ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Zhongyue Zhou,Linyu Zhu,Xintong Xiao,Hairong Ren,Cunhao Cui,Fei Qi
As an abundant, renewable aromatic resource, lignin remains underutilized due to its complex and recalcitrant structure. Molecular-level elucidation of liquid-phase catalytic depolymerization of technical lignin is further hindered by structural heterogeneity and limited accessibility of intermediates under high-pressure conditions. Herein, a decoupled double-bed flow-through reactor integrated with online high-resolution mass spectrometry (HRMS) is employed to investigate the catalytic depolymerization of alkali Kraft lignin. Spatial separation of thermal solvolysis and catalytic hydrogenolysis enables independent characterization of products from each bed. Online HRMS resolves thousands of molecular species from monomers to oligomers up to heptamers, revealing a pronounced shift toward lower degrees of polymerization and reduced unsaturation after catalytic hydrogenolysis. Ring and double bond equivalents–carbon number, van Krevelen, and tandem MS analyses indicate extensive hydrogenation, partial deoxygenation, and the cleavage of β-O-4 linkages, with C–C interunit linkages, either native or formed via condensation, largely preserved in the residual dimers and oligomers. Continuous online monitoring captures the evolution of individual products, highlighting progressive depolymerization and suppressed recondensation under flow-through conditions. This work demonstrates online HRMS as a powerful operando tool for resolving structure–reactivity relationships in lignin depolymerization and provides molecular-level insights relevant to catalytic biomass valorization.
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Analytical Methods
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2026
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IF 3
Wei Liu,Yanhua Sun,Zhiyong Zhu,Zi Li,Hongfang Li,Qiongyao Zeng
This study synthesized nitrogen-doped mesoporous carbon (NMC) using Zn-MOF-8 as a template, followed by the preparation of ZIF-08/NMC composites via π-π adsorption interactions between ZIF-08 and NMC. The composite was characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and electrochemical methods. The resulting ZIF-08/NMC/GCE electrode demonstrated stable and sensitive detection of hesperidin. The modified electrode exhibited a broad linear range from 0.8 to 120 μM with a detection limit of 0.16 μM (signal-to-noise ratio ≥3). Furthermore, the sensor demonstrated excellent stability, repeatability, and interference resistance, and was successfully applied for hesperidin detection in real samples.
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Zhihua Zhao,Bingbing Wang,Yao Wang,Huiqin Li,Zhenzhen Yang
Ammonia (NH 3 ) is a toxic and pungent gas with significant implications for environmental monitoring, industrial safety, and human health. Therefore, the development of high-performance sensors for NH 3 detection at room temperature is of great necessity. This work develops a Bi 2 MoO 6 /Ti 3 C 2 T x 2D/2D heterostructure-based NH 3 gas sensor. The material demonstrated outstanding NH 3 sensing characteristics, involving high sensitivity (R a /R g =25.6 at 100 ppm), quick response time (21 s), and quick recovery time (72 s) at room temperature. Meanwhile, the sensor demonstrated prominent stability, repeatability, humidity-resistant, and an optimal operating temperature for NH 3 detection. Density functional theory (DFT) simulations were applied to examine the adsorption behavior of NH 3 on the Bi 2 MoO 6 /Ti 3 C 2 T X surface, which shed light on the sensing process. Additionally, a prototype detection system was developed to monitor NH 3 emissions from spoiled fish samples, illustrating how this sensor could be applied to monitor food safety.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·270
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IF 5.4
Wang Yuqing,Liu Yutong,Liu Ziqi,Wang Xinyue,Yu Menglu,Gao Guanghui,Zhao Yunli,Hong Jing
A novel MXene nanosheet-supported Fe₃O₄@Ag nanozyme, designed for the dual-mode colorimetric and surface-enhanced Raman scattering (SERS) detection of the pesticide thiram in fruits is presented. The composite ingeniously integrates three key functions: magnetic enrichment, SERS signal amplification, and peroxidase-like nanozyme activity. The resulting nanozyme sensor demonstrates high sensitivity and specificity for thiram detection. The colorimetric method showed a linear range of 0.05 µM to 30 µM with a LOD of 0.016 µM, while the SERS method exhibited a linear range of 10 − 4 M to 10 − 8 M with a LOD of 3.44 × 10 − 9 M. This performance satisfies the demands for agricultural safety monitoring. The present work highlights the significant potential of the developed colorimetric-SERS dual-mode nanozyme platform for on-site pesticide residue determination .
