CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Haiping Zhou,Gang Wang,Liping Wang,Zhenhua Zhang,Huiliang Hou,Qifan Zhong,Jin Xiao
Industrial alumina was used as raw material in the high-temperature calcination process, and AlF 3 was introduced to promote mass transfer in the gas phase. The calcination environment, such as sealing, calcination temperature, and holding time, was analyzed to enhance the effect of AlF 3 to promote the crystal growth of alumina. Here, round-like flake α-Al 2 O 3 with an average particle size (D50) of about 18–38 μm were obtained at low dosages (0.1–0.4 wt%) of AlF 3 . The morphology and particle size of α-Al 2 O 3 were further adjusted by introducing different types of micron-scaled nuclei as template inducers. Round-like flake and spherical-like large single crystals α-Al 2 O 3 with an average particle size greater than 35 μm were obtained, respectively, with 65 wt% of 15 μm flake and 10 μm bulk α-Al 2 O 3 nuclei added. In addition, the regulation mechanism of AlF 3 and nuclei on alumina crystal growth was also discussed. Finally, a theoretical basis and technical support for preparing high-performance, low-cost, and high thermal conductivity alumina fillers was provided.
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INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Xin Wang,Zhi-Jun Zhang,Hui-Zhen Li,Tian-Yu Hou,Ya-Na Zhao,He Li
Perilla seed oil (PSO) is a major source of α-linolenic acid (ALA). In order to better separate ALA from PSO and to improve its purity and yield, a purification method for ALA that combines urea complexation (UC) with rapid preparative reversed-phase liquid chromatography (RP-RPLC) has been studied. Within the selected ranges of conditions, four one-factor experiments were found to have significant effects on the purity and yield of ALA from PSO. A response surface methodology (RSM) has been applied to optimize UC for separating and purifying ALA from PSO, which yielded optimal parameters of 95% ethanol/urea (w/w) = 5:1, urea/esterified fatty acids (E-FAs) (w/w) = 2:1, complexation time 16.3 h, and complexation temperature 17 °C. The optimal purity and optimal yield of the one-time purification ALA (OTP-ALA) obtained by UC thereby reached 86.977 ± 0.082% and 34.696 ± 0.948 %, respectively. Two-time purification conditions of OTP-ALA by RP-RPLC were also determined, and the purity of the two-time purification ALA (TTP-ALA) was increased to 99.200 ± 0.061%, corresponding to a yield of 53.888 ± 0.904 %. The effect of different added amounts of α-tocopherol on the oxidation stability of TTP-ALA has also been studied. Accelerated oxidation tests showed that the addition of α-tocopherol effectively inhibited the oxidation of TTP-ALA by reducing the peroxide value (PV).
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Chenhui Yin,Meng Wu,Ting Liu,Lixing Fu,Qijun Sun,Ligang Chen,Na Niu
A sensitive and effective strategy for the screening of α-glucosidase and its inhibitors was established based on carbon quantum dots (CQDs) and vanadium oxide nanoribbons. B,S,N co-doped CQDs (BSN-CQDs) were prepared by one-step microwave hydrothermal method using o-phenylenediamine, boric acid, and thiourea as raw materials. The prepared CQDs emitted yellow fluorescence (λ em = 565 nm) under excitation of 410 nm, and the quantum yield was 15.3%. The fluorescence of CQDs was firstly quenched by the vanadium oxide nanoribbons via inner filter effect. Then, 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA2G) was introduced as a substrate of α-glucosidase to produce ascorbic acid (AA). Vanadium oxide nanoribbons could be converted to V 4+ by AA, which led to fluorescence recovery. After adding inhibitors (anti-diabetic drugs), the α-glucosidase activity was inhibited and the degree of fluorescence recovery was reduced. The established nanoprobe showed a response linearity to α-glucosidase in the range of 0.01–5 U mL −1 , with a low detection limit of 0.003 U mL −1 . This platform was applied for the screening of acarbose, with a detection limit of 0.02 μM. The constructed sensing strategy had the advantages of high selectivity, sensitivity, and was successfully used for α-glucosidase detection in serum samples and anti-diabetic drugs screening.
