides, RM-EV-miR-1 exacerbates insulin resistance in NCTC1469 insulin resistance cell model by targeting PI3K/AKT signaling pathway. Our findings show that the differential health impacts of red and white meat may be partially attributed to the presence of EV. These results provide novel insights into dietary health from the perspective of EV.
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