COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Haoxiang Wang,Peilun Shen,Dianwen Liu,Rong Peng,Hang Zhu,Xianren Dai,Jinpeng Cai
EDA/2-MP turns inert Cu–O–Si domains into KBX-responsive Cu-organic sites. • EDA unlocks Cu(II) sites for 2-MP anchoring via Cu–N/Cu–S bonding. • A continuous ~30 nm N/S/Cu-rich activation film is visualized on chrysocolla. • Interface reconstruction enables 95% chrysocolla recovery and selective separation. Chrysocolla is one of the most difficult oxide copper minerals to recover by flotation because of its strong hydrophilicity, low reactivity, and poor adaptability to conventional activation methods. In this study, an EDA/2-MP synergistic activation system was developed using KBX as the collector. At pH 10, single-mineral flotation tests were conducted with 38–74 μm chrysocolla at a pulp solid concentration of 10 g/L and a flotation time of 8 min, with three independent tests performed for each condition; an artificial chrysocolla–dolomite mixture at a mass ratio of 1:1 was also used to evaluate separation performance. At EDA, 2-MP, and KBX concentrations of 40, 280, and 60 mg/L, respectively, chrysocolla recovery reached 95.34%. In the mixed-mineral system, concentrate Cu recovery remained above 95%, with a Cu grade of approximately 34%. FIB-TEM revealed a continuous low-crystallinity film approximately 31.2–33.9 nm thick after EDA/2-MP treatment. Raman, XPS, and ToF-SIMS showed that EDA/2-MP altered the chemical environments of surface Cu, N, and S species and promoted the enrichment of KBX-related components at the activated interface. Accordingly, EDA/2-MP pretreatment followed by KBX addition increased the chrysocolla contact angle from 24.52° to 82.65°, confirming surface hydrophobization. This study provides a new selective interfacial activation strategy for efficient flotation recovery of refractory silicate-type oxide copper minerals. Download: Download high-res image (203KB) Download: Download full-size image
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Sheng Liang,Zhihao Wang,Kunhong Hu,Lei Hu,Lili Wang,Lingli Liu,Ningning Zhou,Jiage Yu,Bin Chen,Xin Liang
Lithium‑sulfur (Li S) batteries based on lithium sulfide (Li 2 S) cathodes hold great promise for next-generation energy storage devices but suffer from critical drawbacks, including lithium polysulfides (LiPSs) shuttling, sluggish redox reaction kinetics, and severe safety hazards. Here, a multifunctional separator is designed by coating a nickel hydroxide (Ni(OH) 2 ) nanoflakes-decorated kelp-like porous carbon (Ni(OH) 2 /KLPC) composite onto a polypropylene (PP) membrane. The unique KLPC skeleton derived from mucor hyphae provides a three-dimensional conductive network, while the polar Ni(OH) 2 nanoflakes offer strong chemisorption for LiPSs and high catalytic activation for the interconversion between solid-phase (Li 2 S and S) and liquid-phase (LiPSs). Meanwhile, the Ni(OH) 2 nanoflakes endow the separator with remarkable flame retardancy through an endothermic decomposition process and the formation of highly flame-retardant products nickel oxide and water. Consequently, the Li S battery assembled with the Ni(OH) 2 @KLPC modified PP (Ni(OH) 2 /KLPC/PP) separator and a Li 2 S/multi-walled carbon nanotube cathode delivers a high initial discharge capacity of 1132 mAh g −1 , remarkable rate property of 320 mAh g −1 at 5.0 A g −1 , and stable long-term cycling over 750 cycles. This work presents a promising synergistic strategy for constructing high-performance and safe Li S batteries through multifunctional separator engineering.