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CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Zhaoxin Zhong,Biao Zhang,Jian Ye,Ye Gao,Qiang Liu,Zhiguo Zhang,Feng Ye
Porous SiC ceramics have recently attracted wide attention for their applications in the electrically heatable filter. Further improvement of the thermal and electrical conductivity without sacrificing permeability is a critical parameter for such applications. In the present work, porous SiC/Ti 3 SiC 2 ceramic composites with Ti 3 SiC 2 and micro/nano SiC have been prepared from TiC/Si/α-SiC mixtures at a low sintering temperature (1400 °C). Nano-laminated Ti 3 SiC 2 enhanced the electrical conductivity , while the good thermal conductivity was achieved through in-situ formed nano β-SiC and raw coarse α-SiC in the porous ceramics . Along with the increase of initial α-SiC particle size from 0.76 to 16.13 μm, the permeability, thermal and electrical conductivity improved due to the decreased porosity and increased pore size in porous SiC/Ti 3 SiC 2 ceramics. The results suggested that the decoupling of the electrical conductivity from the thermal conductivity could be tuned by adjusting the initial α-SiC particle size.
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TALANTA
·
2023
·
IF 6.1
Peixi Zhu,Luxi Zhou,Yuxiu Lin,Yixi Wang,Yu Han,Sheng Cai
In this study, a method for the screening and identification of α-glucosidase inhibitors from natural products was developed. The α-glucosidase was immobilized on carboxyl terminated magnetic beads to form a ligand fishing system to screen the potential inhibitors. A total of 9 compounds were fishing out from the crude Houttuynia cordata Thunb. extract. Meanwhile, ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS) was used for the identification of the chemical structures, including 3 chlorogenic acid isomers, 2 flavone C-glycosides and 4 flavone O-glycosides. The combination of enzyme immobilization magnetic beads and UHPLC-QTOF MS could be used for the screening of bioactive multi-components from herbs with appropriate targets. Taking the advantage of the specificity of enzyme binding and the convenience of magnetic separation, the method has great potential for rapid screening of α-glucosidase inhibitors from complicated natural product extracts.
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高影响因子
MOLECULAR NUTRITION & FOOD RESEARCH
·
2023
·Vol. 67
·期 22
·2300258
·
IF 5.2
Yiju Li,Zhi Feng,Tianliang Wu,Haixi You,Wei Wang,Xuebo Liu,Long Ding
Scope The obesity epidemic continues to be a major global public health threat with limited effective treatments. Peptides are a group of promising bioactive molecules. Both in vivo and in vitro studies have demonstrated that quinoa has potential prebiotic benefits. Thus, the present study aims to investigate the influence of quinoa peptides (QP) consumption on obesity and its underlying mechanisms in high-fat diet (HFD)-induced mice. Methods and results QP (1000 mg kg −1 day −1 ) is administered to HFD mice for 8 weeks, and is found to significantly reduce the body weight, and plasma levels of triacylglycerol (TG) and total cholesterol (TC) compare to the HFD group. In addition, QP significantly decreases lipid accumulation in the liver caused by HFD. The liver transcriptome analysis shows that the alleviation of QP on obesity is related to the PPAR signaling pathway. QP upregulates the expressions of PPAR-α and its related genes and downregulates the expressions of PPAR-γ and its downstream genes. Furthermore, QP remodels the community composition of gut microbiota by lowering the ratio of Firmicutes c Bacteroidetes (F/B). Conclusion These findings suggest that QP consumption alleviates HFD-induced obesity by regulating the PPAR-α/γ signaling pathway in the liver and community structure of gut microbiota.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 39
·期 11
·1459-1469
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IF 3.603
Liu Yuan-Biao,Shi Gao-Peng,Wu Guo-Zhang
Introducing small molecule-bridged hydrogen bonds (HBs) between polymer chains has been reported to effectively reduce the interchain cooperativity despite of strengthening the intermolecular interaction. Here, a systematic investigation on tuning the Johari-Goldstein β ( β JG ) relaxation by adding various low-molecular-weight phenols in poly( n -alkyl methacrylate)s is carried out to further clarify the anomalous dynamics. Given these small molecules capable of coupling the motion with pendent groups of host polymers due to forming at least two HBs per molecule, poly( n -alkyl methacrylate) mixtures exhibit rich dynamic changes in the β JG -properties and α, β JG separations. An increased loading of phenols with a small size and strong inter-HB strength (Δ υ i ) clearly benefits for significant retardation and suppression of the β JG -relaxation, narrows the α, β JG separation and converges the β JG -peak with the α -peak, which demonstrates the alleviation of inter-chain topological constraints. However, small molecules with a relatively big size and weak Δ υ i are found to amplify the magnitude of the α, β JG separation of poly(butyl methacrylate), even though experimental results of changes in α -dispersion and dynamic fragility confirm a reduction of the coupling factor n in all of these hybrids. The counterintuitive phenomenon suggests that the crossover time t c in the Coupling Model is no longer a universal quantity if the inter-chain interaction of polymers is strengthened by HBs. These compelling findings shed vital insights into the HB-induced anomalous dynamics, and provide essential guidance for tailoring the β JG behavior and designing glassy polymeric materials.