AQUACULTURE
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2026
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IF 4.4
Jialong Huang,Guohao Chen,Tingyu Wei,Xuemin Wei,Yinghui Wang,Aiguo Huang
Streptococcus agalactiae (Group B Streptococcus, GBS) is one of the most harmful pathogens in aquaculture and its virulence is mainly regulated by the LuxS/AI-2 quorum sensing (QS) system. Developing quorum sensing inhibitors (QSIs) targeting the GBS LuxS protein is not prone to inducing drug resistance, which is of great significance for addressing the antimicrobial resistance crisis in aquaculture. This study identified naringin, a potential LuxS inhibitor with anti-GBS virulence activity, from plant-derived natural products through virtual screening combined with experimental verification. The results showed that naringin bound tightly to the entrance of the GBS LuxS active pocket and effectively inhibited luxS gene transcription. This dual action may reduce AI-2 signal molecule synthesis through both potential steric hindrance at the active site and transcriptional inhibition. At sub-inhibitory concentrations, naringin did not inhibit bacterial growth. Instead, it downregulated key virulence genes, significantly suppressed EPS secretion, and disrupted the biofilm barrier, thereby attenuating bacterial virulence. The results of in vivo challenge experiments showed that naringin intervention significantly alleviated histopathological damage in infected hosts and effectively improved the survival rate after infection. This protective effect may be closely associated with the ability of naringin to inhibit the colonization and dissemination of GBS in the host spleen and brain tissues, while downregulating host pro-inflammatory gene expression and upregulating antioxidant gene expression. This study confirmed that naringin can effectively disrupt the GBS LuxS/AI-2 quorum sensing system and exert significant anti-virulence effects. It also provides a new candidate drug and theoretical basis for the green prevention and control of GBS infection in aquaculture.
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高影响因子
Frontiers in Microbiology
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2026
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IF 5.8
Nesreen Aljahdali
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine (HCA) that is formed during high-temperature meat cooking, especially grilling, and is classified as a carcinogenic food-borne compound that can impact multiple physiological systems. The aim of this study was to evaluate how exposure to PhIP affects the composition of the cecal microbiota in mice. A total of 32 mice were randomly divided into four groups: A negative control group, a positive control group, and two groups treated orally with either 10 or 20 mg/kg PhIP for 2 months. The V3-V4 regions of the bacterial 16S rRNA gene were sequenced to characterize the cecal microbial communities. Microbial richness and diversity decreased in the PhIP-treated mice compared to the negative control group. At the phylum level, the relative abundance of Bacillota and Actinomycetota decreased significantly after PhIP exposure, while the abundance of Campylobacterota and Bacteroidota increased. At the genus level, the abundance of Roseburia, Lactobacillus, and Bifidobacterium decreased, while the abundance of Blautia, Lachnospiraceae-NK4A136 group, Bacteroides, Alistipes, Helicobacter, and Escherichia–Shigella increased. The results highlight that bacterial community composition and its relative abundance in the cecum change with PhIP exposure and offer further evidence of microbiota dysbiosis that occurs with PhIP exposure.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2026
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IF 7.1
Mengxuan Deng,Xu Kang,Shan Qiu,Huijing Wang,Chi Xu,Jie Qiu,Jizhou Jiang
