CATALYSIS LETTERS
·
2019
·Vol. 150
·期 5
·1418-1426
·
IF 2.372
Ma Yuan,Liu Jiao,Chu Mo,Yue Junrong,Cui Yanbin,Xu Guangwen
Abstract The key challenge for CO 2 methanation, an eight-electron process under kinetic limitation, relies on the design of non-noble metal catalysts so as to achieve high activity at low reaction temperatures. In this work, four Ni-based catalysts with different supports were prepared and tested for CO 2 methanation at 250–550 °C in a fixed bed quartz reactor and further characterized to reveal the structure–function relationship. The Ni-based catalysts followed an activity order of Ni/CeO 2 > Ni/Al 2 O 3 > Ni/TiO 2 > Ni/ZrO 2 , especially at temperatures lower than 350 °C. H 2 -TPR and TPD results indicated that the interaction between nickel and support was strong and the metallic nickel was well dispersed in the Ni/Al 2 O 3 catalyst, while more amount of CO 2 was adsorbed on the weak basic sites in the Ni/CeO 2 catalyst. By establishing the correlation between the catalytic performance and the catalyst structure, it was found that the Ni nanoparticles and basic support serve as H 2 and CO 2 active centers respectively and cooperatively catalyze CO 2 methanation, resulting in high low-temperature reaction activity. Graphic Abstract High CO 2 conversion was achieved over Ni/CeO 2 catalyst at 300 °C for its high H 2 uptake on Ni nanoparticles and high CO 2 adsorption capacity on the support with weak basic sites and cooperatively to catalyze CO 2 methanation.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2020
·Vol. 22
·期 5
·1-9
·
IF 2.132
Ma Zhifei,Yang Yu,Yang Tianxue,Wu Daishe,Peng Xing,Xi Beidou,Jiang Yonghai,Jia Yongfeng
To evaluate the longevity of the iron-activated persulfate (PS) oxidation degradation of 2,4-dinitrotoluene (2,4-DNT), zero-valent iron (ZVI), and three different micron-scale iron oxides were used as catalysts for the activation of PS. It was revealed that 2,4-DNT was degraded more effectively by ZVI and maghemite (γ-Fe 2 O 3 ) compared to that of hematite (α-Fe 2 O 3 ) and magnetite (Fe 3 O 4 ) catalyst treatments. Denitration of 2,4-DNT and oxidation of nitro groups as nitrate occurred by Fe 0 /PS and γ-Fe 2 O 3 /PS. When the 2,4-DNT removal rate was 1%, the generated sulfate concentrations of Fe 0 /PS and γ-Fe 2 O 3 /PS were 2.08 mg/L and 1.27 mg/L, respectively. Only micron scale γ-Fe 2 O 3 could activate PS for 2,4-DNT removal. ZVI was cycled and able to activate PS through multiple rounds. The size of the corrosion products of ZVI was more than 100 nm, and the particle size gradually increased in the cycling process. The first cycle of Fe 0 resulted in 45% removal of 2,4-DNT in 360 min. The 2,4-DNT removal efficiency (68.15%) increased after the second cycle, reaching the best removal efficiency in the fourth cycle. Oxidation products formed during degradation covered the ZVI surface, forming a shell. Adsorption of organic pollutants to this shell aids in the removal efficiency of 2,4-DNT and longevity of ZVI in groundwater.
Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 10
·1-9
·
IF 2.8
Xue Ying,Wang Zhuo,Li Yanxin,Yi Zhihui,Li Xin,Wu Dan
The abundant requirements of smart terminals promote the rapid development of dielectric materials to further realize the integration and miniaturization of electronic devices. In this work, based on a solid-state reaction method, (In 0.5 Ta 0.5 ) 0.1 Ti 0.9 O 2 (ITTO) ceramics with dense microstructure, colossal permittivity of 1.18 × 10 5 , and ultralow dielectric loss of 0.0072 were obtained at 1 kHz and room temperature. In addition, the temperature coefficient stability and range of the ITTO ceramics were between ± 3.3% and − 100 to 235 °C, satisfying X9D (− 55 to 200 °C, Δ ε r / ε 25°C < ± 3.3%) requirement at 1 kHz. The dielectric mechanisms could be connected to the electron hopping and internal barrier layer capacitor (IBLC) effects. Thus, the acquired ITTO ceramics have advanced advantages with excellent dielectric properties and temperature stability in the practical applications of microelectronic fields.