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Qing Huang,Zefeng Hou,Yunong Zhao,Ruiqin Gu,Chengli Li,Minghong Yang,Huan Liu
Surface plasmon resonance (SPR) technology, boasting prominent advantages including anti-electromagnetic interference, high sensitivity, rapid response, label-free detection, and minimal sample consumption, holds broad application prospects in life sciences, clinical diagnostics, drug screening, and other related fields. However, current optical fiber biochemical sensors are generally plagued by poor probe practicality and stability, low refractive index sensitivity, and inadequate detection capability for ultra-low concentration biomolecules in clinical settings. In this study, we developed a low-cost, high-sensitivity optical fiber SPR biosensor for SARS-CoV-2 antigen detection in the standard sample, employing gold@silver‑platinum (Au@AgPt) core-shell nanospheres as the sensing enhancement module. Au@AgPt core-shell nanospheres possess unique localized surface plasmon resonance (LSPR) properties. When incident light interacts with the nanomaterial surface, it induces a localized electric field enhancement effect. This surface enhancement effect significantly amplifies the optical signal intensity, thereby effectively improving the sensor's detection sensitivity toward the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. This sensing platform achieves fg/mL-level detection sensitivity, excellent linearity, and rapid response performance, offering new technical support for expanding the application of optical fiber sensors in the quantitative detection of ultra-low concentration disease markers.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Ying-Xin Zhao,Ke-Tian Zhu,Yu-Xuan Tong,Qi-Qian Wang,Jin-Long Li
Abstract Di-2-ethylhexyl phthalate (DEHP) accumulates in the food chain, threatening human and animal health. However, how DEHP induces neurotoxicity by interfering with microglia has not been fully revealed. Our research aims to explore the effects of DEHP on microglia and identify relevant targets that cause neurotoxicity. The results indicated that DEHP damaged neurons, leading to swelling, demyelination, and abnormal autophagy. Inhibition of autophagy resulted in α-Syn misfolding, characterized by an increase in dimers with increasing additive concentrations (P = 0.0096). Dimer formation was promoted by the addition of additives, which increased the electrostatic force, along with interactions between Glu106, Gly51, and Val66. Transmitted from neurons to microglia (Pearson r2 = 0.889), pathological aggregates under DEHP exposure induced microglial M1 subtype switching. This study elucidated a novel mechanism by which DEHP damages the nerves of birds and provided a therapeutic target for the neurotoxic disease risk caused by the transmission of plastic additives through the food chain.
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CHEMICAL ENGINEERING SCIENCE
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2025
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IF 4.3
Qi Liu,Yihan Yin,Hongxia Gao,Lianbo Liu,Shisen Xu,Teerawat Sema,Min Xiao,Zhiwu Liang
Amine degradation is one of the key issues that hampers the implementation of large-scale carbon capture technology. Degradation inhibitors can extend the lifetime of amine solutions, thereby lowering the operating cost of CO 2 capture system in the long term. In this work, different inhibitors including chelating agents, scavengers, and their blends were studied to inhibit the oxidative degradation of 1-amino-2-propanol (1AP). Amine loss, alkalinity loss, NH 3 emissions and heat-stable salt production were measured to evaluate the inhibitory effect. The parameter, namely inhibition factor, was proposed to quantify the effect of inhibitors. Two chelating agents were found to show good inhibitory effects on 1AP degradation, with inhibition factors of 7.1 and 4.3, respectively. In addition, the inhibition factor was increased to 9.4 by blending the inhibitors. A significant reduction in the inhibitor dosage was applied to achieve a similar inhibiting effect due to the excellent synergistic effects between the blended inhibitors.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jun Qin,Xiaoshan Zheng,Dongshu Wang,Chunyu Song,Wenzheng Shi,Ying Lu
Euryale ferox Salisb. seeds (ES) are rich in biologically active polysaccharides, and degradation treatment can enhance the hypoglycemic activities of polysaccharides. However, regulation mechanism of ES polysaccharide (ESP) and its degradation polysaccharide on blood glucose in type 2 diabetes mellitus (T2DM) is still unclear. In this study, a novel degraded polysaccharide (D-ESP) was prepared by H 2 O 2 -ultrasound treatment of ESP. It was found that H 2 O 2 -ultrasound treatment did not disrupt sugar unit structure of D-ESP. Both ESP and D-ESP had α-glucosidase inhibitory activity and good gastrointestinal digestive stability, and D-ESP had better hypoglycemic activity than ESP. D-ESP could restore the glucose metabolism of insulin-resistant (IR) HepG2 cells to 83.22 % of normal level, and reduce the blood glucose of T2DM mice by 46.51 %. D-ESP was found to regulate blood glucose similarly to that of drug metformin. D-ESP could reduce IR levels in T2DM mice via two ways. One was to improve inflammatory response by promoting interleukin 2 release; the other was to promote high-density lipoprotein cholesterol synthesis and inhibition triglyceride production by restoring liver cell damage, thus improving glucose metabolism disorders. Consequently, D-ESP is a promising ingredient in anti-diabetes. This study can provide theoretical basis for the development of hypoglycemic products for T2DM.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Hengyi Wang,Yong-Fei Li,Xueli Niu,Peiyun Dai,Mingyu Dou,Guang Yang,Fatao Gong,Hongjie Zhu,Hua Yang,Jianmin Dou
Due to the consumption of traditional fossil fuels, human society faces global energy shortages and increasing environmental pollution problems. To address water pollution caused by the abuse of antibiotics and to promote green hydrogen production. In this paper, a Bi 2 WO 6 /CdS S-scheme heterojunction was prepared to realize the photocatalytic levofloxacin (LEV) degradation coupled with hydrogen production reaction. Under the introduction of [Co(bpy) 3 Cl 2 ] (CoBpy) as a molecular photosensitizer, the hydrogen production activity of Bi 2 WO 6 /CdS increased remarkably to 5395.9 μmol g −1 h −1 , meanwhile, the degradation rate of LEV could reach 87.5 %, which was much higher than that of the pure phase material and exhibited excellent stability over five cycles. The enhanced photocatalytic activity originates from the S-scheme heterojunction mechanism that enables the oxidizing and reducing abilities of the material to be fully exploited, meanwhile the sensitization of CoBpy further optimizes the charge transfer pathway, which realizes the combination of visible-light-driven wastewater treatment and green hydrogen production. Our findings provide an efficient and safe approach to environmental remediation and green energy production for a sustainable energy future.
