JOURNAL OF APPLIED POLYMER SCIENCE
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2026
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IF 2.8
Menglu An,Jingbo Li,Shaokui Cao,Yingliang Liu,Jingguo Li,Jun Shi
Casein-based nanocarriers have demonstrated significant potential in drug delivery due to their excellent biocompatibility, amphiphilic nature, and pH responsiveness. However, casein-based drug carriers suffer from the problems of single intelligent response and poor controllability of drug release. In this study, casein was combined with hollow copper sulfide (CuS) nanoparticles with near-infrared (NIR) responsiveness through electrostatic self-assembly interaction to generate CuS@casein micelles (CuS@CM) with sustained and pH/NIR dual-responsive drug release properties. The strong negative charge of casein and the hollow structure of CuS ensure a high doxorubicin (DOX) loading efficiency (96.84%) of CuS@CM. Ca 2+ is bound with casein to form inter-casein calcium bridges, thereby providing significant sustained release properties for CuS@CM. The charge inversion property of casein at different pH values and excellent NIR responsiveness of hollow CuS nanoparticles endows CuS@CM with superior pH/NIR dual-responsive drug release performance. In vitro cell viability results demonstrated that the pH/NIR dual-responsiveness of CuS@CM-DOX, as well as its excellent tumor cellular uptake capability, could effectively induce tumor cell death. Overall, this study generates a novel casein-based nanocarrier with sustained and pH/NIR dual-responsive drug delivery properties, which has potential application in the field of tumor-targeted drug delivery.
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JOURNAL OF MOLECULAR LIQUIDS
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2026
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IF 5.2
Jianchao Hou,Wen Zhang,Zhonglong Wang,Xiaoqin Yang,Xiaoping Rao,Ping Zhao,Qian Jiang
Polarity serves as a vital parameter in assessing diagnosing diseases, reflecting quality in cellular metabolic status. In this work, two novel dicyanoisophorone-based fluorescence probes ( DCIV-1 and DCIV-2 ) have designed and synthesized, capable of detecting pH levels and polarity fluctuation effectively. A detailed analysis of the probe's optical properties reveals that DCIV-1 and DCIV-2 exhibit distinct fluorescence and colorimetric responses under varying pH conditions. Meanwhile, DCIV-1 and DCIV-2 exhibit excellent responsiveness to polarity change respectively. Biological application reveals that both probes are successfully applied for distinguishing between cancer cells and normal cells. Furthermore, DCIV-1 and DCIV-2 enable rapid pH values in real water samples. As a convenient detection method, probe-based test strips have developed for detecting pH changes. This work highlights the potential of DCIV-1 and DCIV-2 for pH levels and polarity monitoring in biological and environmental fields.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 2
·124
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IF 5.4
Li Zhe,Gao Zhaodong,Chen Zhijiao,Liu Yuanan,Wang Xiaohui
A dual-mode ratiometric fluorescent nanosensor was developed for ultrasensitive detection of glucose via simultaneous measuring pH and O 2 changes during enzymatic oxidation. The nanosensor integrates pH-sensitive fluorescent probe FITC and O 2 -sensitive probe RuDP into hybrid nanoparticle core, with glucose oxidase (GOx) immobilized poly-L-lysine shell. During GOx-catalyzed reaction with glucose, the nanosensor gives rise of a decrease in pH-sensitive fluorescence due to acidification and an increase in O 2 -sensitive fluorescence owing to oxygen depletion, enabling a dual-mode readout under single-excitation wavelength. The emission ratio between O 2 -sensitive peak and pH-sensitive peak, employs signal amplification and results in high sensitivity, compared to single O 2 and pH testing. The ratiometric fluorescent signal exhibits a strong linear response in the 0–1 mM glucose range with a detection limit of 7.3 µM. The sensor shows robust performance and high reproducibility in DMEM and human sweat. In vivo imaging of zebrafish further confirms the photostability, and sensitivity of nanosensor, highlighting their utility for glucose detection. This study presents the first ratiometric fluorescence amplification strategy employing dual pH/O 2 testing for real-time glucose detection. The proposed nanosensor promotes non-invasive glucose detection in biomedical research and dual-mode ratiometric amplification strategies for monitoring metabolic targets. Graphical abstract
