JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Hongke Li,Yunlei Zhang,Yiran Liu,Qinghua Xia,Maobin Wei,Wen Guan,Fang Wang,Yao Chen
Production of high value-added 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF) is a promising alternative to petroleum derivate of terephthalic acid. However, it is still challenging to construct efficient and easily available catalysts suitable for green production process of FDCA under base-free conditions. Herein, a natural clay mineral sepiolite supported AuPd bimetallic catalysts with varied bimetallic ratio were developed and employed for aerobic oxidation of HMF to produce FDCA under alkali-free hydrothermal conditions. Au 1.2 Pd 1 /sepiolite catalyst showed the best catalytic performance with 100% HMF conversion and 98.4% FDCA yield. The key to excellent catalytic performance benefited from synergistic effect between hydroxy-rich surface property of natural sepiolite support and the positive role of AuPd bimetallic sites in the tandem oxidation of aldehyde and hydroxyl groups. The localized electron transfer between AuPd nanoparticles and carriers was investigated by density functional theory calculations. The bimetal promoted the formation of electron-rich interfaces, modulated the local electron redistribution at the interface, and enhanced the adsorption and activation of O 2 , HMF, and the reacted formed intermediates. This work presents a promising strategy for green synthesis of FDCA as well as offers a facile way for the high-value usage of nanofibrous clay mineral.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2024
·
IF 5.8
Liqiang Zhang,Ningmin Zhu,Chaochao Wang,Rongzheng Cui,Riyi Lin
Two-step catalytic pyrolysis of Nannochloropsis sp (NS) was conducted with SBA-15 and ZSM-5. Thermogravimetric analyzer (TG) and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) were used to investigate the effects of SBA-15 and ZSM-5 on the two-step pyrolysis of NS. The comparative study showed that ZSM-5 and SBA-15 had different effects on the pyrolysis characteristic of NS because of their different property. ZSM-5 had no effects on the kinetic mechanism, but SBA-15 obviously changed DTG curves and the reaction order of the low temperature pyrolysis stage. SBA-15 increased the contents of amines and alkanes to 19.40% and 5.62% in the first step compared with those of the one-step pyrolysis (1.95% and 1.83%). Due to the stronger acid sites, ZSM-5 improved the content of olefins (33.79%) and esters (10.79%) in the first step and the contents of nitriles (11.75%) and aromatic hydrocarbons (31.01%) in the second step compared with those of one-step pyrolysis (10.61%, 5.41%, 0.00%, 8.42%). Acid catalyst had no positive effects on the generation of N-heterocyclic compounds. This study is expected to provide a reference for the efficient pyrolysis utilization of microalgae.
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Virology Journal
·
2025
·Vol. 22
·期 1
·1-14
·
IF 3.8
Liu Xianglan,Hu Jiaming,Wu Jiarui,Tian Yiru,Wang Jinbo,Wu Chunyan,Chen Qingfeng,Krall Leonard,He Yanping,Lu Qun
Background Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or antiviral drug available. Consequently, the development of effective antiviral agents is of critical importance. Methods and results In this study, a series of 41 5-cyano-2-thiacetyl aromatic pyrimidinone compounds were designed and synthesized. A cell viability-based screening for anti-murine norovirus (MNV) compounds was conducted, revealing that compound 29 (hereafter used as Co-29) exhibited antiviral activity against MNV. Co-29 demonstrated effective inhibition of MNV CW3 RNA replication, exhibiting an EC 50 of 58.22 μM. An RdRp enzyme activity assay indicated that Co-29 directly inhibits RdRp activity to both MNV and HNV. Molecular docking studies suggested that Co-29 interacts with the palm region of RdRp via hydrogen bonding with specific residues, which are conserved in RdRps across MNV and HNV norovirus variants. Conclusions In conclusion, our study suggests that the newly synthesized Co-29 may serve as a potential antiviral candidate or lead compound for future studies.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2024
·
IF 5.8
Yanlong Jia,Mengyan Wang,Bolun Li,Jiang Liu,Xueping Song,Min Wu,Yongjun Yin
To solve the long-term environmental pollution caused by black liquor and waste plastics, and achieve high-value utilization, the method about co-pyrolysis of black liquid solid and waste plastics (Polypropylene, Polyethylene) catalyzed by Mo-Ni/HZSM-5 to prepare high-quality bio-oil is studied. The results found that hydrocarbons increased from 14.92% to 42.03% as Polyethylene was co-pyrolyzed with BLS, and hydrocarbons increased from 14.92% to 41.75% as Polypropylene was co-pyrolyzed with BLS, adding plastics can significantly improve the hydrocarbons yield of black liquor. Mo-Ni/HZSM-5 acts as a hydro deoxidizer in the pyrolysis of black liquid and waste plastics, the total hydrocarbons of black liquid solid, black liquid solid& Polypropylene, black liquid solid & Polyethylene increased by 6%, 78%, and 45%, respectively. An appropriate increase of pyrolysis temperature can promote the co-pyrolysis of BLS with PP, and BLS with PE, and can increase the yield of hydrocarbons. Compared with black liquor’s pyrolysis, the yield of hydrocarbons can be increased by 59.65% and 24.52% as Polyethylene or Polypropylene is adapted to pyrolysis with black liquid solid, respectively, the high-quality bio-oil is obtained because of a large number of hydrocarbons and high hydrogen content.