Iron-enriched sludge generated from A-stage chemical capture in two-stage adsorption/bio-oxidation (A/B) wastewater treatment contains concentrated particulate organics, iron and phosphorus, yet its acidogenic conversion behavior and phosphorus speciation remain poorly understood. This work investigated semi-continuous anaerobic fermentation of this sludge under 2-bromoethanesulfonate (BES)-assisted conditions, and calcined fermentation residuals to characterize phosphorus/iron-bearing phases and evaluate their utilization potential. BES significantly enhanced organic solubilization and acidogenesis: the maximum short-chain fatty acid (SCFA) yield reached 373.2 ± 5.0 mg COD/g VS at 4-day sludge retention time, 26.6% higher than the control, with acetic acid dominating (>70% of total SCFAs). Activities of α-glucosidase, protease and phosphotransacetylase increased by 23%–80%. Phosphorus was predominantly retained in the solid phase, with iron-bound phosphorus (Fe-P) accounting for 49.8%–78.3% (elevated to 78.3% by BES) and total phosphorus recovery exceeding 89.1%. XRD and FTIR analyses confirmed iron oxide and inorganic phosphate structures in calcined residues. These findings support simultaneous liquid-phase SCFA recovery and high-value utilization of phosphorus/iron-rich residual solids. Download: Download high-res image (112KB) Download: Download full-size image
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Hao Jiang,Wenhao Wang,Xinyi Wang,Yuchen Xu,Tao Zhu,Siyan Shang,Chaojie Zhou,Xinhua Zhou,Wenbin Zhang,Yuhua Cheng,Longchun Wang,Shaomin Zhang,Gaofeng Wang,Jingquan Liu,Minghao Wang
A PEDOT-MOF/polypeptide modified multi-modal micro-ECoG electrode is proposed. • PEDOT-MOF achieves dual functions of ROS sensing and efficient scavenging. • Polypeptide/DEX enhances electrode biocompatibility and reduces inflammation. • In vivo validation of multi-modal ECoG/ROS recording and immunomodulation The limited biocompatibility of conventional flexible electrode materials often triggers host immune responses, manifesting as glial encapsulation and the overproduction of reactive oxygen species (ROS). Meanwhile, ROS accumulation further exacerbates local inflammation and induces irreversible cellular damage. Therefore, constructing a highly biocompatible electrode-tissue interface and developing multi-modal microelectrodes capable of recording and regulating in-vivo ROS concentrations are critical for alleviating immune responses and clarifying the underlying mechanisms of electrode failure. In this work, we proposed a novel modification strategy for micro-electrocorticography (micro-ECoG) electrodes to enable multi-modal neural recordings (ECoG and ROS) and regulations (drug deliver and ROS catalyze). For this purpose, the electrode surface is modified with Cu-metal-organic framework (Cu-MOF)-doped poly(3,4-ethylenedioxythiophene): polystyrenesulfonate (PEDOT:PSS), denoted as PEDOT-MOF. Additionally, a highly biocompatible polypeptide coating loaded with anti-inflammatory drugs is introduced to further suppress immune reactions. In vitro experiments reveal that PEDOT-MOF exhibits excellent electrochemical performance and detection sensitivity to H₂O₂, indicating its multifunctionality to catalyze the ROS for mitigating oxidative stress and monitor dynamic changes in ROS concentration in real time. In vivo implantation studies confirm that microelectrodes modified with the drug-loaded polypeptide coating exhibit lower interface impedance and higher SNR. Collectively, these results highlight the significant application potential of PEDOT-MOF-modified micro-ECoG electrodes combined with a drug-loaded polypeptide coating, which may address key challenges in current implantable neural electrode technology. It should be noted that, due to partial channel attenuation over chronic implantation and spatial diffusion effects of dexamethasone, this platform is more suited for monitoring relative ROS dynamic trends. Future optimizations will further advance the capability toward accurate in-vivo ROS absolute quantification.
