Medical Gas Research
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2022
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IF 0
Jun-Li Xue,Bo-Yan Liu,Min Zhao,Meng-Yu Zhang,Ming-Yue Wang,Qian-Qian Gu,Xiao-Yi Zhang,Shu-Cun Qin
Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in development of this disease. Recently, numerous studies have reported the therapeutic effects of molecular hydrogen (H 2 ) on oxidative stress and inflammation-related diseases. Here, the effects of H 2 against glycerol-induced AKI and the underlying mechanisms were explored in rats. Low (4%) and high (67%) concentrations of H 2 were prepared using a self-made device to investigate the dose-response. After 72 hours of glycerol injection (8 mL/kg), we found that glycerol triggered oxidative stress, inflammatory reactions, and apoptotic events. These caused subsequent renal damage, evidenced by a significant reduction of antioxidases and up-regulation of the relevant damaged biomarkers. H 2 inhalation reversed the above alterations and exerted renoprotective effects. Interestingly, for RM/AKI-related factors, no consistent dose-response benefits of H 2 were observed. However, higher concentration of H 2 inhalation improved histological and morphological changes better. This study suggests that H 2 is a potential alternative therapy to prevent or minimize RM induced AKI possibly via its antioxidant, anti-inflammatory, anti-apoptotic and anti-necroptotic properties.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Shangjie Wei,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The browning inhibition of cysteine on the Maillard reaction of glycine-xylose performed under stepwise increased temperature was investigated. The browning degrees of the final products prepared with cysteine addition at different time points were found dissimilar, and the addition time point of cysteine yielding the lightest browning products was consistent with the time when the glycine-xylose Amadori rearrangement product (GX-ARP) reached its maximum yield. To clarify the reason for browning inhibition caused by cysteine, the evolution of key browning precursors formed in the GX-ARP model with cysteine involved was investigated by HPLC with a diode array detector. The results on the browning degree of the thermal reaction products of GX-ARP with cysteine addition showed great inhibition of α-dicarbonyl generation, which resulted in a significant increase in the activation energy of GX-ARP conversion to browning formation during heat treatment. Strong evidence suggested that the additional cysteine got involved in GX-ARP degradation and reacted with the deoxyosones derived from GX-ARP to yield cyclic 2-threityl-thiazolidine-4-carboxylic acid (TTCA). TTCA formation shunted the degradation of deoxyosones into short-chain α-dicarbonyls, which were important browning precursors, and consequently inhibited the Maillard browning.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 33
·期 3
·2210551
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IF 19.924
Hang Geng,Mengyang Wang,Songfan Wang,Dongxing Kou,Zhengji Zhou,Wenhui Zhou,Yafang Qi,Shengjie Yuan,Litao Han,Yuena Meng,Sixin Wu
Abundant intrinsic defects and defect clusters in Cu 2 ZnSn(S,Se) 4 (CZTSSe) solar cells lead to severe nonradiative recombination and limited photoelectric performance. Therefore, developing effective method to suppress the detrimental defects is the key to achieve high-efficiency solar cell. Herein, a convenient two-step cooling strategy in selenization process is reported to suppress the Cu Zn and Sn Zn defects and defect clusters synergistically. The results show that rapid cooling during section from selenization temperature to turning temperature can inhibit the volatilization of Sn and restrain the corresponding Sn-related defects, while slow cooling during the subsequent temperature section can reduce the degree of Cu-Zn disorder. Benefitting from the synergistic effect of two-step cooling, a significantly lowered concentration of Sn Zn and Cu Zn defect and their defect clusters [2Cu Zn +Sn Zn ] in absorber is observed, meanwhile, a reduced band tailing effect and promoted carrier collection efficiency of the photovoltaic device is obtained. Finally, a device with improved open-circuit voltage ( V oc ) of 505.5 mV and efficiency of 12.87% is achieved. This study demonstrates the impact of cooling process on defects controlling for the first time and provides a simple and effective new strategy for intrinsic defect control, which may be universal in other inorganic thin film solar cells.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Zhengxu Li,Hao Wu,Baifeng Hu,Jin Guo,Yuxiang Liu,Han Yue,Hongkang Zhao,Qunsheng Li
The solubility of 2′,4′-dihydroxyacetophenone (2′,4′-DHAP) in 10 monosolvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, methyl acetate, ethyl acetate, propyl acetate, and benzene) and two binary solvents (ethanol + ethyl acetate and n-propanol + ethyl acetate) was determined using a gravimetric method at 101.3 kPa from 293.15 to 333.15 K. The experimental solubility was demonstrated to increase with the increasing temperature. The solubility of 2′,4′-DHAP is the highest in pure isopropanol, and the two binary solvents present a solubilizing effect on the solute. Furthermore, six thermodynamic models were employed to fit the solid–liquid equilibrium data, and the correlation results manifested that the modified Apelblat model had minimum ARD values of less than 1%. Finally, the KAT-LSER model was employed to analyze the solvent effect at 298.15 K. The results show that the contribution of the four interaction types α, β, π*, and δH account for 15.84%, 15.30%, 18.33%, and 50.53% of the total interaction force, respectively, and the solvent–solvent interaction represented by δH is the dominant factor affecting the solubility of 2′,4′-DHAP.