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MOLECULAR DIVERSITY
·
2025
·
IF 3.8
Wu Yuyu,Zhang Ximeng,Li Haocheng,Liu Xuelian,Li Jinyao
Ferulic acid, a natural active ingredient, mainly exerts antitumor activity by disrupting mitochondrial function and has the advantages of low toxicity and high efficiency. However, poor water solubility and low bioavailability have limited its further development. This article uses triphenylphosphonium salts (TPP + ) with both amphiphilicity and tumor mitochondrial targeting to modify the structure of ferulic acid, and designs and synthesizes a series of TPP + conjugated ferulic acid derivatives. Compared with ferulic acid, the water solubility, mitochondrial targeting and antitumor activity of TPP-conjugated ferulic acid derivatives were significantly enhanced. Among them, compound I 4 showed excellent anti-cervical cancer activity, mainly by reducing ATP synthesis and promoting ROS production, thus activating mitochondria-mediated apoptotic signaling to induce apoptosis in HeLa cells. I 4 also inhibited HeLa cell migration and caused cell cycle arrest to the G0/G1 phase. In the mouse model, the effective therapeutic concentration of I 4 was 2.5 mg/kg and the LD 50 was 98.11 mg/kg. I 4 demonstrated similar anti-cervical cancer activity, a larger therapeutic window and a higher safety profile than with the first-line anticancer agent cisplatin.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Chen Hao,Lu Gongxun,Cao Zhenjiang,Zhu Qi,Ye Yuxuan,Gao Yuxuan,Shi Yu,Zhao Qi,Li Bin,Du Zhiguo,Tao Xinyong,Yang Shubin
Although commercial lithium-ion batteries have been widely used in portable electronics and electric vehicles, they are still plagued by the uncontrollable dendritic lithium under extreme conditions. Herein, an efficient strategy is developed to produce a MXene-configured graphite via an electrostatic interaction between MXene and silane coupling agent-modified graphite. Typically, MXene layers are adhered onto the basal plane of graphite, with good preservation of the uncovered lateral edges of graphite, effectively strengthening the adsorption energy of Li + and reducing the lithium nucleation energy barrier. Moreover, the MXene interface possesses good lattice compatibility with Li (110) plane, greatly promoting the homogeneous growth of Li along the preferable plane under extreme conditions. Even at −20 °C, Ah-level pouch cell with MXene-configured graphite electrode delivers a high capacity retention of 93% after 1200 cycles (273 Wh kg −1 ) at 1 C, exceeding lithium-ion batteries with bare graphite electrode (43% capacity retention, 191 Wh kg −1 ).
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-16
·
IF 3.9
Logrado Millena,Gaddam Anuraag,Zhuo Fangping,Zhao Changhao,Gao Shuang,Breitzke Hergen,Rosenstihl Markus,Vogel Michael,Rödel Jürgen,Buntkowsky Gerd
Thermal treatments play a crucial role in tuning the functional properties of lithium-based perovskites, which are of interest for applications in energy storage, actuation and sensing. In the present work, the impact of aging and quenching on the local structure and lithium mobility in lithium sodium niobate (LNN) ceramics was investigated using Density Functional Theory (DFT), transmission electron microscopy (TEM) and solid-state Nuclear Magnetic Resonance (NMR) techniques. Our results demonstrate that quenching inhibits the formation of a lithium-rich phase, leading to significant modifications in dipolar and quadrupolar interactions. Aging induces the formation of LiNbO 3 within the perovskite matrix, with no indication of lithium mobility at the boundaries of LiNbO 3 grains. The presence of multiple lithium environments in aged samples was indicated by transmission electron microscopy and confirmed through 7 Li Magic Angle Spinning (MAS) NMR, revealing distinct structural differences between aged and unaged samples. NMR parameters were also compared with parameters calculated by Density Functional Theory. The findings suggest the formation of LiNbO 3 and an additional lithium poor phase in aged LNN samples. These results indicate that the quenching effect reduces dipolar interactions and considerably sharpens the 7 Li NMR spectra, while structural modifications induced by thermal processing affect lithium ordering, providing new insights into the phase behavior of LNN ceramics.
