FOOD CHEMISTRY
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2026
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IF 10.4
Leping Li,Zhengjie Zhou,Jian Du,Yehan Tao,Chao Li,Jinwen Hu,Chenglong Fu,Jie Lu,Jijuan Cao,Haisong Wang
SPI-OTA particles with acid-labile imine bonds fabricated via Schiff-base reaction. • CS electrostatic deposition forms a dense layer to further stabilize the emulsion interface. • The film has a TTO encapsulation efficiency of 83.4% and a DPPH radical scavenging activity of 96.27%. • The shelf life of pork was extended by 7 days when covered by CS-10(STTC 3 ) packaging film. pH-responsive Pickering emulsions were promising for controlled release, yet smart responsiveness and interfacial stability remain fundamentally at odds. Herein, a pH-responsive and structurally robust composite Pickering emulsion, denoted as STTCx (SPI-TTO-TA-CSx), was fabricated using soy protein isolate (SPI), tea tree oil (TTO), tannic acid (TA), and chitosan (CS). Oxidized tannic acid (OTA) reacted with SPI via Schiff-base chemistry to generate SPI–OTA complexes containing acid-labile imine bonds (C=N), as evidenced by macroscopic observations before and after oxidation and further supported by FTIR analysis, which served as interfacial particles to stabilize TTO droplets with an SPI-OTA shell. Subsequent electrostatic deposition of chitosan formed a dense outer layer, markedly enhancing interfacial robustness. The emulsions remained stable for at least 21 days at room temperature. Incorporation of STTCx into a chitosan matrix yielded an active film with high TTO encapsulation efficiency (83.4%), strong antioxidant capacity (96.27% DPPH scavenging and 81.63% ABTS scavenging), and acid-triggered release. It could effectively extend the shelf life of pork by more than 7 days during refrigerated storage at 4 °C. Download: Download high-res image (157KB) Download: Download full-size image
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Yong Zhou,Jiamei Liu,Bin Yang,Wei Zhu,Bing Li,Xiaoyang Liu
Developing broad-pH hydrogen evolution reaction (HER) catalysts is crucial for green hydrogen production. Herein, Pt-MoS 2 heterostructure catalysts supported on nitrogen-doped hollow mesoporous carbon spheres (NHMCS) were synthesized via a two-step microwave-assisted solvothermal strategy. The catalyst exhibits outstanding HER activity in acidic, alkaline, and neutral electrolytes, especially in neutral conditions. Pt-MoS 2 /NHMCS-15 mg delivers a current density of 10 mA cm −2 at an ultralow overpotential of only 5.5 mV in 1.0 m PBS. Negligible performance degradation occurs after 100,000 cyclic voltammetry (CV) cycles and 120 h chronoamperometric operation, showing outstanding stability. X-ray absorption fine structures (XAFS), in situ Raman spectroscopy combined with density functional theory (DFT) calculation, elucidate the origin of the enhanced HER activity in neutral media. Strong metal-support interactions (SMSI) at the Pt-MoS 2 interface significantly lower the dissociation energy barrier of the P─OH bond in H 2 PO 4 – , thereby facilitating proton release. Simultaneously, neutral conditions yield higher hydrogen coverage on Pt sites than acidic or alkaline media. These findings provide fundamental insights into the intrinsic mechanism governing the broad-pH HER performance of Pt-MoS 2 /NHMCS-15 mg, particularly in neutral electrolytes, and offer valuable theoretical and experimental guidance for the rational design of efficient and cost-effective HER catalysts, advancing the practical implementation of electrocatalytic hydrogen evolution technologies.
