CHEMICAL PHYSICS LETTERS
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2024
·
IF 2.8
Lixiang Wang,Jingwen Li,Mingqiang Li,Xinping Duan,Haochen Weng,Shuailiang Xu
In this study, we introduce a novel “water-in-salt” electrolyte for Bromine-ion batteries (BIBs) for the first time: 3M AlCl 3 + 1M NH 4 Br. The 3M AlCl 3 establishes the “water-in-salt” system, while 1M NH 4 Br supplies Br- ions. Employing flexible graphite paper as the cathode, during charging, Br- cooperates with AlCl 3 , forming AlCl 3 Br - ions that embed into the graphite paper, resulting in reversible reactions during discharge. The anode utilizes various metals such as Zn, Cu, Pb, In 2 O 3 , undergoing reversible redox reactions in the charge–discharge process. The designed electrolyte effectively prevents elemental bromine generation, presenting a safe, green, and environmentally friendly aqueous electrolyte suitable for BIBs.
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ACS Applied Nano Materials
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2024
·
IF 5.3
Yu Tian,Lili Cong,Hongda Sun,Wenli Wei,Fengxia Wu,Fenghua Li,Guobao Xu,Wenxin Niu
Determining whether plants are under stress before obvious disease symptoms is crucial for precision agriculture. Intercellular hydrogen peroxide (H2O2) in plants can be used to indicate stress. However, most current H2O2 detection methods are destructive or limited by chlorophyllous autofluorescence. Herein, we constructed an in vivo surface-enhanced Raman scattering (SERS) sensor for nondestructive, in situ, and highly sensitive detection of H2O2 in plant leaves. The sensor with the designed size can enable nondestructive and in situ H2O2 detection without fluorescence interference. In addition, Ag decahedral nanoparticles with sharp edges and tips enhance the SERS effect, and the lowest detection concentration of H2O2 can reach 10 nM in vitro. The utility of the SERS sensor is demonstrated by Oxalis corniculata under wound, heat, and cold stresses. This SERS sensor can provide warnings before plants show visible signs of damage, thereby improving crop yields and potentially becoming an essential tool for precision agriculture.
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PLoS One
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2011
·Vol. 6
·期 6
·e21064
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IF 4.411
Shunzhen Zheng,Shuang Chang,Jinli Lu,Zhihui Chen,Li Xie,Yu Nie,Bin He,Shengquan Zou,Zhongwei Gu
Background
Hepatocellular carcinoma (HCC) is the third most common cause of cancer related mortality worldwide. 9-Nitrocamptothecin (9NC) is a potent topoisomerase-I inhibitor with strong anticancer effect. To increase the solubility and stability, we synthesized a novel 9NC loaded liposomes (9NC-LP) via incorporating 9NC into liposomes. In the present study, we determined the effects of 9NC and 9NC-LP on in vitro and in vivo , and the underlying mechanisms.
Methodology/Principal Findings
We first analyzed the characteristics of 9NC-LP. Then we compared the effects of 9NC and 9NC-LP on the proliferation and apoptosis of HepG2, Bel-7402, Hep3B and L02 cells in vitro . We also investigated their anticancer properties in nude mice bearing HCC xenograft in vivo . 9NC-LP has a uniform size (around 190 nm) and zeta potential (∼−11 mV), and exhibited a steady sustained-release pattern profile in vitro . Both 9NC and 9NC-LP could cause cell cycle arrest and apoptosis in a dose-dependent and p53-dependent manner. However, this effect was not ubiquitous in all cell lines. Exposure to 9NC-LP led to increased expression of p53, p21, p27, Bax, caspase-3, caspase-8, caspase-9 and apoptosis-inducing factor, mitochondrion-associated 1 and decreased expression of Bcl-2, cyclin E, cyclin A, Cdk2 and cyclin D1. Furthermore, 9NC-LP exhibited a more potent antiproliferative effect and less side effects in vivo . Western blot analysis of the xenograft tumors in nude mice showed similar changes in protein expression in vivo .
