COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Renfan Chen,Kaile Zhao,Weilong Wu,Kunxi Huang,Mengyao Zhou,Xiaolong Huang,Bing Deng,Zhen Wang,Wenpu Zhang
Efficient flotation separation of pentlandite from pyrite is central to improving the utilization efficiency of nickel-cobalt sulfide resources. In this work, 3-mercapto-1-propanol (3-MP) was employed as a selective pyrite depressant in Ni-Co sulfide flotation. The selective depression mechanism was elucidated through single-mineral, artificial mixed-mineral and real ore flotation tests, combined with contact angle measurements, adsorption measurements, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy characterizations. Single-mineral flotation results demonstrated that 3-MP reduced pyrite recovery to 19% while maintaining pentlandite recovery steadily at 75%. In artificial mixed-mineral flotation, 3-MP significantly upgraded the nickel concentrate grade, with a nickel recovery of 85.42%. Open-circuit flotation (one rougher, one scavenger and two cleaner stages) on a real ore yielded a nickel concentrate assaying 3.40% Ni and 1.73% Co, corresponding to enrichment ratios of 5.7-fold and 5.6-fold, respectively, and the sulfur recovery to the concentrate was merely 10.07%, indicating favorable practical application potential of this reagent. Surface analyses confirmed that 3-MP chemically bonds with Fe sites on the pyrite surface via its thiol group (–SH), while exhibiting negligible interaction with Ni sites on pentlandite, thereby leaving the surface properties and collector adsorption behavior of pentlandite unaffected and ensuring its excellent floatability. This work provides a theoretical basis and technical support for the efficient separation and utilization of nickel-cobalt sulfide resources. Download: Download high-res image (176KB) Download: Download full-size image
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Frontiers in Cell and Developmental Biology
·
2026
·
IF 5.3
Wenting Song,Xiao Kang,Xueyan Li,Yuyan Yang,Xinke Wu
Polycyclic aromatic hydrocarbon derivatives, as a class of environmental pollutants, often exhibit higher toxicity than their parent polycyclic aromatic hydrocarbons, posing potential health risks. This study selected the potentially estrogenic derivative 3-hydroxybenz[a]anthracene as the research subject. Using the estrogen receptor-positive breast cancer cell line T47D as a model, the effects of this compound on cell proliferation, migration, invasion, and apoptosis were evaluated through EdU staining, colony formation, scratch healing, Transwell invasion, and apoptosis assays to evaluate its effects on cell proliferation, migration, invasion, and apoptosis. Western blot analysis was employed to detect the expression of relevant signaling proteins. Results indicate that 3-hydroxybenz[a]anthracene promotes T47D cell proliferation by activating the PI3K/AKT signaling pathway, thereby upregulating AKT, p-AKT, and c-Myc protein expression. It enhances cell migration and invasion by downregulating E-Cadherin and MMP9 while simultaneously upregulating Vimentin and MMP2 protein expression. Furthermore, this compound simultaneously upregulates Bax and Bcl-2 expression, ultimately inducing apoptosis in T47D cells. This study confirms that 3-hydroxybenz[a]anthracene exhibits estrogen-like activity in vitro and can influence malignant biological behaviors of breast cancer cells by regulating relevant signaling pathways. These findings provide experimental evidence for further evaluating the endocrine-disrupting effects and breast cancer risks associated with such environmental pollutants.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Que Huang,Rui Du,Xu Yang,Yanwu Yu,Zirui Guo,Guohui Li,Qinpei Chen,Jianghui Xie,Hongyuan Ding,Junchao Zhao,Changcheng Liu