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高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Qingyang Li,Wei Zhu,Xiao Han,Peiyu Yang,Changhao Liu,Rubing Zou,Shuying Li,Yihua Liu,Yirong Guo
CPF and TCP showed distinct triglyceride-rich lipidomic profiles. • CPF broadly reprogrammed lipid synthesis and xenobiotic metabolism. • TCP-associated lipid disruption involved mitochondrial energy dysfunction. • Co-exposure increased triglyceride accumulation and expanded gene–lipid networks. Metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasingly linked to environmental chemical exposure, yet the metabolic consequences of pesticide parent–metabolite co-exposure remain poorly understood. HepG2 cells were exposed for 48 h to chlorpyrifos (CPF, 10 mg/L), its major metabolite 3,5,6-trichloro-2-pyridinol (TCP, 1.25 mg/L), or their combination (CTCP). Network toxicology was applied for hypothesis generation, followed by integrated lipidomics and transcriptomics analyses. Under the selected exposure conditions, TCP induced greater lipid-droplet accumulation than CPF despite the lower nominal concentration. Lipidomic profiling revealed that both compounds promoted triglyceride accumulation accompanied by extensive remodeling of cholesterol esters, free fatty acids, phospholipids, and sphingolipids. Transcriptomic analysis indicated that CPF elicited a broader response characterized by CYP-mediated xenobiotic metabolism and lipid-handling pathways, whereas TCP exhibited a more restricted signature associated with energy homeostasis and stress-related pathways. Functional assays further supported these distinct responses, showing that TCP exposure reduced ATP levels and increased reactive oxygen species generation, consistent with disrupted cellular energetic and redox homeostasis, while CPF increased cellular CYP1A2 protein levels. Compared with individual exposures, CTCP was associated with greater lipid accumulation and broader transcriptomic and lipidomic alterations involving membrane remodeling, altered cellular energy homeostasis, and changes in inflammation-associated lipid pathways. CPF and TCP produced distinct but overlapping MASLD-relevant lipid metabolic alterations, and their co-exposure produced greater metabolic alterations than either individual exposure under the tested conditions. These findings highlight the importance of considering pesticide metabolites and parent–metabolite co-exposure in environmental health risk assessment.
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高影响因子
APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Liang Luo,Qi Shen,Lixing Wang,Huiluan Qin,Song Lu,Yeqing Wang,Jiadi Ying,Tiancun Liu,Min Guo,Zhixin Yu
Hierarchical Co(OH) 2 /FeOOH is constructed via a facile one-step heterogeneous nucleation strategy. • Self-sacrificial FeOOH nanoneedles protects Co-based active phases under high current. • Efficient Co 2+ →Co 3+ conversion enriches high-valence active sites for accelerated OER kinetics. • The catalyst delivers an low overpotential of 275 mV at 200 mA cm −2 . • The catalyst achieves remarkable operational stability for over 450 h at 1 A cm −2 for OER. Cobalt hydroxide-based catalysts are promising candidates for electrochemical water splitting, yet their practical application in industrial electrolysis is hindered by insufficient activity under high-current conditions. Herein, we rationally construct a hierarchical Co(OH) 2 /FeOOH composite via a one-step heterogeneous nucleation strategy, where FeOOH nanoneedles are uniformly anchored on Co(OH) 2 nanosheets frameworks. The composite achieves an ultra-low overpotential of 275 mV at 200 mA cm −2 for oxygen evolution reaction (OER), with a lower Tafel slope. More notably, it maintains stability with negligible potential fluctuation over 450 h under an industrially relevant current density of 1 A cm −2 . The FeOOH promotes efficient Co 2+ →Co 3+ valence transition, while the hierarchical interfacial interactions enhance charge transfer efficiency and stabilize high-valence Co active species. A unique self-sacrificial mechanism is unveiled that preferential tip dissolution of FeOOH nanoneedles effectively protects the underlying Co-based active sites from over-oxidation and structural collapse, thereby ensuring long-term catalytic stability. Mechanistic studies further suggest that Co(OH) 2 /FeOOH exhibits enhanced lattice-oxygen-participated character relative to CoFe-LDH, which tends to follow the adsorbate evolution mechanism. This work develops a self-sacrificial interface engineering strategy to boost the activity and stability of Co(OH) 2 , and provides a feasible structural design paradigm for developing durable OER electrocatalysts toward industrial-relevant high-current conditions. A unique self-sacrificial interface engineering strategy to boost the activity and stability of Co(OH) 2 for oxygen evolution reaction. Download: Download high-res image (157KB) Download: Download full-size image
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Advanced Science
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2026
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IF 14.1
Jingdan Lei,Kai Xu,Kunpeng Zhao,Junzhuo Zhou,Haotian Gao,Yifan Yuan,Tian-Ran Wei,Min Zhu,Qihao Zhang,Franck Gascoin,Xun Shi
Thermoelectric Mg 3 (Sb, Bi) 2 has emerged as a rising star in virtue of its promising thermoelectric performance and abundant constituent elements. However, its practical application is hindered by challenges in synthesis and the strong coupling between electrical and thermal transport properties. Herein, we propose a dual-pronged strategy that combines grain boundary engineering and phonon engineering to decouple electron and phonon transport in Mg 3 (Sb, Bi) 2 . By employing a tantalum-tube encapsulated melting technique together with Cu doping, the grain size is markedly increased to ∼25 µm, effectively suppressing carrier grain boundary scattering and enabling single-crystal-like electrical transport with a high carrier mobility exceeding 200 cm 2 V −1 s −1 . Meanwhile, atomic-scale alloy disorder and nanoscale Mg 2 Cu precipitates introduce strong phonon scattering, leading to an ultralow lattice thermal conductivity of 0.36 W m −1 K −1 . Eventually, a peak zT of 1.9 at 750 K and a high conversion efficiency of 10.6% at ΔT = 488 K are achieved, demonstrating the competitive performance of these materials and devices. This study not only provides new insights into the manipulation of grain boundary scattering, but also demonstrates the great promise of Mg 3 (Sb, Bi) 2 for waste-heat harvesting.