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Carbon Neutrality
·
2025
·Vol. 4
·期 1
·1-9
·
IF 12.5
Yang Delong,Dai Jinhang,Du Ziting,Cao Qingya,Chen Gang,Qi Ting,Wang Weilu,Li Fukun
Since 3-acetylamino-5-acetylfuran (3A5AF) has been regarded as a promising nitrogen-containing synthon, the conversion of renewable chitin and its monomer N-acetyl-D-glucosamine (NAG) to 3A5AF is of significance. In this paper, we compared the catalytic activity of several Cl-containing compounds and found that LiCl exhibited superior performance. The effects of solvent, catalyst dosage, reaction temperature, and reaction time on the synthesis of 3A5AF were investigated. Under the optimized conditions, about 60% yields of 3A5AF were obtained in N-methyl-2-pyrrolidone (NMP) or dimethylacetamide (DMA) medium. The spent LiCl and DMA could be recycled and reused, without obvious decrease of 3A5AF yield. Moreover, the formed 3A5AF could be purified by a facile procedure. Experiment results and density functional theory (DFT) calculations revealed that homogeneous Cl − was vital for 3A5AF formation. This study provides an example for the effective conversion of chitin biomass to value-added compounds.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Litian Liu,Qing Wang,Jiacheng Liu,Xiao Chen,Yingguo Li,Danfeng Jiang,Chao Yu
The efficient conversion of fructose to 5-hydroxymethylfurfural (HMF) with high yields is challenging in biorefinery processes. In this study, we synthesized nonprecious metal WO3–SO3H catalysts with various crystalline phases using a simple hydrothermal method for HMF production from fructose. The experimental results revealed that the catalytic performance of the WO3–SO3H catalysts with different crystalline phases followed the order: o-WO3–SO3H > h-WO3–SO3H > m-WO3–SO3H > t-WO3–SO3H. In a conventional batch reactor, the o-WO3–SO3H catalyst exhibited remarkable performance, achieving an HMF yield of 99.2% and nearly complete fructose conversion after 100 min of reaction at 140 °C. When used in our developed modular microreactor, the reaction time was drastically reduced, achieving the same yield as in the batch reactor in just 20 min. This research offers a new approach for the rapid and efficient synthesis of HMF.
