Scientific Reports
·
2025
·Vol. 15
·期 1
·1-20
·
IF 3.9
Wu Honghan,Huang Jun,Wu Hengpeng,Xu Weikang,Zhong Qian,Song Jiaxiang,Linghu Xitao,Gao Botao,Wa Qingde
Autologous and allogeneic bone grafting is currently the clinical gold standard for the treatment of bone defects; however, it is limited by the scarcity of autologous sources and the risk of secondary trauma, as well as the complications of disease transmission and immune rejection associated with allogeneic grafts. The clinical management of bone defects remains a significant challenge. In this study, we prepared a demineralized bone matrix/gelatin methacrylate composite hydrogel loaded with deferoxamine (GelMA/DBM/DFO) using a freeze-drying method and investigated its properties. Assessments using CCK-8, live-dead fluorescence staining, alkaline phosphatase staining, and Alizarin Red staining indicated that the GelMA/DBM/DFO composite hydrogel demonstrated superior biocompatibility and in vitro osteogenic differentiation capacity compared with the GelMA/DBM composite hydrogel. We established a cranial defect model in Sprague–Dawley (SD) rats and examined peripheral blood indices, micro-computed tomography (Micro-CT), hematoxylin and eosin (HE) staining, Masson’s trichrome staining, and immunohistochemical staining for bone morphogenetic protein-2 (BMP-2) and collagen type I (COL-1). Both hydrogels exhibited good biosafety and the GelMA/DBM/DFO hydrogel showed more effective repair of cranial defects in SD rats. This study provides a novel material for bone-defect repair.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Chen Zhibiao,Zhan Bin,Li Shuyi,Wei Dongsong,Zhou Wenting,Fang Zhengping,Liu Yan
With the escalating severity of oily wastewater discharge, the development of novel and efficient adsorption materials is an urgent necessity. Bio-based aerogels, due to their distinctive attributes, including low density, high porosity, sustainability, and safety, have emerged as ideal absorbents for oil spill remediation. In this study, aerogels with ultra-low density were prepared from the renewable biomass material, pectin, through an innovative ice/bubble dual-template method. In this process, with the help of sodium dodecyl sulfate, microbubbles were introduced by high-speed stirring to decrease the density of aerogels. At the same time, phytic acid also played a role in promoting pectin crosslinking and enhancing the flame-retardant properties of aerogels, significantly improving the safety of their transportation and application. After silane modification, the aerogel exhibited ultra-low density (10.91 mg/cm 3 ), exceptional superhydrophobicity (152°), outstanding oil absorption capacity (110 g/g), and flame retardancy. This work underscored the significant and promising prospects of bio-based aerogels in addressing oil pollution challenges, highlighting their potential as optimal candidates for sustainable and effective environmental remediation.
✓ 已验证
产品关联
DOI
高影响因子
PLANT GROWTH REGULATION
·
2025
·
IF 3.9
Tu Chun Yan,Gao Yong Qiang,Zheng Lu,Ma Jun Wei,Shen Ren Fang,Zhu Xiao Fang
Aluminum (Al) toxicity represents a significant constraint on crop growth in acidic soils. Al stress can stimulate the biosynthesis of melatonin (MT) in rice ( Oryza sativa L.). The exogenous application of 20 μM MT markedly reduces Al accumulation in root tips and effectively mitigates Al stress. By enhancing the levels of root hemicellulose and down-regulating the expression of two genes sensitive to aluminum rhizotoxicity ( OsSTAR1 and OsSTAR2) , which function to obscure Al binding sites within the cell wall, MT significantly improves the fixation of Al by the cell wall. Furthermore, MT diminishes cytoplasmic entry of Al by reducing expression levels of nramp aluminum transporter 1 gene ( OsNRAT1 ), while inducing expression of an aluminum-sensitive gene ( OsALS1 ), thereby promoting vacuolar compartmentation to lower cytoplasmic Al concentration. Additionally, MT substantially decreases Nitric oxide (NO) accumulation induced by Al in roots. The alleviation effect exerted by MT on Al toxicity can be replicated through administration of the NO scavenger carboxyl-PTIO (c-PTIO). Moreover, the Al-sensitive phenotype exhibited in the osgsnor mutant, coupled with the absence of mitigation by MT, further substantiates that MT alleviates Al toxicity in rice primarily via regulation of NO content, potentially relying on NO signal transduction pathways. In summary, MT plays a pivotal role in modulating rice resistance to Al toxicity and stimulates multiple pathways to enhance tolerance against this abiotic stressor. This study provides new insights into understanding mechanisms underlying rice resistance to abiotic stresses.
