Food Chemistry-X
·
2024
·
IF 6.5
Jiangyu Zhu,Yujie Fang,Minato Wakisaka,Halimatun Saadiah Hafid,Zhengfei Yang,Yongqi Yin,Taku Omura,Weiming Fang
The massive production of food waste and plastic pollution necessitates innovative solutions. This study reports the first fabrication of a flexible chitosan (CH) film reinforced with lignosulfonate (LS) derived from pulping byproduct as a sustainable alternative to synthetic food packaging. The CH/LS composite film was prepared by a simple casting method with varying LS contents of 1 % and 2 %. Compared to CH film, the addition of 2 % LS increased the tensile strength by over 4 times and decreased water vapor permeability by 11 %. Moreover, the CH/LS film exhibited excellent UV-shielding properties. This novel use of LS to reinforce CH film presents an eco-friendly active packaging material. When used to package cherry tomatoes for 2 weeks, the CH/LS film effectively maintained fruit freshness and hardness while minimizing weight loss. This work provides new scientific evidence on the optimized preparation and application of CH/LS composite films from renewable resources for food preservation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jing Li,Xiaoqin Shi,Kang Yang,Lang Guo,Junjie Yang,Zhengyu Lan,Yong Guo,Longquan Xiao,Xinhui Wang
In this study, carvacrol was effectively encapsulated in gelatin/chitosan composite nanofiber membrane using the electrospinning method with the help of the cationic surfactant cetyltrimethylammonium bromide (CTAB). The effects of CTAB (0.0%, 1.0%, w/w) and bioactive carvacrol (0.0%, 1.0%, 3.0%, 5.0%, 7.0%, 10.0%, w/w) on the structural, physicomechanical, antibacterial, and antioxidant characteristics of the nanofiber membranes were investigated. The results demonstrated that the antibacterial and antioxidant characteristics of the gelatin/chitosan composite nanofiber membrane (GC) and GC-CAR membrane (with the addition of 1.0% carvacrol) were unsatisfactory. As carvacrol and CTAB were both added, the elongation at break, antibacterial, and antioxidant properties of the nanofiber membranes significantly improved (p < 0.05), while the water vapor permeability (WVP) significantly decreased (p < 0.05). When the added amount of carvacrol was 5.0% (w/w), the nanofiber membrane (GC-CAR5-CTAB) exhibited the best antioxidant and antibacterial performance. Finally, the GC-CAR5-CTAB membrane was applied to the preservation of strawberries and Erjingtiao chilies, and their shelf life was effectively extended. The above results indicate that the nanofiber membrane prepared in this study has great potential for application in food-active packaging.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Zhengguo Wu,Shanshan Li,Xiaoqian Qin,Lu Zheng,Jiawei Fang,Lansheng Wei,Changliang Xu,Zhong Alan Li,Xiaoying Wang
The development of highly effective chitosan-based hemostatic materials that can be utilized for deep wound hemostasis remains a considerable challenge. In this study, a hemostatic antibacterial chitosan/N-hydroxyethyl acrylamide (NHEMAA)/Ti 3 C 2 T x (CSNT) composite cryogel was facilely prepared through the physical interactions between the three components and the spontaneous condensation of NHEMAA. Because of the formation of strong crosslinked network, the CSNT cryogel showed a developed pore structure (~ 99.07 %) and superfast water/blood-triggered shape recovery, enabling it to fill the wound after contacting the blood. Its capillary effect, amino groups, negative charges, and affinity with lipid collectively induced rapid hemostasis, which was confirmed by in vitro and in vivo analysis. In addition, CSNT cryogel showed excellent photothermal antibacterial activities, high biosafety, and in vivo wound healing ability. Furthermore, the presence of chitosan effectively prevented the oxidation of MXene, thus enabling the long-term storage of the MXene-reinforced cryogel. Thus, our hemostatic cryogel demonstrates promising potential for clinical application and commercialization, as it combines high resilience, rapid hemostasis, efficient sterilization, long-term storage, and easy mass production.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
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IF 5.7
Kangning Wang,Hui Sun,Zhihan Cui,Jiahui Wang,Jiayi Hou,Fuping Lu,Yihan Liu
In this work, lactoferrin (LF)–chitosan (CS) composite hydrogels with good loading capacity of thermosensitive bioactive substances were successfully obtained by microbial transglutaminase (MTG)-induced cross-linking. We evaluated the rheological, textural, and microstructural characteristics of the composite hydrogels under different conditions. The results demonstrated that the concentrations of LF and CS as well as the amount of MTG could regulate the textural properties, rheological properties, and water holding capability. The results of FTIR and fluorescence spectroscopy indicated that the main interactions within the composite gel were hydrogen and isopeptide bonds. Additionally, in vitro digestion simulation results verified that riboflavin kept stable in stomach due to the protection of LF–CS composite hydrogels and was released in small intestine. These results suggested that thermosensitive bioactive substance could be encapsulated and delivered by the LF–CS composite hydrogel, which could be applied in lots of potential applications in functional food as a new material.
