JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 13
·130517
·
IF 3.721
Zhaoyu Wang,Lihua Jiang,Chen Liang,Chunpeng Zhao,Zesen Wei,Qingsong Wang
The overcharge issue still occupies a high safety risk for NCM cathode materials with less stable structure. In this work, an original overcharge protection electrolyte additive named as 3-fluoroanisol (3FA) is recommended for NCM 622. The anti-overcharge effect of 3FA was verified in detail by cycle voltammetry, constant-current overcharge and discharge, AC impendence and scanning electron microscopy measurement. The electrolyte conductivity and long-term cycle performance tests were conducted to evaluate the impact of 3FA on the cell system operated in conventional voltage range. The 3FA is electro-polymerized at about 4.4 V and the time from upper cut-off voltage to overcharge state is extended from 5.46 h to 11.82 h in CR2032 cell, no adverse effects are shown during normal use at the same time under the additive amount of no more than 5 wt.%. Moreover, C80 micro-calorimeter test shows that 3FA increases thermal stability of electrolyte and NCM 622 cathode system. The heat production during overcharge was measured further. With the increase of the amount of 3FA added, the heat production during overcharge increases and the peak heat release rate occurs near 4.4 V, which further proves the effect of overcharge protection of 3FA. Thus, 3FA enhances overcharge endurance and thermal stability of lithium-ion battery with NCM 622 cathode.
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ADVANCED POWDER TECHNOLOGY
·
2024
·
IF 4.2
Jiuxiang Zhang,Xiaoping Zhang,Shengxing Lu,Yian Wang,Yulei Sui,Keyi Sun,Mengting Deng,Wenbin Fei,Ling Wu
Na 4 MnCr(PO 4 ) 3 is a promising cathode material with high redox potential and high energy density, but the intrinsic poor electronic conductivity and substandard structural stability restrict its practical application. Herein, porous Na 4 MnCr(PO 4 ) 3 /C with conductive networks and improved electrochemical properties is synthesized by a facile modified solid-state process using citric acid as a multifunctional additive. The results reveal that citric acid can be used as a grinding aid to make the raw materials mix more evenly and speed up the efficiency of ball milling. Besides, 3D conductive network and porous structure originated from polycondensation and carbonization of citric acid can promote the electrochemical properties of Na 4 MnCr(PO 4 ) 3 /C by enhancing the electronic/ionic conductivity and (de)intercalation reaction kinetics. As expected, the optimal Na 4 MnCr(PO 4 ) 3 /C delivers a high reversible capacity of 130.5 mAh g −1 at 0.1C rate, and exhibits a capacity retention of 82.62% at 10C rate after 500 cycles. In addition, the reversible biphasic reaction of the cathode is confirmed by the constant galvanostatic intermittent titration technique and ex-situ XRD, which shows great potential of the synthesized Na 4 MnCr(PO 4 ) 3 /C for practical applications.
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Biomedical Materials
·
2024
·Vol. 19
·期 3
·035011
·
IF 3.9
Piaoyi Chen,Qinglin Xiao,Zhaoxiong Guo,Wei Liang,Ou Liu,Liteng Lin,Yugang Huang,Kangshun Zhu,Guodong Ye
Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe3O4@Poly (diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100–300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe3O4 enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.
