FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Yang Guo,Zhi-guo Zhang,Jing Cai,Wei-rong Li,Ling-yun Chen,Wei-cheng Wu
The feasibility of co-folding of soy protein isolates (SPI) and shellac by pH-shifting method to induce a protein hydrogel was firstly investigated. SPI and shellac at different mass ratios (1.3, 1.5, 1.7, 2.1, and 2.5 w/w) were co-folded by adjusting pH back to 7, 8, and 9, after unfolding at pH 12. The pH-shifting treatments resulted in the conformational change of SPI and the formation of covalent bonds between SPI and shellac, as confirmed by sodium dodecyl sulfate−polyacrylamide gel electrophoresis (SDS-PAGE), Fourier-transform infrared (FTIR) spectroscopy, UV–Vis, fluorescence spectroscopy, and as well as the changes of thermogravimetry. The cold-set hydrogel was prepared from the pH-shifting process by adjust pH to 9 which showed the optimal hardness and rheological properties, accompanied by excellent water-holding capacity (WHC> 90%). Meanwhile, the microscopic observations revealed the formation of uniform microstructure in the gel network. The co-folded hydrogels were proved to have a lower degree of protein hydrolysis (DH) than the same pH-shifted SPI alone during in vitro simulated digestion. Thus, the simple pH manipulation of SPI and shellac may be applied to induce hydrogels, reducing the protein DH during in vitro digestion which provides the potential for delivery of sensitive nutrients.
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DOI
高影响因子
Acta Biomaterialia
·
2022
·
IF 10.633
Yang Wang,Danni Jing,Jiawen Yang,Shajun Zhu,Jian Shi,Xiru Qin,Wujie Yin,Jin Wang,Yue Ding,Tingting Chen,Bing Lu,Yong Yao
Carbon monoxide (CO) as one of the therapeutic gaseous molecules has been widely applied for treating various diseases, especially in cancer therapy. However, the in situ-triggered and efficient transport of CO to tumors are the primary obstacles that limit its clinical applicability. To address this obstacle, herein, a H 2 O 2 -triggered CO gas releasing nanoplatform has been designed by embedding manganese carbonyl (MnCO) into Zr (IV)-based metal-organic frameworks (MOFs). The porous structures of MOFs provide encapsulation capacity for glucose oxidase (GOx) loading, thereby catalyzing the endogenous glucose into gluconic acid and H 2 O 2 to accelerate CO release and energy depletion. In the meantime, the Mn 2+ produced by MnCO can react with intracellular H 2 O 2 via the Fenton reaction to form cytotoxic •OH. Therefore, the synthesized gas nanogenerator demonstrated a synergistic efficacy of CO gas therapy, reactive oxygen species (ROS)-mediated therapy, and energy starvation to prevent tumor growth. Both in vitro and in vivo studies indicated that this multifunctional nanoplatform not only successfully inhibited tumors through a synergistic effect, but also provided a new technique for the creation of starvation/gas/chemodynamic combination therapy in a single material. Statement of significance In this study, we developed a H 2 O 2 responsive CO gas nanogenerator to augment the in-situ generation of CO gas for combined modality therapy of tumors. The nanogenerator was constructed by encapsulating glucose oxidase (GOx) and manganese carbonyl (MnCO) into UiO-67-bpy, which can catalyze the conversion of intracellular glucose to H 2 O 2 for cutting off energy supply of cancer cells. Meanwhile, the cumulated H 2 O 2 can trigger the release of CO for gas therapy and generation of •OH for chemodynamic therapy (CDT) via the Fenton-like reaction, thereby resulting in apoptosis of the cancer cells. Collectively, our designed nanotherapeutic agent not only displays the synergistic therapy efficacy of starvation-enhanced CO gas therapy and CDT, but also provides an efficient strategy for developing the intelligent nanocarrier for CO gas delivery and release.