Conclusions/Significance
In conclusion, 9NC and 9NC-LP can inhibit HCC growth via cell cycle arrest and induction of apoptosis. 9NC-LP has a more potent anti-tumor effect and fewer side effects in vivo , which means it is a promising reagent for cancer therapy via intravenous administration.
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高影响因子
Toxics
·
2024
·Vol. 12
·期 6
·411
·
IF 3.9
Junlie Zhou,Jianglin Kang,Chunyan Lin,Qi Xu,Wanrong Yang,Ke Fan,Jinrong Li
The occurrence, distribution, and ecological risk assessment of 36 antibiotics from five groups, including macrolides (MLs), fluoroquinolones (FQs), tetracyclines (TCs), amphenicols (APs), and sulfonamides (SAs), were investigated for the first time in the Anning River, Sichuan Province, China. The results show that antibiotics were widely present in the sediments of the Anning River, with a total of 22 antibiotics detected. FQs were among the most abundant antibiotics, followed by TCs, MLs, APs, and SAs. The total concentrations of antibiotics in surface sediments varied from 0.05 to 53.35 ng/g, with an average of 8.09 ng/g. Among these groups, MLs, FQs, and TCs emerged as the predominant classes of antibiotics. The midstream sediments showed the highest residual levels of antibiotics, with lower levels observed in the downstream and upstream sediments. Anthropogenic activities, such as human clinical practices and animal breeding, might be sources of antibiotics released into the river. An ecological risk assessment revealed that trimethoprim from the SA group exhibited high risks, and MLs showed medium risks in the Anning River, whereas most antibiotics presented minimal to low risks. This study provides valuable information on antibiotic pollution in the upstream region of the Yangtze River, and future management measures are needed for the Anning River.
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Microorganisms
·
2024
·Vol. 12
·期 2
·360
·
IF 4.1
Shengwang Li,Youwei Yu,Peng Xie,Xianran Zhu,Chao Yang,Linjing Wang,Shaoying Zhang
Gray mold caused byBotrytis cinereais a common postharvest fungal disease in fruit and vegetables. The prevention and treatment of postharvest gray mold has been one of the hot research issues addressed by researchers. This study aimed to investigate the effect of L-methionine and L-arginine onBotrytis cinereain vitro and on cherry tomato fruit. The results of the in vitro experiment showed that L-methionine and L-arginine had significant inhibitory effects on the mycelial growth and spore germination ofBotrytis cinerea, and the inhibitory effects were enhanced with increasing L-methionine or L-arginine concentration. In addition, L-methionine and L-arginine treatment increased the leakage ofBotrytis cinereaelectrolytes, proteins and nucleic acids. The experiment involving propidium iodide staining and malondialdehyde content assay also confirmed that L-methionine and L-arginine treatment could lead to cell membrane rupture and lipid peroxidation. The results of scanning electron microscopy further verified that the morphology of hyphae was damaged, deformed, dented and wrinkled after treatment with L-methionine or L-arginine. Fruit inoculation experiments displayed that L-methionine and L-arginine treatments significantly inhibited the occurrence and development of gray mold in postharvest cherry tomato. Therefore, treatment with L-methionine or L-arginine might be an effective means to control postharvest gray mold in fruit and vegetables.