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Journal of Environmental Sciences
·
2026
·
IF 6.3
Qian Sheng,Jinhong Fan,Bin Dong,Zuxin Xu
Protein-based foaming agents exhibit potential for exceptional foaming capacity with broad industrial applicability, yet their high production costs drive the need for cost-effective and sustainable alternatives. This study unveils a novel synergistic strategy combining pH-shifting and calcium ion addition to transform organic waste compost protein (CP) into a high-performance foaming agent. Our approach utilizes pH-driven conformational adjustments to expose latent binding sites for calcium, enabling targeted interfacial reinforcement. The foaming capacity (FC) of the resulting CP was exceptional (>480 %). While untreated CP exhibited limited foam stability (FS, 58.86 %), 0.1 mol/L Ca 2+ alone boosted FS to 81.31 %, and pH-shifting alone achieved 70.21 %. The dual treatment synergized these effects, reaching 85.02 % FS while fully retaining FC. Advanced characterization revealed two mechanisms: (1) calcium-specific interfacial pattern, evidenced by SEM-EDS showing calcium enrichment at bubble surfaces (21.67 % vs. 5.39 % in controls), and (2) protein restructuring, where Ca 2+ coordinated with carboxyl/amino groups to compact CP’s secondary structure with an increase of α-helix content from 5.46 % to 6.96 % and (α-helix/(β-sheet+random coil) ratio increased by 32 %. Crucially, pH-shifting further amplified protein adsorption at air-water interfaces by 113 % (from 12.2 % to 26.06 %), creating viscoelastic films resistant to coalescence. The synergy between molecular-level structural changes and interfacial calcium-protein complexes accounts for the markedly enhanced FS. This study provides a theoretical foundation and a technical pathway for producing cost-effective, eco-friendly foaming agents derived from organic waste compost protein, thereby facilitating its high-value valorization.
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CARBOHYDRATE POLYMERS
·
2010
·Vol. 84
·期 1
·195-202
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IF 3.167
Deqian Wang,Junjun Tan,Hongliang Kang,Lin Ma,Xin Jin,Ruigang Liu,Yong Huang
The pH-responsive ethyl cellulose graft poly(2-(diethylamino) ethyl methacrylate) (EC- g -PDEAEMA) copolymers were synthesized through atom transfer radical polymerization (ATRP). Kinetic analysis confirmed the reaction is living and controllable. The graft copolymers can form micelles in acid aqueous medium. The critical micelle concentration (CMC) of the graft copolymers decreases with the increase of the graft length and graft density. The resultant micelles show the pH-sensitivity. The decrease in the hydrodynamic radius of the micelles at pH 6–6.9 attributes to collapse of the side PDEAEMA chains in the shell of the micelles due to the deprotonation , which was further confirmed by TEM observation. The loading and controlled release of drugs in the micelles was investigated by using rifampicin (RIF) as the model drug. It was found that the cumulant release of RIF in the buffer solution at pH 6.6 is higher than that at pH 7.4.
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BIOSENSORS & BIOELECTRONICS
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2013
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IF 5.437
Xindong Wang,Jing Dong,Xinyu Liu,Yanzhen Liu,Shiyun Ai
A novel pH-controlled immunosensor using hollow mesoporous silica and apoferritin combined system has been reported for the first time. The goal of this study was to introduce more electroactive probes into the electrochemical immunosensor. Under such background, we focused our attention on hollow mesoporous silica and apoferritin, both of which have admirable accommodating performances and can be applied for encapsulating electroactive probes. Based on the pH-controlled disassociation–reconstitution process of apoferritin and the mesoporous channels of silica, after the appropriate chemical modification, apoferritin could be fabricated with silica. The results showed that the hollow mesoporous silica and apoferritin combined system was successfully assembled. The excellent performance of the combined system can be applied for ultrasensitive detection of a target virus.