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DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 5
·826
·
IF 3.164
Chengguo Liu,Qiong Wu,Rongrong An,Qianqian Shang,Guodong Feng,Yun Hu,Puyou Jia,Yonghong Zhou,Wen Lei
New tung oil (TO)-based, unsaturated, co-ester (Co-UE) macromonomers bearing steric hindrance were synthesized by modifying a TO-based maleate (TOPERMA) monomer with an anhydride structure with hydroxyethyl methacrylate (HEMA) and methallyl alcohol (MAA), respectively. The obtained Co-UE monomers (TOPERMA-HEMA and TOPERMA-MAA) were then characterized by1H NMR and gel permeation chromatography (GPC). For comparison, hydroxyethyl acrylate (HEA)-modified TOPERMA (TOPERMA-HEA) was also synthesized and characterized. Subsequently, the obtained Co-UEs were thermally cured with styrene, and the ultimate properties of the resulting materials were studied. It was found that by introducing the structure of steric hindrance into the TO-based Co-UE monomer, the tensile strength and Young’s modulus of the resulting materials were improved. Furthermore, by reducing the length of the flexible chain in the Co-UE monomer, the tensile strength, Young’s modulus, and glass transition temperature (Tg) of the resultant materials were also improved. The TOPERMA-MAA resin gave the best performance in these TO-based Co-UE resins, which showed a tensile strength of 32.2 MPa, Young’s modulus of 2.38 GPa, andTgof 130.3 °C. The developed ecofriendly materials show promise in structural plastic applications.Keywords:tung oil;unsaturated polyester resins;thermosetting polymers;structure–property relationship;structural plastics
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DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2016
·
IF 2.183
Pande Zhang,Benxue Jiang,Jintai Fan,Xiaojian Mao,Long Zhang
Cr and Nd co-doped laser ceramics, as the potential gain materials in inertial confinement fusion (ICF), have been widely investigated. And the study on valence states of chromium ions is important. The effects of sintering additives and annealing atmosphere on the valence state of chromium were studied in detail, and the results shown that the Cr valence states were demonstrated to be Cr 2+ and Cr 3+ ions in HIP-sintered Cr(0.2 at.%), Nd(0.8 at.%): LuAG laser ceramics. And the intensity of the near-infrared absorption band caused by Cr 2+ ions was attenuated with the decreasing SiO 2 concentration and increasing MgO amount. The near-infrared absorption could be eliminated by annealing in air. And the transformation of valence states of Cr ions in the Cr,Nd:LuAG ceramics were also confirmed by electron paramagnetic resonance and X-ray photoelectron spectroscopy.
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DOI
高影响因子
RENEWABLE ENERGY
·
2022
·
IF 8.634
Naveed Ahmad,Ying Chen,Xiaoxiao Wang,Peixu Sun,Yuting Bao,Xia Xu
Electrochemical CO 2 reduction reaction (ECO 2 RR) offers an eco-friendly way to produce value-added products by utilizing the waste CO 2 from the environment. Recently, amines have been utilized as electrolytes for direct conversion of CO 2 but processes were energy-intensive and lack selectivity due to the formation of highly stable carbamate. 2-amino-2-methyl-1-propanol (AMP) is a sterically hindered amine , produces less stable carbamate, and generates more HCO 3 − . Herein, ECO 2 RR performance using AMP aqueous solution as electrolyte was investigated over Ag, Cu, and Zn metal electrodes. Ultimately, 91 ± 7% CO selectivity on HCl modified polycrystalline Ag electrode at −0.91 V vs RHE in 1 M AMP aqueous solution in the presence of CTAB was achieved, 1.7 times greater than in 1 M aqueous ethanolamine (MEA) solution. Synergetic effects of unstable AMP-carbamate, generation of nano-agglomerates on pitted/porous Ag surface arising from HCl treatment, and a compact electrical double layer due to CTAB present are responsible for the high selectivity of CO. Our findings provide the understanding of electrode-electrolyte interactions and offer a facile strategy to directly convert CO 2 to CO from CO 2 capture solutions.