With the increasing depletion of traditional energy resources and the continuous rise in usage costs, the development of new energy storage technologies has become a global focus. Although lithium-ion batteries possess excellent electrochemical performance and a well-established industrial infrastructure, they are prone to thermal runaway and pose significant safety risks. As a potential alternative to lithium, sodium-ion batteries demonstrate promising commercial prospects due to their low cost, similar electrochemical properties, and the fact that they are more resistant to thermal runaway and exhibit less violent reactions. Among the numerous cathode materials for sodium-ion batteries, Na 3 V 2 (PO 4 ) 3 (NVP) has attracted significant attention due to its high energy density, structural stability and excellent thermal safety; however, its inherently low electronic and ionic conductivity limits its practical application. To address this, this study modifies NVP by introducing different transition metal elements to regulate the unit cell volume, broaden the ionic migration pathways, and further enhance its electrochemical performance and thermal safety. Electrochemical test results indicate that the optimal doped sample achieves a half-cell/full-cell capacity of up to 122.3 mAh g −1 ; infrared spectroscopy reveals minimal temperature variation during charge-discharge cycles. Accelerated Calorimetry (ARC), Thermogravimetric Analysis (TG) and Differential Scanning Calorimetry (DSC) tests further confirmed that element doping significantly improves the thermal stability of NVP, increases heat absorption and reduces the risk of thermal runaway. Building on this, a Random Forest (RF) machine learning model was developed to systematically analyze thermal runaway data and predict safety performance under different doping conditions. Model evaluation results indicate that the RF model possesses high predictive accuracy and good generalisation ability, enabling it to effectively identify key features influencing safety. Integrating experimental and modelling results, the combination of transition metal element doping modification and machine learning prediction methods provides a new technical pathway and theoretical basis for the design and feasibility assessment of high-safety sodium-ion batteries. Download: Download high-res image (156KB) Download: Download full-size image
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JOURNAL OF POWER SOURCES
·
2026
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IF 8.4
Zhiguang Qian,Yanpeng Dong,Yu Zhu,Like Yue,Shixue Wang
Polydimethylsiloxane (PDMS) is a promising fluorine-free hydrophobic material for proton exchange membrane fuel cell (PEMFC) microporous layers (MPLs) owing to its low surface energy, environmental compatibility, and low-temperature curing. However, weak adhesion between low-loading PDMS and carbon materials limits the structural stability, especially under hydrothermal and oxidative conditions. Here, 3-aminopropyltriethoxysilane (APTES) is used to modify carbon black and enhance the carbon-PDMS interfacial interaction. An APTES-modified 5 wt% PDMS-MPL is compared with unmodified 5 wt% PDMS-MPL and conventional 20 wt% polytetrafluoroethylene (PTFE)-MPL. Hot-water and Fenton oxidative aging, combined with microstructural, pore, hydrophobicity, X-ray photoelectron spectroscopy (XPS), and single-cell electrochemical analyses, are used to evaluate aging-induced degradation and transport evolution. APTES modification reduces the ultrasonic mass loss rate from 11.67% to 5.17%, indicating improved interfacial stability. After aging, the modified MPL maintains a more stable pore structure and hydrophobicity and shows a mass-transfer resistance of 0.194 Ω cm 2 after Fenton aging. In contrast, unmodified PDMS-MPL exhibits polymer migration, local delamination, and oxidation, whereas PTFE-MPL retains a relatively stable pore structure but shows stronger high-current mass-transport limitations. These results demonstrate that APTES interfacial modification improves the structural stability and aging resistance of low-loading fluorine-free PDMS-based MPLs.
