JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Dongjing Wang,Xiaonan Li,Kunpeng Wei,Suyan Wang,Wen Zuo,Ze Xu,Chen Li,Hui Wang,Xueyan Zhou,Yanzhuo Zhang
Acute kidney injury (AKI) is a prevalent clinical syndrome associated with high morbidity, mortality, and a heavy medical burden. Oxidative stress, inflammation, and ferroptosis are key drivers of AKI, yet current pharmacotherapies are limited by suboptimal efficacy and systemic side effects. An efficient and precise kidney-targeted delivery system that co-delivers complementary therapeutics could overcome these challenges. Herein, we report a platelet membrane–coated, reactive oxygen species (ROS)-responsive nanozyme (BAPCs@PM) for synergistic AKI therapy. Ultrasmall CeO 2 nanodots (∼3 nm) were in situ mineralized on the outer layer of polydopamine cores, and hydrophobic baicalein was loaded into the mesoporous interior, yielding a stable and well-dispersed multifunctional composite nanozyme. Platelet membrane cloaking conferred renal targeting, immune evasion, and prolonged circulation. BAPCs@PM enabled ROS-triggered release of CeO 2 nanodots and sustained baicalein delivery at injured sites, amplifying local antioxidant, anti-inflammatory, and anti-ferroptotic activity. In a cisplatin-induced AKI model, BAPCs@PM markedly suppressed kidney injury molecule-1 upregulation, inhibited cleaved caspase-3 activation and apoptosis, enhanced mitochondrial protection, modulated macrophage polarization, reduced proinflammatory cytokine production, regulated iron homeostasis, restored glutathione peroxidase 4 expression, attenuated ferroptosis and lipid peroxidation, and ultimately improved renal function. Owing to their ultrasmall size, the ceria nanodots achieved efficient renal accumulation and rapid clearance with minimal systemic toxicity. This study provides an innovative biomimetic and responsive therapeutic strategy for AKI by combining ultrasmall nanozymes, natural bioactive molecules, and biomimetic membrane engineering.
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Pharmaceutics
·
2026
·Vol. 18
·期 7
·872
·
IF 6.9
Weinan Li,Sisi Yan,Yingying Gao,Yuhan Fu,Yutong Mei,Yanhong Wang,Zhixin Yang
Background: The highly heterogeneous and dynamically evolving tumor microenvironment leads to the development of drug resistance and recurrence in traditional therapies. Although immunotherapy demonstrates unique advantages, its clinical utility remains constrained by the suboptimal immunogenicity and the limited effect of monotherapy. Herein, a hybrid drug delivery system based on a spatiotemporal hierarchical controlled-release strategy was proposed to achieve dual immunotherapy with immune checkpoint blockade (ICB) and immunogenic cell death (ICD) to promote synergistic anti-tumor therapy.Methods: A liposome–micelle hybrid drug delivery system (RUT-RPP-LP) was constructed using a lipid bilayer composed of dioleoyl phosphatidylethanolamine/hemisuccinyl cholesterol to encapsulate rutin (RUT) and to form an inner cavity-encapsulated resveratrol micelle (RPP). RUT-RPP-LP was characterized, and its pH sensitivity and release behavior were investigated. Subsequently, a colon cancer tumor-bearing mouse model was constructed to evaluate the in vivo targeted anti-tumor effect and biological safety. On this basis, the combined mechanism of ICB and ICD was preliminarily explored.Results: RUT-RPP-LP possessed excellent formulation characteristics, stability, and biocompatibility, achieving graded controlled release of drugs via responding to the TME and lysosomal acidity, respectively. Obviously, RUT-RPP-LP could specifically target the tumor site, induce the occurrence of ICD, and simultaneously block the PD-1/PD-L1 immune checkpoint signaling pathway, thereby enhancing the function of T cells and inducing apoptosis of tumor cells.Conclusions: The RUT-RPP-LP based on the hierarchical controlled-release strategy exerted a spatiotemporally coordinated enhancement of anti-tumor immunity, and may provide a novel combinatorial approach to overcome the low response of immunotherapy in solid tumors.