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DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 71
·40598-40610
·
IF 2.936
Yanxin Liu,Baolin Huang,Jiaoyang Zhu,Kailin Feng,Yuan Yuan,Changsheng Liu
Although multi-drug synergetic therapy is increasingly important in clinical application, sophisticated delivery systems with the ability to deliver multiple drugs and realize sequential release with independently tunable kinetics at different stages are highly desirable. In this study, a dual-generation mesoporous silica nanoparticle (DAMSN) with three-dimensional dendrimer-like structure as an adaptable dual drug delivery system is developed. The DAMSN was synthesized via a heterogeneous interfacial reaction and was of uniformly spherical morphology (150–170 nm) with dendritic structures and hierarchical pores (inner pore, 3.5 nm; outer pore, 8.3 nm). And the inner generation of DAMSN was modified with 3-aminopropyltriethoxysilane (APTMS). The IBU and BSA as model drugs were loaded into the inner generation via covalent conjugation and the outer generation by electrostatic adsorption, respectively. Intriguingly, DAMSN underwent a rapid bio-degradation for about 4 days, partly due to its center-radial dendritic channel structure. The release results showed that IBU was of a typical two-phase release profile with almost zero release in the first 12 h and more sustained release for the following 88 h, while BSA was sustained over a long period of 100 h. Notably, the release behaviors of both drugs can be independently tailored by changing the intrinsic properties of the DAMSN. In addition, DAMSN exhibited good bio-compatibility. These results indicated that the dual-generation, dendrimer-like MSN structure could spatiotemporally present different drugs to realize sequential drug release, and has potential use in the field of tissue engineering and regenerative medicine.
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DOI
PubMed
高影响因子
Molecular Catalysis
·
2022
·
IF 5.089
Yuefeng Deng,Yihui Zhu,Zhenni Jiao,Ziqian Chen,Jianjun Wang,Chengli Yang,Dali Li,Kefeng Ma,Ruofu Shi
Coenzymes are required in the reaction catalyzed by oxidoreductases. The research on coenzyme regeneration has always been a hot topic in the field of biological catalysis. In this work, we tried to construct a co-immobilization system of glucose dehydrogenase (GDH), ( R )-1-phenylethanol dehydrogenase (( R )-PEDH) and coenzyme with functional magnetic nanoparticles as carriers, so as to realize chiral ( R )-1-phenylethanol highly selective production and coenzyme effective recycling. The enzymatic properties of immobilized enzymes were explored. The results showed that the immobilized enzymes had improved stability and fine reusability. In addition, during the catalytic coupling reaction at a final concentration of 2.63 μM NAD + , the total turnover number (TTN) was as high as 924, and the volumetric productivity of ( R )-1-phenylethanol was 37.06 mg·L −1 ·h −1 . After reused for 10 cycles, the catalytic efficiency of immobilized coenzyme can still be maintained at more than 30%. From multiple perspectives, the immobilized dual-enzymes and coenzyme system seems to be a multifunctional system for ( R )-1-phenylethanol production and coenzyme regeneration.
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Yuntao Xu,Yanfei Cao,Li Tan,Qiao Chen,Yuanxing Fang
Photoanodic hydrogen peroxide (H 2 O 2 ) production via water oxidation is limited by low yields and poor selectivity. Herein, four variations of cobalt phosphides, including pristine CoP and Co 2 P crystals, and two mixed-phase cobalt phosphides (CoP/Co 2 P) with different ratios, were applied as co-catalysts on the BiVO 4 (BVO) photoanode to improve H 2 O 2 production. The optimal yield and selectivity were approximately 9.6 µmol‧h −1 ‧cm −2 and 25.2 % at a voltage bias of 1.7 V vs reversible hydrogen electrode (V RHE ) under sunlight illumination, respectively. This performance is approximately 1.8 times that of pristine BVO photoanode. The roles of the Co and P sites were investigated. In particular, the Co site promotes the breaking of one H O bond in water to form OH • radicals, which is the rate-determining step in H 2 O 2 production. The P site plays an important role in the desorption of H 2 O 2 formed from the catalyst, which is responsible for the recovery of fresh catalytic sites. Among the four samples, Co 2 P exhibited the best performance for H 2 O 2 production because it had the highest rate of OH • formation owing to its improved accumulation property. This study offers a rational design strategy for co-catalysts for photoanodic H 2 O 2 production.