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 9
·2553-2563
·
IF 4.157
Li Cong,Zi Yuqiu,Xu Dawei,Jiang Dafeng,Qu Fei,Zhao Xian-En
Herein, the self-assembly of 1-dodecanethiol-capped Cu nanoclusters (DT-Cu NCs) is obtained by annealing of dibenzyl ether solution of nanoclusters. These aggregates are composed of small clusters and emit a high level of aggregation-induced emission (AIE) in water. Based on the quenching effect of 4-nitrophenol (4-NP) on DT-Cu NCs, a fluorescence strategy is developed to monitor α-glucosidase (α-Glu) activity and screen its inhibitors from Chinese herbal medicines. 4-Nitrophenyl-α-D-glucopyranoside (NGP) is selected as the substrate, which is further hydrolyzed to yield 4-NP through the catalysis of α-Glu. The quenching efficiency is positively correlated to the concentration of α-Glu. Furthermore, the inhibitory effects of the extracts from four Chinese herbal medicines (i.e., the rind of Punica granatum L., Momordica grosvenorii Swingle., Crataegus pinnatifida Bge., and Lycium barbarum L.) on the α-Glu activity have been studied. The IC 50 values of extracts from the rind of Punica granatum L. and Momordica grosvenorii Swingle are 0.23 and 0.37 g/L, respectively, so they show obvious inhibitory effects on α-Glu. The extracts of Crataegus pinnatifida Bge. and Lycium barbarum L. exhibit relatively weak inhibitory effects. Hence, the proposed strategy can be applicable for screening α-Glu inhibitors from Chinese herbal medicines. Last but not the least, by immobilizing DT-Cu NCs into agarose hydrogels in polyethylene tubes, a visual device is fabricated to screen α-Glu inhibitors with high throughput and sensitivity. Graphical abstract
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2021
·
IF 3.205
Hua Guo,Yue-Hua Chen,Tian-Min Wang,Ting-Guo Kang,Hui-Yang Sun,Wen-Han Pei,Hui-Peng Song,Hui Zhang
The lack of direct connection between traditional herbal medicines and multiple biological targets is a bottleneck in herbal research and quality evaluation. To solve this problem, a strategy for the discovery of active ingredients from function-similar herbal medicines based on multiple biological targets was proposed in this article. The technical route includes chromatographic separation, mass spectrometry analysis, enzymatic activity detection, pharmacophore analysis and molecular docking. Five citrus herbs of Citri Reticulatae Pericarpium (CRP), Citri Exocarpium Rubrum (CER), Citri Grandis Exocarpium (CGE), Aurantii Fructus Immaturus (AFI) and Aurantii Fructus (AF) were used as the research objects. A total of 136 chemical components were identified from above five herbs based on LC-Q-TOF-MS/MS and database matching. The extracts of the five herbs showed obvious inhibitory effects on α-glucosidase and acetylcholinesterase in a concentration-dependent manner. Interestingly, the different types of components in the herbs exhibited selectivity for different targets: flavanone glycosides are effective on α-glucosidase but ineffective on acetylcholinesterase; polymethoxyflavonoids are effective on acetylcholinesterase but ineffective on α-glucosidase. Furthermore, we found for the first time that the components in citrus herbs exhibit opposite structure-activity relationships on the above two targets. For example, the methoxy group can enhance the activity of compounds on acetylcholinesterase but weaken the activity of compounds on α-glucosidase. The selective action is a supplement to the “multi-components, multi-targets” system of herbal medicines. Pharmacophore analysis and molecular docking were applied to explore the interaction between active ingredients and biological targets from the perspective of ligands and receptors, respectively. By combining the above multiple technologies, a strong connection among herbal medicines, chemical components and multiple biological targets was established. This work not only helps to understand the similar function of citrus herbs for the treatment of diabetes and Alzheimer's disease, but also provides selective lead compounds for the development of related drugs. This strategy is also helpful to improve the quality evaluation of citrus herbs from the perspective of biological activity.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Adeel Ahmed,Muhammad Usman,Bing Yu,Youqing Shen,Hailin Cong