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ENVIRONMENTAL MONITORING AND ASSESSMENT
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2012
·Vol. 185
·期 1
·39-44
·
IF 1.4
Jiao Fang,Gao Hong-Wen
An on-site solid-phase extraction, consisting of the sorption, the separation and the elution function units, was designed for in situ preconcentration of heavy metals ions. The D401 resin powder was employed as sorbent to capture Pb 2+ , Cu 2+ , Zn 2+ , Cd 2+ , Co 2+ , and Ni 2+ , and then they desorbed with 2 mol/L nitric acid as eluent. Under the optimized conditions, these heavy metals ions in West Lake, Taihu Lake, and Yangtze River of China were captured and then determined by ICP-OES with the recovery of 92.5% to 111.5%. The on-site solid-phase extraction achieved a quick preconcentration of heavy metals to avoid the transport and storage of a large volume water sample. It is suitable for in situ monitoring of water quality in mountains, tablelands or other remote areas.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2024
·Vol. 31
·期 23
·34159-34169
·
IF 0
Cao Yu,Zhong Zehui,Zeng Fanqi,Zhou Yang
To ensure the safety of food contact materials, a liquid chromatography method was established to determine the migration of formaldehyde in paper packaging with various food simulants (10%, 25%, 50%, 75%, and 95% ethanol by volume) and to investigate the migration behavior of formaldehyde after various durations and with various materials. The results showed that the method has good linearity with a correlation coefficient of R 2 > 0.9990, a detection limit of 0.0011 ~ 0.0027 mg L −1 , and a spiked recovery of 89.7 ~ 103.2% in the range of formaldehyde determination; the migration of formaldehyde in all six paper contact materials showed a trend of gradual increase with time until equilibrium was reached. At the same time and temperature, the migration of formaldehyde in paper packaging was the highest in low-concentration ethanol. With the same food simulants and materials, the maximum migration of formaldehyde in printed materials was greater than that in nonprinted materials; with different materials and the same food simulant, the thickness value was higher, with the use of water-based ink as a printing material, and the maximum migration value of formaldehyde by offset printing technology was low.
CAS / MDL:
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Zhaojie Wang,Yuanhao Qiu,Chunyan Hou,Dongdong Wang,Feifei Sun,Xiaojun Li,Feng Wang,Hong Yi,Haibo Mu,Jinyou Duan
Aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity. Here we used hyaluronic acid (HA) as a carbohydrate carrier of the aminoglycoside antibiotic, amikacin (AM) to deal with intracellular bacterial infections. The hyaluronan-amikacin conjugate (HA-AM) was synthesized by ‘click’ reaction between HA-propargyl amide (HAPA) and AM-azide. This conjugate with little cytotoxicity retained antibiotic effects on planktonic bacteria and showed better intracellular bactericidal activity than the antibiotic did. In addition, this conjugate was more efficient in reducing bacteria burden in an in vivo acute infection model than amikacin did. These results suggested that hyaluronic acid conjugation could reduce the dosage of antibiotic in treatment of intracellular bacterial infection, and further helping to alleviate the emergence of drug resistance in bacteria due to a long-term, high-dosage treatment.
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MATERIALS RESEARCH BULLETIN
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2024
·
IF 5.3
Lili Han,Jihao Zhao,Yifan Miao,Wenqian Zhou,Minglang Yuan,Jinghao Cui,Zhipeng Ci
Copper-based halides have emerged as promising scintillator materials for X-ray imaging, attributed to their favorable photophysical characteristics, such as negligible self-absorption, high light output, and fast decay. Within this category of materials, Cs 3 Cu 2 Cl 5 composite polymer scintillator films stand out, delivering excellent performance as flexible X-ray detector screens. However, severe scattering and light degradation induced by the inevitable agglomeration during recombination restricted the application in high-resolution and flexible X-ray imaging. In this study, a Cs 3 Cu 2 Cl 5 @PMMA film prepared by in-situ growth strategy is successfully developed, which represents uniform area, adjustable flexibility and excellent scintillation performance. The prepared large-area film exhibits green emission at 527 nm, with a high light yield, low detection limit and excellent spatial resolution. Meanwhile, the Cs 3 Cu 2 Cl 5 @PMMA film exhibits a remarkable degree of flexibility, enabling imaging applications on non-planar surfaces. Furthermore, it also demonstrates excellent resistance to high temperature environment, maintaining its high-quality imaging performance at 403 K.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Song Ningbo,Yin Wanzhong,Xie Yu,Yao Jin
Using seawater for mineral flotation conserves fresh water resources and offers significant environmental and economic benefits. However, the adverse effect of seawater restricts its application in mineral flotation. The regulators can eliminate the adverse effect caused by seawater during flotation separation of lead and copper. In this paper, the flotation separation of galena and chalcopyrite in seawater was tested. Compared with those in deionized water, the lead grade of concentrate in seawater flotation declined from 50.10% to 48.90%. Meanwhile, the recovery of galena declined from 74.33% to 60.58% and the SI value declined from 1.565 to 1.324. With the addition of SHMP (sodium hexametaphosphate), SS (sodium silicate) and EDTA (ethylenediamine tetraacetic acid), the SI value increased from 1.324 to 1.923, 2.002 and 1.939, respectively. Noteworthy, when EDTA was excessive, the grade of Pb was 60.80%, the recovery of galena was 60.86% and the SI value was 2.113. X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Atomic force microscopy, Density functional theory calculation and E-DLVO calculation verified the micro-flotation results and revealed the mechanism of action.