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ARCHIVES OF MICROBIOLOGY
·
2025
·Vol. 207
·期 12
·1-19
·
IF 2.6
Xu Jingjing,Sun Meng,Chang Jiangcheng,Xie Qingchao,Wang Yongjie,Chen Lanming
Klebsiella oxytoca can cause gastrointestinal infections in humans. Within the instestinal tract, the bacterium encounters diverse host-derived signals (most notably bile salts, BS) and secondary metabolites (such as short-chain fatty acid salts, SCFAs) produced by microbial community. However, the mechanism of K. oxytoca response to BS and SCFAs stresses has been rarely reported. Recently, we found K. oxytoca in 14 species of aquatic food animals, of which K. oxytoca 7-7-27 of mussel origin had strong biofilm formation characteristics and many putative virulence-associated genes. Herein, we investigated the impact of normal physiological concentrations of BS (0.2% – 2.2%) and SCFAs (0.4% – 2.0%) in the tract on survival and virulence of K. oxytoca 7-7-27. The results revealed that the major BS (0.2% sodium cholate, or 0.8% sodium glycocholate) and SCFAs (0.4% sodium acetate, or 0.4% sodium butyrate) stimulated the bacterial growth, and significantly increased cell surface hydrophobicity, auto-aggregation rate and biofilm formation, as well as adhesion and invasion rates of K. oxytoca 7-7-27 toward the human colon Caco-2 cell ( p < 0.05). Notably, comparative secretomic and proteomic analyses uncovered a number of differentially secreted (i.e., 53) and produced (i.e., 1,049) proteins, as well as putative virulence-associated proteins (i.e., 69) triggered by the BS and SCFAs. K. oxytoca adopted multiple strategies to cope with the BS and SCFAs stresses. The results of this study highlighted the potential risk of ingestion of K. oxytoca -contaminated aquatic products.
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Neuroscience Bulletin
·
2025
·
IF 5.8
Zhang Haifeng,Su Tiantian,Wu Xiaoke,Shi Mengmeng
There is a vicious cycle between brain metabolism and epileptic seizures that compounds the deleterious consequences of seizures. Human epilepsy samples implicate cholesterol 25-hydroxylase (CH25H) in linking lipid metabolism and immunity. CH25H expression increased in microglia after status epilepticus, with its product 25-hydroxycholesterol (25-HC) accumulating in the hippocampus and blood. Thus, we generated microglia-specific CH25H knockdown mice to study the role of CH25H specifically in epilepsy. CH25H knockdown inhibited the assembly and activation of NLRP3 inflammasome and restrained the loss of neurons in the hippocampal area in epileptic mice. More importantly, CH25H knockdown reduced the number of recurrent seizures and time in seizure by electroencephalogram recording, which was partly reversed after 25-HC treatment. Untargeted metabolomics showed that another lipid metabolite, arachidonic acid, might be a potential biomarker of CH25H-mediated epilepsy. These findings suggest that microglial CH25H regulated the status epilepticus in a hydroxylase-dependent mechanism.
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Food Production Processing and Nutrition
·
2025
·Vol. 7
·期 1
·56
·
IF 5.7
Zhou Shiyang,Ren Fengming
In order to explore the in vitro hypoglycemic effect of lonicerae flos polysaccharides and its mechanism of action, the crude lonicerae flos polysaccharide was prepared by hot water extraction and ethanol precipitation. After sevage, dialysis, DEAE-52 and Sephadex G-100, the homogeneous component lonicerae flos polysaccharide was finally separated and purified. HepG2 cell experiment was used to investigate the hypoglycemic activity and mechanism of lonicerae flos polysaccharide, detecting the active polysaccharide components, and preliminarily analyze its monosaccharide composition, molecular weight and hypoglycemic pathway. The results showed that lonicerae flos polysaccharide was mainly composed of fucose (Fuc, 0.42%), rhamnoose (Rha, 7.81%), arabinose (Ara, 27.54%), galactose (Gal, 7.86%), glucose (Glu, 4.68%), xylose (Xyl, 0.33%) and galacturonic acid (Gal-UA, 51.36%). The results of total sugar, uronic acid, protein and molecular weight showed that total sugar content was 92.13% of lonicerae flos polysaccharide, the content of uronic acid was 48.66%, the protein content was 0.15%, weight average Mw was 121.994 k–Da and the Mn was 37.088 k–Da. In normal HepG2 cells, lonicerae flos polysaccharide could significantly promote glucose transport and increase glucose consumption in HepG2 cells. In insulin-resistant HepG2 cells, lonicerae flos polysaccharide could promoted the uptake of glucose, and there was a positive correlation with the mass concentration. The mechanism of hypoglycemic action showed that the lonicerae flos polysaccharide of 320 μg/mL could significantly regulate the abnormal expression of GLUT4, GSK-3β and IRS1 proteins in insulin-resistant HepG2 cells. This study provides a valuable scientific basis for the mechanism and effect of hypoglycemic action of the active components of lonicerae flos. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·10264