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OPTICS AND LASER TECHNOLOGY
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2026
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IF 5.2
Jinglei Zhang,Haiwei Zhang,Qi Lu,Zhihong Chen,Lifang Xue,Jia Shi,Wei Shi,Jianquan Yao
The core-offset structure exhibits a theoretical RI sensitivity of 17714.286 nm/RIU. • The maximum sensitivity is 42.713 nm/pH with a correlation coefficient of 0.998. • Temperature sensitivity is 1.970 nm/°C, with a cross-sensitivity of 0.046 pH/°C. • Dual-wavelength demodulation enables simultaneous pH and temperature measurement. A hydrogel-coated core-offset fiber pH sensor is proposed and demonstrated for sensing the acidic environments with a pH-range of 2 –6. The fiber structure consists of an 800 μm single mode fiber core-offset fused between two sections of 2 mm no-core fiber with an offset of 62.5 μm. The core-offset structure is demonstrated to have a sensitivity of 17714.286 nm/RIU through finite element simulation. The pH sensing is realized by encapsulating a smart hydrogel at the core-offset structure, whose refractive index varies with pH. Within the pH range of 2–6, a cubic polynomial fitting yields a correlation coefficient of 0.999. The sensor shows a linear operating region from pH 3 to 5 with an ultra-high sensitivity of 42.713 nm/pH and a correlation coefficient of 0.998. Additionally, temperature response experiments reveal a sensitivity of up to 1.970 nm/°C, with a corresponding temperature cross-sensitivity of approximately 0.046 pH/°C. By employing a dual-wavelength demodulation method, simultaneous pH and temperature measurement is achieved, effectively eliminating temperature cross-sensitivity. Meanwhile, the experimental for consistence, stability, response time and repeatability are all carried out. It is indicated that the proposed hydrogel-coated core-offset sensor has excellent performance and is expected to have potential applications from environmental to industrial to biomedical.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Zhongyu Wang,Mohamed M. Abdel-Halim,Jiaqi Yan,Huifang Song,Zongrong Zhou,Ling Wang,Boyuan Ban,Jifei Sun,Xuesong Jiang,Jian Chen
Flotation of quartz under neutral conditions (pH 7) achieved using a mixed-reagent system (BDAB and SDBS). • Proposal of a novel mechanism: Surface Steric Hindrance Effects. • High flotation separation purity: quartz (92.06%) and feldspar(85.66%). • Excellent water solubility and extremely low reagent concentration (7.14 μM). The separation of quartz and feldspar from silicate tailings is a critical challenge in solid waste resource recovery. Addressing the challenge of separating quartz from feldspar, this work investigates a flotation process operating under neutral conditions. Based on flotation reagent molecular engineering, an innovative mixed flotation system comprising Benzyldodecyldimethylammonium Bromide (BDAB) and Sodium Dodecylbenzenesulfonate (SDBS) with benzene ring steric hindrance groups was employed. Under condition of pH 7 and an SDBS:BDAB ratio of 1:1.2, high-grade mineral concentrates were achieved, with quartz purity at 92.06% and feldspar purity at 85.66%. The mechanism is governed by specific steric hindrance-enhanced electrostatic interaction, as revealed through FTIR, XPS, and MD simulations. By proposing a novel treatment approach for silicate tailings, this work offers a new perspective for the development of flotation agents and the design of flotation systems. Download: Download high-res image (118KB) Download: Download full-size image
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Quan Liao,Shichao Zhang,Yuhan Xie,Qidan Tan,Tengfei Li,Shushuai Yang,Chenglong Xu,Zhouting Tuo,Rui Yao,Longchao Zhang,Haiwen Zhou,Yuanjiong Qi,Shiyong Qi
Background Acute kidney injury (AKI) remains a major clinical challenge and is largely driven by excessive oxidative stress, inflammatory responses, and tubular cell apoptosis. However, effective therapeutic strategies that simultaneously target these pathological processes are still lacking. Results We developed a pH-responsive ultrasmall Fe–kaempferol (Fe–Kae) nanoplatform with coordinated antioxidant and anti-inflammatory activities for AKI treatment. Owing to their ultrasmall size and pH-responsive properties, Fe–Kae nanoparticles preferentially accumulated in injured renal tissues and exhibited robust renoprotective effects in multiple murine AKI models, including ischemia–reperfusion injury, cisplatin-induced nephrotoxicity, and calcium oxalate–induced kidney injury. Integrated transcriptomic and metabolomic analyses of ischemia–reperfusion–injured kidneys revealed that Fe–Kae treatment markedly enhanced efferocytosis-associated pathways and induced coordinated metabolic reprogramming, characterized by optimized tricarboxylic acid cycle activity and enhanced glutathione metabolism. Conclusions This study establishes a nanomedicine-based therapeutic strategy that couples efferocytosis enhancement with metabolic reprogramming to achieve effective renoprotection. Our findings highlight pH-responsive ultrasmall metal–polyphenol nanoplatforms as a promising paradigm for the treatment of AKI. Graphical Open in a new tab Graphical Supplementary Information The online version contains supplementary material available at 10.1186/s12951-026-04534-8.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Jiakang Zhang,Jiahui Xu,Chen Peng,Chenlong Mo,Hanchen Lin,Zhen Zhang,Zhen Chen,Chaoqun You,Daihui Zhang
