ADVANCED SYNTHESIS & CATALYSIS
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2026
·Vol. 368
·期 5
·e70307
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IF 3.7
Wei Rao,Yifan Jiang,Qiong Liu,Junjun Zhang,Die He,Rong Chen
While high-valent copper intermediates are pivotal for efficient peroxydisulfate (PDS) activation, their generation and role in heterogeneous catalysis remain unclear. Herein, we demonstrate that a nonstoichiometric Cu 0.84 Bi 2.08 O 4 catalyst enables the dark activation of PDS via a novel pathway dominated by a surface-bound Cu(III)-peroxo intermediate ( ≡ Cu(III)-O−O−SO 3 ). A suite of spectroscopic and chemical probes revealed that this Cu(III)-peroxo species, along with superoxide radicals (•O 2 − ), acts as the primary oxidant, enabling the highly selective and rapid degradation of bisphenol A (BPA) and other phenolic pollutants. Furthermore, H 2 O 2 generated from PDS hydrolysis synergistically participates in the reaction, accounting for the exceptionally high PDS utilization efficiency of the system. The system exhibits remarkable robustness, maintaining high activity over a wide pH range (4–11) and demonstrating strong resistance to interference from ions. This study elucidates a distinct Cu(III)-peroxo-mediated mechanism and offers a new strategy for designing highly selective catalysts for environmental remediation.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Dong Liu,Songkai Zhu,Jiayang Li,Yuexing Zhang,Yu Xia,Yong Liang,Bolei Chen
Leaves are ubiquitous substrates for multiphase reactions, with growing evidence indicating that various multiphase reactions occurring on leaf surfaces influence the transformation of chemicals adsorbed by leaves. However, the critical role of ambient water in mediating such multiphase reactions on leaf surfaces has often been overlooked. Here, using isotopic tracing techniques, we demonstrate that reactive oxygen species generated in the leaf surface condensate can mediate the oxidation of urea adsorbed on leaves, leading to the formation of nitrite (NO2–). This phenomenon is widespread across various leafy vegetables. At 5 °C and an 80% relative humidity (RH), condensate-mediated oxidation of residual urea on leaf surfaces resulted in NO2– accumulation exceeding the food limit standard. Hydroxyl radicals (•OH), amino radicals (•NH2), and nitric oxide radicals (•NO) were produced during water vapor condensation, collectively driving the conversion from urea to NO2–. Density functional theory calculations verified that radical-mediated transformation occurs spontaneously. Further studies indicate that controlling urea residues on vegetable leaves below 60 ppm and maintaining RH in cold storage below 60% can effectively suppress NO2– formation. Our results demonstrate that water vapor condensation on leaf surfaces can influence the oxidation of organic compounds adsorbed by leaves, providing new insights into the environmental transformation of organic pollutants on plant surfaces.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Yaqi Zhang,Shiyao Liu,Hongman Xu,Jiahui Wu,Ruquan Zhang,Yongzhen Tao
Polyanionic polysaccharide-based hydrogels were developed as multistimuli-responsive drug carriers. Methacrylated pullulan (MP) acted as a thinner and rigidity regulator. Carboxymethylated-methacrylated xanthan gum (CMMXG) provided negative charges, ionic conductivity, and viscoelasticity. The cumulative ciprofloxacin hydrochloride (CPFXH) release mass dropped dramatically, whether the hydrogel was set at the anode or cathode with a potential of 3 V, due to irreversible electrochemical oxidation. Hydrogels with lower drug-loading amounts exhibited higher release efficiency when an electric stimulus was applied in the initial 5 h. A high CPFXH-loading amount led to rapid diffusion and quick electrochemical oxidation. For CMMXG3-MP7.5-CPFXH1680-LAP, the CPFXH release efficiency ratio of 3 to 0 V decreased from 1.33 ± 0.43 to 1.01 ± 0.06 over a duration of 0.5 ∼ 2 h, further indicating that the encouraged release and electrochemical degradation occurred simultaneously. The CPFXH release efficiency in phosphate buffer saline (pH = 7.4) was 1.5 times higher than that in simulated gastric fluid (pH = 1.2), and the CPFXH diffusion coefficient with loading weight was 6 times higher than that without loading, indicating that it was sensitive to pH and compressive force. The hydrogels exhibited electric, pH, and mechanical stimuli-responsiveness due to the presence of charged groups along the chains and viscoelasticity with robustness enough to respond and withstand compressive loading.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jingyi Yu,Mei Xiang,Mingqun Li,Sicong Zeng,Jicheng Cai,Zhiqiang Mao,Fan Zhang
Developing highly efficient and robust membrane systems for the selective identification and screening of chiral drugs is an exceptionally challenging task. Herein, we report that functional metal–organic framework (MOF)-packed nanochannels can serve as an excellent chiral recognition platform for enantioselective detection and separation of chiral drugs. Through the precise regulation of the nanoconfinement size and the anchoring of cyclodextrin active sites, the functionalized nanochannel membrane exhibits high enrichment efficiency and enables the highly selective detection of l-penicillamine, as demonstrated by monitoring the transmembrane ionic current signature. Importantly, the engineered nanochannel membrane system can be further utilized for highly efficient racemic penicillamine separation, achieving a remarkable enantiomeric excess (ee) value of up to 89.88%. This research not only puts forward an innovative strategy to establish versatile chiral sieving devices by manipulating the well-defined functional materials but also offers valuable insights for the development of high-performance membranes to meet the demands of chiral drug separation and wide practical applications.
