ACS Sustainable Chemistry & Engineering
·
2017
·
IF 5.951
Xinzhi Ma,Jing Wen,Shen Zhang,Haoran Yuan,Kaiyue Li,Feng Yan,Xitian Zhang,Yujin Chen
Development of noble-metal-free and active electrocatalysts is crucial for the oxygen evolution reaction (OER) in the water-splitting process. Herein, crystal CoxB catalysts (x = 1–3) of the OER are fabricated by a ball-milling method. Among these CoxB catalysts, Co2B exhibits the best OER activity, with a current density of 10 mA cm–2 at an overpotential of 287 mV in 1 M KOH solution. Such OER activity of Co2B is favorably comparable to that of the commercial IrO2 and most recently reported OER catalysts. Furthermore, the Co2B catalyst exhibits excellent stability with a stable current density of 50 mA cm–2 over 12 h of continuous electrolysis operation. X-ray photoelectron spectroscopy and cyclic voltammetry demonstrate that the B in CoxB makes oxidation easier, leading to their enhanced OER activities in comparison to metal Co. In addition, the Co2B electrocatalyst also exhibits high activity in the hydrogen evolution reaction; thus, the catalyst can be used as a bifunctional catalyst for full water splitting.
✓ 已验证
DOI
高影响因子
Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-21
·
IF 8.9
Jia Yifan,He Muchen,Wang Fan,Zhan Yaqing,Deng Qiwen,Shen Jiantong,Wang Xiwen,Ran Qi,Huang Wenqi,Ling Yihong,Wen Shihong
Background & Aims Dysfunction of the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB) contributes to the development of intestinal ischemia/reperfusion (IR) injury. Tryptophan (TRP), an essential amino acid, plays a crucial role in maintaining intestinal homeostasis, yet its regulatory effects on the GVB following IR remain unexplored. We aimed to better define the role of TRP in intestinal IR in vivo and in vitro. Methods Mice underwent intestinal ischemia/reperfusion (IR) and were fed control, TRP-recommended (TRP-r), or TRP-sufficient (TRP-s) diets. Fecal metagenomic sequencing analyzed microbial composition, and targeted metabolomics quantified tryptophan and its metabolites in intestinal and serum samples. ILA’s effects on barrier integrity were assessed via tight junction protein expression and FITC-dextran permeability assays. RNA sequencing of intestinal endothelial cells elucidated mechanisms by which ILA modulated GVB function. The STAT3-claudin 2 relationship was validated in vitro by ChIP-qPCR. Results TRP supplementation significantly reshaped the gut microbiota, mitigated tissue damage and enhanced the integrity of both the IEB and GVB. Indole-3-lactic acid (ILA), a key tryptophan metabolite, was identified as an important factor in preserving GVB function. Mechanistically, our results show that the aryl hydrocarbon receptor (AhR)/Nrf2/signal transducer and activator of transcription 3 (STAT3) pathway is essential for ILA-mediated improvement of GVB integrity and downregulation of the pore-forming protein claudin 2. Conclusions Our findings highlight the dual role of ILA in reinforcing both IEB and GVB functions and shed light on the molecular mechanisms underlying ILA’s GVB-protective effects. This study implicates that ILA or other AhR-activating metabolites may serve as promising pharmacological agents for alleviating IR-induced intestinal damage. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jiaxi Jin,Yuyang Xiao,Hao Lai,Ruixing Fu,Peilun Shen,Dianwen Liu,Xinyi Liang,Bo Peng
The efficient separation of chalcopyrite from sphalerite remains a significant challenge in flotation due to their similar surface properties. In this study, Trisodium 4-carboxy-5-mercapto-3-hydroxy-isothiazole (TCMHI) was introduced as a novel, eco-friendly, and selective organic depressant for sphalerite. Micro-flotation tests demonstrated that TCMHI (73 mg/L) could selectively depress sphalerite flotation (recovery <14%) at pH 7.0 while maintaining high chalcopyrite recovery (> 94%). Successful separation was achieved in artificially mixed mineral tests, yielding a concentrate with a Cu grade of 32.01% and a recovery of 96.65%. To validate its industrial applicability, bench-scale flotation tests were conducted on a real Cu Zn sulfide ore. The results showed that TCMHI achieved metallurgical performance comparable to the conventional depressant zinc sulfate (ZnSO 4 ), maintaining a copper recovery of 71.32% while effectively suppressing zinc recovery to 21.18% in the concentrate. Surface characterization techniques, including contact angle, zeta potential, and Atomic Force Microscopy (AFM), revealed that TCMHI preferentially adsorbs onto the sphalerite surface, forming a dense hydrophilic layer that hinders collector adsorption. X-ray Photoelectron Spectroscopy (XPS) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) analyses confirmed that TCMHI chemically adsorbs on sphalerite through the formation of stable Zn-TCMHI surface complexes. Density Functional Theory (DFT) calculations further elucidated the mechanism, showing that TCMHI forms a stable five-membered chelate ring with surface Zn atoms via its nitrogen and endocyclic sulfur atoms. Crucially, the adsorption energy of TCMHI on sphalerite (−209.76 kJ/mol) was found to be significantly more negative than that of the collector (−95.88 kJ/mol), explaining its superior depression performance. This work provides a promising reagent for the sustainable and efficient flotation separation of Cu Zn sulfide ores.
