CATALYSIS LETTERS
·
2026
·Vol. 156
·期 8
·220
·
IF 2.5
Shi Yinhu,Ma Jiping,Zhang Yunwei,Wang Shuwei,Wang Xinhong
The selective and sustainable production of methyl lactate from biomass-derived polyols remains a significant challenge due to the frequent requirement of homogeneous bases. Herein, an integrated Au/CuO catalyst is reported for the base-free oxidative esterification of 1,2-propanediol to methyl lactate. The Au/CuO catalyst exhibits superior catalytic performance compared with Au supported on other oxides, affording high conversion and selectivity under optimized conditions. Systematic studies reveal that moderate Au loading and reaction conditions are crucial for suppressing over-oxidation and C-C bond cleavage. Mechanistic investigations suggest that the reaction proceeds via parallel oxidation pathways involving both primary and secondary hydroxyl groups, while the Au-CuO interface plays a key role in regulating intermediate oxidation and stabilizing methyl lactate. This work highlights the importance of metal-oxide interfacial effects in base-free oxidative esterification and provides a sustainable route for methyl lactate production from renewable polyols. Graphical
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Wu Shuang,Li Xiaoyu,Xu Jiayi,Zeng Rong
Microneedle patch (MNP) technology offers a promising strategy for effectively transdermal delivery of macromolecular agents for treating various diseases, in particularly, dissolvable MNPs containing liposomes with tunable physicochemical properties have received widespread attention for improving macromolecular therapeutic efficacy. However, their design and optimization remain challenging. In this work, a series of liposomes with different size and modulus (100 vs. 500 nm, ~ 0.2 vs. ~ 100 kPa) were prepared and then integrated with poly( γ -glutamic acid) ( γ -PGA) to form dissolvable MNPs containing liposomes with good loading capacity, mechanical properties and biocompatibility via centrifugation-assisted micromolding for transdermal macromolecular delivery, and more uniformly dispersed liposomes appeared in the microneedle matrix for smaller liposomes (100 nm). Using FITC-dextran as the model macromolecule loaded in liposomes (100 nm) in PGA-based MNPs, in vitro and in vivo transdermal experiments revealed that MNPs containing liposomes were beneficial for improving macromolecular therapeutic efficacy, and low-modulus liposomes (~ 0.2 kPa) delivered had a more pronounced effect on the extension of the retention duration and region of macromolecular cargo in skin than high-modulus liposomes (~ 100 kPa) possibly due to their lower macrophage uptake and stronger diffusion ability. Our findings will be useful to guide the design and construction of MNP-based transdermal macromolecular composite-delivery systems. Graphical abstract
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Horticulture Advances
·
2026
·Vol. 4
·期 1
·22
·
IF 6.3
Ashraf Muhammad Atiq,Ateeq Muhammad,Du Haowei,Yang Jinzhi,Gao Xusheng,Kaleem Muhammad Mohsin,Daud Muhammad,Khalid Burhan,Asim Muhammad,Nawaz Shumaila,Shabala Sergey,Zhu Kaijie,Liu Junwei
Waterlogging (WL) stress severely affects the growth and productivity of fruit crops. Cytosolic calcium (Ca 2+ ) is recognized as a secondary messenger that initiates adaptive responses to environmental stresses. However, the mechanisms by which exogenously applied Ca 2+ enhances WL tolerance remain poorly understood. In this study, we investigated whether exogenous Ca 2+ , applied as calcium chloride (CaCl 2 ) and calcium oxide nanoparticles (CaO-NPs), might mitigate WL-induced damage in peach ( Prunus persica ) seedlings. We found that both Ca 2+ formulations significantly alleviated WL-induced growth inhibition, restored photosynthetic efficiency, and maintained root system architecture and metabolic activity. Two Ca 2+ treatments markedly reduced intracellular superoxide (SOD) and hydrogen peroxide accumulation, thus attenuating membrane lipid peroxidation and electrolyte leakage. Hormonal profiling demonstrated that Ca 2+ suppressed excessive abscisic acid and salicylic acid accumulation while restoring jasmonate homeostasis under WL conditions. Furthermore, at the transcriptional level, Ca 2+ enhanced stress tolerance by upregulating the expression of genes encoding antioxidant ( PpSOD ; and peroxidase , PpPOD ), photosynthetic ( photosystem II subunit Q , PpPsbQ ; and photosystem I subunit K , PpPsaK ), and Ca 2+ ( CBL-interacting protein kinases , PpCIPK5 and PpCIPK11 ). In line with reduced oxidative stress, Ca 2+ also adaptively downregulated genes related to the fermentative pathway ( alcohol dehydrogenase , PpADH ; and lactate dehydrogenase , PpLDH ), indicating a shift away from anaerobic metabolism. Notably, comparative analysis revealed that ionic Ca 2+ and CaO-NP treatments resulted in largely similar outcomes under WL conditions, with only marginal differences in some parameters. Taken together, these results indicate that Ca 2+ -associated signaling is a putative regulatory network underlying adaptive responses to WL stress in woody fruit crops.