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Microbiology Spectrum
·
2024
·
IF 3.7
Yanjun Xie,Fangyi Xu,Huali Dong,Jianfeng Mao,Chuanling Zhang
The colonization of Enterococcus in the female vagina leads to neonatal and pediatric enterococcal septicemia. Linezolid (LZD) is a kind of mainstream drug for treating multidrug-resistant Gram-positive infections. OptrA is the main LZD-resistance gene at Enterococci in human isolates. It is essential to explore the prevalence of optrA-carrying Enterococcus in vaginal secretions of late pregnant women and the drug resistance of optrA. From May to June 2023, this study recruited 340 volunteers in late pregnancy (35–40 weeks of pregnancy) to provide non-repetitive vaginal discharge samples. Luria-Bertani broth and florfenicol (10 µg/mL) were used to enrich bacteria. Enterococci was identified through time-of-flight mass spectrometry. Additionally, antimicrobial susceptibility, polymerase chain reaction, and next-generation sequencing assays were applied to this study. Fifty-four optrA-carrying Enterococcus strains were obtained, the proportion of the whole vagina of late pregnant women was 15.88% (54 out of 340), and Enterococcus faecalis account the highest proportion. All optrA-carrying Enterococcus were resistant to at least three drugs. Tetracycline, chloramphenicol, erythromycin, and LZD have higher bacterial resistance rates. Genetic environment analysis revealed that IS1216E, fexA, and erm(A) may synergistically exert multidrug resistance with optrA. It is necessary to strengthen the surveillance of optrA-carrying Enterococcus in pregnant women. This study provides scientific support for controlling hospital infections and managing antibiotic-resistant bacteria, and provides a scientific basis for rational clinical medication.
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Arabian Journal of Chemistry
·
2024
·
IF 5.3
Qinhai Xu,Kang Li,Peng Wang
The reaction mechanism of p -hydroxystyryl-substituted BODIPY (BOH) with two oxidative cations, namely ABTS •+ and Fe 3+ , was investigated in a water–ethanol mixed solution and in liposome suspensions, respectively, using different spectroscopic methods. In solution, the oxidation of BOH (with orange fluorescence) by the two cations occurred at the ethylene group (C C) locating between the dipyrrole and phenol groups and resulted in conjugation-truncated products exhibiting characteristic green fluorescence emission. In heterogeneous small unilamellar vesicles (SUV), water soluble ABTS •+ was evidenced to oxidize BOH embedded in the lipid bilayers of SUV, while Fe 3+ did not. The lack of reaction between Fe 3+ and BOH was attributed to the complexation between Fe 3+ and the phenolic hydroxyl group of BOH on the surface of the SUV. The reaction kinetics results indicated that, in homogeneous solution, the oxidation rate of Fe 3+ was three orders of magnitude slower than that of ABTS •+ for BOH. The location and orientation of BOH within the SUV were discussed based on the reaction phenomena. BOH could be as a good antioxidant fluorescent prober for ABTS •+ detection with a detection limit of 1.5 * 10 −7 M and a linear rang of 0–4.93 μM. What’s more, the amphiphilic BOH dispersed in the round GUV (BOH + GUV) could show the bright red fluorescence. This research suggests the significant potential of BOH as an antioxidant fluorescent probe for in situ bioimaging.
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