Frontiers in Microbiology
·
2021
·
IF 5.64
Long Gao,Hu Yuting,Tao Enfu,Chen Bo,Shu Xiaoli,Zheng Wei,Jiang Mizu
The intestinal microbiota has emerged as a critical regulator of growth and development in the early postnatal period of life. Cesarean section (CS) delivery is one of the strongest disrupting factors of the normal colonization process and has been reported as a risk factor for disorders in later life. In this study, we dynamically and longitudinally evaluated the impact of CS on the initial colonization pattern and development of gut microbiota by 16 healthy Chinese infants with fecal samples collected at 9 time points (day 5, day 8, day 11, week 2, week 4, week 6, week 7, month 2, and month 3) during the first 3 months of life. The V3–V4 regions of 16S rRNA gene were analyzed by Illumina sequencing. In comparison with vaginally delivered (VD) infants, infants born by CS showed decreased relative abundance of Bacteroides and Parabacteroides and enrichment of Clostridium_sensu_stricto_1, Enterococcus, Klebsiella, Clostridioides, and Veillonella. Most interestingly, Firmicutes/Bacteroidetes ratio was found to be significantly higher in the CS group than in the VD group from day 5 until month 3. Besides, the results of microbial functions showed that the VD group harbored significantly higher levels of functional genes in vitamin B6 metabolism at day 5, day 8, week 2, week 4, week 6, week 7, month 2, and month 3 and taurine and hypotaurine metabolism at day 5, while the phosphotransferase system and starch and sucrose metabolism involved functional genes were plentiful in the CS group at day 11, week 2, week 4, week 6, week 7, and month 2 and at week 2, week 7, and month 2, respectively. Our results establish a new evidence that CS affected the composition and development of gut microbiota in the first 3 months and provide a novel insight into strategies for CS-related disorders in later life.
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高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Zhenyuan Shi,Shuanghui Li,Bolin Chen,Zihan Chen,Tao Li,Yingxue Chen,Dandan Wang,Liming Lin,Jun Gao,Jingzheng Weng,Minquan Tian
To enhance the lithium ion transport properties of solid polymer electrolytes, a novel lithium salt—poly(acrylic acid)–boric acid–anhydrous lithium hydroxide–oxalic acid composite (LiPAAOB)—was designed and synthesized. This composite lithium salt was introduced into a polymer system with polyvinylidene fluoride (PVDF) as the matrix, along with LiTFSI, and NASICON-structured Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) was added as an inorganic filler. The resulting solid polymer electrolyte (SPE) exhibits a three-dimensional ion conduction network. LiPAAOB, with its rich carboxyl and borate ester structures, effectively stabilizes anions, increases lithium salt dissociation, and promotes the ordered migration of Li + by providing continuous lithium-affinitive functional groups, significantly improving the Li + transference number. LATP, as an inorganic filler, forms a three-dimensional spatial framework in the polymer system, offering more pathways for Li + migration. This solid polymer electrolyte achieved an ion conductivity of up to 2.34 × 10 −3 S·cm −1 , a Li + transfer number of 0.7 and an enlarged electrochemical window of 5.3 V (vs. Li + /Li), exhibiting excellent electrochemical reversibility. The assembled LiFePO₄|LiPAAOB@LATP SPE|Li full cell retained 90.2 % of its capacity after 500 cycles at 1C rate, and the Li symmetric cell operated stably for over 1800 h at a current density of 0.2 mA·cm −2 , demonstrating excellent interface compatibility and dendrite suppression capability.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Zhangxing He,Yingqiao Jiang,Jing Zhu,Yuehua Li,Zhen Jiang,Huizhu Zhou,Wei Meng,Ling Wang,Lei Dai