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Nature Communications
·
2026
·
IF 18.1
Wang Yujie,Liu Guangyu,Gao Feng,Zhang Hongwei,Chen Aobo,Pan Jiangyuan,Xiong Wei,Jiang Meng,Wang Nana,Cui Xiaofeng,Kong Tingting,Gao Chao,Xiong Yujie
The biocatalytic conversion of green methanol, a promising feedstock, into high value-added products is seen as an attractive way to establish sustainable biomanufacturing. Although natural and engineered microorganisms can utilize methanol, efficiently converting C1 carbon into valuable chemicals in growing cells remains challenging because non-native pathways often suffer from low carbon utilization and limited catalytic stability. Here, we report the integration of an engineered enzyme cascade into resting cells and its coupling with a screened alcohol oxidase enzyme to develop an efficient and stable enzyme-resting cell cascade system for methanol conversion, achieving customizable production of L-erythrulose (C4 sugar) or L-sorbose (C6 sugar). This system shows a stimulated carbon atom economy for L-erythrulose production from methanol and significantly improved stability compared to free enzyme catalysis. By integrating enzyme cascades with durable resting cells, this strategy provides a versatile platform for converting methanol and other C1 substrates into value-added products.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·433
·
IF 38.5
Zhao He,Sun Jiaqi,Soomro Razium Ali,Sun Ning,Hong Song,Xu Bin
In the ongoing pursuit of energy-dense lithium-ion batteries (LIBs), Li-rich layered oxide (LLO) cathodes provide an attractive path forward with extraordinary capacity delivery and low raw material cost. However, the surface-originated degradations and local structure rearrangement incur severe capacity and voltage fading, which fundamentally impedes the practical deployment of LLOs. Here, we report a pre-constructed multifunctional carbon/fluorine-rich artificial cathode electrolyte interface (CEI) layer via a facile thermal treatment. This surface integrated layer, with high-voltage tolerance and amorphous features, is designed to mitigate surface-originated parasitic reactions and phase transformations induced by electrochemistry. Multiscale characterizations reveal that the artificial CEI layer exhibits excellent interfacial compatibility with both the LLO cathode and the electrolyte system, ensuring highly reversible anionic redox and low activation barrier for Li + transport. Profiting from this architecture, remarkable cycling stability is achieved including 90.6% retention after 300 cycles in half cell, along with high energy efficiency and markedly alleviated voltage fading. More importantly, the artificial CEI layer demonstrates a distinct depolarization effect, which almost completely prevents the rise in charging voltage upon cycling. This work provides valuable insights into surficial/interfacial modulations and broadens research directions for designing high-voltage cathodes with more durable interphases for next-generation batteries.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Quan Liao,Shichao Zhang,Yuhan Xie,Qidan Tan,Tengfei Li,Shushuai Yang,Chenglong Xu,Zhouting Tuo,Rui Yao,Longchao Zhang,Haiwen Zhou,Yuanjiong Qi,Shiyong Qi
Background Acute kidney injury (AKI) remains a major clinical challenge and is largely driven by excessive oxidative stress, inflammatory responses, and tubular cell apoptosis. However, effective therapeutic strategies that simultaneously target these pathological processes are still lacking. Results We developed a pH-responsive ultrasmall Fe–kaempferol (Fe–Kae) nanoplatform with coordinated antioxidant and anti-inflammatory activities for AKI treatment. Owing to their ultrasmall size and pH-responsive properties, Fe–Kae nanoparticles preferentially accumulated in injured renal tissues and exhibited robust renoprotective effects in multiple murine AKI models, including ischemia–reperfusion injury, cisplatin-induced nephrotoxicity, and calcium oxalate–induced kidney injury. Integrated transcriptomic and metabolomic analyses of ischemia–reperfusion–injured kidneys revealed that Fe–Kae treatment markedly enhanced efferocytosis-associated pathways and induced coordinated metabolic reprogramming, characterized by optimized tricarboxylic acid cycle activity and enhanced glutathione metabolism. Conclusions This study establishes a nanomedicine-based therapeutic strategy that couples efferocytosis enhancement with metabolic reprogramming to achieve effective renoprotection. Our findings highlight pH-responsive ultrasmall metal–polyphenol nanoplatforms as a promising paradigm for the treatment of AKI. Graphical Open in a new tab Graphical Supplementary Information The online version contains supplementary material available at 10.1186/s12951-026-04534-8.
