CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jing Huang,Li Wang
This study demonstrates a green and sustainable strategy for efficient single-step recovery of cerium through the rational design of core–shell Fe 3 O 4 @ZIF-8 nanocomposites. The material is comprehensively characterized in terms of morphology, magnetic properties, functional groups, and pore structure. Adsorption studies reveal pH-dependent recovery behavior, with optimal performance in the pH range of 3.9–7.2. Analysis of isotherms and thermodynamics confirms the endothermic nature of the recovery process, showing a monotonic increase in the maximum adsorption capacity from 110 mg g −1 to 185 mg g −1 as temperature rises from 283 K to 328 K. Notably, the effect of ionic strength (IS) suggests that NaCl significantly enhances Ce(III) recovery efficiency, while K 2 SO 4 exhibits marked suppression. Competitive adsorption experiments reveal stronger interference from heavy REEs (Ho 3+ /Tm 3+ ) compared to light REEs (La 3+ ). The fundamental mechanisms are elucidated through multiscale interaction analysis, revealing a synergistic process combining dual-phase transition dynamics and photoinduced redox reactions. The surface architecture of magnetic core evolves from initial ZnO-dominant nanocrystals to ZnO/CeO 2 heterostructures, and ultimately stabilizes as a CeO 2 -enriched framework with increasing Ce(III) concentrations. Moreover, across the time scale, the speciation of surface-adsorbed cerium underwent a gradual transition from Ce(III)-dominance to Ce(IV)-dominance, ultimately forming a regime where Ce(IV) (CeO 2 ) served as the primary species. This progressive transformation enables in situ immobilization and single-step recovery of Ce(III) under mild conditions, establishing a novel paradigm for REEs recovery technology.
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INORGANIC CHEMISTRY
·
2023
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IF 4.6
Nan Zhang,Shan-Shan Han,Yun Xie,Da-Li Chen,Wen-Dong Yao,Xiao Huang,Wenlong Liu,Sheng-Ping Guo
Rare-earth (RE) chalcogenide borates are very rarely discovered in view of the difficulties in synthesis though they have demonstrated attractive physical performances. Here, the first mixed RE chalcogenide borates Eu5.4Sm3.6MgS2B20O41 (1) and Eu3Gd6MgS2B20O41 (2) are synthesized by combining RE, sulfur, and borate ions into one structure. They crystallize in the centrosymmetric hexagonal space group P63/m, and their 3D honeycomb-like {[B20O41]22–}∞ open frameworks are built by [B6O9(O0.5)6]6– and [B7O13(O0.5)3]8– polyanionic clusters and consolidated by Mg2+ ions; both of which are formed by BO4 tetrahedra and BO3 planar triangles. The coordination modes of RE ions are rare REO6S2 bicapped trigonal prisms and REO8S irregular polyhedra, and their band gaps are determined to be 2.25 and 2.22 eV, respectively. They exhibit antiferromagnetic interactions and distinct photocurrent responses. The corresponding theoretical calculations are also performed. The study of 1 and 2 perhaps stimulates interest in exploring new functional RE chalcogenide borates.
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RARE METALS
·
2025
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IF 11
Huang Huoshuai,Wei Zhidong,Yan Jiawei,Chi Jiasheng,Su Qianxiang,Ma Linlin,Chen Mingxia,Jiang Zhi,Sun Yangzhou,Shangguan Wenfeng
Photocatalytic hydrogen evolution, a promising clean energy conversion technology, faces efficiency limitations due to the mismatched timescales between sub-picosecond bulk photocarrier recombination and microsecond-scale surface reaction. Herein, a dual-strategy involving selenium decoration and NiS x cocatalyst loading was proposed to ameliorate the carrier dynamics bottleneck in CdS-based photocatalysts. The in situ loading of NiS x cocatalysts established an interfacial built-in electric field (BIEF) that enabled spatially oriented carrier separation and transfer, while the selenium modification optimized the light absorption range and Fermi energy level, obtaining an increase in the photocarrier concentration and further modulated the BIEF. Femtosecond transient absorption spectroscopy revealed a dual-channel carrier dynamics enhancement mechanism that BIEF-driven directional charge migration synergistically coupled with NiS x -mediated holes trapping. This synergistic effect achieved an approximately tenfold enhancement of hydrogen evolution rate (461.71 μmol h −1 ) relative to that of bare CdS under visible light (> 420 nm). This study elucidated the regulatory mechanism of element decoration and cocatalyst loading on carrier dynamics, providing an insight for designing high-performance photocatalysts.