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MARINE CHEMISTRY
·
2025
·
IF 2.5
Yu Meng,Meng Lv,Xiao-Tong Zhang,Xiao-Yan Cao,Rong Chen,Gui-Peng Yang
The runoff input of mineral particles in coastal areas affects the migration and transformation of nutrients. Organic phosphorus (OP) has attracted much attention due to coastal eutrophication, while the migration under the influence of mineral inputs has not been understood deeply. This study investigated the sorption behavior of an OP compound (Adenosine 5’-monophosphate, AMP) on goethite, kaolin, and two mixtures of the minerals with natural sediment. FTIR spectra and surface acid-base characteristics revealed interactions presented within the mixtures. Sorption kinetics and thermodynamics experiments were carried out through batch methods. The kinetic data were described using a two-compartment first-order equation, and the sorption isotherms were well-fitted by both the Freundlich and Langmuir models. Goethite exhibited a higher sorption ability than kaolin, and the sorption was more sensitive to salinity. The sorption capacity of mineral-added sediments was significantly lower than predicted, particularly for sediments mixed with kaolin, which decreased by 57.4 %. The analysis of OP fractions during sorption revealed an obvious increase in exchangeable or loosely sorbed organic phosphorus (Ex-Po) and iron/aluminium-bound organic phosphorus (NaOH-Po), with NaOH-Po dominating. The sum of Ex-Po and NaOH-Po, as the bioavailable OP, in goethite and kaolin was estimated to be around half of the total sorption amount. Compared to the discrete original ones, the Ex-Po in the sediment with the mineral addition increased while NaOH-Po decreased after sorption, suggesting that the presence of interactions between the minerals and sediment matrix reduced their ability to retain AMP. These findings highlight the significant role of mineral-sediment interactions in altering OP sorption characteristics, with important implications for their biogeochemical fate.
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MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 17
·期 4
·1600262
·
IF 3.68
Qin Yun,Si Song Wang,Shan Xu,Jin Ping Yang,Juan Fan,Ling Lin Yang,Yue Chen,Shao Zhi Fu,Jing Bo Wu
Colorectal peritoneal carcinomatosis (CRPC) is a common systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy against CRPC is at present the preferred treatment. The aim of this study is to develop a novel hydrogel drug delivery system through the combination of 5-fluorouracil (5-FU) loaded polymeric micelles and cisplatin (DDP) in biodegradable thermosensitive chitosan (CS) hydrogel. The prepared CS hydrogel drug is a free-flowing solution at room temperature and forms a stationary gel at body temperature. Therefore, a CRPC mouse model is established to investigate the antitumor activity of CS hydrogel drug system. The results suggest that intraperitoneal administration of CS hydrogel drug can inhibit tumor growth and metastasis, and prolong survival time compared with other groups, thus improving the chemotherapeutic effect. Ki-67 immunohistochemical analysis reveals that tumors in the CS hydrogel drug group has lower cell proliferation in contrast to other groups ( P < 0.001). Furthermore, hematoxylin-eosin staining of liver and lung tissue indicates that the CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung. Hence, the work highlights the potential clinical applications of the CS hydrogel drug.
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JOURNAL OF PINEAL RESEARCH
·
2021
·Vol. 71
·期 3
·e12765
·
IF 13.007
Jinpeng Wu,Zengqi Tan,Hongjiao Li,Meixuan Lin,Yazhuo Jiang,Liang Liang,Qilong Ma,Junjie Gou,Lulu Ning,Xiang Li,Feng Guan
Melatonin helps to maintain circadian rhythm, exerts anticancer activity, and plays key roles in regulation of glucose homeostasis and energy metabolism. Glycosylation, a form of metabolic flux from glucose or other monosaccharides, is a common post-translational modification. Dysregulated glycosylation, particularly O-GlcNAcylation, is often a biomarker of cancer cells. In this study, elevated O-GlcNAc level in bladder cancer was inhibited by melatonin treatment. Melatonin treatment inhibited proliferation and migration and enhanced apoptosis of bladder cancer cells. Proteomic analysis revealed reduction in cyclin-dependent-like kinase 5 (CDK5) expression by melatonin. O-GlcNAc modification determined the conformation of critical T-loop domain on CDK5 and further influenced the CDK5 stability. The mechanism whereby melatonin suppressed O-GlcNAc level was based on decreased glucose uptake and metabolic flux from glucose to UDP-GlcNAc, and consequent reduction in CDK5 expression. Melatonin treatment, inhibition of O-GlcNAcylation by OSMI-1, or mutation of key O-GlcNAc site strongly suppressed in vivo tumor growth. Our findings indicate that melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of CDK5.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaochen Qi,Fuli Li,Chih-Huang Weng,Kai Liu,Renchuan Fu,Na Liu,Longzhen Ding