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PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Ang Li,Xiangji Li,Pengtao Wang,Zitian Sun,Hongyi Liu,Kaifeng Yu,Ce Liang
Aqueous zinc-ion batteries (AZIBs) are emerging as a promising candidate for large-scale energy storage systems due to their inherent safety and cost-effectiveness. However, the vigorous growth of dendritic crystals and severe side reactions caused by the decomposition of a large number of active water molecules in aqueous electrolytes significantly hinder their practical application. In this study, 3-pyridinesulfonic acid (3-PSA) molecules were introduced at an optimized concentration as an electrolyte additive for AZIBs. Through a combination of electrochemical characterization and theoretical calculations, it was found that the directed coordination interaction between the sulfonic acid group (−SO3H) and Zn2+ leads to the restructuring of the solvation shell of (Zn(H2O)6)2+, which adsorbs onto the Zn metal surface, promoting uniform Zn2+ deposition and significantly reducing the number of free H2O molecules. Additionally, the introduction of 3-PSA disrupts the original hydrogen bond network, adjusts the hydrogen bond bond angles, and suppresses water-induced corrosion and side reactions. The Zn//Zn symmetric cell using the designed 50 mM 3-PSA/2 M ZnSO4 electrolyte demonstrated excellent cycle life (2700 h) under 1 mA cm–2/1 mAh cm–2 conditions, while the Zn//MnO2 full cell achieved 1500 ultrastable cycles under 2 A g–1 conditions, significantly outperforming the control group using pure ZnSO4 electrolyte. This study provides new insights and strategies for the engineering design of high-performance AZIB electrolytes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xi Wang,Yuying Wang,Ziqi Li,Bin Zou,Li Lin,Zhifeng Xue,Ruzhi Zhang,Weimin Wan
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide due to late diagnosis, high metastasis, and poor therapeutic outcomes. Curcumin (Cur), a natural polyphenol with potent antitumor activity, is severely limited in clinical application by poor water solubility, low bioavailability, and insufficient tumor-targeting capability. Herein, a dual-targeted pH-responsive nanocarrier based on cellulose nanocrystals (CNCs) co-functionalized with folic acid (FA) and 3-carboxyphenylboronic acid (CA) was fabricated for enhanced Cur delivery to HCC cells. CNCs were aminated via silane coupling, followed by covalent co-grafting of FA and CA to obtain ACNCs@FA- CA. FA enabled targeting of folate receptors overexpressed on HCC cells, while CA played a dual role by reversibly binding Cur through boronate ester formation and recognizing sialic acid-rich tumor cell membranes. Cur was loaded with an efficiency of 13.90 ± 2.00% and exhibited pH-responsive release, reaching 81.61 ± 1.60% at pH 5.4 and 26.29 ± 1.47% at pH 7.2. In vitro studies demonstrated that Cur-loaded ACNCs@FA-CA significantly enhanced intracellular drug accumulation and cytotoxicity in HepG2 cells, with improved growth inhibition in a 3D hepatoma spheroid model. Collectively, this dual-targeted pH-responsive nanoplatform offers a promising strategy to improve the anti-HCC efficacy of Cur.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 16
·D908
·
IF 3.12
Xinkuai He,Zhengyang Sun,Qingtian Zou,Jingjing Yang,Luye Wu
The codeposition behavior of Co(II) and Ni(II) in 1-ethyl-3-methylimidazolium bisulfate ([EMIM]HSO4) ionic liquid (IL) and ethylene glycol (EG) system is recorded using cyclic voltammetry (CV). The result indicates that the mechanism of Co-Ni codeposition is an anomalous codeposition, and both the inhibition for Ni(II) reduction and the anomalous codeposition phenomena can be improved by the increase of Co(II) concentration in the system. These Co-Ni deposits are characterized using EDS, XRD and SEM. SEM micrographs indicate that the surface morphology of Co-Ni deposits can be changed by the increase of Co content, and these deposits with many additional elongated acerose crystals, which are germinated on the spherical “nodules” surface, can be prepared. XRD pattern reveals the feature peak of crystalline Co1.2Ni2.8 with a preferred orientation direction and the average size of grains is calculated to be about 14.6 nm. Moreover, the electrocatalytic activity for hydrogen evolution reaction (HER) on the prepared Co-Ni catalyst surface is investigated using linear sweep voltammetry (LSV) and electrochemical impedance spectra (EIS). These results indicate that the obtained catalyst presents an excellent electrocatalytic activity and durability for HER with an overpotential of 139 mV at 10 mA cm−2 in 1 M KOH solution.