In this paper, LiTi 2-x Sn x (PO 4 ) 3 /C (x = 0, 0.2, 0.3, 0.4) composites were synthesized by sol-gel approach, and were investigated as anodes for aqueous lithium ion battery . Sn doping with proper content has no obvious influence on phase and morphology of the composite, while excessive dosage of Sn can affect its crystal structure. Sn doping can enhance the electrochemical properties of LiTi 2 (PO 4 ) 3 /C (LC). Among LiTi 2-x Sn x (PO 4 ) 3 /C composites, LiTi 1.7 Sn 0.3 (PO 4 ) 3 /C (LC-Sn-0.3) demonstrates the best electrochemical properties. Most importantly, the rate performance of LC can be improved dramatically by Sn doping on Ti sites. LC-Sn-0.3 delivers a discharge capacity of 118.9, 115.3, and 104.2 mAh g −1 at 0.2, 6, and 20 C (1 C = 150 mA g −1 ), respectively, with significant increase of 15.2, 27.4, and 41.9 mAh g −1 compare with LC. In addition, LC-Sn-0.3 exhibits superior cycling performance. The capacity retention for LC-Sn-0.3 can keep 76.8% after 1000 cycles at relatively high rate of 10 C, while only 51.7% of initial discharge capacity is retained for LC. Our study reveals that Sn doping on Ti sites is an efficient and facile method to improve the performance of LiTi 2 (PO 4 ) 3 /C composite for aqueous lithium ion battery.
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ChemCatChem
·
2019
·Vol. 12
·期 5
·1376-1384
·
IF 4.495
Wen-Di Guo,Lei Liu,Shu-Qing Yang,Xiao-Chao Chen,Yong Lu,Giang VO-Thanh,Ye Liu
Graphical Synergetic catalysis : The one-pot tandem bis-alkoxycarbonylation of alkynes was accomplished over the bi-functional catalytic system containing Xantphos-modified Pd-complex and Lewis super-acid of Al(OTf) 3 . Via the synergetic catalysis, the involved Xantphos-modified Pd-complex was responsible for the activation of CO and the alkynes through coordination to Pd-center while Al(OTf) 3 was in charge of the activation of the alcohol to facilitate the formation of [Pd−H] + active species. Tandem bis-alkoxycarbonylation of alkynes allows for the preparation of 2-substituted succinates from alkynes and nucleophile alcohol via two successive alkoxycarbonylation with advantages of 100 % atomic economy and simplified one-pot operation. Herein, the one-pot tandem bis-alkoxycarbonylation of alkynes was accomplished over the bi-functional catalytic system containing Xantphos-modified Pd-complex and Lewis super-acid of Al(OTf) 3 . It was found that, via the synergetic catalysis, the involved Xantphos-modified Pd-complex was responsible for the activation of CO and the alkynes through coordination to Pd-center while Al(OTf) 3 was in charge of the activation of the alcohol to facilitate the formation of [Pd−H] + active species. The in situ high-pressure FT-IR analysis, coupled with 1 H/ 13 C NMR spectral characterizations, confirmed that the introduced Al(OTf) 3 with intensive oxophilicity (via acid-base pair interaction) was able to activate nucleophilic MeOH to be a reliable proton-donor ( i. e . hydride-source) to warrant the formation and stability of [Pd−H] + species upon the oxidation of Pd 0 by H + (Pd 0 +H + →[Pd II −H] + ). Over the developed bi-functional catalytic system, the yields of the target diesters were obtained in the range of 36∼86 % in this sequence with the wide substrate scope.