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ACS Omega
·
2026
·
IF 5.2
Tao Yang,Tao Wang,Tao Shen,Mingrong Dong,Jinkun Liu,Ming Ni,Yan Zhu
Targeting tumor-specific characteristics of acidic microenvironment, elevated H2O2 levels, and thermosensitivity, this study proposed and developed a copper-doped ZIF-8 nanoplatform coloaded with indocyanine green (ICG) and doxorubicin hydrochloride (DOX), designated as Cu-ZIF-8@ICG&DOX (CZID), to establish a multimodal therapeutic system integrating chemodynamic therapy, photothermal therapy, and chemotherapy. Results showed that the 25% copper doping level optimized the structure, achieving 7.46% actual doping content while limiting the average nanoparticle size to 99.6 nm. Dual loading of ICG and DOX induced morphological transition to spherical core–shell architectures, as confirmed by zeta potential reversal, with maximum drug loading capacities of 23.01 μg/mg for ICG and 122.43 μg/mg for DOX. The ZIF-8 framework exhibited pH-responsive degradation under acidic conditions. Released Cu2+ ions mediated continuous hydroxyl radical generation through glutathione-depletion redox cycling, confirming chemodynamic efficacy. Under 808 nm laser irradiation, ICG enabled enhanced photothermal conversion, showing concentration- and power-dependent temperature elevation. Cellular assays revealed efficient CZID internalization by MCF-7 cells, generating significantly higher intracellular reactive oxygen species levels under irradiation and more intense dead cell staining compared to CZI and CZD groups. Such an enhancement was attributed to photothermally accelerated ZIF-8 degradation, promoting Cu2+ ions and DOX release, thereby strengthening chemodynamic–chemotherapy synergy. At the working concentration of 50 μg/mL, CZID induced 95.36% apoptosis in MCF-7 cells while maintaining over 70% viability in MCF-10A normal cells, validating its precise antitumor potential.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Jian Yang,Ziheng Chai,Jiarui Wang,Xiang Zhang,Zhihang Xu,Dongdong Zhao,Xudong Rong,Chunsheng Shi,Chunnian He,Naiqin Zhao
MoAlB, a MAB phase, exhibits significant potential as a reinforcement material for copper matrix composites due to its exceptional overall properties. However, its application is limited by the tendency to decompose at elevated temperatures during processing, leading to fragmentation and a reduction in the copper matrix’s electrical conductivity. Addressing this challenge, this study successfully prepared two-dimensional (2D) MoAlB nanosheets (NSs) via viscous-solvent-assisted ball milling. Subsequently, these nanosheets were employed as reinforcement to fabricate MoAlB NSs/Cu composites through an impregnation-reduction-sintering route. Characterization of the resulting composite revealed a limited interfacial reaction between the 2D MoAlB NSs and the copper matrix, leading to the formation of a distinctive gradient interface structure. The gradient interface consists of a Cu/MoB atomic-scale composite transition zone and a Mo2AlB2/Cu semicoherent interface. This reaction-limited and robust interface synergistically activates multiple strengthening mechanisms, including significant grain refinement, efficient load transfer, and dislocation strengthening. Moreover, this structure effectively mitigates solute atom electron scattering in the copper matrix by constraining Al atom diffusion to the interfacial regions. Consequently, the 0.5 wt % MoAlB NSs/Cu composite achieved a notable balance of mechanical and electrical properties: a tensile strength of 333.3 MPa, which represents a significant improvement over pure Cu (255.1 MPa) and the 0.5 wt % MoAlB/Cu composite (268 MPa), combined with an elongation of 15.5% and an electrical conductivity of 92.6% IACS. Additionally, the composites demonstrated superior resistance to high-temperature softening, retaining high hardness even after annealing at 900 °C. These findings present a new design strategy for creating next-generation high-performance metal matrix composites.