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2025
·
IF 2.3
Hu Lingling,Lu Weichao,Li Zhongjian,Liu Yue,Zhang Yun
A method is proposed to replicate the spectral curves of standard dyestuffs based on the mixing of absorption spectra between non-primary dyestuffs to quickly screen out the dyestuff components for the matching color of blended dyestuffs, so as to solve the problems of low color matching efficiency and high resource consumption in the dye development process. The relationship between the dye absorption spectra and color was explored first. The screening of non-primary dyes based on spectral and color characteristics of single dyes formed the initial formulation. A computer program implementing the least squares method was then developed to replicate the spectra of 15 different specimen dyes using their blending formulations, and the feasibility of these formulations was assessed by comparing them with the actual dyeing. It was found that 13 formulations could achieve the same color as the specimens under the illuminant D65, and 11 of them did not show any metamer mismatching under any of A and F02 light sources. The Goodness-of-Fit ( R n ) values of the spectral curves between all these 11 formulations and their specimens were greater than 0.95. After R n decreased from 0.95, four formulations showed metamerism, and 2 formulae could not achieve the same color under the illuminant D65. The above results indicated that there was a good correspondence between the consistency of the spectral curves and that of colors, and the method is feasible to match color and avoid metamer mismatching by successfully screening non-primary dyes.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-16
·
IF 5.3
Feng Luping,Li Xinfeng,Wang Jianghong,Chen Enjun,Fan Yujie,Jin Leyao,Tang Peisong,Zhang Lixiang
A visible-light-powered photoelectrochemical (PEC) sensor was devised for chlorpyrifos (CPs) determination using metallic Bi-decorated BiVO 4 nanosheets (Bi@BiVO 4 NSs) with localized surface plasmon resonance (SPR) synthesized via a one-step hydrothermal method. It was observed that Bi@BiVO 4 -based PEC sensors exhibit significantly enhanced PEC responses over pristine BiVO 4 due to the collaborative effect of metallic Bi’s SPR phenomenon and BiVO 4 ’s visible-light-driven properties. Furthermore, the addition of CPs selectively suppresses the photocurrent signal of the sensor due to the in-situ formation of Bi-CPs complexes, which hindered electron transfer through specific chelation reactions between Bi sites and CPs. The designed PEC sensor achieved high-sensitivity detection of CPs, with a linear concentration range from 0.02 to 20 ppb and a detection limit of 0.01 ppb. These attributes may offer a blueprint for developing diverse PEC sensing systems to monitor various environmental pesticide contaminants like CPs by synergistic integration of visible-light-responsive BiVO 4 and SPR-active metallic Bi. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2025
·Vol. 36
·期 1
·1-17
·
IF 4.5
Wang Zheng,Ye Minhua,Wang Chunguo,Ma Dehua,Zhang Jian,Fang Fang
This study aimed to develop a versatile aptamer-conjugated, photothermal responsive camptothecin (CPT)-loaded chitosan-bimetallic (Pd/Au) nanoparticles (Ap-CH-CPT-Pd/Au NPs) to enhance cytotoxicity in lung cancerous NCI-H446 and H1299 cells. The CH-CPT-Pd/Au NPs exhibited polydispersity with a diameter of 33.87 ± 2.23 nm. FTIR investigation revealed the presence of chitosan and camptothecin in chitosan-camptothecin-palladium/gold nanoparticles. The 2θ of CH-CPT-Pd/Au corresponded to chitosan and palladium/gold. The Ap-CH-CPT-Pd/Au NPs (180 μg/mL) subjected to near-infrared (NIR) treatment elevated the temperature to over 50 °C. The optimum CPT concentration was 0.075% in CH-CPT-Pd/Au, demonstrating a hydrodynamic diameter of 113.12 ± 16.78 nm, a drug loading efficiency (DLE) of 10.89 ± 0.53%, and a drug encapsulation efficiency (DEE) of 63.97 ± 4.21%. A CPT release rate of 7.23 ± 3.25% was recorded at pH = 5.4 after 74 h. In addition, NIR+Ap-CH-CPT-Pd/Au NPs exhibited negligible toxicity to red blood cells (RBCs). However, enhanced cytotoxicity in NCI-H446 and H1299 lung carcinoma cells is achieved through the induction of oxidative stress-mediated apoptosis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-9
·
IF 3.9
Sun Dan,Xie Bin,Si Yulin,Yin Xi,Xu Zhijin,Zhang Xia,Wang Hangzhou