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MOLECULES
·
2026
·Vol. 31
·期 17
·2989
·
IF 5.1
Dongdong Shi,Guiqin Yan
Herein, a highly selective and sensitive fluorescent sensing system is developed for the accurate quantitative determination of γ-Hexachlorocyclohexane (γ-HCH, Lindane). With carboxyl-functionalized CdSe/ZnS core–shell quantum dots (QDs) as the substrate, 3-Aminophenylboronic acid (3-APBA) is covalently conjugated onto the quantum dot surface via an amidation reaction. Systematic characterizations are used to confirm the successful fabrication of the CdSe/ZnS-COOH@3-APBA fluorescent probe, which exhibits excellent luminescence properties and superior colloidal dispersion stability. Under optimal experimental conditions, an increased γ-HCH concentration induces gradual attenuation of the probe fluorescence intensity. A favorable linear correlation is achieved within 10–140 nM, and the limit of detection is 2.62 nM. Mechanistic studies reveal that γ-HCH binds to 3-APBA on the probe surface via halogen bonding to form non-fluorescent ground-state association complexes, thereby triggering static quenching of the probe. This method can effectively distinguish α-, β-, and δ-hexachlorocyclohexane isomers. With the merits of simple operation, high sensitivity, excellent stability, and strong anti-interference capability, it provides a new strategy for the rapid screening and accurate quantification of γ-HCH residues in environmental and food matrices.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
·Vol. 74
·期 30
·23674-23683
·
IF 6.7
Xu Meng,Liu Han,Lin Guangyu,Jing Zijian,Wen Tao,Xue Weijie,Wang Hualei,Wei Dongzhi
Transaminases
provide an effective approach for the asymmetric
synthesis of chiral amines. However, native ω-transaminases
often suffer from low catalytic efficiency and poor substrate concentration
tolerance, limiting industrial applicability. Targeting the synthesis
of ( S )-1-Boc-3-aminopiperidine, this study engineered
the ( S )-selective ω-transaminase CC1012 from Caulobacter sp. D5 through active pocket remodeling and
substrate tunnel engineering. Hydrophobic remodeling of the small
binding pocket yielded the single mutant M1 (Q25F) with a 27-fold
improvement in intrinsic catalytic efficiency ( k cat / K m ). Conservation analysis
and virtual saturation mutagenesis further identified R424 and D320
as key residues in the loop region at the substrate tunnel entrance.
Iterative saturation mutagenesis on these sites using M1 as a template
produced the optimal mutant M3 (Q25F/D320M/R424L), exhibiting a 45-fold
enhancement in k cat / K m over the wild type, achieving 98% conversion with ee > 99.9% at 1000 mM substrate concentration. This study
provides a superior biocatalyst for the efficient synthesis of ( S )-1-Boc-3-aminopiperidine.
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ACS Photonics
·
2025
·
IF 6.7
Yingming Wang,Lingyan Xu,Lu Liang,Zhentao Qin,Shuai Han,Chongqi Liu,Lixiang Lian,Wei Zheng,Yanyan Lei,Qinzeng Hu,Tao Wang,Wanqi Jie
Achieving real-time, high-sensitivity radiation detection with stability and precision remains a critical challenge in medical diagnostics and radiation therapy. Here, we report the development of MDABCO-NH4(BF4)3 single crystals (SCs), a metal-free perovskite material with exceptional performance for both X-ray and charged particle detection. Large-scale MDABCO-NH4(BF4)3 SCs (15 × 13 × 5 mm3) were synthesized via a simple low-temperature solution method, achieving superior crystallinity with a full width at half-maximum (fwhm) of 0.0061°. The MDABCO-NH4(BF4)3 detectors exhibit high resistivity (1.31 × 1012 Ω·cm), low trap density (1.09 × 109 cm–3), and excellent charge transport properties ((μτ)h = 3.15 × 10–5 cm2·V–1). For α-particle detection, the MDABCO-NH4(BF4)3 detectors achieve a high energy resolution of 35.0% at 5.49 MeV and a fast response time of 5 ms, demonstrating single-particle sensitivity. For X-ray detection, MDABCO-NH4(BF4)3 detectors exhibit high sensitivity (13,529 μC·Gyabs–1·cm–2) and an ultralow detection limit (17.1 nGyair·s–1), significantly lower than the 5.5 μGyair·s–1 standard for active personal dosimeters used in regular medical diagnostics. The combination of superior charge transport properties with stability and high signal-to-noise ratio establishes MDABCO-NH4(BF4)3 SCs as a versatile material for real-time radiation monitoring and high-precision medical imaging applications.