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Qingqing Han,Kunjie Zhu,Ting Jin,Zewen Yang,Yuchang Si,Yijing Wang,Lifang Jiao
Sn is considered as a promising anode for lithium-ion batteries due to its low cost and high theoretical capacity (992 mA h g −1 with Li 4.4 Sn). However, the volume expansion (∼300%) during lithiation/delithiation process can result in the continuous pulverization of active materials and exfoliation from current collector, deteriorating the capacity and cycling performance. Here Co/Co 3 SnC 0.7 N-doped carbon nanofibers are successfully synthesized by a feasible electrospinning method. And the materials as the self-standing anode for lithium-ion batteries reveal a high-rate performance as delivering reversible capacities of 480 mA h g −1 at 100 mA g −1 and 290 mA h g −1 at 2000 mA g −1 . In addition, the specific capacity can still maintain 320 mA h g −1 at 500 mA g −1 even after 900 cycles, showing the outstanding cycling stability. The inactive metal Co and one-dimensional N-doped carbon nanofibers synergistically promote the electrochemical performance of the Sn-based anode by inhibiting the aggregation of the nanoparticles and buffering volume variation during lithiation/delithiation process.
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DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 6
·504
·
IF 2.8
Zheng Xiuxin,Gong Lin,Zou Zhengguang,Xie Zhuojia
In this paper, La 0.7 Sr 0.15 Ca 0.15 Mn 0.95 A 0.05 O 3 (A = Fe, Co and Ni) were fabricated via the sol–gel (S-G) approach. The samples are all rhombohedral structure shapes and belong to the trigonal space group R-3c, as shown by XRD. ZEISS Gemini SEM 300 scans showed irregular sub-micron particles with decreasing particle size for La 0.7 Sr 0.15 Ca 0.15 Mn 0.95 A 0.05 O 3 (A = Fe, Co and Ni). The magnetic properties were characterized utilizing an MPMS, and the magnetocaloric effects (MCE) were further investigated. The investigations of La 0.7 Sr 0.15 Ca 0.15 Mn 0.95 A 0.05 O 3 (A = Fe, Co and Ni) found that their Curie temperatures (Tc) were 289.5 K, 290.2 K, and 300 K, respectively. The maximum magnetic entropy change ( \(-\Delta {S}_{M}^{max}\) ) for La 0.7 Sr 0.15 Ca 0.15 Mn 0.95 A 0.05 O 3 (A = Fe, Co and Ni) at 5 T is 5.107 J/(kg∙K), 4.177 J/(kg∙K) and 3.852 J/(kg∙K), and the relative cooling power ( RCP ) is 264.819 J/kg, 275.3409 J/kg and 288.7435 J/kg. The Arrott curve, normalization and Curie–Weiss law (CW) fit together to determine that the second-order ferromagnetic-to-paramagnetic (FM-to-PM) transition is observed in the three samples, along with a small magnetic hysteresis and thermal hysteresis, the super-exchange interactions (SE) and the double-exchange interactions (DE) competed with each other to increase half peak width and RCP , with La 0.7 Sr 0.15 Ca 0.15 Mn 0.95 A 0.05 O 3 (A = Ni) having the largest RCP . While conventional low-temperature magnetic materials need to work in a liquid helium environment, room-temperature magnetic materials do not need to rely on extreme cooling conditions, which greatly reduces the cost of refrigeration equipment, and thus room-temperature magnetically cooled materials have a greater potential for research and development. In this paper, Ni is used as the doping element, and its RCP can reach 288.7435 J/kg, and its Tc is close to room temperature, so it is possible to be used as a room-temperature magnetic cooling material.