Self-driven monitoring technique is specifically requested in remote areas. Microbial fuel cell (MFC) was a galvanic cell that has been applied for various environment monitoring. However, MFC is a self-driven probe rather than sensor, since external power was needed for data acquisition. Here, a real self-driven MFC based sensor was developed by using a simplified energy management system (EMS) to enable MFC to power data logger. In this simplified EMS, some common electronics of capacitor, voltage comparator, resistance and trigger switches were removed to reduce power dissipation. As a result, the logger was powered without longtime energy harvesting from MFC. Moreover, since the MFC current generation is changeable with the sampling signal, a rechargeable battery was added as backup power when the current from MFC was too low, or as an energy storage for surplus energy collection other times. Take a dissolved oxygen (DO) sensor as an application example, a MFC was able to detect DO (with a very short energy harvesting time of 10 s), and power logger (with a 1.6% deviation to that with an AC powered Keithley logger), and charge backup battery at the same time, when DO > 5.3 mg/L. When DO < 0.8 mg/L, the power generated from MFC was too low to drive the EMS, and logger was only powered by the rechargeable battery. Besides DO monitoring, this self-driven system may work for other types of MFC sensor as well, such as toxicant sensor, biochemical oxygen demand (BOD) sensor and so on. With a 38$ cost, this self-driven MFC sensor was competitive and attractive for in-situ environment survey.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-14
·
IF 3.9
Huang Yonghua,Zhao Cong,Liang Shuai,Wu Zheng,Peng Daoping,Li Yao,Liu Yun
Bisulfite (BS)-based advanced oxidation processes (AOPs) are attractive for pollutant degradation, but often depend on costly transition metals with leaching risks. Herein, we report a citric acid-modified red mud catalyst (RMAC) for efficient Congo Red (CR) removal. Citric acid acted Simultaneously as an acid activator and carbon template, enlarging the surface area from 31.10 to 116.40 m 2 g −1 (3.74-fold increase). Under optimal conditions (5 mM BS, pH = 5, 80 mg L −1 CR), RMAC3-800 achieved 98.8% CR removal with a pseudo-first-order rate constant of 0.1399 min −1 and retained > 80% efficiency after three reuse cycles. Radical scavenging and EPR analyses confirmed SO 4 •− (53.7%) and •OH (46.3%) as the dominant species, whereas XPS identified Fe 0 as the principal active site. GC-MS detected six intermediates, supporting the proposed oxidative cleavage and mineralization pathways of the degradation process. A preliminary bench-scale cost analysis estimated an operating cost of ~ 13.94 RMB m −3 (≈ 1.95 USD m −3 ), underscoring its economic feasibility. This study demonstrates a cost-effective, recyclable, and sustainable catalytic system for wastewater treatment and red mud valorization.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Wei Shilei,Hua Hang,Zhao Yuxuan,Luo Jingshan
Zero-gap membrane electrode assembly (MEA) CO 2 electrolysers offer high energy efficiency and promise for industrial application. However, the transport of carbonates within an anion exchange membrane (AEM) electrolyser leads to CO 2 loss, thereby limiting carbon utilization efficiency. Emerging acidic anolyte electrolysers using cation exchange membrane (CEM) can address this challenge but face critical stability issues, including accelerated hydrogen evolution reaction (HER) and persistent salt precipitation. Here, we propose a porous membrane (PM) as an alternative to the CEM in acidic anolyte electrolysers. The system demonstrates continuous operation at 100 mA cm −2 for 200 h without salt precipitation, while maintaining nearly 100% CO selectivity. Furthermore, large-scale device (100 cm 2 ) also shows stable performance. Mechanism analysis suggests that enhanced water permeation and bidirectional ion transfer are critical for achieving stable performance in acidic anolyte electrolysers. These findings offer a feasible approach for high-performance, stable and scalable acidic MEA CO 2 electrolysers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Hu Xinchao,Shen Shuqi,Li Jiantao,Wen Jiansen,Fan Mengjian,Lee Sungsik,Zhang Yinggan,Wu Hualong,Gao Guiyang,Liu Yuanyuan,Zhang Shiyu,Zhang Chengkun,Sa Baisheng,Wang Laisen,Peng Dong-Liang,Amine Khalil,Xie Qingshui
Li-rich layered oxides exhibit promising potential applications in high-energy-density solid-state lithium metal batteries. Nevertheless, the strong oxidative oxygen species generate at high voltage, which poses great challenges to positive electrode-side interface stability. Herein, a robust in-situ polymerization gel polymer electrolyte with bifunctional additives is designed for interface modification. These additives, include lithium difluoro(oxalate) borate and LiPO 2 F 2 , regulate the Li + chemical environment in gel polymer electrolyte to enhance crosslink density without residual oligomer, which reduce gas generation and suppress contact loss, thus avoiding interfacial impedance divergence. Concurrently, the designed gel polymer electrolyte enables a wide electrochemical stability window (up to 4.7 V) and a high Li + transference number (0.82). Additionally, the additives induced F- and B-rich inorganic cathode-electrolyte interphase inhibits side reactions and oxygen/transition metal loss effectively, stabilizing the chemical interface. The as-constructed Li-rich layered oxides-based ceramic solid-state lithium metal batteries with gel polymer electrolyte interface modification exert a high discharge capacity of 276.5 mAh g -1 at 30 °C without external pressure, delivering a retention of 81.7% after 100 cycles at 25 mA g -1 during 2.0-4.7 V. This work provides a guideline for developing high-voltage solid-state lithium metal batteries via interfacial design.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Translational Medicine