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Journal of Nanomaterials
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2022
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IF 3.791
Yuping Fu,Peng Deng,Xiaoxia Li
In this study, the effect of copper oxide (CuO) with different sizes on the heat-induced catalysis decomposition of typical molecular perovskite-based energetic material DAP-4 was studied. Pure CuO with different sizes and DAP-4 are characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Heat-induced catalysis decomposition performances of DAP-4 with adding CuO were investigated by differential scanning calorimeter (DSC). Results demonstrated that with a lower-addition CuO at the nanoscale added (1 wt%), DAP-4 had decreased at least by 36°C with the heating rate of 10°C/min, compared with pure DAP-4. With the CuO particle size of 50 nm, the of DAP-4 heat-induced decomposition in DAP-4/CuO-50 had reduced from 159.8 kJ/mol to 120.2 kJ/mol, which is lower than DAP-4/CuO-150. The heat-induced catalysis decomposition mechanism of DAP-4 by using CuO as a nanoadditive was proposed.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Pan Li,Xiaorui Jia,Jinping Zhang,Jieqiong Li,Jinqiang Zhang,Lijing Wang,Junmei Wang,Qingfeng Zhou,Wei Wei,Xiaoli Zhao,Shuaijun Wang,Hongqi Sun
The construction of hybrid catalysts composed of inorganic semiconductors and molecular catalysts shows great potential for achieving high photocatalytic carbon dioxide (CO 2 ) conversion efficiency. In this study, ZnIn 2 S 4 was first synthesized via a solvothermal route. Gold (Au) and silver (Ag) nanoparticles were then deposited on ZnIn 2 S 4 via the reduction of noble metal precursor by sulfur vacancy defects. The obtained composite was further combined with tetra(4-carboxyphenyl)porphyrin iron(III) chloride (FeTCPP) molecular catalyst for efficient photocatalytic CO 2 conversion. The roles of different noble metal nanoparticles in charge separation and interfacial electron transfer have been comprehensively studied. The photocatalytic performance and photoelectrochemical characterizations demonstrate that the introduction of Ag or Au nanoparticles is beneficial for charge separation. More importantly, the presence of Ag nanoparticles plays a crucial role in promoting the interfacial charge transfer between ZnIn 2 S 4 and FeTCPP, whereas, Au nanoparticles function as active sites for the water reduction reaction.
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高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Yang Zhang,Yuanlu Cui,Jiyu He,Rongjie Yang
A series of novel 1-oxo-4-hydroxymethyl-2,6,7-trioxy-1-phosphabicyclo[2,2,2]octane (PEPA)-functionalized metallophthalocyanines (PEPA-MPcs, M = Al, Co, Ni, Zn, and Ce) have been successfully synthesized and characterized. The obtained PEPA-MPcs were added to epoxy resin (EP) to prepare a variety of flame retardant composites (EPP-MPcs) and their thermal behavior and flame retardancy were investigated using thermogravimetric analysis (TGA), the limiting oxygen index (LOI), and cone calorimetry. The flame-retardant mechanism was systematically analyzed in the gas and condensed phases, respectively. The highest LOI value of EP containing 2 wt.% PEPA-MPcs was increased by 19% to 27.6% when compared to pure EP. The peak of heat release rate (pHRR) and the total heat release (THR) values observed for EPP-AlPc were reduced by 64.3% and 48.6%, respectively. The main flame retardant mechanism of the PEPA-MPcs is the synergistic effect of the P and N atoms, including the dilution of highly non-flammable gases in the gas phase and the formation of an intumescent char layer from the condensed phase. Furthermore, the char residues of the EPP-MPcs were significantly increased via the catalysis and surface enrichment of the metal atoms, which reduced the fire hazards of the EP composites. In addition, the EPP-MPcs exhibit excellent mechanical properties and uniform dispersions. This work provides a new approach to the preparation of metal containing/non–halogen/phosphorus-containing flame retardants.
