COLLOID AND POLYMER SCIENCE
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2024
·
IF 2.2
Hu Guang,Khan Humayun,Ali Farman,Begum Siddiqa,Mehmood Sahid,Arif Umar,Ali Nisar,Hayat Mudassir
This study focuses on advancing epoxy-polyamide composites through the incorporation of chitosan, derived from crab shells, a sustainable polymeric bio filler known for its ability to enhance mechanical and thermal properties. Utilizing a solution casting technique, composites were fabricated by blending various concentrations of chitosan into the epoxy-polyamide matrix. Several analytical methods, including FT-IR, XRD, SEM, DSC, and mechanical testing, were used to evaluate the modifications and properties of the composites. FT-IR confirmed successful chitosan incorporation into the ER-PA composites, supported by SEM analysis showing improved structural integrity. XRD revealed prominent diffraction peaks, reflecting increased crystallinity and efficient chitosan integration. SEM indicated uniform chitosan dispersion on smooth surfaces, enhancing fracture toughness. Mechanical study of the 1% chitosan blend demonstrated superior results, with an elasticity of 6.79 GPa and fracture elongation of 2.2%, surpassing the 5% blend. DSC data showed improved thermal stability, with the uncured composite exhibiting endothermic behavior at 100 °C and exothermic behavior at 400 °C. TGA confirmed enhanced thermal properties up to 780 °C, particularly for the 1% Cs blend, which also displayed outstanding amorphous characteristics. Overall, the mechanical study confirmed Young’s best modulus, toughness, and tensile strength in the 1% blend. A noticeable shift toward higher temperatures during accelerated heating indicated enhanced material durability. These findings highlight the significant potential of chitosan to improve the mechanical strength and thermal stability of epoxy-polyamide composites, making them suitable for demanding engineering applications where endurance and performance are critical. Graphical abstract
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Toxics
·
2024
·Vol. 12
·期 3
·230
·
IF 3.9
Lingli Min,Yahui Ma,Bi Zhang,Dulan He,Jinhua Chen,Xuerong Li,Shuhua Wang,Yulang Chi
Efficient removal of extremely mobile and toxic As(III) from water is a challenging but critical task. Herein, we developed a functionalized sorbent of chitosan nanofiber with iron–manganese (Fe-Mn@CS NF) using a one-step hybrid electrospinning approach to remove trace As(III) from water. Batch adsorption studies were performed to determine the adsorption efficiency under a variety of conditions, including contact time, starting concentration of As(III), ionic strength, and the presence of competing anions. The experimental results demonstrated that the concentration of As(III) dropped from 550 to less than 1.2 µg/L when using 0.5 g/L Fe-Mn@CS NF. This demonstrates the exceptional adsorption efficiency (99.8%) of Fe-Mn@CS NF for removing As(III) at pH 6.5. The kinetic tests revealed that the adsorption equilibrium was reached in 2.6 h, indicating a quick uptake of As(III). The ionic strength effect analysis showed that the adsorbed As(III) formed inner-sphere surface complexes with Fe-Mn@CS NF. The presence of SO42−or F−had a negligible impact on As(III) uptake, while the presence of PO43−impeded As(III) absorption by competing for adsorption sites. The exhausted sorbent could be effectively regenerated with a dilute NaOH solution. Even after 10 cycles of regenerating Fe-Mn@CS NF, the adsorption efficiency of As(III) in natural groundwater was maintained over 65%. XPS and FTIR analyses show that the presence of M–OH and C–O groups on the sorbent surface is essential for removing As(III) from water. Overall, our study highlights the significant potential of Fe-Mn@CS NF for the efficient and quick elimination of As(III) from water.