Section
Graphical
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Petroleum Science
·
2026
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IF 6.4
Yuan Gao,Lei Yang,Sheng Huang,Tao Zhen,Miao Xu,Zao-Yuan Li,Zi-Yan Ren,Xin-Zhe Zhou,Hai-Bo Cheng,Xing-Yu Peng,An-Ming Liao
During cementing operations, unavoidable contact between water-based mud (WBM) and oil well cement (OWC) often degrades OWC performance. This is particularly problematic in natural gas or offshore wells, where zonal isolation failure can result in gas or liquid leakage, posing significant environmental and safety risks. To alleviate this problem, a masking agent was incorporated into the OWC to suppress contamination. The masking agent functions by shielding the active sites on cement particles and chelating metal ions, thereby inhibiting the cross-linking between WBM and OWC. Experimental results demonstrated that the addition of 0.5% of the masking agent increased the thickening time of the contaminated OWC system by 276%, while also doubling both its fluidity and compressive strength. To gain a more comprehensive understanding of the underlying mechanism, quantum chemistry and molecular dynamics simulations were employed. The results indicate that the masking agent exhibits superior adsorption properties, allowing it to compete effectively with the polymers for reaction sites. Overall, this study emphasizes the critical role of the masking agent in mitigating WBM contamination and proposes a viable strategy to improve the safety and quality of cementing operations. Furthermore, this approach can reduce or eliminate the need for spacer fluids, thereby addressing environmental challenges associated with the disposal of wellbore waste fluids.
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LANGMUIR
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2026
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IF 4.4
Yong Wang,Chunxiao Yan,Weiye Liang,Qiang Zhang,Gang Cheng,Jicheng Dong,Lin Jin,Huan Tang,Fang Cheng,Lijun Zhang
Orthokeratology (OK) lenses for myopia correction are susceptible to biofouling by tear-derived biomolecules, escalating the risks of ocular infection and inflammation. Prevailing studies that rely on end point protein quantification fail to capture the real-time kinetics of fouling formation. Here, we fabricated a UV pressure-assisted polymer-grafted quartz crystal microbalance with dissipation monitoring (QCM-D) sensor exhibiting exceptional stability, nanoscale smoothness (RMS roughness ≈2 nm), and interfacial peel resistance. This platform enables in situ tracking of adsorption/desorption kinetics for four critical tear components: native/denatured lysozyme and oxidized/native lecithin. Key findings reveal a flow-dependent fouling behavior, wherein low flow rates increase biomolecule adsorption by 37–80% compared with higher flows. We further identify denatured lysozyme and native lecithin as resilient contaminants characterized by a stronger deposition affinity and pronounced resistance to elution. Quantitative screening of multipurpose solutions (MPSs) demonstrates that MPS #2 achieves 20–100% elution rate across biomolecules, outperforming commercial benchmarks. By leveraging dissipation–frequency (D–F) analysis, we clarify the fundamental mechanisms of biofouling formation at the molecular level. Collectively, this work establishes three critical advances: (1) a real-time biofouling diagnostic platform for OK lens interfaces, (2) molecular design principles for antifouling materials based on adhesion remodeling theory, and (3) an accelerated MPS formulation screening paradigm for ocular device safety.
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BME Frontiers
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2026
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IF 9.1
Xingfang Qiao,Yiwen Hao,Yinglan Yu,Zhe Qiang,Xingjian Wen,Yanlei Guo,Zhen Wu,Hao Shao,Lei Luo
Objective: This study aims to engineer a tigecycline–hemoglobin nanoparticle (TIG–HBNP) system to enhance the targeting effect of tigecycline (TIG) on Klebsiella pneumoniae , thereby improving its antibacterial efficacy. Impact Statement: This study represents the first report of loading TIG onto hemoglobin (HB) nanoparticles. This system utilizes the iron dependence of K. pneumoniae to enhance the targeting ability of TIG and increase the drug concentration at the infection site, thereby enhancing the antibacterial activity and providing a promising strategy for combating drug-resistant gram-negative bacterial pneumonia. Introduction: K. pneumoniae is a gram-negative bacillus that causes severe primary pneumonia with high pathogenicity and increasing drug resistance. TIG is a key therapeutic option, but its clinical effectiveness is limited by extensive systemic distribution and insufficient drug concentration at infectious foci. HB serves as a promising protein nanocarrier and provides iron, an essential nutrient for K. pneumoniae growth, suggesting great potential for targeted antibiotic delivery. Methods: Molecular docking was performed to analyze the binding affinity and interaction between HB and TIG. TIG–HBNP was fabricated via a drug–protein self-assembly approach. The nanoparticles were characterized in terms of particle size, zeta potential, drug-loading efficiency, morphology using transmission electron microscopy and atomic force microscopy, stability, and biocompatibility. Targeting capability was evaluated. Pharmacokinetic profiles and antibacterial activity were further assessed. Results: Molecular docking verified stable binding between TIG and HB. TIG–HBNP exhibited a uniform spherical morphology, a particle size of approximately 200 nm, a negative surface charge, and a drug-loading efficiency exceeding 20%. The nanoparticles showed favorable stability and safety. Enhanced targeting to K. pneumoniae was confirmed in both in vitro and in vivo models. Improved pharmacokinetic behavior and enhanced antibacterial activity against K. pneumoniae were also observed. Conclusion: TIG–HBNP enhances TIG’s therapeutic efficacy against K. pneumoniae infections. Furthermore, HB holds promise as a versatile carrier for diverse antibiotics, offering a scalable platform to combat multidrug-resistant pathogens.