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Molecular Catalysis
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2022
·
IF 5.089
Li-Chao Wang,Lian Xu,Bing-Mei Su,Xin-Qi Xu,Juan Lin
L- threo -4-methylsulfonylphenylserine ethyl ester [(2 S , 3 R )- 1d ], a key building block of florfenicol which synthesized by esterification using ethanol and L- threo -4-methylsulfonylphenylserine [(2 S , 3 R )- 1b ] as substrates. L-threonine aldolase (LTA) is a promising biocatalyst for producing (2 S , 3 R )- 1b through a one-step process taking 4-Methylsulphonyl benzaldehyde ( 1a ) and glycine as substrates under the mild condition. However, the moderate C β -stereoselective blocked the industrial application of LTA. To address this issue, rational design by combination with prereaction state molecular dynamics (MD) simulation and per-residue energy decomposition algorithm are employed to engineer LTA for enhancing C β -stereoselective. As a result, a triple mutant N16A/E98S/Y314R (Mu3) is screened out to produce (2 S , 3 R )- 1b with 93.7% de and 90.2% conversion under the 300 mM 1a substrate loading. Furthermore, esterification is applied to synthesize (2 S , 3 R )- 1d with over 99% chiral purity and 99% product purity. The success of this study provides new insights for the rational design of LTA with improved C β -stereoselectivity and proves a chemo-enzymatic route for green synthesis of (2 S , 3 R )- 1d .
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SOLVENT EXTRACTION AND ION EXCHANGE
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2022
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IF 3.695
Huifang Xing,Liangrong Yang,Lu Wang,Mengfang Li,Jiemiao Yu,Diannan Lu,Gang Ye,Huizhou Liu
The effect of ion species and concentration on the extraction percent of Cs+ by 1,3-Diisopropoxycalix [4] arenecrown-6 (BPC6) in octanol/water solvent extraction system has been studied by molecular dynamics simulations and experiments. The results show that the anionic species play an important role on the enhancement of the extraction percent of Cs+. Specifically, the order in which anions promote the extraction percent is different at different total anion concentrations. At a relatively low anion concentration of 0.5 M, the extraction percent follows the sequence: ClO4−> I−> NO3−> Br−> Cl−> SO42−> F−. At a relatively high concentration of 2 M, the extraction percent of Cs+ follows the following sequence: I−> ClO4−> Br−~ NO3−> Cl−> SO42−> F−. It is indicated that the extraction percent is dominated by the anion’s interface propensity, which is the probability of anion distribution in the interface compared to the water phase. However, at low concentration of anions, strong coordination effect of NO3− promotes the extraction effect compared to Br−. At the high anion’s concentration, the stronger salting-out capacity of Br− leads to a considerable increase of extraction percent. In addition, the cations also slightly affect the extraction percent. The extraction percent is affected by both cations’ concentration and the salt-out effect. On this basis, a neutral Cs+ extraction system has been established, and one stage extraction percent could reach 62.5%.