2-(2-Hydroxy-5-methylphenyl) benzotriazole (UV-P), a high-production and structurally complex benzotriazole derivative, has an uncertain degradation pathway and transformation dynamics in aquatic environments, raising concerns about its potential toxicological risks to human health and the ecological systems. This study investigated the oxidative degradation of UV-P by ferrate(VI) in aqueous solution under controlled experimental conditions. The results demonstrated that ferrate(VI) efficiently degraded UV-P under alkaline conditions, achieving a maximum removal efficiency of 91.76 % at pH 8.0. Furthermore, the influence of various environmental factors, including pH, oxidant dosages, inorganic ions (HCO 3 − , Cl − , Br − , NO 3 − , Ca 2+ , K + , Mg 2+ , and NH 4 + ), and humic acid, on the ferrate(VI)-mediated oxidative degradation of UV-P were systematically examined. The results indicated that although inorganic ions and humic acid partially inhibited the degradation process, a satisfactory degradation efficiency was still attained. The intermediate identification results indicated that the ferrate(VI)-mediated oxidative degradation of UV-P primarily proceeded via bond cleavage, oxygen atom transfer, and radical coupling reactions, resulting in the formation of cleavage products, hydroxylated derivatives, and polymeric compounds. The oxidative degradation pathway of UV-P and key reactive sites targeted in the ferrate(VI) degradation system were examined through quantum chemical methods, including analyses of atomic charge distribution and frontier electron density. The toxicity assessment highlighted the need to focus on the chronic toxicity of specific aminated degradation products. This study is essential for elucidating the degradation mechanism of the benzotriazole compound UV-P in aquatic environments and comprehensively assessing its potential biotoxicity.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Yun Lin,Xinyi Gong,Yangcan Chen,Xiaoli Wu,Dongfei Lu,Jingjing Yu,Rengui Weng,Yu Zhang,Fanan Wang,Gang Xu
The electrochemical oxidation of HMF (HMFOR) to FDCA presents a promising alternative to the anodic oxygen evolution reaction (OER) in water electrolysis, offering reduced energy consumption and enhanced safety. However, achieving efficient FDCA production is hindered by the instability of HMF in alkaline media and the critical challenge of generating and stabilizing the high-valence metal active centers required for oxidizing the less reactive alcohol group in HMF at practical rates and potentials. This study addresses this challenge by constructing a Co(OH)2/Cu(OH)2 heterostructure on copper foam (CF) via a facile two-step synthesis. Comprehensive characterization, including in situ Raman spectroscopy, reveals significant electron transfer from Co to Cu within the heterostructure. This electronic interaction elevates the oxidation state of Co, thereby facilitating the generation of high-valence CoO2 and enhancing its stability compared to that of pure Co(OH)2. Consequently, the Co(OH)2/Cu(OH)2/CF electrode exhibits a high current density of 200 mA·cm–2 at 1.4 V vs RHE in 20 mmol/L (mM) HMF, along with nearly 100% carbon balance within 60 min. Mechanistic studies confirm that the stabilized CoO2 centers promote strong adsorption of HMF, particularly activating the alcohol group for efficient oxidation to FDCA. This work provides a viable electronic structure modulation strategy for stabilizing high-valent metal centers through interfacial electronic modulation toward efficient biomass electrooxidation.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Mengchuan Li,You Zhou,Tongsheng Zhang,Rensheng Li
The sluggish advancement in technology for the recovery of rare earth elements from secondary resources can be largely attributed to an inadequate understanding of the thermodynamic properties of cerium oxide-based slag systems. This study systematically investigates the phase equilibrium of the Ce 2 O 3 -CaO-SiO 2 -5 wt% MgO quaternary system at 1500 °C and 1600 °C. High-temperature equilibrium experiments followed by rapid quenching were conducted, and phase assemblages were characterized by XRD, SEM and EPMA. For the first time, the results accurately determined the isothermal liquidus lines for the first time and identified the stable regions of key phases such as SiO 2 , Ce 2 Si 2 O 7 , CaO·2Ce 2 O 3 ·3SiO 2 , CaO·Ce 2 O 3 ·2SiO 2 , the Ce-doped dicalcium silicate (i.e., (Ca, Ce) 2 SiO 4 ), and the monticellite (i.e., CaMgSiO 4 ), as well as their coexistence relationships. Furthermore, the isothermal sections at 1500 °C and 1600 °C were constructed based on experimental data and fundamental thermodynamic principles. This study not only fills a critical gap in the thermodynamic database for rare-earth slag systems but also provides a theoretical basis for optimizing slag design and enhancing cerium recovery from waste slags.
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