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JOURNAL OF MATERIALS SCIENCE
·
2025
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IF 3.9
Ma Wencheng,Cheng Yankui,Fan Qinglu,Zhao Xiaoying,Zhang Meng,Jiang Yong,Chen Zehua
Lithium (Li)-metal anode undergoes large volume expansion during repeated charging and discharging processes, which leads to serious damage to the structural integrity of the Li-metal surface, uneven current density distribution at the interface, and the generation of uncontrollable Li dendrites or inactive Li. Herein, we have designed an easily scalable, low-cost iodine-containing electrolyte engineering for releasing inactive Li and constructing high-integrity interfacial Li-metal anodes. X-ray photoelectron spectroscopy (XPS) verifies that the LiI is involved in the composition of solid–electrolyte interphase (SEI) in the battery after activation. Furthermore, density functional theory (DFT) calculations indicate that the LiI has higher electronic insulation and ionic conductivity compared with the conventional inorganic component of SEI, which not only inhibits the inhomogeneous nucleation of Li + , but also improves the interfacial migration kinetics. Benefiting from this elaborated iodine-containing electrolyte, an ultra-long-cycle number of 1370 cycles at a current density of 5 mA cm −2 were achieved in Li symmetric battery, and the structural integrity of the Li anode surface was still maintained. In addition, to verify the feasibility of this strategy for practical applications, the Li-metal full batteries assembled with highly loaded LiFePO 4 (17.4 mg cm −2 , 3.0 mAh cm −2 ) cathode also demonstrated satisfactory long cycle stability and capacity retention.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-12
·
IF 7.8
Yu Xiaolong,Zhang Shengtao,Wei Zhiqi,Xu Qiang
Osteoporosis is a metabolic disorder characterized by progressive bone loss, particularly affecting postmenopausal women. Excessive osteoclast activity contributes to bone resorption and skeletal fragility. Celastrol, a natural triterpene, has demonstrated anti-inflammatory and anti-resorptive effects, but its clinical application is limited by poor solubility and systemic toxicity. In this study, we engineered a bone-targeted nano-sustained-release system using mesoporous silica nanoparticles loaded with celastrol. The nanocarrier displayed high bone affinity, sustained drug release, and favorable biocompatibility. In vitro, it suppressed RANKL-induced osteoclast formation and function by downregulating NF-κB and MAPK signaling. In vivo, treatment of ovariectomized rats improved bone mineral density, preserved trabecular microarchitecture, and reduced osteoclast numbers without apparent systemic toxicity. These findings demonstrate that bone-targeted celastrol nanoparticles provide an efficient and safe therapeutic strategy for postmenopausal osteoporosis by inhibiting osteoclastogenesis and protecting bone structure.