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Chinese Medicine
·
2026
·Vol. 21
·期 1
·129
·
IF 7.4
Dong Jinwang,Cao Yang,Chen Xiujin,Xie Tao,Zhang Xiaobo,Zhao Qingpeng,Shi Cunhu,Miao Qiangqiang,Xu Zhengwei,Yan Liang,Dong Liang
Background Spinal cord injury (SCI) induces gut microbiota dysbiosis, which significantly affects recovery. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine formula, has shown therapeutic effects on SCI. Although BHD is known to modulate gut microbiota, whether its benefits are mediated through the gut–spinal cord axis remains unclear. Methods A rat SCI model was established. BHD was administered orally, and fecal microbiota transplantation (FMT) from BHD-treated rats (BHD-FMT) was performed to assess neuroprotective and gut-protective effects. Behavioral testing, histology, and immunofluorescence evaluated motor recovery, inflammation, and neuroregeneration. Gut microbiota profiling was performed using 16S rDNA sequencing and metagenomics, while targeted metabolomics quantified tryptophan metabolites. Transcriptomics validated key pathways, and a microbiota–metabolite–signaling network was constructed. Results BHD significantly improved motor function, reduced spinal inflammation, and promoted neuronal survival and axonal regeneration. It restored gut function, reduced colonic inflammation, and enhanced ZO-1 and Occludin expression, which were further confirmed by FMT. BHD-FMT reshaped the gut microbiota and enriched Lactobacillus johnsonii , which correlated positively with recovery. Metabolomics showed increased tryptophan metabolites, including indole-3-lactic acid (ILA) and indole-3-propionic acid (IPA), with ILA strongly associated with functional improvement. Transcriptomic analysis and Western blot validation demonstrated that BHD-FMT activated the AhR–PI3K/Akt pathway, which was suppressed by an AhR antagonist. Conclusion BHD promotes neuroregeneration after SCI by reshaping gut microbiota and enhancing tryptophan metabolism, potentially exerting its effects through the L. johnsonii –ILA–AhR–PI3K/Akt network. These findings reveal a gut–spinal cord axis–mediated mechanism of BHD and highlight microecological targets for SCI therapy. Graphical
The alternative text for this image may have been generated using AI.
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高影响因子
International Journal of Nanomedicine
·
2026
·
IF 8.7
Yan Yan,Ke Wang,Li Ren,Jun-jie Ma,Xing-chun Zhu,Hao-feng Ding,Jia-xin Chu,Zhi-gao Zhu,Jing-yi Xia,Yi Xia,Yuan Xu,Meng-han He,Wen-rui Wang,Cong-li Zhang
Purpose This study aims to address the issues that limit the clinical application of Dl-3-n-butylphthalide (NBP) due to its poor water solubility and low bioavailability, and to explore its therapeutic potential in renal ischemia-reperfusion (I/R) injury. We attempted to utilize layered double hydroxide (LDH) to construct a novel nano-drug delivery system to enhance the stability and efficacy of NBP, and to deeply investigate its potential mechanism of action.Methods By loading NBP onto LDH, LDHs-NBP nanocomplexes were successfully constructed. Subsequently, the effects of LDHs-NBP on renal function, tissue pathology, cell apoptosis, oxidative stress and mitochondrial function were systematically evaluated in rat renal ischemia-reperfusion injury models and HK-2 cell hypoxia/reoxygenation models. The molecular mechanism of the PI3K-AKT-Nrf2 signaling pathway was analyzed through immunohistochemistry and Western Blot.Results The experimental results show that the drug loading capacity of LDHs-NBP nanocomplexes is 24.26%. Compared with pure NBP, LDHs-NBP more effectively improve renal function in rats, reduces serum creatinine (SCr) and blood urea nitrogen (BUN), decreases inflammatory infiltration and structural damage in renal tissues, and exhibits stronger antioxidant capacity—evidenced by decreased malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) activities. At the cellular level, LDHs-NBP significantly inhibits apoptosis and ROS production in HK-2 cells, alleviates mitochondrial dysfunction, and its protective effect is closely associated with activation of the PI3K-AKT-Nrf2 signaling pathway.Conclusion This study successfully constructed an NBP nano-complex based on LDH, and confirmed that LDHs-NBP has significant therapeutic advantages in renal ischemia-reperfusion injury. The mechanism may be related to the activation of the PI3K-AKT-Nrf2 pathway. This study provides experimental evidence for the application of LDHs-NBP in the treatment of renal ischemia-reperfusion injury, and shows a promising translational prospect and clinical value.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jiaxi Jin,Yuyang Xiao,Hao Lai,Ruixing Fu,Peilun Shen,Dianwen Liu,Xinyi Liang,Bo Peng