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Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-21
·
IF 8.9
Jia Yifan,He Muchen,Wang Fan,Zhan Yaqing,Deng Qiwen,Shen Jiantong,Wang Xiwen,Ran Qi,Huang Wenqi,Ling Yihong,Wen Shihong
Background & Aims Dysfunction of the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB) contributes to the development of intestinal ischemia/reperfusion (IR) injury. Tryptophan (TRP), an essential amino acid, plays a crucial role in maintaining intestinal homeostasis, yet its regulatory effects on the GVB following IR remain unexplored. We aimed to better define the role of TRP in intestinal IR in vivo and in vitro. Methods Mice underwent intestinal ischemia/reperfusion (IR) and were fed control, TRP-recommended (TRP-r), or TRP-sufficient (TRP-s) diets. Fecal metagenomic sequencing analyzed microbial composition, and targeted metabolomics quantified tryptophan and its metabolites in intestinal and serum samples. ILA’s effects on barrier integrity were assessed via tight junction protein expression and FITC-dextran permeability assays. RNA sequencing of intestinal endothelial cells elucidated mechanisms by which ILA modulated GVB function. The STAT3-claudin 2 relationship was validated in vitro by ChIP-qPCR. Results TRP supplementation significantly reshaped the gut microbiota, mitigated tissue damage and enhanced the integrity of both the IEB and GVB. Indole-3-lactic acid (ILA), a key tryptophan metabolite, was identified as an important factor in preserving GVB function. Mechanistically, our results show that the aryl hydrocarbon receptor (AhR)/Nrf2/signal transducer and activator of transcription 3 (STAT3) pathway is essential for ILA-mediated improvement of GVB integrity and downregulation of the pore-forming protein claudin 2. Conclusions Our findings highlight the dual role of ILA in reinforcing both IEB and GVB functions and shed light on the molecular mechanisms underlying ILA’s GVB-protective effects. This study implicates that ILA or other AhR-activating metabolites may serve as promising pharmacological agents for alleviating IR-induced intestinal damage. Graphical
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Defence Technology
·
2025
·
IF 5.9
Zhe Zhang,Zhuowei Sun,Haoming Zou,Xijuan Lv,Ziyang Guo,Shuai Zhao,Qinghai Shu
3-Nitro-1,2,4-triazol-5-one (NTO) is a typical high-energy, low-sensitivity explosive, and accurate concentration monitoring is critical for crystallization process control. In this study, a high-precision quantitative analytical model for NTO concentration in ethanol solutions was developed by integrating real-time ATR-FTIR spectroscopy with chemometric and machine learning techniques. Dynamic spectral data were obtained by designing multi-concentration gradient heating-cooling cycle experiments, abnormal samples were eliminated using the isolation forest algorithm, and the effects of various preprocessing methods on model performance were systematically evaluated. The results show that partial least squares regression (PLSR) exhibits superior generalization ability compared to other models. Vibrational bands corresponding to C=O and –NO 2 were identified as key predictors for concentration estimation. This work provides an efficient and reliable solution for real-time concentration monitoring during NTO crystallization and holds significant potential for process analytical applications in energetic material manufacturing.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Gang Huang,Chenggong Wang,Danil Bukhvalov,Yingchun Yang,Jialu Gao,Fengyan Han,Xiaofei Yang,Caiqin Wang
Urea-assisted water electrolysis is a significant and sustainable strategy to optimize electrolyte system to promote the efficiency of hydrogen producing in overall water splitting. Here we construct excellent catalysts (NiCoRu-X) by introducing Ru into reduced dual metal-organic frameworks (MOFs) via a mild chemical reduction method, which preserves multi hetero-interfaces that are spontaneously formed. Interestingly, excellent performances in urea oxidation reaction (UOR) can be observed on all NiCoRu-X samples but without obvious difference in the activity, while the optimal catalyst can be distinguished by testing their catalytic activity in hydrogen evolution reaction (HER). Dependent density functional theory (DFT) calculations are applied