A biobased nanogel enables pH/temperature-dual responsive matrine delivery. • Nanogel boosts leaf deposition by 23.3% and rainfastness 3.9‑fold vs. free MT. • pH 8.0 triggers 87.99% drug release, matching alkaline pest gut conditions. • Nanogel shows superior activity against P. xylostella (EC₅₀ = 3.71 mg/L). • Nanogel exhibits low toxicity to zebrafish at effective application doses. The development of intelligent pesticide delivery systems based on nanomaterials offers a promising strategy to enhance targeted utilization and reduce environmental residues. Such systems enable dynamic modulation of drug release through environmental response mechanisms while improving pesticide adhesion to leaf surfaces and resistance to rainwater erosion. In this study, we constructed an environmentally responsive controlled-release pesticide system using carboxymethyl cellulose (CMC) as the backbone. Tea saponin (TS), tannic acid (TA), and polyethyleneimine (PEI) were integrated to form a biocompatible interpenetrating network gel (CPTT). Matrine (MT) was further loaded into this network to generate a stable three-dimensional mesh structure (MT@CPTT@SLS). The resulting nanogel exhibited high drug encapsulation efficiency (88.7%) and loading capacity (34.5%). It achieved 23.3% foliar deposition and significantly improved rainfastness, retaining 71.6% of the pesticide under moderate rain (20 mm/h) and 52.3% under heavy rain (40 mm/h). The nanogel showed pH-sensitive drug release, with cumulative release reaching 87.99% at pH 8.0 (alkaline pest gut condition) compared to only 51.2% at pH 5.7. Insecticidal toxicity tests revealed enhanced efficacy against diamondback moth larvae with an EC₅₀ value of 3.71 mg/L, which is notably lower than that of free matrine. Moreover, zebrafish acute toxicity assays confirmed favorable aquatic biosafety (80% survival at 1 mg/L after 108 h). Collectively, this study provides a promising strategy for the application of intelligent nanogel pesticides in green plant protection, integrating efficient targeted delivery with environmental sustainability. Download: Download high-res image (126KB) Download: Download full-size image A Stimuli-Responsive Nanogel for Intelligent Pesticide Delivery
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高影响因子
Materials Today Chemistry
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2026
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IF 7.4
Tianyu Chen,Bingxin Sun,Xiyun Wang,Wang Zhang,Yuanzhe Piao
CUM encapsulated by β-CDP enhances water solubility and stability, improving its effects. • CUM-β-CDP shows lower MIC on E. coli (40 mg/ml) and S. aureus (5 mg/ml) than pure CUM. • CUM-β-CDP effectively inhibits HepG2 cell proliferation, showcasing potent anti-cancer ability. A pH-responsive delivery system based on supramolecular vesicles was fabricated via a novel host–guest inclusion complex between water-soluble pillar[5]arene (WP5) and cuminaldehyde (CUM). This CUM-WP5 inclusion complex was studied using 1 H NMR, UV-vis, and FT-IR spectroscopy. The resulting inclusion complex could self-assemble into well-defined supramolecular vesicles via host–guest interactions and exhibited significant pH-responsive behavior, which was investigated using dynamic light scattering, transmission electron microscopy, and UV-vis spectroscopy. The preservation time of CUM-WP5 and the molar ratio between host and guest molecules were both significant for the aggregated morphology of the supramolecular vesicles. Furthermore, the CUM complexes demonstrated good antibacterial activity, inhibiting the proliferation of Agrobacterium tumefaciens GV3101 and EHA105. These vesicles therefore present a promising platform for drug delivery and antibacterial applications. The assembly CUM-WP5 through host-guest interaction and the drug release of vesicle in the acid condition, which applied for corn root soaking test. Download: Download high-res image (232KB) Download: Download full-size image
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高影响因子
Materials Today Chemistry
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2026
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IF 7.4
Tianxin Weng,Guodong Zhang,Kexin Ding,Yuying Wang,Yahui Zhou,Xiufeng Wang,Ting Zhou,Fang Wang,Zhiqing Zhang