The efficient separation of chalcopyrite from sphalerite remains a significant challenge in flotation due to their similar surface properties. In this study, Trisodium 4-carboxy-5-mercapto-3-hydroxy-isothiazole (TCMHI) was introduced as a novel, eco-friendly, and selective organic depressant for sphalerite. Micro-flotation tests demonstrated that TCMHI (73 mg/L) could selectively depress sphalerite flotation (recovery <14%) at pH 7.0 while maintaining high chalcopyrite recovery (> 94%). Successful separation was achieved in artificially mixed mineral tests, yielding a concentrate with a Cu grade of 32.01% and a recovery of 96.65%. To validate its industrial applicability, bench-scale flotation tests were conducted on a real Cu Zn sulfide ore. The results showed that TCMHI achieved metallurgical performance comparable to the conventional depressant zinc sulfate (ZnSO 4 ), maintaining a copper recovery of 71.32% while effectively suppressing zinc recovery to 21.18% in the concentrate. Surface characterization techniques, including contact angle, zeta potential, and Atomic Force Microscopy (AFM), revealed that TCMHI preferentially adsorbs onto the sphalerite surface, forming a dense hydrophilic layer that hinders collector adsorption. X-ray Photoelectron Spectroscopy (XPS) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) analyses confirmed that TCMHI chemically adsorbs on sphalerite through the formation of stable Zn-TCMHI surface complexes. Density Functional Theory (DFT) calculations further elucidated the mechanism, showing that TCMHI forms a stable five-membered chelate ring with surface Zn atoms via its nitrogen and endocyclic sulfur atoms. Crucially, the adsorption energy of TCMHI on sphalerite (−209.76 kJ/mol) was found to be significantly more negative than that of the collector (−95.88 kJ/mol), explaining its superior depression performance. This work provides a promising reagent for the sustainable and efficient flotation separation of Cu Zn sulfide ores.
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Toxics
·
2026
·Vol. 14
·期 3
·222
·
IF 4.9
Xiao Kang,Wenting Song,Xueyan Li,Yuyan Yang,Xinke Wu
Breast cancer is the most common malignant tumor among women worldwide, and its occurrence is closely associated with long-term exposure to environmental pollutants. Polycyclic aromatic hydrocarbons (PAHs) are a class of persistent organic pollutants widely present in the living environment. Epidemiological studies indicate that exposure to PAHs increases the risk of breast cancer. PAH derivatives exhibit stronger toxicity or endocrine-disrupting activity than their parent compounds; however, research on their specific effects and mechanisms in breast cancer cells remains limited. For this purpose, this study selected 3-Hydroxybenz[a]anthracene, a PAH derivative with potential estrogenic activity, as the target compound. Using the estrogen receptor-positive breast cancer cell line MCF-7 as the model, we performed EdU staining, colony formation assays, scratch healing assays, Transwell invasion assays, and apoptosis assays and preliminarily examined changes in relevant signaling proteins via Western blot. Results indicate that 3-Hydroxybenz[a]anthracene promotes proliferation and migration in MCF-7 cells while inhibiting apoptosis under certain conditions, but it has no effect on cell invasion. Mechanistically, it upregulates key proteins including AKT, c-Myc, E-Cadherin, Vimentin, MMP2, MMP9 and Bcl-2 while downregulating p-AKT expression. This study confirms through in vitro experiments that 3-Hydroxybenz[a]anthracene exhibits estrogen-like effects and modulates malignant behavior in breast cancer cells by regulating relevant signaling pathways. These findings provide experimental evidence for further evaluating the potential role of this environmental contaminant in breast cancer initiation and progression.