·
IF 15.7
Li Boyu,Ma Jiabin,Yang Ke,Li Yuhang,Ng Maggie,Ma Yuetao,An Xufei,Cheng Xing,Mi Jinshuo,Tang Man-Chung,He Yan-Bing,Kang Feiyu
The limited proton transfer kinetics within organic positive electrodes restricts the proton storage capacity and hinders achieving high energy density in aqueous zinc-organic batteries. Herein, we obtain superharmonic motion of proton by crosslinking short hydrogen-bonds network within the positive electrode matrix to achieve fast proton transfer. Specifically, the pyrazino[2, 3-g]quinoxaline-5, 10-dione owing strong electrostatic and hydrogen-bond interactions with hydrogen ions is synthesized, which could attract concentrated hydronium and trigger local proton enrichment. Spatially confined water-hydronium domains are therefore formed to generate short hydrogen bonds around pyrazino[2, 3-g]quinoxaline-5, 10-dione molecules. Moreover, the 4,4’-diaminodiphenylamine and polytetrafluoroethylene binder exhibits a mutual affinity with pyrazino[2, 3-g]quinoxaline-5, 10-dione due to the strong hydrogen-bond interactions of them, which reduce the intermolecular distance within positive electrode and construct a highly interconnected state of water-hydronium domains, thereby establishing the short hydrogen bonds network throughout the electrode matrix. The rapid proton transport through short hydrogen bonds consequently reduces the polarization of aqueous zinc-organic batteries (1.47 × 10 −3 S cm −1 ). As a result, the composite positive electrode delivers specific energy of 400 Wh kg −1 at 0.1 A g −1 .
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Nature Communications
·
2026
·Vol. 17
·期 1
·11161
·
IF 18.1
Feng Linan,Wang Kangkang,Xi Aike,Guo Zhenyu,Su Weiyin,Zhao Siming,Huang Ya,Zhao Zhuojing,Zhang Rufan
Aerogel fibers have many advantages for personal thermal management because of their three-dimensional porous structures, high porosity, thermal insulation, and effective passive daytime radiative cooling (PDRC) capabilities. However, the porous structure of aerogel fibers significantly weakens their mechanical strength, thereby reducing their cooling efficiency. Here, we develop a method for the continuous production of radially gradient porous bacterial cellulose (BC) aerogel fibers (GP-BCAFs) fabrics. The multilevel gradient micro- and nano-porous structures of the GP-BCAFs provide a high solar reflectivity, while the nano-entangled networks and distinctive wrinkled pores improve their mechanical properties by dissipating stress. The designed structure achieves a balance between strong mechanical properties and cooling performance. The GP-BCAF fabrics exhibit a high mechanical and PDRC performance, including a tensile strength of 50 MPa, a solar reflectivity of 94.7%, a mid-infrared (MIR) emissivity of 97.3%, and an outdoor cooling performance with 8.5 °C temperature lower than that of commercial cotton fabrics. Moreover, a self-powered sensor is built using the GP-BCAF fabric, and its electrical signals allow real-time monitoring of human physiological activities. This work provides a universal, sustainable, and scalable approach to producing PDRC aerogel fibers and multifunctional textiles for outdoor personal thermal management.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Liu Hui,Chen Yalan,Liu Zimai,Wu Zixian,Li Kai,Lu Jiao,Wei Yuanyuan,Zhu Pingping,Wang Xiaoxi,Wang Yongchao,Chen Zhenzhen
Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly malignancies due to its aggressive nature, poor prognosis and lack of targeted treatment. Sorafenib is a clinical first-line multi-targeted tyrosine kinase inhibitor (TKI) drug for advanced HCC, but its responsiveness limits its long-term utility. Tumor stemness and epithelial-mesenchymal transition (EMT) contribute to TKI drug sensitivity. Sox4 can promote tumor resistance by endowing cancer cells with stemness and invasive properties. Therefore, reversing tumor stemness gene expression and improving tumor malignant phenotype is a promising strategy to increase the sensitivity of HCC to sorafenib. Here, we constructed a functional nanoplatform LE-T@SOR/shSox4 combines gene therapy with targeted therapy, and selectively delivers sorafenib and knockdown plasmid to tumor site. In vitro experiments demonstrate that LE-T@SOR/shSox4 can effectively inhibit the expression of stemness-related genes, reverse the EMT process and promote differentiation in HCC, thereby increasing the drug sensitivity of HCC to sorafenib. Compared with the control groups, administration of LE-T@SOR/shSox4 dramatically suppressed CD133 expression, reduced the tumor size, and effectively improved the antitumor effect of sorafenib in vivo . In conclusion, our study provides an effective therapeutic strategy for the clinical treatment of HCC. Graphical
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