✓ 已验证
产品关联
DOI
高影响因子
Toxics
·
2026
·Vol. 14
·期 3
·222
·
IF 4.9
Xiao Kang,Wenting Song,Xueyan Li,Yuyan Yang,Xinke Wu
Breast cancer is the most common malignant tumor among women worldwide, and its occurrence is closely associated with long-term exposure to environmental pollutants. Polycyclic aromatic hydrocarbons (PAHs) are a class of persistent organic pollutants widely present in the living environment. Epidemiological studies indicate that exposure to PAHs increases the risk of breast cancer. PAH derivatives exhibit stronger toxicity or endocrine-disrupting activity than their parent compounds; however, research on their specific effects and mechanisms in breast cancer cells remains limited. For this purpose, this study selected 3-Hydroxybenz[a]anthracene, a PAH derivative with potential estrogenic activity, as the target compound. Using the estrogen receptor-positive breast cancer cell line MCF-7 as the model, we performed EdU staining, colony formation assays, scratch healing assays, Transwell invasion assays, and apoptosis assays and preliminarily examined changes in relevant signaling proteins via Western blot. Results indicate that 3-Hydroxybenz[a]anthracene promotes proliferation and migration in MCF-7 cells while inhibiting apoptosis under certain conditions, but it has no effect on cell invasion. Mechanistically, it upregulates key proteins including AKT, c-Myc, E-Cadherin, Vimentin, MMP2, MMP9 and Bcl-2 while downregulating p-AKT expression. This study confirms through in vitro experiments that 3-Hydroxybenz[a]anthracene exhibits estrogen-like effects and modulates malignant behavior in breast cancer cells by regulating relevant signaling pathways. These findings provide experimental evidence for further evaluating the potential role of this environmental contaminant in breast cancer initiation and progression.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Xinze Wu,Hu Wang,Jiangchao Chen,Pengfei Pang,Haiping Li,Kunpeng Jiang,Yunyun Zhao,Wenping Liu,Guisheng Zhu,Huarui Xu
Dendrite growth and interfacial instability in conventional liquid electrolytes limit the practical application of lithium metal batteries (LMBs). Composite solid electrolytes (CSEs) offer a promising alternative, yet challenges remain in achieving high ionic conductivity and low interfacial resistance. In this study, a series of sponge-like porous Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 @PMMA/PVDF-HFP CSE membranes (LPPH1:x) were fabricated via phase separation-solution casting. A multistage ion transport channel was constructed through the synergistic combination of the polymer matrix, inorganic fillers, and liquid electrolytes. The incorporation of PMMA suppressed the crystallization of PVDF-HFP, while the ester groups in PMMA facilitated Li salt dissociation through coordination with Li + . LPPH1:3 exhibited optimal comprehensive performance: a high ionic conductivity of 2.75 × 10 −3 S·cm −1 at room temperature, a Li + transference number of 0.62, and an electrochemical stability window of 4.9 V. Moreover, the symmetric cell demonstrated stable cycling for over 2000 h at 0.2 mA·cm −2 . The LiFePO 4 full cell retained 96.4% capacity after 200 cycles at 0.5C. Post-cycling characterization confirmed that LPPH1:3 suppressed lithium dendrite growth and maintained a stable interfacial structure. This work provides an innovative material design strategy and theoretical foundation for developing high-performance solid-state LMBs.