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PubMed
高影响因子
CERAMICS INTERNATIONAL
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2026
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IF 6
Xiaolei Shi,Fuyu Li
Currently, microwave communication devices are rapidly evolving toward miniaturization, high stability, and cost-effectiveness. However, traditional microwave dielectric ceramics with moderate dielectric constants require excessively high sintering temperatures and exhibit poor microwave dielectric properties. Here, 2 wt % V 2 O 5 -modified Ba 3 Ti 4 Nb 4 O 21 (BTN) ceramic is prepared via solid-state reaction method. The sintering temperature of the BTN ceramic is successfully reduced from 1270°C to 975°C. This ceramic exhibits excellent microwave dielectric properties ( ε r = 47 (@5.78GHz), Q × f = 15,841 GHz (@5.78GHz), τ f = + 14.3 ppm/°C). Using XRD, SEM, EDS, Raman spectroscopy, and first-principles calculations, the changes in the microwave dielectric properties of BTN ceramics and their effects are elucidated. Based on this ceramic, a slot-coupled side-fed cylindrical dielectric resonant antenna was designed and investigated by full-wave electromagnetic simulation. The simulated antenna achieves excellent impedance matching and polarization isolation while maintaining a compact size: simulated center frequency is 6.74 GHz, BW = 200 MHz, and S 11 = -36.26 dB. This work demonstrates that BTN + 2 wt % V 2 O 5 microwave dielectric ceramics hold great potential for development in the field of 5G microwave communications.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Chengcheng Yang,Zerui Zhang,Xueqing Gao
A coral-like Mn 3 O 4 -Ni 2 P/Ni(PO 3 ) 2 heterostructure material is designed for electrocatalytic water and seawater splitting. • The construction of Mn 3 O 4 -Ni 2 P/Ni(PO 3 ) 2 heterostructure regulate the electronic structure and expand more reactive sites. • Both Mn 3 O 4 and Ni(PO 3 ) 2 lower the adsorption energy of Cl − , inhibiting the Cl − oxidation side reaction. • As both anode and cathode, Mn 3 O 4 -Ni 2 P/Ni(PO 3 ) 2 demonstrates stable operation over 200 h. • The generation of phosphate effectively avoid the impact of chlorine evolution during seawater electrolysis. Seawater splitting represents a highly viable method for sustainable hydrogen generation. Nevertheless, the substantial energy demands involved in seawater electrolysis present considerable obstacles, primarily stemming from the chlorine evolution reaction (CER) and the suboptimal hydrogen generation. In this study, multi-component synergistic Mn 3 O 4 -Ni 2 P/Ni(PO 3 ) 2 heterostructure nano-coral catalyst was prepared by a gentle two-step method. It exhibits excellent corrosion resistance and electrochemical performance during alkaline seawater splitting. The generation of phosphate on its surface can effectively avoid the impact of CER during seawater electrolysis. Moreover, as both the anode and cathode, it demonstrates exceptional stability, maintaining consistent performance over 200 h. The Mn 3 O 4 -Ni 2 P/Ni(PO 3 ) 2 heterogeneous structure efficiently controls its electronic structure and expands its reactive regions. This work introduces an innovative design approach for catalysts, revealing their substantial potential for practical seawater splitting applications. Download: Download high-res image (32KB) Download: Download full-size image
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AICHE JOURNAL
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2026
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IF 4.4
Yaxing Zhang,Liju Bai,Xiaotong Jiang,Yimin Deng,Helei Liu
Mass transfer performance is an important design criterion for the absorption of CO 2 by amines in packed columns. In this paper, the effects of diethylenetriamine (DETA)–1-dimethylamino-2-propanol (1DMA2P)–H 2 O biphasic solvent on the total mass transfer coefficient ( K G a v ) of different operating parameters (liquid flow rate, gas flow rate, liquid temperature, CO 2 partial pressure, and CO 2 loading) were investigated in a mesh-structured (DX) packed column. The mass transfer mechanism of this biphasic solvent to capture CO 2 was assessed by determining the control step of mass transfer. In addition, the experimental data were compared with two empirical models, the Sheng model and the modification, and the results showed that the modification could better fit the experimental results. Further analysis was conducted on the differences in packed column design among several different amine systems and the DETA–1DMA2P–H 2 O system. The findings revealed that the DETA–1DMA2P–H 2 O system required the least column volume, highlighting its strong potential for industrial application.