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产品关联
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高影响因子
NANO
·
2025
·
IF 1.1
Yi Gou,Jinghong Du,Zilong Wang,Shengyang He,Jiahao Lv
La 3+ single-doped and La 3+ -Mo 6+ co-doped TiO 2 nanotubes were synthesized via anodic oxidation combined with a two-step electrochemical process. Their crystalline structure, microstructure, and light absorption properties were characterized using XRD, SEM, and UV-Vis spectroscopy, followed by methylene blue photocatalytic degradation experiments. The results indicate that both La 3+ single-doping and La 3+ -Mo 6+ co-doping can suppress the transformation of the anatase phase to the rutile phase and inhibit grain growth. The diameters of both types of nanotubes range between 60-80 nm, with La and Mo uniformly distributed throughout the nanotubes. Both La 3+ single-doped and La 3+ -Mo 6+ co-doped induced red shifts in the TiO 2 light absorption peaks. The most pronounced red shift in the light absorption band edges occurred at a La 3+ -Mo 6+ ratio of 3:7, reducing the bandgap width to its minimum value of 2.99 eV. Both La 3+ single-doped and La 3+ -Mo 6+ co-doped TiO 2 exhibited first-order photocatalytic degradation of methylene blue. As the La 3+ single-doped concentration increased or the La 3+ -Mo 6+ co-doped ratio varied from 1:9 to 9:1, both the methylene blue degradation rate and photocatalytic reaction rate initially increased before decreasing, while the half-life initially decreased before increasing. At a La 3+ -Mo 6+ co-doped ratio of 3:7, the photocatalytic activity of the TiO 2 nanotubes was optimal, achieving a maximum degradation rate of 89.73% within 8 hours-a 52% improvement over pure TiO 2 nanotubes.
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DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Jiaxin Yin,Shengcai Yang,Zengguang Liu,Songchen Zhao,Siyu Sun,Ziling Liu,Quanshun Li
The metabolic reprogramming of immunosuppressive tumor microenvironment (ITME) greatly influences the anti-tumor immunity. Bioinformatic analysis demonstrates that indoleamine 2,3-dioxygenase 1 and 3-hydroxy-3-methylglutaryl coenzyme A reductase (key enzymes of kynurenine (Kyn) and cholesterol metabolism, respectively), are overexpressed in human colon adenocarcinoma tissues. Herein, biomimetic and pH/ROS dual-responsive nanoparticles (PTSK@CRM) loaded with simvastatin and kynureninase (KYNase) are prepared to regulate Kyn and cholesterol metabolism, thereby enhancing the immunotherapeutic efficacy of PD-1 antibody (αPD-1). The monodisperse spherical PTSK@CRM is stable at pH 7.4, while it can release simvastatin and KYNase under low pH and high H 2 O 2 concentration. PTSK@CRM achieves excellently homologous tumor targeting to CT26 cells and induces cell apoptosis more effectively than PTSK. Moreover, PTSK@CRM significantly reduces the contents of Kyn and cholesterol and decreases the activation of the Kyn-AhR pathway in tumor metabolism. In vivo experiments show that PTSK@CRM possesses a favorable tumor-targeting ability to effectively suppress tumor growth and increase the infiltration of immune cells, including CD8 + T cells, CD4 + T cells, M1-like macrophages, and mature dendritic cells. Further, PTSK@CRM reduces the infiltration of immunosuppressive cells, thereby reversing ITME to improve the therapeutic efficacy of αPD-1. Overall, this immune-metabolic therapeutic strategy provides a potential route for remodeling ITME to enhance tumor immunotherapy.
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DOI
PubMed
高影响因子
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