·
2025
·
IF 7.5
Liuzhu Chen,Linpei Zhuo,Jie Zheng,Xiaoyun Sun,Jing Sun,Jiaming Liu
Background Recent studies have highlighted the vital role of gut microbiota in the pathogenesis of Ischemic stroke (IS). However, the effects and underlying mechanisms of atorvastatin on IS via regulating gut-brain axis remain unclear. Thus, this study aimed to explore the relationship between atorvastatin, gut microbiota and IS through animal experiments, clinical trials and Mendelian randomization (MR) analysis. Methods Male mice were induced with bilateral common carotid artery occlusion (BCCAO) to establish an IS animal model, and then intragastrically treated with atorvastatin. Neurological deficits, microglia activation, and the levels of NLRP3 inflammasome and NF-κB pathway-related proteins were detected. Meanwhile, gut microbiota composition and intestinal barrier integrity were evaluated. In this prospective study, we recruited IS patients undergoing atorvastatin treatment, evaluated their functional outcomes, collected fecal samples, and assessed gut microbiota functions. Moreover, the causal relationships between specific bacteria, inflammation and IS were assessed via MR analysis. Results Our results showed that atorvastatin treatment significantly improved neurobehavioral deficits, suppressed activation of microglia, and inhibited NF-κB pathway as well as the formation of the NLRP3 inflammasome, reduced the release of inflammatory cytokines, including IL-1β and IL-18, which were reversed by antibiotics treatment. We further identified an increase in the genus Lachnospiraceae NK4A136 in atorvastatin-treated mice. Subsequent clinical experiments were conducted to explore the effects by analyzing the characteristic bacteria, such as Ruminococcus torques and Lachnospiraceae NK4A136 . The higher abundances of Ruminococcus torques and Lachnospiraceae NK4A136 were associated with a good outcome in atorvastatin-treated IS patients. MR analysis further revealed that these microbes were negatively correlated with inflammatory factor levels, and showed inhibitory effects on the Akt/NF-κB/NLRP3 pathway and PLA2G7 gene expression. Conclusion These findings demonstrated the roles of atorvastatin in regulating Akt/NF-κB/NLRP3 pathway to inhibit neuroinflammation through specific bacteria, which implied a novel way for IS treatment. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-025-06803-w.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BMC Oral Health
·
2025
·Vol. 25
·期 1
·1-11
·
IF 3.1
Wang Yuxi,Tang Mengzhen,Yang Xinyu,Yang Jian
Background This study evaluated the penetration, interfacial adaptation, and push-out bond strength of four bioceramic-based root canal sealers (iRoot SP, Well-Root ST, C-Root SP, and KP-Root SP). Methods A total of ninety mandibular first premolar teeth were used in this study, with eighty teeth randomly divided into eight groups ( n = 10). Four groups were designated for sealer penetration analysis, using each of the four sealers mentioned above mixed with 0.1% rhodamine B and applied using the single-cone technique. Horizontal root sections were prepared at 2 mm (apical), 5 mm (middle), and 8 mm (coronal) from the root apex, resulting in a total of 120 slices. Penetration was evaluated using confocal laser scanning microscopy. The other four groups were used for marginal adaptation analysis, with the same sealers applied without rhodamine B, and adaptation was assessed using scanning electron microscopy on sections prepared at the same depths. The remaining ten teeth were used to evaluate push-out bond strength, with 30 dental slices prepared from the middle third, each drilled with four 1 mm diameter holes and randomly filled with one of the four sealers; bond strength was measured using a universal testing machine. Results There was no statistically significant difference in the depth and circumference of dentin tubule penetration between different materials ( P > 0.05). However, the coronal third was significantly higher than the apical third ( P < 0.001). For iRoot SP, the percentage of dentin tubule penetration circumference at the middle third was significantly higher than that at the apical third ( P < 0.05). Additionally, Well-Root ST demonstrated superior adaptability for interfacial adaptation than C-Root SP at all the sites ( P < 0.05). However, the adaptability of iRoot SP was superior to C-Root SP at the coronal and middle thirds ( P < 0.05). Moreover, the push-out bond strength conformed to the following order: Well-Root ST > iRoot SP > KP-Root SP > C-Root SP, with notable variations ( P < 0.05). Conclusion The Well-Root ST sealer demonstrated the best interface adaptation and push-out bonding strength, as well as iRoot SP showed better permeability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）