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2026
·
IF 3.3
Yang Pan,Cong-Min Fan,Tiancheng Feng,Haoyang Peng,Xiaolian Xu,guiqi gao
The slow kinetics of the oxygen evolution reaction hinders the efficiency of water decomposition, so it is crucial to develop noble metal-free electrocatalysts for the efficient decomposition of water via oxygen evolution reaction (OER) in alkaline electrolytes. In this study, flower-like structured hydroxides grown in situ consisting of ultrathin nanosheets stacked on Fe Foam (FF) were prepared by a one-step hydrothermal method for efficient electrocatalytic oxygen evolution reaction. M(OH)(OCH 3 ) (M=Co, Cu) requires only a low overpotential of 270 mV and 379 mV of the OER, to provide 20 mA⋅cm -2 and 100 mA⋅cm -2 current densities respectively. With the synergistic effect of Co 2+ and Cu 2+ , the adsorption capacity of the intermediate OH* and the conductivity are improved, and the structural surface reconstruction are promoted by methoxide. In this work, the structure of FF-based electrocatalysts was modulated by Co 2+ and Cu 2+ introducing and synthesizing methoxy anions, which improved the catalytic activity of the catalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 5
·2654-2666
·
IF 2.779
Huang Xiaocong,Wei Aixiang,Jun Liu,Zhao Yu,Liu Zhen,Yang Xi
Perovskite solar cells (PSCs) based on hole-transporting-materials (HTM)-free and carbon electrodes have attracted intensive attention due to their low material cost, simple manufacturing process, and high stability. However, their power conversion efficiencies (PCE) need further improvement. In this work, the effect of Br - component x on properties of the MAPb(I 1− x Br x ) 3 thin films as well as photovoltaic performance of PSCs were studied. The MAPb(I 1− x Br x ) 3 thin films were prepared using two-step solution deposition method in ambient air. The Br − component x was varied from 0 to 1 by changing the PbBr 2 to PbI 2 molar ratio in the precursor solution. PSCs based on the HTM-free and carbon electrodes were fabricated in ambient air in this work, aiming to realize reduction of fabrication cost and improve the stability of PSCs. The results indicated that when Br − component x increase, the XRD diffraction peaks of MAPb(I 1− x Br x ) 3 thin films continuously shift to larger diffraction angle, meanwhile, the absorption edge and PL peak continuously shift toward to the shorter wavelength. The PSCs based on MAPbI 2.7 Br 0.3 exhibits an optimal photovoltaic performance, yielding V oc of 0.95 V, J sc of 17.61 mA/cm - 2 , FF of 0.70, and PCE of 11.70%. Its PCE remains 93.3% of the initial efficiency after being exposed in the atmosphere for 700 h.
✓ 已验证
DOI
高影响因子
Science China-Materials
·
2021
·Vol. 64
·期 8
·2008-2016
·
IF 8.273
Wen Xin,Lin Chensheng,Luo Min,Fan Huixin,Chen Kaichuang,Ye Ning
[PO 4 ] 3− possesses small microscopic second-order susceptibility and polarizability anisotropy, which inherently result in weak second-harmonic generation (SHG) and small birefringence. Herein, a new noncentrosymmetric phosphate, [C(NH 2 ) 3 ] 3 PO 4 ·2H 2 O, was successfully designed and synthesized by a solution evaporation method. [C(NH 2 ) 3 ] 3 PO 4 ·2H 2 O without metal ions is composed of planar conjugated guanidine cations and PO 4 tetrahedrons, which are connected by hydrogen bonds, forming a three-dimensional network. Physical property measurements indicate that the title compound displays an SHG response of 1.5 × KH 2 PO 4 (KDP) and a larger birefringence (0.055@546.1 nm) compared with most reported ultraviolet nonlinear optical phosphates. Furthermore, first-principles calculations reveal that the π-conjugated planar [C(NH 2 ) 3 ] + cations and [PO 4 ] 3− groups are responsible for its excellent linear and NLO properties.