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Cell and Bioscience
·
2025
·Vol. 15
·期 1
·159
·
IF 6.2
Sun Weikang,Zhang Mengyu,Wang Ruilin,Yang Jie,Rasool Ameena Tur,Luo Renjie,Liu Xiangdong,Cao Peng,Li Erguang
Background The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in virus infection is undefined. Results We show that genetic ablation of PTBP1 renders cell resistant to herpes simplex virus 1 (HSV-1) infection. HSV-1 utilizes 3-O-sulfated heparan sulfate proteoglycans (HSPGs) for attachment and for infection of epithelial cells. We found that knockout of PTBP1 expression resulted in loss of HS3ST3A1 and HS3ST3B1, heparan sulfate glucosaminyl 3-O-sulfotransferase genes for 3-O-sulfation of the heparan sulfate (HS) chains of HSPGs. Each of the HS3ST3A1/HS3ST3B1 genes is composed of 2 exons separated by an extraordinarily long intron whose removal requires PTBP1-associated looping. We found that PTBP1 interacted with the intronic region of HS3ST3A1/HS3ST3B1 pre-mRNAs and modulated their processing to mRNA. The essential role of PTBP1 in functional HS3ST3A1 expression and in HSV-1 infection was demonstrated by ectopic re-expression in the knockout (ko) cells. In addition, we showed that targeting PTBP1 expression by microRNA mimics reduced disease symptoms in a mouse herpetic stromal keratitis (HSK) model. Conclusions The results demonstrate that PTBP1 mediates HSV-1 infection of epithelial cells through splicing regulation of HS3ST3A1/HS3ST3B1. These studies provide a new area for novel therapeutic strategies through splicing regulation. Graphical abstract By Sun et al. RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression.
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DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 32
·10630-10634
·
IF 4.029
Mei-Yan Gao,Shumei Chen,Lan-Xia Hu,Lei Zhang,Jian Zhang
Four titanium-oxo-clusters with cyclohex-3-ene-1-carboxylate (Cec) ligands, Ti6(μ2-O)2(μ3-O)2(Cec)4(OiPr)12 (PTC-91; HOiPr = isopropanol), Ti6(μ3-O)6(Cec)6(OiPr)6 (PTC-92 and PTC-93) and H2[Ti18(μ2-O)11(μ3-O)14(Cec)20(OiPr)4] (PTC-94), have been solvothermally synthesized under different conditions, respectively. These clusters with the same Cec ligand show totally different structures, and they are stable in water and other common solvents. The Ti6 clusters with different conformations are presented in PTC-91, PTC-92 and PTC-93, while PTC-94 is an unusual Ti18 cluster. The photocatalytic studies reveal that PTC-91 and PTC-94 have good H2 evolution ability.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xuan Wang,Shuo Huang,Benben Wei,Min Liu,Bo Yang,Ruoqing Liu,Hongyun Jin
All-solid-state batteries with oxide electrolytes and high-nickel layered oxide cathodes (LiNixCoyMnzO2 and LiNixCoyAlzO2, x + y + z = 1, x ≥ 60%) have received widespread attention owing to their high energy density and high safety. However, they generally suffer from interfacial structural instability when coupled with solid-state electrolytes, which strongly diminishes the longevity of the battery. In this work, we propose adding a sacrificial additive C60 to the catholyte buffer layer between Li1.4Al0.4Ti1.6(PO4)3 (LATP) and LiNi0.8Co0.1Mn0.1O2 (NCM811) to enhance the electrochemical stability under high-voltage operating conditions. A uniform and robust cathode–electrolyte interphase (CEI) film enriched with LixPOyFz, LiPxFy, and C60Fn is spontaneously formed on the surface of the cathode particles. In addition, the NCM811/Li solid-state battery delivers a discharge capacity of 150.3 mAh g–1 with a retention of 85% after 200 charge–discharge cycles at 0.5 C. This study offers a practical approach toward realizing LATP-based all-solid-state high-voltage batteries characterized by exceptional cycling stability.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Jing Jiang,Chenyang Zhang,Meng Na,Shangqi Xu,Xiaoping Li,Shoubiao Zhou,Jihai Zhou