to identify the potential activity sites of different heterostructure in NiCoRu-X, and reveal that the hetero-interface promotes the formation of dynamic Ni 3+ actives like NiOOH, which benefit for UOR. In the urea-assisted electrolytes, the reaction potential difference by coupling the LSV curves of HER and UOR is 155 mV lower than that in the electrolyte without urea at 20 mA cm −2 , and 70 mV lower than that in overall water splitting. It reaches a high faraday efficiency (FE) of 98.5 % at 2.0 V in urea-assistant water electrolysers, higher than that without urea assistant (92.9 %). This work highlights the possibility of using urea oxidation to decrease the reaction overpotential and to further improve the efficiency of producing hydrogen in overall water splitting by introducing urea in electrolyte system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xunda Hu,Shiyan Sun,Yunxuan Weng,Caili Zhang
The advancement of high-performance poly(3-hydroxybutyrate- co -4-hydroxybutyrate) (P34HB) bioplastics is limited by their inherent brittleness and narrow processing window. In this study, a novel class of reactive citrate-based plasticizers was developed by combining short-chain butyl esters with long-chain polyethylene glycol diglycidyl ether (PEGDE). Three derivatives—TE1B2, TE2B1, and TE3—were synthesized, with TE3 containing three epoxy groups for covalent network formation. Comprehensive characterization showed that TE3 significantly outperforms commercial tributyl citrate (TBC) in thermal stability ( T d- 10% = 275.3 °C vs. 179.2 °C), migration resistance (<1 % mass loss in petroleum ether), and mechanical performance (elongation at break, ε b = 51.2 %; tensile strength, σ = 15.8 MPa). The PEGDE segments of TE3 enable (1) covalent crosslinking with P34HB terminals via epoxy–carboxyl and epoxy–hydroxyl reactions and (2) topological entanglement maintaining the storage modulus of neat P34HB. This molecular architecture suppressed spherulite formation and established a stress-dissipating network, as evidenced by SEM. Rheological analysis further revealed TE3's shear-thinning behavior with high-frequency elasticity retention, enabling reliable fused deposition modeling (FDM). By overcoming the traditional strength–ductility trade-off, this work introduces a synergistic strategy combining chemical crosslinking and physical entanglement, offering new insights into covalently anchored plasticization and network dynamics in biopolymer design.
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BIOCATALYSIS AND BIOTRANSFORMATION
·
2021
·
IF 2.181
Hongqian Dai,Yuan Lu,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe3O4 magnetic nanoparticles were prepared by chemical co-precipitation and modified with 3-aminopropyltriethoxysilane (APTES) and CS2 to form Fe3O4-APTES-CS2 magnetic carriers. Magnetically immobilized enzymes are attractive owing to their potential applications in many biological fields. When an alternating magnetic field is applied, the magnetic nanoparticles experience a force in the direction of the field, and the magnetic moments of the magnetic nanoparticles are apt to align in the direction of the field. Thus, magnetic nanoparticles behave like microscopic stirrers. The optimal reaction conditions of the acylation reaction using Fe3O4-APTES-CS2-lipase were 200 mmol/L 1-methyl-3-amphetamine, 100 mg immobilized lipase, 200 μL ethyl acetate, 12.6 × g rotating speed, 40 °C, and 5 days in the shaker. The conversion and enantiomeric excess of R-2a reached a maximum of 36.8% and 98.5%, respectively. 1-Methyl-3-phenylpropylamine was resolved using Fe3O4-APTES-CS2-lipase in an alternating magnetic field. The optimal magnetic field frequency and magnetic field intensity were determined to be 500 Hz and 12 Gs, respectively. The conversion and enantiomeric excess of R-2a reached a maximum of 40.3% and 98.5%, respectively. The results revealed that conversion under a magnetic field was significantly higher than that without a magnetic field. Highly optically active (R)-N-acetyl-1-methyl-3-amphetamine can be obtained via an efficient resolution of racemic 1-methyl-3-phenylpropylamine with immobilized lipase magnetic nanoparticles as a catalyst and ethyl acetate as an acyl donor in organic solvents in an alternating magnetic field.
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