研究领域:
材料科学
·
光学工程
·
无机化学
·
晶体工程
·
非线性光学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.5
Chengcheng Liu,Lin Shao,Guo-Heng Wei,Yi-Fan Li,Pan Guo,Ligang Zhang,Cong Wang,Xiao-Yan Zhao,Dejin Zhang,Jing-Pei Cao
Lignin, due to its structural rigidity, tends to form coke deposits during catalytic hydrodeoxygenation (HDO), causing catalyst deactivation, and eliminating coke to restore performance is challenging. In this study, Co 3 O 4 shows excellent HDO performance toward lignin model dimers with high selectivity for demethoxylation and deethoxylation under mild conditions via a one-step strategy integrating in-situ reduction and HDO, and enables lignin HDO. At 240 o C, 2 MPa, and 20 h, lignin achieved a 73 % liquid yield, with 64%, 30%, and 6% selectivities to alkanes, alcohols, and phenols. This is attributed to Co 3 O 4 's high Co-O bond energy, dominant (220) crystal plane exposure, and high Co 3+ /Co 2+ ratio, facilitating in-situ reduction to metallic cobalt active sites. Coke on Co 3 O 4 can be removed by calcination to restore performance, with 90% of the initial liquid yield retained after five cycles. This low-cost commercial non-noble metal Co 3 O 4 enhances the economic feasibility of lignin's high-value utilization.IntroductionLignin, accounting for 15-30 wt% of lignocellulose, is the most abundant renewable aromatic resource on earth, holding immense potential to replace fossil feedstocks in producing high-value
✓ 已验证
DOI
高影响因子
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2017
·
IF 0.809
Huili Ma,Shuyun Liu,Shaohua Zhu,Wenzhu Bi,Xiaolan Chen,Yufen Zhao
Display full size
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xi Wang,Yuying Wang,Ziqi Li,Bin Zou,Li Lin,Zhifeng Xue,Ruzhi Zhang,Weimin Wan
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide due to late diagnosis, high metastasis, and poor therapeutic outcomes. Curcumin (Cur), a natural polyphenol with potent antitumor activity, is severely limited in clinical application by poor water solubility, low bioavailability, and insufficient tumor-targeting capability. Herein, a dual-targeted pH-responsive nanocarrier based on cellulose nanocrystals (CNCs) co-functionalized with folic acid (FA) and 3-carboxyphenylboronic acid (CA) was fabricated for enhanced Cur delivery to HCC cells. CNCs were aminated via silane coupling, followed by covalent co-grafting of FA and CA to obtain ACNCs@FA- CA. FA enabled targeting of folate receptors overexpressed on HCC cells, while CA played a dual role by reversibly binding Cur through boronate ester formation and recognizing sialic acid-rich tumor cell membranes. Cur was loaded with an efficiency of 13.90 ± 2.00% and exhibited pH-responsive release, reaching 81.61 ± 1.60% at pH 5.4 and 26.29 ± 1.47% at pH 7.2. In vitro studies demonstrated that Cur-loaded ACNCs@FA-CA significantly enhanced intracellular drug accumulation and cytotoxicity in HepG2 cells, with improved growth inhibition in a 3D hepatoma spheroid model. Collectively, this dual-targeted pH-responsive nanoplatform offers a promising strategy to improve the anti-HCC efficacy of Cur.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 16
·D908
·
IF 3.12
Xinkuai He,Zhengyang Sun,Qingtian Zou,Jingjing Yang,Luye Wu
The codeposition behavior of Co(II) and Ni(II) in 1-ethyl-3-methylimidazolium bisulfate ([EMIM]HSO4) ionic liquid (IL) and ethylene glycol (EG) system is recorded using cyclic voltammetry (CV). The result indicates that the mechanism of Co-Ni codeposition is an anomalous codeposition, and both the inhibition for Ni(II) reduction and the anomalous codeposition phenomena can be improved by the increase of Co(II) concentration in the system. These Co-Ni deposits are characterized using EDS, XRD and SEM. SEM micrographs indicate that the surface morphology of Co-Ni deposits can be changed by the increase of Co content, and these deposits with many additional elongated acerose crystals, which are germinated on the spherical “nodules” surface, can be prepared. XRD pattern reveals the feature peak of crystalline Co1.2Ni2.8 with a preferred orientation direction and the average size of grains is calculated to be about 14.6 nm. Moreover, the electrocatalytic activity for hydrogen evolution reaction (HER) on the prepared Co-Ni catalyst surface is investigated using linear sweep voltammetry (LSV) and electrochemical impedance spectra (EIS). These results indicate that the obtained catalyst presents an excellent electrocatalytic activity and durability for HER with an overpotential of 139 mV at 10 mA cm−2 in 1 M KOH solution.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）