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EMBO REPORTS
·
2026
·Vol. 27
·期 12
·3303-3339
·
IF 6
Guo Ruiyang,Guo Yabo,Shu Runguo,Qian Jiajia,Wang Jiawei,Li Ruobing,Qin Ti,Wang Ziyi,Tian Hongtao,Wu Mengchen,Zhou Long,Guo Xiaogang,Zhang Shan
Eukaryotic mRNAs typically encode a single functional polypeptide, a principle challenged by the discovery of widespread non-canonical peptide-coding ORFs within 5’UTRs. However, their functional significance at the protein level remains underexplored. Using a four-layered pipeline, we identify 14 human transcripts predominantly transcribed in polycistronic forms, each encoding two conserved proteins. Focusing on the SLC35A4 transcript, we show that its 5’UTR encodes a mitochondrial inner membrane-localized microprotein that we name STREMI ( S LC35A4 s t ress re sponse regulating M ICOS i nteractor). Sharing topology and motifs with the MICOS core subunit MIC10, STREMI regulates mitochondrial cristae morphogenesis in mice and human cells. Additionally, the STREMI-encoding uORF mediates stress-responsive translation of SLC35A4 —a Golgi nucleotide sugar transporter—upregulating its translation during the integrated stress response. Evolutionary analyses indicate that these bicistronic transcripts likely arose through transcriptional readthrough following retroposition. We propose a mechanism of “gene symbiosis” that enables functional partitioning and coordinated translation of protein pairs from bicistronic transcripts.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 8
·710
·
IF 3
Guo Lin,Shi Zhitian,Zhan Jifan,Qu Lanfeng,Tan Jiawei,Yan Tingting
Large-scale bone defects resulting from trauma, infection, aging, tumors, and other diseases present significant clinical challenges. Current treatment modalities primarily involve surgical intervention, chemotherapy, and radiotherapy. However, conventional bone repair materials exhibit limitations in addressing tumor-associated defects, including inadequate drug loading capacity, uncontrolled release kinetics, and insufficient mechanical adaptability. To address these deficiencies in existing bone repair materials, we developed a novel composite bone scaffold utilizing a biphasic calcium phosphate (BCP) osteoconductive matrix. This matrix was integrated with polyacrylamide-modified gelatin (GelMA) hydrogel to enhance mechanical strength and oxidized sodium alginate (OSA) hydrogel containing pH-sensitive acylhydrazone bonds. The incorporation of the hydrogels significantly increased the compressive strength of the composite scaffold from 1.920 MPa to 2.515 MPa. Furthermore, the scaffold was physically adsorbed with the anti-tumor drug bortezomib (BTZ), demonstrating sustained release under simulated physiological conditions (pH 7.4). Notably, the release rate accelerated under acidic conditions that mimic the tumor microenvironment (pH 5.4 and 6.8).
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Nature Communications
·
2026
·
IF 18.1
Li Qiaodong,Yao Jingming,Wang Yiran,Liu Xinyu,Lei Jiuwei,Yin Wen,Yu Zhixuan,Wang Shaojie,Li Lin,Yan Xinlin,Shao Zongpu,Wang Zhenyu,Xia Wei,Chen Yue,Yu Chuang,Wang Lin,Wen Bin,Xu Bo,Huang Jianyu,Zhang Long
The development of high-energy all-solid-state batteries is critically hindered by the electrochemical instability of solid electrolytes against high-voltage oxide positive electrodes. While fluorination is a promising strategy to enhance electrolyte stability, conventional methods are ineffective, resulting in insufficient fluorine content and a debilitating trade-off with ionic conductivity. Here, we report a solid-state anion-exchange strategy that overcomes these limitations by producing core-shell Li-fluoride/LiCl nanocomposite precursors. These precursors enable the synthesis of heavily fluorinated lithium-halide and lithium-sulfide electrolytes that combine high ionic conductivity with good oxidative stability. This stability originates from the formation of a robust, self-limiting LiF-rich interphase at the positive electrode. Consequently, an all-solid-state battery using a Li-rich oxide positive electrode achieves high performance, retaining over 77.5% capacity after 2000 cycles at a high rate of 3 C (1 C = 275 mA/g) and a 5.0 V cutoff. This anion-exchange approach is broadly applicable to other systems and establishes a versatile platform for designing advanced fluorinated materials for next-generation batteries.