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JOURNAL OF POWER SOURCES
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2018
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IF 6.945
Xiaodeng Wang,Hongpeng Zhou,Dingke Zhang,Mingyu Pi,Jiajia Feng,Shijian Chen
Developing stable and high-efficiency hydrogen generation electrocatalysts , particularly for the cathode hydrogen evolution reaction (HER), is an urgent challenge in energy conversion technologies. In this work, we have successfully synthesized Mn-doped NiP 2 nanosheets on carbon cloth (Mn-NiP 2 NSs/CC), which behaves as a higher efficient three dimensional HER electrocatalyst with better stability at all pH values than pure NiP 2 . Electrochemical tests demonstrate that the catalytic activity of NiP 2 is enhanced by Mn doping. In 0.5 M H 2 SO 4 , this Mn−NiP 2 NSs/CC catalyst drives 10 mA cm −2 at an overpotential of 69 mV, which is 20 mV smaller than pure NiP 2 . To achieve the same current density , it demands overpotentials of 97 and 107 mV in 1.0 M KOH and phosphate-buffered saline (PBS), respectively. Compared with pure NiP 2 , higher HER electrocatalytic performance for Mn−NiP 2 NSs/CC can be attributed to its lower thermo-neutral hydrogen adsorption free energy , which is supported by density functional theory calculations.
研究领域:
材料科学
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电化学
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能量转换
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纳米材料
·
催化
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CARBOHYDRATE POLYMERS
·
2026
·
IF 12.5
Junhao Ye,Ruiquan Hou,Kang Xie,Guangmin Ou,Zhixiang Zhang,Dongmei Cheng
The plant-derived photoactivated fungicide α-Terthienyl (α-T) exerts antimicrobial effects through light-induced reactive oxygen species generation. However, its agricultural application has been constrained by poor targeting capability and low photostability. To address these challenges, we developed a dual-responsive nanoparticle delivery system (α-T NPs) based on a pectin-chitosan polymer network that specifically recognizes the acidic and pectinase-rich microenvironment created by Botrytis cinerea hyphae secretions. Controlled release studies demonstrated that both acidic conditions (pH 5.0) and pectinase exposure substantially promoted α-T release, achieving cumulative release rates of 71.73% and 74.49% respectively over 60 h. The nanoparticle system showed no adverse effects on healthy tomato leaf growth while forming a protective barrier that effectively suppressed fungal infection. Targeted delivery significantly enhanced fungicidal efficacy, with α-T NPs exhibiting an EC₅₀ of 0.419 mg/L compared to 1.943 mg/L for α-T (technical material, TC). Confocal microscopy and quantitative analysis confirmed the enhanced targeting mechanism, revealing substantially stronger fluorescence intensity and higher α-T accumulation specifically on treated fungal hyphae. Additionally, α-T NPs significantly improved photostability, extending the half-life by approximately 1.93-fold under continuous illumination compared to α-T (TC). This work establishes an innovative “pathogen-activated” delivery platform with promising applications in sustainable crop protection.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Yufan Sun,Mingming Zhong,Qin Liu,Qingzhen Liang,Qiufang Liang,Xinyu Chen,Haile Ma,Xiaofeng Ren
To solve the problem of poor swallowing mouthfeel caused by the low stability and insufficient lubrication of plant protein based emulsions, this study focused on soybean oleosomes and applied multifrequency ultrasound-assisted pH treatment to investigate their effects on physicochemical properties, rheology, and lubrication performance. The results showed that, at pH 9.0 compared with pH 6.0, surface electrostatic repulsion of oleosomes was enhanced and adsorption of extrinsic proteins was inhibited. On this basis, applying moderate ultrasound further improved their dispersibility and increased extraction efficiency, among which pH 9.0 dual frequency ultrasound treatment (pH 9.0 DUT) performed best; its extraction yield, particle size, and ζ potential were 28.54%, 390.4 nm, and − 35.7 mV, respectively, and good stability was maintained during storage. The rheological results showed that ultrasound assisted pH treatment promoted interfacial interactions among droplets, formed a dense interfacial layer, and enhanced viscoelasticity. The tribological results indicated that the stability of oleosomes determined whether a continuous lubricating film could be formed and maintained during friction; pH 9.0 DUT, through binding with the mucin layer, induced the formation of a water rich hydration layer, and oleosomes followed a ball-bearing mechanism, thereby achieving efficient friction reduction and improving mouthfeel. In summary, ultrasound assisted pH extraction not only improved the extraction efficiency of oleosomes but also optimized the interfacial structure, significantly improved the rheological and tribological performance of the emulsion, and provided a theoretical basis for the formulation design of plant based emulsions and sustainable processing.