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yixuan Jiang,Yanlin Zhao,Fan Zhao,Xiaowei Cao,Dingding Jing,Haifeng Huang,Qinglei Hang
Chiral D Au NCs capillary SERS for label-free non-invasive saliva D-Glc assay. • Sensor achieves 0.30 nM LOD, covering clinical saliva glucose ranges. • Assay finishes in 10 min with 50 μL sample, high accuracy and anti-interference. • Assay shows correlation with GOD-POD gold std. (R 2 = 0.9313) and 0.947 AUC. • It offers a promising tool for early diabetes screening and clinical translation. Early, non-invasive screening and risk prediction of diabetes are crucial for effective prevention and control, as well as for delaying the onset and progression of complications. In this study, we developed a capillary surface-enhanced Raman scattering (SERS) sensor based on chiral gold nanocubes (D Au NCs) for the non-invasive, label-free, and rapid detection of d -glucose (D-Glc) in saliva. By leveraging the chiral recognition capability and strong SERS activity of D Au NCs, the sensor specifically identifies D-Glc and significantly amplifies its characteristic Raman signals, enabling quantitative analysis in complex saliva matrices without labeling. The sensor demonstrates outstanding analytical performance, covering the clinically relevant range of salivary glucose concentrations with a detection limit as low as 0.30 nM. Based on a capillary detection platform, the assay is simple and rapid, completed within 10 min using only a 50 μL micro-sample, while demonstrating strong anti-interference capability and high detection accuracy. Clinical saliva testing showed strong correlation with the glucose oxidase-peroxidase (GOD-POD) gold standard (R 2 = 0.9313), enabling reliable discrimination between healthy individuals and diabetic patients. Receiver operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.947, confirming its high efficacy in diabetes risk screening and strong diagnostic performance. Consequently, the D Au NCs-based capillary SERS sensor provides a promising strategy for early, non-invasive diabetes screening and prevention, possessing broad potential for clinical translation and application.
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Food Bioscience
·
2026
·
IF 6.2
Yangfan Hu,Yulong Yao,Cheng Li,Huizhen Li,Tianyu Hou,Zhijun Zhang
To improve the comprehensive utilization of perilla meal, dual-enzyme hydrolysis was optimized to prepare antioxidant peptides (PAP). The optimal conditions were pH 8.0, 50°C, 6 h, solid-liquid ratio of 1:22 g mL −1 , 1:1 compound enzymes and 6% enzyme dosage. The dual-enzyme product presented higher hydrolysis degree and antioxidant capacity than single-enzyme groups, with excellent solubility and processing stability against food additives, metal ions and food ingredients. The ultrafiltration screened active fraction PAP-SF-4 effectively alleviated oxidative damage in H 2 O 2 -stressed 4T1 cells by regulating ROS, MDA and endogenous antioxidant indexes. A key antioxidant peptide GDF was identified, which tightly bound to Keap1 through hydrogen bonds and hydrophobic interactions. This study provides a theoretical basis for the development and application of perilla-derived bioactive peptides.