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WATER RESEARCH
·
2026
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IF 12.8
Ying Liu,Zhenyu Wang,Ducheng Yao,Chengcheng Chu,Zhong Chen,Wei Xiaojie,Jinguo Wang,Shun Mao
The widespread adoption of donor-acceptor polymer photocatalysts remains constrained by two fundamental limitations: inefficient charge carrier separation and the practical drawbacks of powdered catalysts. To overcome these challenges, we implement a synergistic local polarization and mass-transfer engineering strategy. Through rational molecular design, we developed a thiazole-bridged d -A polymer (TATZ) with strong π-conjugation and an enhanced built-in electric field. This molecular architecture not only promotes exceptionally efficient electron-hole separation but also directs the oxygen reduction pathway almost exclusively toward superoxide radical (•O 2 ⁻) formation, responsible for 96.7% of the observed photocatalytic activity. The optimized material achieves a tenfold improvement in photo-oxidation kinetics, enabling complete degradation of ciprofloxacin within 25 min. To translate these molecular advantages into practical implementation, we constructed a macroscopic, scalable sponge-based reactor (20 × 20 cm) through controlled deformation of a TATZ-incorporated hydrogel. This integrated system demonstrates excellent contaminant removal efficiency under continuous-flow operation using natural sunlight, confirming its potential for real-world application. Our work establishes a comprehensive design framework for advancing photocatalytic technology across multiple scales—from molecular motifs to functional macroscopic systems.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Rong Guo,Junran Xu,Pengcheng Xue,Guangfu Qian,Changzhou Chen,Douyong Min,Minsheng Lu
Inspired by the catechol chemistry of mussel adhesive proteins, we designed a multifunctional hydrogel that combines antibacterial activity, self-healing, excellent biocompatibility, enhanced mechanical properties, adjustable adhesion, and controlled drug release. A P(AA-co-UH) primary network was synthesized through the copolymerization of acrylic acid and urushiol, while a P(CNC-PB) secondary network was assembled from cellulose nanocrystals, polyvinyl alcohol, and borax. The two networks were interlaced to form an interpenetrating polymer network, which substantially enhanced mechanical performance, achieving a tensile strength of 61.45 kPa and excellent fatigue resistance. The cis -hydroxy groups in cellulose nanocrystal and polyvinyl alcohol, along with the hydroxyl groups of urushiol, engage in dynamic covalent borate ester bonds with borate ions in borax solution. This dynamic covalent crosslinking provides a way to control the concentration of catechol groups, thereby tuning the adhesive performance. Moreover, the incorporation of borax modifies the pore structure and swelling behavior of hydrogels, enabling controlled drug release. This hydrogel exhibits excellent self-healing properties, wet adhesion, and drug-loading capacity. It can self-heal within 5 h, with wet adhesion increasing from 14.13 kPa to 17.51 kPa and drug loading capacity rising from 10.9 mg/g to 19.6 mg/g. Antibacterial and cytotoxicity assays confirmed its favorable biocompatibility and antimicrobial efficacy. In summary, these multifunctional hydrogels are highly promising for smart medical dressing applications.
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JOURNAL OF FOOD PROCESS ENGINEERING
·
2026
·Vol. 49
·期 2
·e70338
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IF 3.5
Yingjian Liu,Chenhong Zhong,Haoxuan Li,Dingjin Li,Chunli Deng,Yipeng Gu,Mubo Song
Mango, as a highly perishable climacteric fruit, incurs significant postharvest losses due to rapid ripening and spoilage. To address this challenge, environmentally friendly bioactive coating technology has emerged as a promising preservation strategy. This study developed a novel coating based on fish gelatin (FG), enhanced by a metal-phenolic network (MPN) formed through the coordination between tannic acid (TA) and Fe 3+ ions. By systematically optimizing the molar ratio of TA to Fe 3+ , the formulation with a 0.2% Fe 3+ concentration (FG/MPN 2 ) was identified as optimal, exhibiting the best system stability (zeta potential: +16.32 ± 1.21 mV) and micro-uniformity (PDI < 0.3). Structural analyses via Fourier-transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy confirmed the formation of a stable composite structure within the FG matrix. Benefiting from this, the FG/MPN 2 coating demonstrated significantly enhanced barrier properties, interfacial adhesion, and excellent antioxidant activity. Finally, the coating was applied to mango preservation (25°C, 60% RH). The preservation results indicated that the coating could significantly inhibit weight loss, maintain higher fruit firmness (17.92 ± 0.50 N) on the 12th day, effectively delay color yellowing, and reduce lipid peroxidation damage, thereby extending the shelf life.