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ACS Nano
·
2022
·
IF 18.027
Ke Li,Chuanchuan Lin,Menghuan Li,Kun Xu,Ye He,Yulan Mao,Lu Lu,Wenbo Geng,Xuemin Li,Zhong Luo,Kaiyong Cai
Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities for the treatment of chemotherapy-resistant tumor indications, but its efficacy can be affected by the glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1) antioxidant mechanisms, posing significant challenges for its clinical translation. In this study, we report a Cu-tetra(4-carboxyphenyl)porphyrin chloride(Fe(III)) (Cu-TCPP(Fe)) metal organic framework (MOF)-based nanosystem for the efficient incorporation of Au nanoparticles (NPs) and RSL3, which can demonstrate enzyme-like activities to universally suppress the antiferroptotic pathways in tumor cells for amplifying ferroptotic damage. Herein, Cu-TCPP(Fe) MOF nanosheets were integrated with Au NPs via in situ nucleation and loaded with RSL3 via π–π stacking, which were eventually modified with polyethylene glycol (PEG) and iRGD for tumor-targeted drug delivery. Specifically, the Au NPs can demonstrate glucose oxidase-like activities for efficient glucose depletion, thus disrupting the pentose phosphate pathway to impede reduced glutathione (GSH) biosynthesis and prevent the recycling of coenzyme Q10 (CoQ10) to CoQ10H2, while Cu species can oxidize GSH into oxidized glutathione (GSSG). These nanocatalytic activities can lead to the simultaneous inhibition of the GPX4/GSH and FSP1/CoQ10H2 pathways and cooperate with the GPX4-deactivating function of RSL3 to cause pronounced ferroptotic damage, thereby providing a strong rationale for the application of ferroptosis therapy in the clinic.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Yi Han,Mingjie Huang,Wei Xiang,Chen Wang,Yongjie Li,Xiaohui Wu,Juan Mao,Tao Zhou,Hong Li,Deming Wu
Fe-based metal–organic frameworks (MOFs) are popular in activating oxidants e.g·H 2 O 2 and persulfate (PS) for degrading recalcitrant organic substances, generally regarded with a simple interfacial efficient iron cycle. This study has revealed that a novel two-steps single-electron transfer mechanism would occur initially to activate the rapid degradation 4-chlorophenol (4-CP) in the MIL-88B(Fe)/H 2 O 2 system (88B/H 2 O 2 system). The degradation of 4-CP was acidic favorable (pH 0 ≤ 6.0) and could be divided into two reaction stages, i.e., initial lag phase (0–10 min) and following rapid decay phase (10–50 min). In the first stage, H 2 O 2 was slowly activated on the surface of 88B to form superoxide radical (O 2 •– ), which would lead to the accumulation of the key intermediate hydroquinone (HQ) through reducing 4-CP. Afterwards, HQ could reductively dissolve iron ions which would lead to the subsequent efficient homogeneous Fenton reaction for the rapid oxidation of 4-CP by hydroxyl radical (•OH) in the following rapid decay phase. It was interesting to note that specific aromatic compounds, which would form reductive benzenediols intermediates by O 2 •– , could be efficiently degraded in the 88B/H 2 O 2 system. The result of this study is expected to provide a new insight for understanding the catalytic oxidation process based on MOFs, and its application if possible.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jiaxin Zhu,Zekun Liu,Yihua Chen,Zhiqiang Chen,Hang Ma,Jian Sun,Liao Meng,Tongzhou Liu
The discharge of widely used fluorinated aromatics (FAs) leads to their notoriously high persistence and toxicity in natural environments. Defluorination is the key step for FAs pollutants detoxification. Due to its easy operation and mild reaction conditions, hydrodefluorination (HDF), especially electrochemical HDF, is a promising approach for FAs detoxification. A comprehensive and detailed investigation of the effective cathode and mechanism insights are contributable for the development of effective FAs defluorination techniques. In this study, 4-fluorophenol (4-FP) was selected as a model compound to optimize the electrochemical HDF process and understand the reaction mechanism. Cathode coating material investigation revealed that Rh outperformed Pd due to its higher reactivity towards C F bond cleavage. The Rh coating was primarily elemental and in Rh(1 1 1) crystalline form which helped store the generated atomic hydrogen (H*). Reaction conditions optimizations showed 4-FP degradation favored acidic > alkaline > neutral environment and a cell potential higher than −3 V was required for efficient 4-FP degradation. Dissolved oxygen (DO) negatively affected 4-FP degradation and the rapid 4-FP decay only occurred after DO depleted in the solution. Based on quenching experiments and ESR analysis, H* was determined as the main reactive species. In situ Raman characterization suggested that electrochemical 4-FP degradation was initiated by 4-FP adsorption through R···F···Rh bridging and H* generation/adsorption on Rh coated cathode, resulting in phenol generation. The generated phenol further experienced hydrogenation to yield cyclohexanone and cyclohexanol with lower toxicity and better biodegradation potential, demonstrating that electrochemical treatment of 4-FP simultaneously achieved defluorination along with detoxification. The outcomes of this work provide support for electrocatalyst technology development towards efficient FAs treatment while providing in-depth observation of the electrochemical HDF process.
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