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PubMed
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Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-17
·
IF 8.9
Song Ke,Jing Tao,Yang Xinyan,Xia Junjun,Wang Zehui,Luo Fang,Qiu Chunhua,Liu Zhaoting,Zhao Xiao-Yang,Wang Guang,Ou Xianghong
Type 2 diabetes mellitus (T2DM) is frequently associated with testosterone deficiency, which affects male reproductive function. Currently, exogenous testosterone replacement therapy poses inherent risks, underscoring the need to develop safer and more effective treatment strategies. This study aimed to elucidate the mechanism by which ML221, a potent apelin receptor (APJ) functional antagonist, promotes testosterone secretion, and alleviates reproductive dysfunction. Diabetic mouse models demonstrated reduced testosterone levels, impaired spermatogenesis, and low sperm quality. Elevated APLN expression impaired Leydig cell function and testosterone synthesis. Treatment with ML221 restored testosterone levels and spermatogenesis in diabetic mice. Mechanistically, ML221 regulated Leydig cell metabolism by elevating S-D-lactoylglutathione levels, reducing mitochondrial reactive oxygen species, preserving mitochondrial membrane potential, and enhancing adenosine triphosphate production. At the epigenetic level, ML221 enhanced the binding of nuclear receptor subfamily 2 group F member 2 to the promoters of testosterone-synthesizing genes, thereby facilitating testosterone biosynthesis. These findings advance the understanding of the male reproductive system in the context of diabetes and highlight ML221 as a potential therapeutic approach for T2DM-induced testosterone deficiency.
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PHARMACEUTICAL RESEARCH
·
2025
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IF 4.3
Bai Wanting,Li Yang,You Feng,Duan Xiaoyan,Hu Jiahuan,Wu Jinjin,Sun Tao,Wang Xing,Lan Pei,Hu Jinping
Objective Bicyclol, a hepatoprotective agent, is often used in combination with other drugs for liver diseases, including drug-induced liver injury (DILI), raising concerns about potential drug-drug interactions (DDIs). This study investigates the interaction between bicyclol and key transporters (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2-K, P-gp, BCRP, BSEP) to predict transporter-related DDI risks. Methods Transporter interaction studies were conducted using cell lines or membrane vesicles overexpressing human uptake and efflux transporters. The substrate and inhibitory potential of bicyclol were systematically evaluated through transport and inhibition assays. The static model and criteria were applied to assess the risk of transporter-related DDIs in vivo . Results Bicyclol was not a substrate of above-mentioned transporters. Regarding inhibition, it was not an inhibitor of OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, or BSEP (IC 50 s > 100 μM). However, it was a marginal inhibitor of OCT2 (IC 50 = 76.2 μM), a weak inhibitor of P-gp (IC 50 = 123 μM), and a strong inhibitor of BCRP (IC 50 = 8.5 μM). The static model predicted that only BCRP would be inhibited in vivo by bicyclol, suggesting dose optimization might be required for BCRP substrates. Conclusions Here, we systematically elucidated the substrate and inhibition potential of bicyclol on major human drug transporters for the first time, which may provide the basis for rational co-administration of bicyclol, potentially broadening its clinical application.
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BMC Pharmacology & Toxicology
·
2025
·Vol. 26
·期 1
·1-13
·
IF 2.7
Fu Wenying,Lu Hui,Yan Ying,Shu Chongchong,Xu Chenxin,Chen Yinghua,Xia Yiqun,Chen Jundixia,Chen Yunzhi,Zou Peng,Cui Ri,Ni Daoyong
Section
Background
Lung cancer continues to rank as a leading cause of cancer-related mortality worldwide. Despite notable advances in medical research, therapeutic options for advanced-stage lung cancer remain inadequate. Heat shock protein 90 (HSP90) has been identified as a potential therapeutic target in multiple malignancies, such as lung and colon cancers, owing to its pivotal role in stabilizing numerous oncoproteins. Nonetheless, the clinical application of HSP90 inhibitors has faced challenges, including suboptimal efficacy and the development of resistance mechanisms. B-AP15 is a promising small molecule in cancer therapy that functions by inhibiting deubiquitinating enzymes, which regulate protein degradation through the proteasome pathway. In this study, we aim to investigate its combinatorial activity with the HSP90 inhibitor tanespimycin (TAU) in lung cancer cells.
Section
Methods
The levels of the specified molecules were measured by Western blot analysis. Reactive oxygen species (ROS) levels were determined using the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) probe. 53BP1 foci formation and C/EBP homologous protein (CHOP) expression were assessed by immunofluorescence. Autophagic flux was monitored using mRFP-GFP-tagged microtubule-associated protein 1 light chain 3 (LC3) lentivirus.