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高影响因子
Materials Today Chemistry
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2024
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IF 6.7
Zhizhu Yue,Yonghe Yu,Tianjun Hu,Ying Wang,Lulu Cao,Yanxia Zhang,Yuhong Chang,Linjuan Pei,Jianfeng Jia
The development of economical multiphase photocatalysts is a significant challenge in achieving large-scale industrialization. Rational catalyst design can help in achieving efficient, energy-saving, and green catalytic reactions, making it more feasible to screen potential catalyst candidates. In this paper, we have successfully developed a high-efficiency photocatalyst Cu-doped Cu 2 WO 4 (OH) 2 (CWOH-y, where y represents the molar ratio of copper tungsten source), which can catalyze the aerobic coupling reaction of amines to produce corresponding imines under visible light irradiation. N-benzylidenebenzylamine is synthesized under visible light at 25 °C with an 89 % yield. Under natural light at around 35 °C (mean light intensity of 50 mW/cm 2 ), 94 % of the benzylamine is converted, and 97 % of the product is N-benzylidenebenzylamine. The catalyst exhibits high efficiency due to the synergistic effect of doped Cu, Cu 2 WO 4 (OH) 2 , and visible light. This combination generates a significant amount of superoxide free radicals and singlet oxygen when exposed to visible light. Furthermore, the catalyst demonstrates universality and stability with a wide range of amine derivatives. This study introduces a new environmentally friendly photocatalytic pathway for the synthesis of imines and emphasizes the potential applications of Cu 2 WO 4 (OH) 2 .
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
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IF 5.6
Xizhi Li,Tingting Zhou,Yixi Wu,Jiayi Sun,Ziyu Wang,Yuhan Huang,Ke Xu,Hongwei Ling,Na Li,Tingting Yang,Tao Wang
Exenatide, the first glucagon-like peptide-1 receptor agonist (GLP-1RA), exerted multiple beneficial effects, including stimulating insulin secretion, slowing gastric emptying, and improving insulin resistance (IR). Our previous work demonstrated that the peroxisome proliferator-activated receptor delta (PPARδ) gene ( PPARD ) polymorphisms correlated with exenatide monotherapy efficacy, possibly due to the pivotal role of PPARδ in regulating IR. Specifically, PPARδ has been shown to modulate the nucleotide-binding domain and leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome, a key regulator of pyroptosis, thereby participating in the regulation of this inflammatory cell death pathway. However, the underlying mechanisms by which exenatide ameliorated hepatic IR in patients with type 2 Diabetes Mellitus (T2DM) remained incompletely understood. Herein, we found that exenatide suppressed pyroptosis and ameliorated hepatic IR; furthermore, it could bind to PPARδ and upregulate PPARδ protein expression both in vitro and in vivo. Notably, PPARδ knockdown abolished the protective effects of exenatide against pyroptosis and hepatic IR, whereas pharmacological activation of PPARδ enhanced these beneficial effects. Moreover, T2DM patients carrying the AA genotype at PPARD rs3777744 and exhibiting higher baseline homeostasis model assessment of insulin resistance (HOMA-IR) showed a superior response to exenatide. Collectively, our findings revealed that exenatide ameliorated hepatic IR by suppressing pyroptosis via PPARδ, underscoring the potential of PPARD rs3777744 as a biomarker for personalized exenatide therapy in T2DM.