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高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Xinze Wu,Hu Wang,Jiangchao Chen,Pengfei Pang,Haiping Li,Kunpeng Jiang,Yunyun Zhao,Wenping Liu,Guisheng Zhu,Huarui Xu
Dendrite growth and interfacial instability in conventional liquid electrolytes limit the practical application of lithium metal batteries (LMBs). Composite solid electrolytes (CSEs) offer a promising alternative, yet challenges remain in achieving high ionic conductivity and low interfacial resistance. In this study, a series of sponge-like porous Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 @PMMA/PVDF-HFP CSE membranes (LPPH1:x) were fabricated via phase separation-solution casting. A multistage ion transport channel was constructed through the synergistic combination of the polymer matrix, inorganic fillers, and liquid electrolytes. The incorporation of PMMA suppressed the crystallization of PVDF-HFP, while the ester groups in PMMA facilitated Li salt dissociation through coordination with Li + . LPPH1:3 exhibited optimal comprehensive performance: a high ionic conductivity of 2.75 × 10 −3 S·cm −1 at room temperature, a Li + transference number of 0.62, and an electrochemical stability window of 4.9 V. Moreover, the symmetric cell demonstrated stable cycling for over 2000 h at 0.2 mA·cm −2 . The LiFePO 4 full cell retained 96.4% capacity after 200 cycles at 0.5C. Post-cycling characterization confirmed that LPPH1:3 suppressed lithium dendrite growth and maintained a stable interfacial structure. This work provides an innovative material design strategy and theoretical foundation for developing high-performance solid-state LMBs.
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Surfaces and Interfaces
·
2026
·
IF 6
Mohamed M. Abdel-Halim,Zhongyu Wang,Zhenyi Hu,Xuesong Jiang,A. Shahboub,Zongrong Zhou,Boyuan Ban,Jian Chen
A new collector, N-Oleyl-1, 3-propanediamine (NOPDA), has strong collecting power and excellent selectivity. • NOPDA achieves effective separation of mica and quartz using a low dosage a 0.016 mmol/L at pH 2.5. • NOPDA preferentially adsorbs onto mica surfaces through hydrogen bonding and electrostatic interactions. • NOPDA is demonstrated as a new flotation collector for the mica surface with high-efficiency separation. The selective separation of mica from quartz remains a significant challenge because of their similar physicochemical properties. In this study, a cationic diamine collector, N-oleyl-1,3-propanediamine (NOPDA), was evaluated for the flotation separation of mica from quartz under acidic conditions. Single-mineral flotation results demonstrated a substantial recovery difference of approximately 84%, with mica recovery reaching 95%, whereas quartz recovery remained low (10.91%) at pH 2.5, indicating a strong selectivity. Mixed-mineral flotation further confirmed effective separation, yielding a concentrate enriched in mica-associated components, including Al 2 O 3 (33.05%, 94.41% recovery) and K 2 O (11.39%, 98.46% recovery), with a relatively low SiO 2 recovery (32.50%). The flotation mechanisms were analyzed through zeta potential testing, contact angle, zeta potential, FTIR, and XPS analyses, which revealed that NOPDA preferentially adsorbs on mica surfaces, significantly enhancing hydrophobicity, whereas only weak interactions were observed on quartz. The adsorption mechanism is primarily attributed to the electrostatic attraction and hydrogen bonding of the protonated amine species with the surface Al–O and Si–O sites of the adsorbent. Density Functional Theory (DFT) calculations indicated that the adsorption energy difference between NOPDA on mica and quartz was 2.75 eV, which is consistent with the flotation results. Overall, these findings demonstrate that NOPDA exhibits promising selective flotation performance for mica–quartz separation under acidic conditions. The combined flotation experiments, surface characterization, and DFT analysis provide insights into the preferential adsorption behavior of NOPDA on the mica surface. Download: Download high-res image (175KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）