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高影响因子
MOLECULES
·
2024
·Vol. 29
·期 8
·1836
·
IF 4.2
Guiling Chen,Yitong Yin,Xianting Zhang,Andong Qian,Xiaoyang Pan,Fei Liu,Rui Li
To develop valuable applications for the invasive weed Palmer amaranth, we utilized it as a novel biochar source and explored its potential for methyl orange adsorption through the synthesis of chitosan-encapsulated Palmer amaranth biochar composite microspheres. Firstly, the prepared microspheres were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy and were demonstrated to have a surface area of 19.6 m2/g, a total pore volume of 0.0664 cm3/g and an average pore diameter of 10.6 nm. Then, the influences of pH, dosage and salt type and concentration on the adsorption efficiency were systematically investigated alongside the adsorption kinetics, isotherms, and thermodynamics. The results reveal that the highest adsorption capacity of methyl orange was obtained at pH 4.0. The adsorption process was well fitted by a pseudo-second-order kinetic model and the Langmuir isotherm model, and was spontaneous and endothermic. Through the Langmuir model, the maximal adsorption capacities of methyl orange were calculated as 495.0, 537.1 and 554.3 mg/g at 25.0, 35.0 and 45.0 °C, respectively. Subsequently, the adsorption mechanisms were elucidated by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy investigations. It is indicated that electrostatic interactions, hydrogen bonding, π–π interactions and hydrophobic interactions between methyl orange and the composite microspheres were pivotal for the adsorption process. Finally, the regeneration studies demonstrated that after five adsorption–desorption cycles, the microspheres still maintained 93.6% of their initial adsorption capacity for methyl orange. This work not only presents a promising method for mitigating methyl orange pollution but also offers a sustainable approach to managing Palmer amaranth invasion.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yiwen Lu,Wen Geng,Lili Li,Fang Xie,Mingchang Zhang,Huatao Xie,Jie Cai
Multidrug-resistant (MDR) bacterial infections pose a severe threat to global public health and present significant challenges in the treatment of bacterial keratitis. The escalation of antimicrobial resistance (AMR) underscores the urgent need for alternative therapeutic strategies. In this study, we report the homogeneous synthesis of quaternized ultra-highly deacetylated chitosan (QUDCS) using a sequential acid-base combination approach. The optimized QUDCS-2 exhibits broad-spectrum antibacterial activity through a membrane-disruption mechanism driven by electrostatic, hydrogen bonding, and hydrophobic interactions, while maintaining low cytotoxicity and high selectivity. Compared to less deacetylated counterparts, QUDCS-2 demonstrates superior stability in enzyme-rich environments and effectively inhibits and eradicates mature biofilms of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa . Furthermore, QUDCS-2 exhibits a remarkable ability to prevent the development of antimicrobial resistance. In a mouse keratitis model, QUDCS-2 shows excellent biocompatibility and significant antibacterial efficacy, providing strong support for its potential as a long-term, effective antimicrobial agent.
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ACS Nano
·
2024
·
IF 15.8
Peilei Wang,Jingwen Wu,Xiaolin Xiao,Yujiang Fan,Xianglong Han,Yong Sun
The application of enzyme-like molybdenum disulfide (MoS2) in tissue repair was confronted with stable dispersion, solubilization, and biotoxicity. Here, the injectable self-healing hydrogel was successfully designed using a step-by-step coassembly of chitosan and MoS2. Polyphenolic chitosan as a “structural stabilizer” of MoS2 nanosheets reconstructed well-dispersed MoS2@CSH nanosheets, which improved the biocompatibility of traditional MoS2, and strengthened its photothermal conversion and enzyme-like activities, guaranteeing highly efficient radical scavenging and antimicrobial properties. Furthermore, the polyphenol chitosan was employed again as a “molecular cross-linking agent” to form the injectable NIR-responsive MoS2@CSH hydrogel by accelerating hydrogen-bond interaction among chitosan and the multicross-linking reaction among polyphenols. The rapid self-healing ability was conducive to wound closure and dynamic adaptability. An experimental study on infected wound healing demonstrated that MoS2@CSH hydrogel could substantially eradicate bacteria and accelerate the angiogenesis of infected wounds. The photothermal-driven coassembly of MoS2 and polycation provided an alternative strategy for infected wound healing.