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TALANTA
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2026
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IF 6.7
Chen-Chen Bai,Chen-Ri Su,Yu-Jun Shi,Jun-Li Qian,Long-Xin Yang,Zhi-Peng Li,Sen Gao,Lin Zhao,Xian-Hua Wang
Listeria monocytogenes ( L. monocytogenes ), as a prevalent foodborne pathogen, is a major threat to global public health due to its high mortality rate and strong survival ability under limited conditions. Herein, a novel ampicillin grafted tetracarboxylic functionalized magnetic nanoparticles (ATMN) was fabricated and combined with real-time loop-mediated isothermal amplification (LAMP) for ultrasensitive detection of L . monocytogenes . Within one tube, ATMN could specifically capture target L. monocytogenes by the selective recognition between ampicillin on ATMN and penicillin binding proteins on the surface of L. monocytogenes , and then effectively isolate its DNA mainly through hydrogen bonds between carboxy on ATMN and DNA after in situ lysis. Interestingly, continuous enrichment and separation within one tube could obtain template DNA. Subsequently, the DNA was analyzed by real-time LAMP for accurate detection, in which the specific hly gene of L . monocytogenes was selected as an indicator. To prove the practicability, ATMN linked real-time LAMP (ATMN-LAMP) strategy was proposed for rapid, specific, and ultrasensitive detection determination of L . monocytogenes in lettuce and raw pork. The ATMN-LAMP strategy exhibited ultrahigh sensitivity with limit of detection of 78 CFU mL −1 , and was successfully used for detecting L . monocytogenes in spiked real samples with recovery between 97.2% and 102.8% and relative standard deviation no more than 5.3%, respectively. Therefore, we believe that the ATMN-LAMP strategy exhibits the characteristics of low cost, high efficiency, and simple operation, and is expected to become a universal method for detecting various pathogens in complex biological samples.
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BIOMATERIALS
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2026
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IF 13.6
Zheyuan Zhou,Yixuan Hou,Ziyang Yao,Qian Han,Siqi Wang,Hua Mei,Haobin Chen,Bo Tian,Ming Li,Lamei Cheng,Chao Zeng,Zhuxin Dong
Stem cell-based therapies and liposome-integrated hydrogel matrix strategies are promising for articular cartilage regeneration. However, challenges persist due to the loss of stemness during in vitro expansion and the lack of control over stem cell behavior in vivo . Herein, we design a cartilage-inspired hydrogel scaffold similar to the native stem cell niche and expect to enhance chondrogenesis for cartilage repair. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are encapsulated within a composite hydrogel composed of methacrylate hyaluronic acid and collagen networks, mimicking the extracellular matrix of native cartilage. Additionally, embedded liposomes participate to form a lubrication mechanism, the boundary layer in the synovial joints, which lowers the coefficient of friction close to the native level. In vitro , our hydrogel niche system enhances cell-cell and cell-matrix interactions, induces hUC-MSCs mesenchymal condensation, establishes the hypoxic microenvironment formation, and therefore improves the chondrogenic differentiation. Moreover, SOX9, COL2, and HIF-1α expression are all upregulated, whereas MMP13 is downregulated. Meanwhile, in vivo implantation in an osteochondral defect model demonstrates our repair strategy is superior to the conventional hydrogel scaffolds. The advantages include the restoration of PRG4, the suppression of MMP13 and the increasement of ICRS II score to the native levels at 6 weeks post-implantation. These findings are important biophysical cues in regulating stem cell fate in a three-dimensional hydrogel niche and conducive to developing biomimetic scaffolds for cartilage repair.