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DESALINATION
·
2026
·
IF 9.9
Xin Shi,Qiuyan Bi,Zizhen Peng,Zhicheng Wang,Yakai Lin,Wenzhong Ma,Chuanjie Fang,Chao Zhang,Shiai Xu
In situ SiO 2 growth with DA-g-C 3 N 4 co-doping yields hybrid crosslinked PA layer. • Compound strategy mitigates DA-g-C 3 N 4 aggregation in PA layer. • Achieved simultaneous gains in Mg 2+ /Li + selectivity and permeability performance. • MgCl 2 rejection stayed >93% over 160 h, demonstrating excellent long-term stability. It is often difficult for thin-film composite (TFC) nanofiltration (NF) membranes to balance high separation selectivity and high permeability, and the contradiction between the two will lead to their overall performance constraints. In this study, a dual-phase regulation strategy is proposed, which adopts the in-situ sol method and the composite strategy of introducing two-dimensional materials for the preparation of organic-inorganic cross-linked polyamide (PA) NF membranes. A trimesoyl chloride (TMC) organic phase solution containing tetraethyl orthosilicate was first introduced onto the polyethersulfone (PES) substrate, followed by contact with a polyethyleneimine (PEI) aqueous phase solution containing dopamine-functionalized carbon nitride (DA-g-C 3 N 4 ), during which silicon dioxide (SiO 2 )/Si–O–Si domains were generated in situ within the PA layer. These domains restricted the free volume of the PA layer, narrowed the effective pore-size distribution, and suppressed nonselective defects, while the embedded DA-g-C 3 N 4 improved the compatibility between the nanofillers and the PA layer, thereby producing P-1Si-0.025CN membranes with an effective pore size of 0.4 nm. Compared with the P-NF membrane prepared by reverse interfacial polymerization of TMC and PEI directly on the PES substrate, Mg 2+ /Li + separation factor (SF) increased to 67.2 (Mg 2+ /Li + mass ratio is 20), salt solution flux was 27.1 LMH, separation and permeation capacity of mixed salt was enhanced, salt solution flux has increased by 4 times, and the SF has increased by 7 times, Mg 2+ /Li + ratio decreased from 20 in feed to 0.71 in permeation process. Moreover, it exhibited excellent separation performance in diluted salt lake brine, with an Mg 2+ rejection rate exceeding 98%, and it also exhibited high fouling resistance and long-term stability. Download: Download high-res image (155KB) Download: Download full-size image
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ACS Nano
·
2026
·Vol. 20
·期 30
·21403-21422
·
IF 17.3
Yu Wang,Zhao Ru,Miao Liming,Bian Jie,Zhou Yiyao,Zhao Xiaoyu,Song Wei,Wang Yue,Jiang Xiue
Glioblastoma
(GBM) is a highly lethal brain tumor, with
therapeutic
efforts hampered by the restrictive blood–brain barrier (BBB)
and a profoundly immunosuppressive tumor microenvironment (TME). Driven
by bioinformatics analysis identifying epidermal growth factor receptor
(EGFR) and caspase-3 as key regulators of an immune-evasive pyroptosis
pathway, we screened natural compounds and identified quercetin (Q)
and chlorogenic acid (C) as dual-targeting agents, thereby laying
a therapeutic foundation for amplifying pyroptosis in GBM treatment.
The compounds were conjugated into a glutathione-responsive prodrug
(QSSC) and encapsulated in a tumor-derived exosome-liposome nanoplatform
(QSSC@Exo-LNP), enabling enhanced BBB penetration and intracranial
targeting. Mechanistic studies revealed a dual-pathway amplification
of pyroptosis, in which C directly activates caspase-8 to initiate
gasdermin E (GSDME)-mediated pyroptosis, while Q/C-mediated EGFR inhibition
activates mitochondrial pro-apoptotic protein, thereby augmenting
caspase-3 and intensifying pyroptotic cell death. Upon intravenous
injection, QSSC@Exo-LNP triggers robust pyroptosis, releasing DAMPs
and tumor antigens for immune activation and macrophage reprogramming,
converting the TME from “cold” to “hot”
state. Moreover, this treatment strategy can significantly inhibit
the distant tumors in the primary-distal orthotopic GBM model. This
study proposes a strategy for the precise immunotherapy of GBM by
exploiting natural products to target overexpressed GSDME and induce
the pyroptotic cascade.