A pH-responsive DNA nanocarriers (RAM) was designed for combination therapy. • The interaction between TBO/DOX and RAM affected their loading and release. • The multivalent interaction enables RAM to accurately identify tumors. • TBO promoted siMCT1 to inhibit MCT1 expression through PCI effect. • TBO and DOX loaded by RAM exhibited better synergistic anti-tumor effect. Improving the efficiency of drug targeted delivery and alleviating tumor cell hypoxia were crucial for photodynamic-based combination therapy to improve the anticancer effect. Herein, a novel multifunctional DNA nanocarrier (RAM) was developed for targeted delivery and pH-responsive release of toluidine blue O (TBO), doxorubicin (DOX) and anti-MCT1 siRNA (siMCT1) combined drugs. RAM was prepared by two-step self-assembly of RCA scaffold prepared by rolling circle amplification technology with multivalent AS1411 aptamer, complementary chain of i-motif sequence and siMCT1 modified by i-motif sequence. The existence of i-motif enabled RAM to respond to the micro-acid environment of tumor cells to quickly release drugs. Multispectral and molecular docking experiments showed that TBO and DOX were intercalated into RAM. Thermodynamic analysis indicated that RAM exhibited superior drug loading capacity, and the pre-loading of TBO enhancing the co-loading efficiency of combined drugs. The release of RAM-loaded drugs was expedited by an acidic environment and deoxyribonuclease I, with the release rate inversely related to the binding capacity. The multivalent AS1411 aptamer enhanced the targeting ability of RAM to MCF-7 cells. TBO could promote siMCT1 to inhibit the expression of monocarboxylate transporter 1 through PCI effect, thereby inhibiting lactic acid-driven respiration, effectively increasing local oxygen pressure, and thus significantly improving PDT efficacy. Cytotoxicity assays confirmed superior synergistic antitumor efficacy of (RAM + TBO) + DOX system. This study established a theoretical grounding for using multifunctional DNA nanocarriers in synergistic PDT-chemotherapy to co-deliver drugs and mitigate tumor hypoxia. Download: Download high-res image (383KB) Download: Download full-size image
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高影响因子
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
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2026
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IF 6.6
Yaqi Liu,Biao Luo,Yun Xu,Dexiang Liu,Qiujing Wang
Ischemic stroke (IS) remains a leading cause of global disability and mortality, with limited effective anti-inflammatory interventions. Targeting histone deacetylase 3 (HDAC3) to reprogram microglial polarization holds great therapeutic promise, but the HDAC3-specific inhibitor RGFP966 suffers from poor blood-brain barrier (BBB) penetration and systemic toxicity. Herein, we developed a pH-responsive brain-targeted lipid nanoparticle (CD-TLNP@RGFP966) by integrating T7 peptide modification for BBB transcytosis and cinnamaldehyde-α-cyclodextrin (CA-αCD) encapsulation for acidic lesion-triggered drug release. CD-TLNP@RGFP966 exhibited favorable colloidal stability, biosafety, and pH-dependent release behavior. It efficiently crossed the BBB, accumulated in ischemic brain tissue, promoted microglial M2 polarization, attenuated neuroinflammation, reduced infarct volume, and improved neurological function in tMCAO mice. This study provides a novel targeted nanocarrier strategy for the anti-inflammatory treatment of IS.
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高影响因子
APPLIED CLAY SCIENCE
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2026
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IF 5.2
Guixiang Teng,Hongyu Wang,Shuting Zhang,Mengyuan Yu,Yanzan Meng,Meng Zhao,Yan Yang,Peng Pu,Chun Zhang
Amid the push for sustainable agriculture, developing eco-friendly and efficient bio-agricultural solutions is essential for strengthening ecological protection and decreasing reliance on chemical pesticides. This study developed a pH/temperature dual-responsive nano-sustained-release antifungal system (OEO/PDA-MMT) based on polydopamine (PDA)-modified montmorillonite (MMT) for the encapsulation of oregano essential oil (OEO). This system exhibited multifunctional responsiveness in release behavior and synergistic photothermal enhancement. Specifically, PDA modification not only extended the essential oil release period to 360 h and imparted dual pH−/temperature-responsive characteristics but also enhanced the photothermal conversion efficiency of the material, enabling rapid heating from 20.2 °C to 50.2 °C within 10 min under 808 nm near-infrared irradiation, thereby effectively promoting the release and antifungal activity of OEO. In terms of antifungal performance, the plate assays revealed that the half-maximal effective concentration (EC 50 ) and minimum inhibitory concentration (MIC) values of OEO/PDA-MMT were reduced by over 50% and 30%, respectively, compared with free OEO. In vitro experiments against Astragalus root rot further demonstrated superior control efficacy in the prevention group, showing a 97.88% reduction in lesion area at the two times the MIC (2MIC) concentration. In summary, by constructing a nanocarrier system that integrates sustained release, environmental responsiveness, and photothermal enhancement, this study established a long-acting antifungal system with sustained-release performance, providing a novel smart-material strategy for sustainable agricultural disease management.