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高影响因子
JOURNAL OF RARE EARTHS
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2026
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IF 9.6
Jiashuo Lv,Liming Xu,Fan Zhang,Danqin Li,Jie Li,Yufei Hu,Wenjing Zhou,Meisi Yu,Furui Lin,Jian Hou,Weiqiang Zhou
Nickel-based catalysts are attractive for methanol oxidation owing to their structural tunability and intrinsic activity for C–H bond activation. However, their limited ability to capture OH – at the reaction interface results in reduced energy-conversion efficiency. In this work, we demonstrate that La-Ni(OH) 2 /graphene oxide (GO) delivers a multilevel synergistic optimization that markedly enhances photoelectrochemical methanol oxidation. The random doping of La disturbs the periodicity of Ni–O lattice, which promotes surface reconstruction and the enrichment of OH – at the electrified interface. Notably, La doping-induced oxygen vacancies act as charge-trapping sites, promoting the separation of photogenerated electron-hole pairs. More photogenerated holes can reach the reaction interface and participate in oxidation, synergistically enhancing the photoelectrocatalytic efficiency. By optimizing the interfacial microenvironment, the La-Ni(OH) 2 /GO catalyst achieves a current density of 179.8 mA/cm 2 in alkaline medium and increases to 222.6 mA/cm 2 under illumination.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Haijie Cai,Xingyu Wang,Jingting Han,Yayao Song,Jingwen Wang,Zhaomin Gao,Tianjun Ni,Yongheng Zhu
Gas sensors for detecting foodborne pathogen biomarkers offer a promising approach to enhance food safety monitoring. However, sensors based on conventional sensing materials often lack the requisite sensitivity for trace-level pathogen metabolites. Herein, PdPt/ZnO hollow concave nanocages are rationally designed through a surface-tailored strategy to achieve rapid and ultrasensitive detection of the Listeria monocytogenes biomarker 3-hydroxy-2-butanone at ultralow concentrations. The representative 1%PdPt/ZnO-based sensor exhibits superior sensing properties: high response (R a /R g = 92.8@5 ppm), rapid response/recovery kinetics (14/15 s), ultralow detection limit (20 ppb), excellent selectivity, and over 30-day stability at an operating temperature of 150 °C. The combination of ex-situ / in-situ characterization and DFT calculations reveals that the hollow concave nanocage morphology synergistically activated by PdPt bimetallic sites dramatically increases active site density, accelerates oxygen diffusion, and lowers the reaction energy barrier, thereby enabling the efficient adsorption and conversion of oxygen species and 3-hydroxy-2-butanone. Crucially, the sensor enables rapid response of Listeria monocytogenes in actual food samples and distinguishes it from other foodborne pathogens, demonstrating its significant potential for accurate, real-time, and non-invasive monitoring of Listeria monocytogenes contamination.
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高影响因子
Asian Journal of Pharmaceutical Sciences
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2026
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IF 12.6
Fengkai Qiu,Xiaoxiao Chen,Qianhui He,Kai Li,Xinlong Chai,Shiji Fang,Fazong Wu,Dengke Zhang,Liyun Zheng,Zhongwei Zhao,Minjiang Chen,Jin Su,Jiansong Ji,Gaofeng Shu
Hepatocellular carcinoma (HCC) is commonly diagnosed at intermediate or advanced stages. While transcatheter arterial embolization (TAE) is the accepted locoregional therapy, embolization inevitably induces severe intratumoral hypoxia, leading to excessive lactate accumulation, metabolic reprogramming and the formation of an immunosuppressive tumor microenvironment (TME), factors that collectively limit durable therapeutic efficacy and promote tumor recurrence. Although immunotherapy has shown promise in HCC, the efficacy of combining TAE with immune-based strategies remains suboptimal, largely due to metabolic constraints and T cell dysfunction within the post-embolization TME. Interleukin-2 (IL-2) therapy can stimulate effector T cells but suffers from the drawbacks of systemic toxicity, a short half-life and TME-induced dysfunction. Recent evidence indicates that lactate-rich, acidic TMEs impair IL-2 stability and signaling, suppress CD8⁺ T cell function, and promote Treg cell activity, thereby further compromising IL-2-based immunotherapy following TAE. Here, we developed a nano-immunotherapy platform (Syr/IL-2@MPDA) using mesoporous polydopamine (MPDA) nanoparticles co-loaded with His-tagged IL-2 and the monocarboxylate transporter inhibitor Syrosingopine (Syr). Syr-mediated lactate regulation alleviates TME acidity and restores IL-2 activity, while MPDA enables mild photothermal therapy (mPTT) to transform immunologically "cold" tumors into "hot" phenotypes, thereby enhancing the immune response. This integrated strategy significantly enhanced antitumor immunity, achieving a tumor growth inhibition rate of 70.87% in a murine subcutaneous tumor model. In an orthotopic N1S1 HCC rat model, the treatment demonstrated strong therapeutic efficacy in combination with αPD-L1 and TAE, overcoming the hazards of TAE-induced lactate accumulation and immune suppression. Overall, this study demonstrates a safe and effective strategy that enhances IL-2 immunotherapy through mPTT and metabolic modulation, offering a promising combination treatment for advanced HCC.
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高影响因子
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