Soil cadmium (Cd) pollution has become increasingly severe, negatively affecting plant growth, soil safety, the ecological balance, and public health. Phytoremediation technology is an effective method for remediating soil Cd contamination because of its low cost, environmentally friendly nature, and minimal soil disturbance. However, phytoremediation efficiency is affected by factors such as the plant species, Cd concentration, and soil environment. In this study, a 180-day indoor potted experiment was conducted to explore the influences of various indole-3-acetic acid (IAA) levels on the growth, physiological and biochemical responses, Cd uptake, and soil enzyme activity of Cinnamomum (C.) camphora seedlings using 20 mg kg −1 Cd-contaminated soil with or without IAA treatments. The results showed that Cd stress significantly suppressed C. camphora seedling growth, whereas IAA application improved the basal diameter of seedlings by 22.22–133.33 %. This effect of IAA was observed primarily at low concentrations, while higher concentrations showed diminished effects. Compared to the Cd pollution treatment, adding 20 mg kg −1 IAA significantly enhanced the activities of antioxidant enzymes (SOD, POD, CAT), reduced the malondialdehyde (MDA) content, and decreased soil basal respiration (SBR). Moreover, IAA treatment promoted Cd uptake in the roots, stems, and leaves, and reduced the soil Cd content by 22.90–41.17 %. In conclusion, exogenous IAA addition effectively alleviates Cd stress by regulating the plant’s physiological and biochemical characteristics and soil enzyme activities. These findings suggest that the combined use of IAA and C. camphora represents a promising remediation method for soil heavy metal pollution.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Chunjuan Wang,Qin Guo,Ao Gao,Jingmei Zhang,Hailong Wan,Qianchen Liu,Junli Song
A smartphone-assisted fluorescent and colorimetric detection method for nitrite based on 2,3-diaminonaphthalene (DAN) and gold nanoclusters (AuNCs) paper strip was developed. DAN reacts with NO 2 - via a coupling reaction under acidic conditions to generate naphthotriazole (NAT), emitting strong blue fluorescence at 435 nm. The red fluorescence of AuNCs at 650 nm is quenched by the reduction of nitrite. The ratio of fluorescent intensity (I 435 /I 650 ) exhibits a good linear relationship with NO 2 - concentration (0.01–9.0 μg/mL), with LOD and LOQ of 2.3 μg/L and 8.7 μg/L, respectively. The fluorescent detection mode was successfully applied to the determination of nitrite in water and food samples, with recoveries ranging from 80.0 % to 103.0 %. Furthermore, a smartphone-integrated paper strip platform was designed for on-site colorimetric analysis. It was noteworthy that the strip's fluorescence color transitions dynamically from red to blue under ultraviolet light, thereby enabling visual semi-quantification.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2024
·
IF 6.3
Yanqing Wang,Mengzhu Li,Dongchen Guo,Min Fan,Jingjun Zhang,Juan Guo,Hongzhan Dong,Chengwu Shi
Antimony selenosulfide (Sb 2 (S,Se) 3 ) solar cells hold significant promise for sustainable photovoltaic technology due to their adjustable band gap, high absorption coefficient and good stability. In terms of device operation, the transfer of electrons from the Sb 2 (S,Se) 3 layer to the electron transport layer (ETL) plays a crucial role in improving the photovoltaic performance of solar cells. Until now, high-efficiency Sb 2 (S,Se) 3 solar cells have typically employed cadmium sulfide (CdS) as the ETL. However, inadequate interface contact between the CdS and the Sb 2 (S,Se) 3 layer often results in severe interface recombination, and the parasitic light absorption of CdS restricts the short-circuit current density ( J sc ). Therefore, the development of high-quality CdS film along with reduction of cadmium element usage remains an import issue for the Sb 2 (S,Se) 3 solar cells. Herein, the poly(acrylic acid)-modified tin oxide (PAA-SnO 2 )/CdS double ETLs are introduced to improve the quality of both the CdS film and Sb 2 (S,Se) 3 film, while also strengthening the interface contact between CdS and Sb 2 (S,Se) 3 . The power conversion efficiency of the corresponding solar cells increases from 7.45% in the control device to 8.15% in the modified device. This work provides a simple PAA-modified SnO 2 -assisted CdS ETL strategy to improve the interface of CdS/Sb 2 (S,Se) 3 , thereby achieving efficient and stable Sb 2 (S,Se) 3 solar cells.