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ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Maoxue Li,Guoping Cheng,Shimeng Xiao,Bo Jiang,Shujuan Guo,Yi Ding
Commercial mammalian collagen-based membranes used for guided tissue regeneration (GTR) in periodontal defect repair still face significant challenges, including ethical concerns, cost-effectiveness, and limited capacity for periodontal bone regeneration. Herein, an enhanced biomimetic mineralized hydroxyapatite (HAp)–fish-scale collagen (FCOL)/chitosan (CS) nanofibrous membrane was developed. Specifically, eco-friendly and biocompatible collagen extracted from grass carp fish scales was co-electrospun with CS to produce a biomimetic extracellular matrix membrane. An enhanced biomimetic mineralized HAp coating provided abundant active calcium and phosphate sites, which promoted cell osteogenic differentiation, and showed greater in vivo absorption. In vitro experiments demonstrated that the HAp-FCOL/CS membranes exhibited desirable properties with no cytotoxicity, provided a mimetic microenvironment for stem cell recruitment, and induced periodontal ligament cell osteogenic differentiation. In rat periodontal defects, HAp-FCOL/CS membranes significantly promoted new periodontal bone formation and regeneration. The results of this study indicate that low-cost, eco-friendly, and biomimetic HAp-FCOL/CS membranes could be promising alternatives to GTR membranes for periodontal regeneration in the clinic.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Jingxi Wang,Kun Li,Yunxue Jia,Tianran Song,Junwei Xu,Xuemei Sun,Meili Liu,Ping Li,Yubo Fan
The single structure, poor mechanical properties, and low biological activity of wound dressings usually lead to unsatisfactory treatment effects. Gelatin and chitosan possess excellent biofunction, but they lack sufficient mechanical support. Magnetic biomaterials and magnetic fields have shown surprising tissue repair potential. Herein, inspired by the skin structure and considering the bioactive composition, a superparamagnetic asymmetric membrane was constructed by incorporating gelatin, chitosan, and magnetic Fe 3 O 4 nanoparticles. The proposed membrane exhibited a high degree of asymmetry, achieving functional diversification. The surface of the top layer was highly hydrophobic as an isolation barrier. The top layer consisted of dense fibrous chitosan with high mechanical strength and excellent antibacterial properties. The bottom layer was composed of gelatin sponge with distributed magnetic nanoparticles, possessing high porosity and swelling ratio to effectively absorb tissue exudates and support cell growth. Furthermore, the membrane demonstrated significant promotion of human dermal fibroblast proliferation under a static magnetic field. In a full-thickness mouse skin wound model, the membrane effectively accelerated wound healing with reduced wound area, abundant collagen disposition, and enhanced vascularization. Therefore, the superparamagnetic gelatin/chitosan asymmetric membrane with a biomimetic structure and function exhibits remarkable superiority and provides a promising approach to effective wound healing.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Yang Yu,Liang Zhang,Bin Hu,Zhengyue Wang,Qiuping Gu,Wenyi Wang,Chunping Zhu,Shige Wang
Chitosan has been widely used in biomedical fields due to its good antibacterial properties, excellent biocompatibility, and biodegradability. In this study, a pH-responsive and self-healing hydrogel was synthesized from 3-carboxyphenylboronic acid grafted with chitosan (CS-BA) and polyvinyl alcohol (PVA). The dynamic boronic ester bonds and intermolecular hydrogen bonds are responsible for the hydrogel formation. By changing the mass ratio of CS-BA and PVA, the tensile stress and compressive stress of hydrogel can controlled in the range of 0.61 kPa - 0.74 kPa and 295.28 kPa - 1108.1 kPa, respectively. After doping with tannic acid (TA)/iron nanocomplex (TAFe), the hydrogel successful killed tumor cells through the near infrared laser-induced photothermal conversion and the TAFe-triggered reactive oxygen species generation. Moreover, the photothermal conversion of the hydrogel and the antibacterial effect of CS and TA give the hydrogel a good antibacterial effect. The CS-BA/PVA/TAFe hydrogel exhibit good in vivo and in vitro anti-tumor recurrence and antibacterial ability, and therefore has the potential to be used as a powerful tool for the prevention of local tumor recurrence and bacterial infection after surgery.
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FUEL
·
2011
·
IF 3.604
Lei Wang,Shuzhen Li,Haijun Cai,Yanyan Xu,Xihui Wu,Yujing Chen
Ultraviolet-assisted oxidative desulfurization (UODS) was applied to diesel, gasoline and petroleum product feedstock containing model sulfur compounds (thiophene, thiotolene, thioxene and benzothiophene). The influence of oxidant amount, volume of acetonitrile, reaction time and temperature on the sulfur removal efficiency from model sulfur compounds and real oils in the presence of ultraviolet was investigated in the presence of ultraviolet. By using the optimized conditions for UODS, desulfurization rates of thiophene and benzothiophene increased to 98.87% and 99.87%, respectively, and desulfurization rates of thiotolene and thioxene to 96.86% and 98.37%, respectively, which were achieved for model compounds in petroleum product feedstock. By using the same conditions, the removal of sulfur for real gasoline and diesel samples was 98.34% and 97.17%, respectively. For model compounds, real gasoline and diesel samples, sulfur removal without ultraviolet and on the same conditions was lower than that with ultraviolet, which shows that ultraviolet improved the efficiency of oxidative desulfurization. The results for sulfur removal from gasoline and diesel samples prove the feasibility of the proposed UODS procedure for sulfur removal from real oil samples.