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Materials Today Communications
·
2024
·
IF 3.7
Xiaoyan Li,Fuxun Qi,Jixiang Zhu,Xinsheng Niu,Shengbing Yang,Deng-Guang Yu
Constructing bio-based antibacterial composite multilayer coatings with sustained drug release is important for reducing the infection risk of bone tissue repair. In this paper, a layer-by-layer aqueous electrodeposition method was applied to prepare a bio-based composite coating of chitosan, hyaluronic acid, and chitosan quaternary ammonium salt on the titanium surface. By pretreating with poly (acrylic acid), controlling the electrochemical deposition process, and post-treating with glutaraldehyde, a multi-layer composite coating with a smooth surface, good interface bonding with the titanium substrate, and a thickness more than ten microns was obtained. The composite coating was used as a drug-carrying system for gentamicin sulfate, which showed obvious antibacterial effects against Escherichia coli and Staphylococcus aureus . The bio-based composite coating with a sandwich structure loaded with antibiotics effectively inhibited the burst release of antibiotics, and the 14-day release rate is only 68.4 ± 2.1 %, achieving sustained release of the drug. The hydrophilic chitosan quaternary ammonium salt on the surface of the composite coating can effectively inhibit the early adhesion of bacteria, while the slow release of gentamicin sulfate in the interlayer can exert a long-lasting antibacterial effect. The preparation of bio-based antibacterial composite coatings using a layer-by-layer electrodeposition strategy has promising applications in titanium orthopedic implants.
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RSC Advances
·
2024
·Vol. 14
·期 15
·10410-10415
·
IF 3.9
Jingjing Zhao,Dou Qian,Luyang Zhang,Xiao Wang,Jianfeng Zhang
Epigallocatechin gallate (EGCG) has attracted increasing attention thanks to its multi-bioactivities, and people are keen on improving the antioxidative and antibacterial performance of EGCG. Based on the favorable biofunctionality of Zn2+ and chitosan (CS), an EGCG derivative with a novel formula, i.e., EGCG–Zn–CS, is presented in this study. The structure of EGCG–Zn–CS was characterized by FT-IR, UV-vis, TGA, XPS, and SEM–EDS. The radical elimination results indicate that 0.1 mg mL−1 of EGCG–Zn–CS demonstrates DPPH radical and hydroxyl radical scavenging activities of 94.8% and 92.3%, while 0.1 mg mL−1 of EGCG exhibits only 78.5% and 75.6%, respectively, which means improved antioxidative activity of EGCG–Zn–CS was obtained. Inhibitory experiments against Staphylococcus aureus and Escherichia coli reveal that the minimal inhibitory concentrations (MICs) of EGCG–Zn–CS were 15.625 μg mL−1 and 187.5 μg mL−1, whereas the minimal bactericide concentrations (MBCs) were 46.875 μg mL−1 and 750 μg mL−1, respectively, which indicate that EGCG–Zn–CS exerts much higher antibacterial activity than EGCG. It can be concluded that the complexing of zinc cations and CS could amazingly improve both the antioxidative and antibacterial activity of EGCG, and it is expected that an exploration of EGCG–Zn–CS may inspire the development of simultaneous effective antioxidant and antibacterial agents.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Haoxin Cai,Jiaojiao Yan,Weiguang Zhao,Shuai Ma,Jun Wu,Ze Zhao,Hongbing Deng
Injectable hydrogels with heterogeneous fibrous structures possessing good mechanical and biological characteristics are attracting increasing research interest in cartilage repair. The integration of nanofibers into hydrogel would largely enhance mechanical property, but impedes the gelation process and formation of hydrogel structures. Construction of biocompatible and mechanical supporting hydrogel with low fiber content remains a challenge. In this study, we developed a chemical cross-linked fibrous hydrogel, namely Thiol chitosan-Poly (lactic- co -glycolic acid)-Polydopamine (CSSH-PP), for facilitating cell proliferation and promoting cartilage tissues regeneration. Compared to conventional CSSH hydrogels, the compressive strength of CSSH-PP scaffolds exhibited a significant increase percentage of 100 %. Incorporation of CSSH-PP upgraded the cell migration with a four-fold increase. Besides, the infiltration of host cells and the formation of new blood vessels were observed in rat models when implanted with CSSH-PP, enhancing the native tissue microenvironmental reconstruction and leading a sustained repair in articular cartilage.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xiao Han,Weijia Gao,Zhe Zhou,Yongli Li,Duo Sun,Heyi Gong,Mengyuan Jiang,Yulu Gan,Xin Fang,Yuanzheng Qi,Junjie Jiao,Jinghui Zhao