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Scientific Reports
·
2026
·
IF 3.9
Wang Aqin,Zhou Zhengbing,Hang Zhou,Lyu Zhengbing,Yang Jingchun,Zhang Lu,Wang Meng,Liu Wei,Zou Liqiang,Yu Jun
Direct oral intervention of spleen aminopeptide (SA) would be limited because of its varied swelling and release rate in different pH environments of digestive fluids. Herein, pH-responsive hydrogel microspheres (3.67 ± 0.04 mm) with positive SA-loaded chitosan (Cs) core and negative alginate (ALG) shell were prepared. Entrapment efficiency was 76.22% and loading rate of SA was 35.17%. Besides the hydrogen bonding, a strong core/shell structure was constructed by forming imine bond via the Schiff base reaction of amino group in Cs with ketone group on SA. In vitro simulated digestion showed that the swelling rate of microspheres was 192.8% (pH 1.2), 2481.5% (pH 6.8), and 1144.3% (pH 7.4). The release rate of SA was 0.9% in simulated gastric fluid for 2 h, 6.0% in simulated intestinal fluid for 2 h and continuous release in simulated colonic fluid for 24 h with a cumulative release rate of 92.4%. After treatment, the observation group exhibited increasing levels of CD3 + , CD4 + , CD4 + /CD8 + , IgA, IgG and IgM. Total effective rate in observation group was 96.15%, being higher than that in control group (84.31%). This work provided a valuable reference for preparing drug-loaded hydrogels to improve the recurrent respiratory infection in children.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4
Xu Peng,Bao Jia-Wei,Li Qun,Shi Wei-Shan,Xing Gang,Yu Lei
Smart pesticide delivery systems based on stimuli-responsive nanocarriers have attracted considerable attention because of their potential to enhance pesticide efficiency while reducing environmental risks. In this study, a novel pH/glutathione dual-responsive pesticide delivery system was constructed through the synthesis of disulfide-bridged hollow mesoporous organosilica nanospheres (HMONs) via the Stöber method, followed by poly(acrylic acid) (PAA) coating through distillation-precipitation polymerization to form HMONs@PAA nanocomposites. The resulting abamectin-loaded system (Abamectin-HMONs@PAA) demonstrated a 12.73% pesticide loading capacity and significantly improved photostability, retaining twice as much active ingredient as free abamectin after 250 h of UV irradiation (36 W). Release studies revealed pH- and glutathione-dependent characteristics, with cumulative releases in acidic conditions exceeding those in neutral and alkaline environments by 18.66% and 40.98%, respectively, and a 14.2% increase in glutathione-containing solution (0.2 mmol·L −1 in 70% ethanol) after 97 h. Bioassays showed superior performance against Plutella xylostella , with a 13.33% reduction in survival rate compared to conventional suspension at equivalent dosage (40 mg·L −1 ), while maintaining efficacy after extensive rainfall simulation (20 events over 10 days). This study provides a promising approach for developing environmentally responsive nanopesticides with enhanced durability and controlled-release properties, offering significant potential for sustainable crop protection.
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Desalination and Water Treatment
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2026
·
IF 1
Hui Xia,Quanhui Hu,Qingchao Zhang,Bangwen Lu,Xiaorui Guo,Jungang Guo,Wenjing Zhang
The formation process of contaminated groundwater is invariably associated with pH fluctuations caused by the intrusion of anthropogenic contaminants, including heavy metals and organic compounds. In this study, a pH-responsive CaO 2 nanocomposite wrapped in chitosan (CS/CaO 2 ) was successfully synthesized via a pH-regulated chemical precipitation method. The CS/CaO 2 exhibited a well-defined core-shell bilayer structure with particle sizes ranging from 100 to 200 nm. Significantly, the incorporation of the chitosan (CS) coating not only enhanced the pH responsiveness but also reduced nanoparticle agglomeration. The sequence of reagent addition was found to be critical in achieving successful encapsulation. Simulation experiments were performed to assess the remediation effect on organic p- nitrophenol (PNP) and inorganic heavy metals. The inner core CaO 2 , acting as a solid source of H 2 O 2 , would be released as the external CS was broken after experiencing pH response. A CaO 2 modified Fenton system was then provided for the oxidative degradation of PNP, and its concurrently generated Ca(OH) 2 could facilitate the precipitation and immobilization of heavy metals. Removal efficiency exceeded 95 % under the optimized experimental conditions, demonstrating the high effectiveness of this approach. Overall, this study presents an enhanced pH-responsive nucleocapsid CS/CaO 2 nanocomposite with promising applications in the multi-contaminant remediation.
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