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Cell Reports Physical Science
·
2026
·
IF 6.9
Qi Yi,Yi-Qi Sheng,Dong-Qi Han,Xue-Wei Lin,Chi-Kit Siu,Zhong-Ping Yao
Chiral recognition in mass spectrometry typically relies on one chiral selector (CS) to distinguish enantiomers through dissociation of diastereomeric complexes. Here, we report an innovative approach employing two different CSs to form trimeric complexes with analytes in the presence of Cu 2+ . Nineteen proteinogenic chiral amino acids are investigated as both analytes and selectors, and complexes involving proline and aromatic amino acids exhibit superior chiral discrimination. Notably, the two selectors can play distinct roles: one plays an anchoring role, while the other only contributes to the degree of discrimination. Computational modeling reveals that the copper-bound trimers (e.g., [Cu II (Pro)(Phe)(Tyr) − H] + ) adopt a pentacoordinated geometry with a square-planar base and an elongated axial bond. Three energetically similar precursor structures co-exist, with dissociation occurring exclusively at the axial position. The strong agreement between experimental and computational results validates this binary CS concept and provides a framework for designing advanced CSs for unknown samples.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2026
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IF 9.2
Nabi Bux,Danruo Luo,Shan Qian,He Guo,Sadam Hussain Tumrani,Razium Ali Soomro,Guodong Zhang,Qiuling Ma,Jian Zhou,Tiecheng Wang
The wide occurrence of sulfonamide antibiotics in water environments poses a great threat to ecological system and human health. Cobalt-based catalysts are well known for advanced oxidation processes (AOP), but the synergistic role of heteroatoms is still uncertain. In this work, a new type of heterogeneous Co based catalyst with sulfur as the ligand (Co@S-N-C) was transferred through a straightforward one-pot pyrolysis approach for efficient activating peracetic acid (PAA) to degrade sulfadiazine (SDZ). Systematic characterization confirmed that the co-doping by S and N in carbon induced the formation of several cobalt species (Co 0 , Co 2+ , and Co 3+ ) and built a unique electronic structure featuring in abundant defects and large specific surface area. The Co@S-N-C/PAA system exhibited exceptional catalytic efficacy, accomplishing total SDZ degradation in 25 min and a substantial mineralization rate of 78.2% within 90 min, markedly surpassing the performance of single heteroatom-doped catalysts (Co@N-C and Co@S-C). Mechanistic investigations indicated that •OH and CH 3 COO• contributed 66.4% and 34.1% to SDZ degradation, respectively. DFT calculations revealed that S-N co-doping increased the electron transfer from low-valent cobalt sites to PAA, promoting O-O bond splitting. The catalyst exhibited excellent stability with 71% activity retention and minimal Co leaching (5%) after four cycles. Based on these results, five primary degradation pathways for SDZ were proposed, and the results of ecotoxicity analysis showed that the transformation products were less toxic. Overall, this work provides significant insights into the development of high-performance dual-heteroatom-doped catalysts to form the PAA-mediated AOP for wastewater treatment.
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Letters in Drug Design & Discovery
·
2026
·
IF 1.6
Daoyong Hu,Qun Dai,Hao Xiong,Tian Zhong
Background Oral squamous cell carcinoma (OSCC) is a highly metastatic malignant tumor that originates from the squamous epithelium of oral mucosa. Squamocin, a compound derived from traditional Chinese medicine, has been shown to inhibit head and neck squamous cell carcinoma, yet its mechanism in OSCC remains unclear. Methods Cell functions were assessed using the 3-(4, 5)-dimethylthiahiazo (-z-y1)-3, 5-di-phenytetrazoliumromide (MTT), 5-ethynyl-2’-deoxyuridine (EdU), flow cytometry, transwell, wound healing, and sphere-formation assays. Potential targets of Squamocin in OSCC were predicted via the SwissTargetPrediction and GeneCards databases. A protein-protein interaction (PPI) network was constructed with STRING and visualized in Cytoscape. Gene and protein expression levels were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Molecular docking and cell thermal shift assay (CETSA) were used to examine the binding between Squamocin and peroxisome proliferator activated receptor-gamma (PPARG). Results Squamocin treatment inhibited OSCC cell viability ( P < 0.05), proliferation ( P < 0.01), migration ( P < 0.01), and sphere formation ( P < 0.01), while promoting apoptosis ( P < 0.01). PPARG was identified as the key target of Squamocin and was down-regulated in OSCC cells ( P < 0.05). Notably, PPARG expression was increased by Squamocin ( P < 0.01), and the stable binding between them was confirmed by molecular docking (-6.6 kcal/mol) and CETSA ( P < 0.01). Functional assays revealed that PPARG overexpression suppressed OSCC malignancy ( P < 0.05), while its knockdown attenuated the inhibitory effects of Squamocin ( P < 0.01). Conclusion Squamocin inhibits the malignant phenotypes of OSCC by activating PPARG. These findings provide the first evidence that PPARG is a direct functional target of Squamocin in OSCC, suggesting its potential as a novel therapeutic agent for OSCC. Furthermore, given the central role of PPARG in OSCC progression, these findings highlight its potential as a target for novel small RNA-based therapeutics, such as microRNA (miRNA) mimics or antisense oligonucleotides, offering a promising direction for future precision medicine approaches in oral cancer.
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