Clinically, open wounds caused by accidental trauma and surgical lesion resection are easily infected by external bacteria, hindering wound healing. Antibacterial photodynamic therapy has become a promising treatment strategy for wound infection. In this study, a novel antibacterial nanocomposite material (QMC NPs) was synthesized by curcumin, quaternized chitosan and mesoporous polydopamine nanoparticles. The results showed that 150 μg/mL QMC NPs had good biocompatibility and exerted excellent antibacterial activity against Staphylococcus aureus and Escherichia coli after blue laser irradiation (450 nm, 1 W/cm 2 ). In vivo, QMC NPs effectively treated bacterial infection and accelerated the healing of infected wounds in mice.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Dafeng Deng,Deyi Peng,Jianhua Lv,Wenchang Zhang,Huaqin Tian,Tieqiang Wang,Mi Wu,Yan Zhao
Developing robust wet tissue adhesives remains challenging due to interfacial water and irregular surfaces. While polyelectrolyte coacervates demonstrate promising hydrophobic/fluidic properties for wet adhesion, their low cohesion limits practical applications. Herein, a wet tissue bioadhesive based on coacervates formed from low- molecular-weight methacrylated chitosan (CSMA) and hyaluronic acid (HA) is reported. These homogeneous and transparent coacervates displayed high solid content (∼18.0%), fluidity (∼105 mPa·s), and tunable mechanical properties. Upon application to wet tissue surfaces, the coacervate can be photo-cross-linked to form a double-network hydrogel in situ, resulting in improved cohesion and durable adhesion. The resulting CSMA-HA hydrogel demonstrated robust adhesion to tissues, with a bursting pressure of 374 mmHg. Remarkably, the bursting pressure can be further enhanced (∼623 mmHg) after 24 h of PBS immersion due to dynamic bond reorganization and low swelling. The demonstrated stability under physiological conditions and robust wet adhesion position CSMA-HA coacervates as a transformative platform for tissue adhesive applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xiaojie Zhang,Kangrui Ma,Liqin Zhao,Hong Peng,Yuefa Gong
To enhance the stability and adsorption performance of chitosan in Cr(VI)-contaminated acidic wastewater, a novel EDAC-modified-EDTA-crosslinked chitosan derivative (CSEC) was synthesized via a one-pot method with chitosan, 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDAC), and Na 2 EDTA as raw materials. To further improve the mechanical strength and separation performance of CSEC, a novel composite bead (CSEP) of CSEC and imidazolium-functionalized polysulfone (IMPSF) was prepared through a phase inversion method. The chemical composition and microstructure of CSEC and CSEP were characterized by FESEM, FTIR, NMR and XPS techniques. The maximum adsorption capacities of CSEC and CSEP for Cr(VI) were 145.96 and 135.82 mg g −1 at pH 3, respectively, and the equilibrium time for Cr(VI) adsorption by CSEC and CSEP was 5 min and 8 h, respectively. The adsorption process of Cr(VI) by both CSEC and CSEP was exothermic and spontaneous. Compared to CSEC, CSEP has significantly enhanced resistance to interference from coexisting anions. The removal mechanism of Cr(VI) by CSEP might involve redox reaction as well as electrostatic attraction between Cr(VI) oxyanions and various nitrogen cations, including protonated amino groups, guanidinium groups, protonated tertiary amine groups, and imidazolium cations. The CSEP beads have potential application value in the treatment of acidic wastewater containing Cr(VI).