Section
Results
Our findings reveal that the combination of TAU and B-AP15 induces significant synergistic antitumor effects, characterized by substantial accumulation of ROS. This ROS accumulation serves as a crucial mediator of the enhanced therapeutic response elicited by the combination treatment. Mechanistic analyses further demonstrated that the combined treatment induces cell death via activation of endoplasmic reticulum (ER) stress and the c-Jun N-terminal kinase (JNK) pathway.
Section
Conclusion
In summary, our study provides robust evidence supporting the potential of combining TAU with B-AP15 as a viable therapeutic option for lung cancer treatment.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-20
·
IF 12.6
Shen Jiayi,Luo Yuwen,Hu Wuming,Zhang Susu,Yang Yu,Lan Linwen,Liu Enqian,Xu Jian,Hu Tingting,Nie Jingjun,Chen Dafu,Liang Ruizheng,Lyu Lingchun
Myocardial ischemia/reperfusion (I/R) injury represents a major global health concern, driven by excessive reactive oxygen species (ROS), which closely correlates with subsequent myocardial infarction and fibrosis. Combining ROS scavenging with ischemic myocardium revascularization holds therapeutic promise. However, developing multifunctional therapeutic agents that can simultaneously scavenge ROS and promote angiogenesis remains unreported. Herein, we propose MgSrCeAl-layered double hydroxide (LDH) nanosheets as a multifunctional ROS scavenger and angiogenesis promoter for efficient myocardial I/R injury treatment. MgSrCeAl-LDH nanosheets not only exhibit exceptional hydroxyl radicals (·OH) and superoxide anions (·O 2 − ) scavenging capabilities, which is 1.78 times and 1.61 times that of CeO 2 , respectively, but also respond to the ischemia-induced acidic microenvironment to release angiogenic Sr 2+ with a concentration of 32.65 ppm (pH 5.0), which is conducive to efficient angiogenesis. Specifically, the ROS levels in I/R-injured myocardium decreased to 66.2% of its original value following intervention with MgSrCeAl-LDH nanosheets, while the vascular density in the peri-ischemic myocardium increased by approximately 3.6-fold. Ultimately, the infarcted myocardial area is reduced 60.9% compared to the group without MgSrCeAl-LDH intervention. Mechanistically, MgSrCeAl-LDH nanosheets alleviate myocardial infarction and fibrosis caused by I/R injury through activating PI3K/Akt pathway and inhibiting TGF-β pathway, ultimately improving cardiac function and inhibiting ventricular remodeling. Graphical abstract
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Emergent Materials
·
2025
·
IF 4.1
Ali Romzan,Amin Ruhul,Khaleque Abdul,Zohra Fatema-Tuj,Aly Saad Aly Mohamed,Khan Zaved H.