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高影响因子
ACS Applied Materials & Interfaces
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2026
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IF 7.8
Chaoqi Shen,Wei Lin,Lulu Liu,Peng Yang,Chenxi Fu,Lianbang Wang
The escalating demand for lithium-ion batteries emphasizes the urgency of developing cobalt- and nickel-free cathodes ascribed to the high cost of these two metals. LiMnxFe1–xPO4 (LMFP) emerges as a promising candidate due to high operating voltage compared to LiFePO4 while suffering from inferior kinetics and cycling instability. This study demonstrates that precise pH control during the solvothermal process is pivotal for optimizing the LMFP/C microstructure and performance; furthermore, the mechanism of morphology evolution along with pH value and reaction duration is summarized. LiMn0.7Fe0.3PO4/C composites synthesized under varied pH conditions were thoroughly characterized and electrochemically evaluated. Results reveal that a moderately acidic environment (pH 4) facilitates the formation of a unique nanoflower architecture composed of (010)-oriented nanosheets with a highly graphitized carbon coating and minimal antisite defects after calcination. This optimal structure endows LiMn0.7Fe0.3PO4/C composite sample LMP/C-P4-24 with superior Li+ diffusion kinetics and charge-transfer efficiency, enabling a high discharge capacity (151.5 mAh g–1 at 1 C), outstanding cycling stability (96.1% retention after 500 cycles), and excellent rate capability (110.3 mAh g–1 at 10 C). In contrast, synthesis at higher pH induces structural disorder and inferior carbon quality with rapid performance degradation. This work establishes pH-mediated structural control as a powerful strategy for high-performance, resource-conscious, Mn-rich LiMn0.7Fe0.3PO4 cathode materials.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Meiyue Zhao,Jialing Wu,Lihua Geng,Ning Wu,Yang Yue,Quanbin Zhang,Huaide Liu,Jing Wang
Chronic diabetic wound healing remains challenging owing to impaired angiogenesis, persistent inflammation, and a high risk of infection. To address these limitations, we developed an injectable, pH-responsive hydrogel based on dynamic crosslinking between phenylboronic acid-grafted oxidized agarose (pOA) and alginate oligosaccharide-conjugated ε-polylysine (AE). This hydrogel exhibits antibacterial and antioxidant properties, enabling on-demand drug release triggered by the acidic microenvironment of chronic wounds. To enhance therapeutic efficacy, low-molecular-weight fucoidan (LF), a potent pro-angiogenic marine polysaccharide, was encapsulated within the hydrogel. Physicochemical characterizations confirmed that the hydrogel possesses excellent structural stability, injectability, and pH-responsive sustained release properties for LF and AE. Subsequently, In vitro tests showed that the AE&LF@pOA hydrogel effectively controlled infection with a 77.3% antibacterial rate against Staphylococcus aureus and showed ROS scavenging activity. It also regulated the inflammatory response, reducing pro-inflammatory cytokines IL-1β and IL-6 by 53.8% and 64.4%, respectively while increasing anti-inflammatory cytokines IL-10 and TGF-β1 by 2.8-fold and 1.0-fold. Moreover, the hydrogel stimulated neovascularization, leading to a 4.7-fold increase in VEGF expression and a 50% increase in CD-31 microvessel density. Animal studies confirmed that the dressing accelerated macroscopic healing. The hydrogel accelerated wound closure to 85.8% by day 7, 2.7-fold higher than controls, with the residual wound area shrinking to just 1.4% by day 14. Histological analysis further demonstrated complete re-epithelialization to 80.3 μm thickness, and mature collagen deposition. Overall, this responsive hydrogel offers a promising strategy for treating chronic diabetic wounds.
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高影响因子
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