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JOURNAL OF FLUORESCENCE
·
2025
·Vol. 36
·期 2
·1445-1456
·
IF 3.1
Huang Weihui,Tang Jidong,Ma Wenjin,Tao Xiaoqi
Structure-switching aptamers (SSAs) generate measurable signals through target-induced conformational changes, serving as sensitive molecular recognition elements. We developed a dual-fluorescence SSA for ochratoxin A (OTA) detection by inserting 2-aminopurine (2AP) into the OTA aptamer and hybridizing a complementary DNA (cDNA) strand at the 5’ end. OTA binding induced the aptamer-cDNA duplex to form a G4, enhancing 2AP fluorescence at 370 nm. Together with the intrinsic fluorescence of OTA at 450 nm, this enabled ratiometric dual-fluorescence measurements without external quenchers or fluorophores. To elucidate the molecular mechanism, all-atom molecular dynamics (MD) simulations and spectroscopic experiments assessed the effects of cDNA hybridization sites and strand lengths on sensing performance. Simulations further examined OTA binding at various 2AP insertion sites. Apt@2AP-cDNA1, with cDNA hybridized to bases 1–12, exhibited a binding pattern closely resembling the original aptamer. Umbrella sampling simulations revealed similar binding affinities: 46.3 kJ/mol for Apt@2AP-cDNA1 and 43.2 kJ/mol for the original aptamer. Experimentally, Apt@2AP-cDNA1 converted to G-quadruplexes more efficiently than other designs. A ratiometric dual-fluorescence aptasensor using Apt@2AP-cDNA1 was developed, with a linear detection range of 10–800 nM, a detection limit of 5.9 nM. The dual-fluorescence ratiometric aptasensor has good selectivity and was proven effective for detecting OTA in beer samples.
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Communications Chemistry
·
2026
·
IF 6.9
Fu Jiayi,Jiang ChengRui,Xiang Wanping,Chang Guangtao,Li Ruoxin
Flexible hydrogel-based strain sensors have attracted increasing attention for applications in wearable electronics and health monitoring due to their tissue-like mechanical properties and electrochemical responsiveness. However, most existing hydrogels suffer from mechanical brittleness, environmental instability, and humidity-sensitive conductivity, which limit their use in dynamic human motion detection. This study presents a high-performance flexible strain sensor based on PALCC hydrogel, which integrates hydrophobic association, ionic coordination, and deep eutectic solvent (DES) to enhance both mechanical and electrical properties. The hydrogel demonstrates exceptional mechanical strength (296.4 kPa), high elongation (434.6%), and stable electrical conductivity, making it ideal for wearable electronics and health monitoring applications. The synergistic interactions within the hydrogel network, including covalent bonding, ionic crosslinking, and hydrophobic associations, enable a two-stage linear strain response with outstanding durability (over 2000 cycles). Molecular dynamics simulations further elucidate the dynamic co-aggregation and strengthening mechanisms of the network. The sensor shows excellent dual-mode strain sensing under both tensile and compressive deformations, stable signal output for human motion and vocal vibration detection, and the capability to transmit information through Morse code via fingertip pressure. These results provide a promising solution for real-time health monitoring and wearable sensor applications, paving the way for future advancements in flexible strain-sensing technologies.
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Nature Communications
·
2026
·
IF 18.1
Yang Jiawei,Zhu Rui,Li Ming,Mei Zengxia,Chen Ling,Wu Li-Ming
Sustainable thermal management of high-heat-flux electronics beyond Moore’s Law requires micro thermoelectric coolers (μ-TECs) that are both high-performance and environmentally sustainable. However, state-of-the-art μ-TECs rely on Bi 2 Te 3 -based materials, whose tellurium scarcity, toxicity concerns and limited mechanical robustness hinder widespread adoption. Mg-based thermoelectric materials offer a promising alternative but remain challenging to integrate into microscale devices. Here we show that a low-temperature, water-free fabrication strategy enables tellurium-minimized μ-TECs based on n -type Mg 3 (Bi,Sb) 2 and p -type MgAgSb. Using magnetron sputtering as a cold bonding approach, we fabricate compact 12-pair microdevices (2.95 × 4.35 × 1.4 mm 3 ), with thermoelectric legs approximately 3% the size of previously reported Mg-based devices. The resulting μ-TECs achieve a power density of 4.34 W cm −2 and a packing density of 93.5 pairs cm −2 . Our work establishes a scalable route for sustainable thermoelectric cooling and a viable alternative to conventional Bi 2 Te 3 technologies.
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