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Small
·
2026
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IF 11.8
Xinyi Han,Ziliang Deng,Yongping Yang,Zipeng Zhao
Self-supported electrodes represent a promising anode architecture for anion exchange membrane water electrolyzers; however, their practical implementation is hindered by an insufficient understanding of their formation mechanisms and the consequently limited catalytic efficiency and stability. In this work, we developed a self-supported electrode comprising a composite catalyst of β-Ni(OH) 2 and NiFe layered double hydroxide (LDH), grown on nickel felt (denoted as Ni(OH) 2 /NiFe-LDH/NFt) via a one-step hydrothermal process. We systematically investigated and clarified the role of NH 4 F in governing the synthesis of self-supported Ni(OH) 2 /NiFe-LDH/NFt. The coordination effect of F − with Fe 3+ and etching effect of NH 4 + on the surface oxide layer of nickel felt leads to favorable heterogeneous nucleation. Moreover, the etching effect provides an additional Ni source that favors the deposition of Ni(OH) 2 on NiFe-LDH. However, excess NH 4 + leads to the formation of Ni-based complex compounds in solution during the hydrothermal process and suppresses the deposition of Ni(OH) 2. When applying as the Ni(OH) 2 /NiFe-LDH/NFt anode catalyst in practical anion exchange membrane water electrolysis, it requires only 1.81 V to deliver 1.0 A cm −2 and exhibits outstanding durability, with no noticeable performance decay after 750 h of continuous operation at 0.5 A cm −2 .
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PubMed
高影响因子
ACS Applied Materials & Interfaces
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2026
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IF 7.8
Juan Tao,Xinrui Lu,Yuning Wei,Jiayi Feng,Jinlong Yang,Jianping Qi
Oral delivery of peptide therapeutics remains challenging due to gastrointestinal degradation, poor epithelial permeability, and extremely low bioavailability. To address these limitations, we developed an enteric solid formulation based on sorbic acid–choline ionic liquids (ILs) for the oral delivery of semaglutide (Sema), a glucagon-like peptide-1 (GLP-1) analogue. The IL-based enteric system was designed to enhance peptide stability, reduce gastric degradation, and promote intestinal absorption. In vitro studies demonstrated strong resistance to acidic conditions and pH-responsive release in simulated intestinal fluid. In vivo imaging further revealed prolonged intestinal retention of the IL-loaded enteric particles. Pharmacokinetic evaluation showed a 2.3-fold increase in maximum plasma concentration compared to the reference Rybelsus. In type 2 diabetes mellitus (T2DM) mice, the formulation achieved glucose-lowering efficacy comparable to subcutaneous Sema administration, with additional improvements in hepatic histology. Importantly, repeated-dose studies indicated favorable systemic and gastrointestinal tolerability under the tested conditions. Collectively, these results demonstrate that IL-based enteric formulation enhances oral peptide exposure while maintaining safety, offering a promising strategy for noninvasive T2DM management.
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PubMed
高影响因子
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