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Polymers
·
2024
·Vol. 16
·期 7
·995
·
IF 4.7
Song Zhang,Yunxu Ji,Yiwei He,Juan Dong,Haohang Li,Shirui Yu
Chitin and chitosan are important structural macromolecules for most fungi and marine crustaceans. The functions and application areas of the two molecules are also adjacent beyond their similar molecular structure, such as tissue engineering and food safety where solution systems are involved. However, the elasticities of chitin and chitosan in solution lack comparison at the molecular level. In this study, the single-molecule elasticities of chitin and chitosan in different solutions are investigated via atomic force microscope (AFM) based single-molecule spectroscopy (SMFS). The results manifest that the two macromolecules share the similar inherent elasticity in DOSM due to their same chain backbone. However, obvious elastic deviations can be observed in aqueous conditions. Especially, a lower pH value (acid environment) is helpful to increase the elasticity of both chitin and chitosan. On the contrary, the tendency of elastic variation of chitin and chitosan in a larger pH value (alkaline environment) shows obvious diversity, which is mainly determined by the side groups. This basic study may produce enlightenment for the design of intelligent chitin and chitosan food packaging and biomedical materials.
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COLLOID AND POLYMER SCIENCE
·
2024
·
IF 2.2
Hu Guang,Khan Humayun,Ali Farman,Begum Siddiqa,Mehmood Sahid,Arif Umar,Ali Nisar,Hayat Mudassir
This study focuses on advancing epoxy-polyamide composites through the incorporation of chitosan, derived from crab shells, a sustainable polymeric bio filler known for its ability to enhance mechanical and thermal properties. Utilizing a solution casting technique, composites were fabricated by blending various concentrations of chitosan into the epoxy-polyamide matrix. Several analytical methods, including FT-IR, XRD, SEM, DSC, and mechanical testing, were used to evaluate the modifications and properties of the composites. FT-IR confirmed successful chitosan incorporation into the ER-PA composites, supported by SEM analysis showing improved structural integrity. XRD revealed prominent diffraction peaks, reflecting increased crystallinity and efficient chitosan integration. SEM indicated uniform chitosan dispersion on smooth surfaces, enhancing fracture toughness. Mechanical study of the 1% chitosan blend demonstrated superior results, with an elasticity of 6.79 GPa and fracture elongation of 2.2%, surpassing the 5% blend. DSC data showed improved thermal stability, with the uncured composite exhibiting endothermic behavior at 100 °C and exothermic behavior at 400 °C. TGA confirmed enhanced thermal properties up to 780 °C, particularly for the 1% Cs blend, which also displayed outstanding amorphous characteristics. Overall, the mechanical study confirmed Young’s best modulus, toughness, and tensile strength in the 1% blend. A noticeable shift toward higher temperatures during accelerated heating indicated enhanced material durability. These findings highlight the significant potential of chitosan to improve the mechanical strength and thermal stability of epoxy-polyamide composites, making them suitable for demanding engineering applications where endurance and performance are critical. Graphical abstract
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危险品化学品经营许可证（带存储）