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Xinyu Yang,Demeng Liu,Siyu Pan,Delong Hou,Yao Jin,Zhonghui Wang,Yi Chen
Bio-derived C 2 -C 4 SCFAs and methyl acrylate were converted into SAF alkanes. • Electrocatalysis enabled C 8 -C 16 branched alkane synthesis under mild conditions. • C 8 -C 16 branched alkanes were obtained in overall yields of up to 72.5 %. • This route provides a complementary route to mainstream HEFA technology. Branched C 8 -C 16 alkanes are highly desirable sustainable aviation fuel (SAF) components, as they confer low freezing points and favorable combustion properties. Currently, these alkanes are produced predominantly via the hydroprocessed esters and fatty acids (HEFA) pathway, which requires harsh hydrogenation and hydroisomerization conditions that often promote cracking and carbon loss, resulting in high energy consumption and limited yields (20–40 %). Here, we present a mild electrocatalytic strategy that converts bio-derived C 2 -C 4 fatty acids and methyl acrylate into C 8 -C 16 branched alkanes. Using a platinum electrode at ambient pressure and ice-bath temperature, this strategy integrates radical addition, hydrolysis, and decarboxylative coupling in a tandem sequence to achieve efficient carbon-chain growth from short-chain feedstocks. In contrast to HEFA, the process is driven by electrochemical radical generation and selective C- C bond formation rather than hydrogenation, thereby avoiding external H 2 and suppressing the cracking reactions. As a result, the target branched alkanes are obtained in yields of up to 72.5 %, while the mild operating conditions also substantially reduce both energy input and carbon footprint. This work establishes a mild electrosynthetic paradigm for upgrading bio-based chemicals into SAF-range branched alkanes, thereby offering a complement to mainstream HEFA technology. Download: Download high-res image (169KB) Download: Download full-size image
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2026
·
IF 5
Jianmin Chen,Wanhui Wu,Baozhu Feng,Meilian Ning,Ziyan Cai,Qiulong Zhang,Liyang Du,Yunhua Gao
SPFX-SLNs were systematically optimized using BBD-RSM for infected wounds. • Optimized SLNs showed uniform spherical morphology with a size of ∼87 nm. • SPFX-SLNs exhibited 2-fold higher antibacterial potency than the free drug. • MNs enabled efficient skin penetration for targeted SLNs delivery. • Optimized MNs achieved a 98.61% wound closure rate by Day 14. The efficient management of infected skin wounds is severely limited by the thick bacterial biofilm within the lesion, the intractable stratum corneum barrier of the perilesional skin, and the high toxicities of potent antibiotics. Sparfloxacin (SPFX) was withdrawn from the market due to its severe systemic side effects and UV-induced phototoxicity, while its severe hydrophobicity causes localized crystalline cytotoxicity upon topical application. To safely rejuvenate this potent drug, an integrated transdermal system combining photoshielding, SPFX-loaded solid lipid nanoparticles (SPFX-SLNs) with dissolving microneedles (MNs) was developed. This study primarily focuses on the systematic screening, formulation development, and optimization of SPFX-SLNs via Box-Behnken Design-Response Surface Methodology (BBD-RSM). The optimized nanocarriers exhibited a uniform size (86.85 ± 1.89 nm) and a two-fold higher antibacterial potency against Escherichia coli ( E. coli ) than free SPFX. Mechanistically, the solid lipid core locked SPFX in a safe amorphous state to preclude crystal-induced irritation, while functioning as a physical photoshield against UV activation. By depositing the nanomedicine exclusively into infected dermis, the MN platform minimized systemic drug exposure. In a rat model of E. coli -infected biofilm wounds, the formulated SPFX-SLNs MNs achieved over 50% (58.44%) wound closure within 3 days and near-complete re-epithelialization by day 11, and a 98.61% final closure rate by day 14. Ultimately, this work establishes a comprehensive formulation development strategy for a safety-enhanced, biofilm-penetrable nanomedicine-MN hybrid that successfully repurposes a clinically restricted antibiotic for advanced wound regeneration. Download: Download high-res image (242KB) Download: Download full-size image