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PROGRESS IN ORGANIC COATINGS
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2026
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IF 7.9
Lingtong Li,Yao Chen,Zhiheng Zhao,Ke Lei,Sitong Liu,Hong Wu,Shaoyun Guo
Photothermal phase change microcapsules (PCM), which integrate solar-thermal conversion with energy storage, represent one of the most promising materials to address the challenges of intermittent light sources and low energy density. However, such materials often face critical issues in balancing photothermal conversion efficiency and storage capacity, along with structural stability. In this work, a triple-layered shell strategy was proposed to achieve not only stable structure but also a combination of high photothermal conversion efficiency and energy storage in the PCM. In detail, the fabricated PCM utilizes n-octadecane as the core and constructs a triple-layered shell structure composed of silica, polydopamine and copper sulfide via layer-by-layer assembly, achieving full-spectrum absorption with a high photothermal conversion efficiency (95.6%), high latent heat (120 J/g) and excellent stability. The phase change temperature and enthalpy of this PCM remains in good consistency after 100 cycles. Furthermore, the energy transfer is improved due to enhanced thermal conductivity (2.36 W/m·K). Combined PCM with the hydrolysis product of octadecyl trichlorosilane and modified organosilicon resin, a superhydrophobic composite coating with photothermal energy storage is successfully prepared by a two-step method. This coating demonstrates exceptional anti-/de-icing performance under low-temperature condition, offering a synergistic protection mechanism. This study introduces an innovative strategy for developing high-performance PCM and paves the way for anti-/de-icing application of superhydrophobic composite coatings with photothermal energy storage.
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Analytical Methods
·
2026
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IF 3
Nan Wang,Jing Wang,Hongfei Liu,Ruxi Huang,Jun Lu,Duo Lin
Pesticide residue contamination poses a significant threat to food safety and public health, necessitating the development of rapid and accurate on-site detection technologies. Herein, we report a flexible surface-enhanced Raman spectroscopy (SERS)-based tape fabricated through a three-phase liquid interface self-assembly approach, which integrates a paper-based substrate with uniformly deposited silver nanoparticles (AgNPs) and a commercially available adhesive tape. The developed platform demonstrates high sensitivity for two commonly used pesticides-thiram and thiabendazole (TBZ), with detection limits substantially lower than the national maximum residue limits (MRLs). The pre-immobilization of AgNPs on the paper matrix effectively addresses the nanoparticle detachment issue inherent to conventional tape-based methods. Using portable Raman spectrometers, the system features two operational modes: (1) a "paste-and-peel" mode for nondestructive sampling of pesticide residues from fruit/vegetable surfaces, and (2) a direct-drop mode for rapid analysis of liquid samples such as fruit juices. This work presents a reliable tool for on-site monitoring of agricultural product safety and demonstrates promising potential for food safety applications.
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Advanced Science
·
2026
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IF 14.1
Lijun Li,Hao Zhang,Lingtong Sun,Yingfeng Su,Yang Xu,Jian Huang,Jingchao Wen,Jinjin Zhu,Jianjun Ma,Wenbin Xu
Critical-sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self-healing capacity. Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have emerged as promising cell-free therapeutic candidates for bone regeneration, owing to their paracrine effects in regulating bone regeneration-related processes. However, enhancing exosome bioactivity via biomimetic preconditioning and developing efficient delivery vectors remain key bottlenecks in this field. Herein, we developed a synergistic bone regenerative system composed of biomimetic preconditioned BMSC-derived exosomes (BioPre-Exos) and injectable porous polydopamine (PDA)-modified gelatin methacryloyl (GelMA) microspheres. The biomimetic preconditioning strategy adopted 3% hypoxia combined with 3D GelMA microsphere culture, mimicking the bone marrow microenvironment to regulate BMSC functions and significantly boost exosome bioactivity. Functional experiments verified that BioPre-Exos robustly promoted BMSC migration, osteogenic differentiation, angiogenesis, and macrophage polarization toward an anti-inflammatory phenotype in vitro. Furthermore, in a rat femoral condyle defect model, the composite system markedly improved neovascularization density and bone volume fraction, thus achieving efficient vascularized bone regeneration. These findings indicate that this cell-free biomimetic synergistic delivery system holds great application potential in the clinical treatment of bone defects.
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