Seeking an effective strategy to develop inexpensive and highly stable photocatalyst materials for dye degradation is of great significance to resolve the global environmental problems caused by dye abuse. Herein, we have reported the environmental-friendly synthesis of exceptionally efficient and highly sustainable hematite nanoparticles (α-Fe 2 O 3 NPs) using Punica granatum seed extract biomolecules. The morphology and phase purity of the synthesized α-Fe 2 O 3 NPs were executed through a series of characterization techniques. FESEM and TEM analysis exhibited that the synthesized α-Fe 2 O 3 NPs were irregular-shaped with an average size of 26.53 nm, while the BET surface area of nanoparticles was estimated to be 31.52 m 2 /g with an average pore diameter of 5.54 nm. α-Fe 2 O 3 NPs exhibited typical ferromagnetic behavior at room temperature. The oxidation states of elements in α-Fe 2 O 3 NPs were confirmed through X-ray photoelectron spectroscopy (XPS) analysis, while the charge on α-Fe 2 O 3 NPs was found to be −10.6 mV. The as-prepared α-Fe 2 O 3 NPs were utilized in solar-light driven photocatalytic degradation of anionic Congo red (CR) and Bromophenol blue (BPB) dye. Experimental results indicated the remarkable photocatalytic activity of α-Fe 2 O 3 NPs, and approximately 89.42% of CR and 87.96% of BPB was degraded in 240 min under sunlight irradiation at ambient conditions. The photocatalytic degradation experiments were also performed under different reaction conditions which followed the pseudo-first-order kinetics. The presence of reactive species generated in the reaction system liable for the CR and BPB degradation were corroborated through radical quenching experiments and further confirmed by EPR analysis. The excellent photocatalytic potential of α-Fe 2 O 3 NPs suggested that the synthesized nanoparticles could effectually be applied to remove organic dyes from the wastewater.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Lifang Pan,Shihai Cao,Rui Liu,Huan Chen,Fang Jiang,Xin Wang
Aldehyde-functionalized α-Fe 2 O 3 /graphitic carbon nitride (α-Fe 2 O 3 -DBD/g-C 3 N 4 ) was successfully synthesized through Schiff-based reaction between aromatic aldehydes in 3,4-dihydroxybenzaldehyde and NH 2 groups in urea. The 3,4-dihydroxybenzaldehyde around α-Fe 2 O 3 were advantageous to in situ growth of graphitic carbon nitride on α-Fe 2 O 3 to form the contact interface by chemical bonds and beneficial to the electron transfer , leading to the formation of Z-scheme photocatalytic system. The α-Fe 2 O 3 -DBD/g-C 3 N 4 photocatalysts exhibited a remarkable improvement in the degradation of bisphenol A (BPA) compared with bulk g-C 3 N 4 . The enhanced photocatalytic activity was attributed to the enhanced charge separation efficiency and higher redox potential . This study presents a simple and efficient method to construct all-solid-state Z-scheme photocatalytic system with the formation of tight contact interface and nonmetal materials (aromatic rings) as electron mediators for the removal of complex pollutants.
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JOURNAL OF FOOD BIOCHEMISTRY
·
2019
·Vol. 44
·期 1
·e13086
·
IF 1.358
Hui Liu,Yang Jiang,Hui Guan,Feng Li,Dongxiao Sun-Waterhouse,Yilun Chen,Dapeng Li
Rutin is a bioflavonoid found in many plants and derived foods, accordingly, rutin likely interacts with α-amino acids such as Lys, Ile, His or Glu to give Maillard reaction products (MRPs). The heated rutin-Lys system exhibited highest brown intensity and in vitro antioxidant activities. The 30–50 kDa rutin-Lys fraction had higher in vitro antioxidant activities than the other fractions, and at a dose of 0.4 mg/ml preserved over 90% cell viability for HepG2 cells exposed to H 2 O 2 . The dose-dependent protective effects against H 2 O 2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM). Practical applications Rutin is widely distributed in vegetables and grains. The Maillard reaction is a common reaction occurring during food processing, and produces Maillard reaction products (MRPs) with distinct processing and biological properties. This study shows that a 30-min thermal treatment at 120°C generates antioxidative MRPs in the rutin-Lys, rutin-His, rutin-Ile and rutin-Glu model systems, which can directly inhibit reactive oxygen species generation and enhance SOD and CAT activities while activating the Nrf2-dependent pathway and upregulating the expression of phase II detoxifying antioxidant genes. Therefore, for food systems containing phenolic antioxidants and proteins (such as rutin and Lys), one may enhance the antioxidant properties of these food systems through a 30-min thermal treatment at 120°C. Also, the resultant rutin-Lys MRPs may be isolated and used as commercial preparations of natural antioxidants.
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危险品化学品经营许可证（带存储）