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Advanced Energy Materials
·
2023
·Vol. 14
·期 3
·2303063
·
IF 27.8
Junhua Zhou,Chi Zhang,Chuan Xie,Huimin Wang,Haining Fan,Yanpeng Guo,Chao Wang,Fan Chen,Yichun Ding,Qiyao Huang,Zijian Zheng
Lithium–sulfur battery (LSB) possesses high theoretical energy density, but its poor cycling stability and safety issues significantly restrict progress in practical applications. Herein, a low-cost and simple Al(OH) 3 -based modification of commercial separator, which renders the battery outstanding fire-retardant and stable cycling, is reported. The modification is carried out by a simple blade coating of an ultrathin composite layer, mainly consisting of Al(OH) 3 nanoparticles and conductive carbon, on the cathode side of the separator. The Al(OH) 3 shows strong chemical absorption ability toward Lewis-based polysulfides and outstanding fire retardance through a self-decomposition mechanism under high heat, while the conductive carbon material acts as a top current collector to prevent dead polysulfide. LSB using the Al(OH) 3 -modified separator shows an extremely low average capacity decade per cycle during 1000 cycles at 2 C (0.029%, 1 C = 1600 mA g −1 ). The pouch cell exhibiting high energy density (426 Wh kg −1 ) can also steadily cycle for more than 100 cycles with high capacity retention (70.2% at 0.1 C). The effectiveness and accessibility of this Al(OH) 3 modification strategy will hasten the practical application progress of LSBs.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2017
·
IF 3.615
Xingzhong Guo,Pengan Yin,Hui Yang
Hierarchically porous composites constructed by ZnAl-Cl type layered double hydroxides (LDH) nanosheets and amorphous Al(OH) 3 nanosheets were synthesized via a facile sol-gel route for the adsorption of two typical anionic dyes Methyl Orange (MO) and Congo Red (CR) from aqueous solutions. The micro-macrostructure and adsorption properties of hierarchically porous ZnAl-LDH/Al(OH) 3 composites before and after calcination were investigated in detail. The adsorption mechanism and adsorption–desorption cycles were also discussed. Materials characterization confirm that the resultant hierarchically porous composites possess three-dimensional macrostructure with interconnected macropores and co-continuous skeletons constructed by ZnAl-LDH and Al(OH) 3 nanosheets . Calcination at 500 °C allows the transformation from LDH composite to layered double metal oxides (LDO), while the macrostructure is basically maintained with a macropore size of 0.5 μm, a porosity of 53.1% and a BET surface area as high as 122 m 2 g −1 . Adsorption performances show that hierarchically porous composites exhibit ultrafast adsorption rates and high adsorption capacities in the removal of anionic dyes CR and MO. The maximum adsorption capacities of hierarchically porous LDH-based composites and LDO composites via calcination at 500 °C are 2348.3 and 1574.4 mg g −1 for CR and 1013.5 and 1015.1 mg g −1 for MO, respectively. XRD and FTIR results after the dyes adsorption indicate that the intercalation of MO − and CR − anions into the LDH structure via ion exchange with the pristine chloride ions group and the attachment on the external Al(OH) 3 surface determine the adsorption behavior , thus leading to an expansion of the interlayer space . And the calcined products LDO-based composites can be reversibly transformed back into the LDH structure via reconstruction procedure in the presence of dyes aqueous solution. Furthermore, the adsorption–desorption cycles confirm that the as-prepared hierarchically porous composites own excellent recyclable properties and the removal efficiency for CR and MO are 80.2% and 73.7% even after five cycles, respectively.
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