Metronidazole (MZ) is a nitroimidazole antibiotic utilized to cure a numerous infection. But metronidazole presents significant health risks for both animals and human, due to its mutagenic, carcinogenic, and genotoxic properties. Furthermore, long-term use can lead to severe central nervous system issues. Thus, the concentration level of the drug must be monitored to avoid such health complications, highlighting the significance of developing rapid, accurate, and highly sensitive methods for detecting metronidazole levels. Herein, a polyglutamic acid (PGA) functionalized carbon black nanoparticle (CB NPs), CB NPs/PGA nanocomposite modified electrode-based electrochemical sensor for the quantification of MZ in animal feed is developed. The electrochemical performance of the proposed sensor was evaluated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and impedance spectroscopic analysis. The proposed sensor displayed a wide linear range of 500–10 4 nM with a 0.17 µM limit of detection, and 0.35 µM limit of quantification. This is the first to report on the synthesis of CB NPs/PGA nanocomposite and its application for the detection of MZ. The selectivity of the modified electrode to detect MZ while minimizing interference from various ions was assessed, exhibiting remarkable resilience, remaining unaffected even when the interfering ions were present at 100-fold concentrations. Additionally, after two successive weeks of storage, the proposed sensor showed no discernible reduction current (< 1.4%), demonstrating an excellent stability. The developed sensor successfully detected MZ within 2 min in differ animal feeds with recovery rates range of 96–99%. The proposed sensor lays a groundwork in critical domains like food safety regulation, veterinary medicine, and agricultural monitoring. Graphical abstract
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-15
·
IF 3.9
Li Jiameng,Liu Xiaodan,Sun Chaofan,Wang Mingyang,Zhang Qianqian,Wang Hongyu,Ji Xu,Jin Erhui,Zhang Feng
Enterotoxigenic Escherichia coli (ETEC) causes diarrhea and triggers intestinal inflammation posing a significant threat to children which is a global health concern. Berberine (BBR) has diverse pharmacological properties can alleviate diarrhea and intestinal damage. This metabolomics study analyzed the effects of berberine on the hepatic function, lipid metabolism, and inflammatory responses in weaned piglet model infected with ETEC. A total of 18 piglets were randomly divided into three groups: basal diet (BD) + Saline, BD + ETEC, and BBR + ETEC. Compared with the BD + Saline group, ETEC infection significantly increased the contents of aspartate aminotransferase (AST), AST/alanine aminotransferase (ALT), total protein, globulin, triglycerides, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-8, IL-12, interferon γ (IFN-γ), IL-4, IL-10, and transforming growth factor β (TGF-β) and significantly decreased the contents of total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in the serum of weaned piglets. There were 14 metabolites upregulated and 21 metabolites downregulated after ETEC infection, and total cholesterol, LDL, IL-1β, IL-8, and TGF-β were correlated with fructose and mannose metabolism. Compared with the BD + ETEC group, dietary berberine significantly increased the contents of total cholesterol, LDL, and HDL and significantly decreased the contents of AST, AST/ALT, total protein, globulin, triglycerides, TNF-α, IL-1β, IL-6, IL-8, IL-12, IFN-γ, and IL-4 in the serum of weaned piglets. There were 111 metabolites upregulated and 48 metabolites downregulated after berberine addition, and total protein, IL-1β, IL-6, IL-8, and IL-12 were correlated with cholinergic synapse. Both ETEC infection and berberine addition can induce changes in taste transduction and affect the physiological functions of weaned piglets through metabolic pathways.
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IONICS
·
2025
·
IF 2.6
Gu Bonwun,Kang Chankyu
In this study, the flash points and ionic conductivity of three ternary electrolyte solvents (ethylene carbonate (EC); diethyl carbonate (DEC); and dimethyl carbonate (DMC)) were investigated in lithium-ion batteries. The flash points of the solvent mixtures were experimentally measured and compared with predictions using Raoult’s law and multiple regression analysis. These results indicate that EC increases flash point temperature and ionic conductivity owing to its high dielectric constant and boiling point. In contrast, DMC has a lower flash point because of its low boiling point and high reactivity. The coefficient of determination ( R 2 ) and mean absolute error (MAE) suggest that Raoult’s law better predicts overall trends in flash points. Simultaneously, multiple regression analysis provided higher accuracy for specific mixture compositions. Additionally, the ionic conductivities of the ternary electrolyte mixtures were analyzed, demonstrating that DMC maintained high conductivity through polar conformers despite its low dielectric constant. The optimal mixture ratio of EC: DEC: DMC at 7:2:1 achieved a balance with a high flash point (55.5 °C) and high ionic conductivity (9.0 mS cm⁻ 1 ), enhancing battery safety and ionic conductivity. This study highlights the critical role of solvent composition in optimizing lithium-ion battery electrolytes for improved safety and ionic conductivity. Graphical
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危险品化学品经营许可证（带存储）