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Biomaterials Research
·
2024
·
IF 8.1
Chenyang Li,Shuai Wang,Chenghui Liao,Ying Li,Yunfeng Zhou,Haiqiang Wu,Wei Xiong
Klotho (KLO) is an anti-fibrotic protein expressed in the kidneys and has been decreasing in the development of renal fibrosis (RF). However, restoring the decline in KLO levels remains a great challenge during RF treatment. Herein, an injectable KLO-loaded chitosan (CS) hydrogel (KLO-Gel) is designed to achieve localized and prolonged release of KLO in the RF treatment. KLO-Gel was prepared by cross-linking CS with β-glycerophosphate (β-GP), followed by rapid (within 3 min) thermosensitive gelation at 37 °C. Furthermore, KLO-Gel exhibited a slow and sustained release (over 14 d) of KLO both in PBS and in the kidneys of mice with unilateral ureter obstruction (UUO). A single local injection of KLO-Gel into the renal capsule of UUO mice was more effective at reducing RF (i.e., maintaining renal function and tissue structure, alleviating extracellular matrix accumulation, and inhibiting the TGF-β1/Smad2/3 signaling pathway) over a 14-d period than daily intraperitoneal injections of free KLO or captopril. Crucially, CS was found to induce endogenous KLO secretion, highlighting the added value of using CS in RF treatment. Overall, this study demonstrated that KLO-Gel enhanced the anti-fibrotic efficacy of KLO while minimizing its off-target toxicity, and its clinical potential awaits further validation.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2012
·Vol. 38
·期 7
·1421-1429
·
IF 0.697
Li He-ping,Qin Long,Wang Zhou-dong,Li Shan
In order to improve drug loading and achieve a good release effect, this paper adopts the ramose method, choosing chitosan as the carrier and 5-fluorouracil (5-Fu) as a model drug. Ramose chitosan-lysyl-5-Fu(3) and ramose tetralactosyl-lysyl-chitosan-5-Fu(6) were synthesized successfully, then the in vitro release of (6) was researched. The results show that the drug loading of (3) and (6) are 9.17 and 1.63% (w/w), respectively. The in vitro release behavior of (6) in pH 7.4 phosphate buffer solution and pH 1.2 HCl–KCl solution were studied. The zero order release time that (6) maintains in alkaline and acidic media are 64 and 24 h, and the total release by 184 h are 71.97 and 82.34%, respectively. The performance is smooth throughout the whole stage of release, and the concentration of cumulative release is lower in the alkaline environment than in the acidic environment over the same time.
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REACTIVE & FUNCTIONAL POLYMERS
·
2012
·
IF 2.479
Chunyan Liao,Junchao Huang,Shaofa Sun,Bo Xiao,Nuo Zhou,Dengke Yin,Ying Wan
Nerve growth factor (NGF)-loaded chitosan microspheres were prepared via emulsification method using sodium tripolyphosphate as a crosslinker. Some selected chitosan microspheres were embedded into chitosan–polycaprolactone (CH–PCL) multi-channel conduits that can potentially be used for long-gap nerve repair. PCL percentages in the CH–PCLs were optimized into a region changing from around 30 to 42 wt.% while the porosity and average channel diameter of the resulting multi-channel conduits were selected as about 80% and 200 μm, respectively. SEM images confirmed that the channels inside the conduits were longitudinally arrayed with an approximately parallel arrangement, and the NGF-loaded microspheres appeared to be embedded into the wall of channels without blocking. The compressive properties in wet state and in vitro degradation rates of CH–PCL multi-channel conduits were found to be mainly manipulated by the PCL content in the CH–PCLs whereas the cumulative amount of released NGF from the conduits could be independently regulated by altering the initial NGF load inside the embedded microspheres. The optimal microsphere-embedded CH–PCL multi-channel conduits with a dimension of around 6 mm in outer diameter and 30 mm in length were able to administrate bioactivity-preserved NGF release in a sustained and controlled manner without significant initial burst release, and the release rates of the conduits could be maintained with approximately linear characteristic over a period of time longer than 6 weeks.
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