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Qin Yao,Meiling Liang,Kunling Yang,Cheng Qi,Tiantian Kong,Bernard P. Binks,Zhou Liu
Motivated by gas-accessible thin liquid films in lung alveoli, we develop gas marble-film reactors in which particle-stabilized bubbles confine an ultrathin freestanding liquid film within a jammed solid shell. Hexagonal PET (poly(ethylene terephthalate)) plates, in addition to conventional spherical particles, generate faceted gas marbles with planar film regions that improve optical access. We quantify the pressure limits of microsphere- and plate-stabilized shells during inflation and deflation, and describe their response using a capillary–granular framework. In this framework, inflation rupture is governed by capillary breakthrough at particle-defined throats, whereas deflation collapse reflects the combined resistance of capillarity and interparticle jamming. The mechanically defined films then serve as gas-accessible interfacial reactors in two proof-of-concept demonstrations. In a Tollens reaction, aerosolized glucose delivery through the external gas phase localizes silver reduction to liquid-wetted regions of the particle shell, producing spatially patterned silver-deposited microspheres. In biological assays, plate-stabilized shells provide flat observation windows for monitoring aerobic E. coli growth and its inhibition by levofloxacin. These results establish gas marbles as programmable colloidal film reactors whose structure, pressure stability, and interfacial function can be coupled through particle geometry and capillary jamming. Download: Download high-res image (101KB) Download: Download full-size image
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DESALINATION
·
2026
·
IF 9.9
Zhouxiao Zhai,Jingce Bi,Linshan Wang,Ningning Liu,Yi Wang,Xia Zhang,Zhuopeng Wang,Yide Han
A g-C 3 N 4 /Bi 2 MoO 6 /Bi 2 WO 6 ternary heterojunction was constructed via simple mechanical grinding and thermal treatment. • GBMW follows a dual Z -scheme charge-transfer pathway, preserving strong redox capability for enhanced photocatalysis. • U(VI) acts as an electron acceptor to promote charge separation and improve photocatalytic performance. Due to the difficulty of conventional photocatalytic systems in simultaneously achieving strong oxidation and reduction processes, the treatment of wastewater containing coexisting uranium and organic pollutants remains a critical challenge in the field of photocatalysis. Herein, a novel g-C 3 N 4 /Bi 2 MoO 6 /Bi 2 WO 6 (GBMW) ternary photocatalyst with a dual Z -scheme heterojunction architecture was rationally constructed for the removal of U(VI) and tetracycline (TC) under visible-light irradiation. The dual Z-scheme heterojunction extends the visible-light response range and accelerates interfacial charge transfer, while preserving strong redox potentials. Within 100 min, GBMW achieves a U(VI) reduction efficiency of 91.6% and a TC degradation efficiency of 97.6%, with corresponding k obs values of 0.02332 and 0.03664 min −1 , respectively, which are significantly superior to those of BiMO, BiWO, GCN and GBW. Notably, U(VI) can act as an efficient electron acceptor to promote the separation of electrons and holes in GBMW, which significantly facilitates the degradation of TC. Moreover, GBMW demonstrates excellent stability and anti-interference performance in various real water matrices. This work not only provides a feasible strategy for constructing high-efficiency dual Z -scheme heterojunctions photocatalysts, but also offers an effective solution for treating complex wastewater containing coexisting organic pollutants and radioactive contaminants. Download: Download high-res image (264KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Yongsheng Ni,Yuran Zhang,Xiandong Huang,Jianmei Zhang,Ye Zhang,Tian Li,Dazheng Pang,Kequan Xing,Baocai Xu
Two plant oils were used as raw materials to synthesize a more stable edible coating. • The coating offered antibacterial-antioxidant, moisture-retaining, and aroma-preserving functions. • The addition of β-carotene enhances the dispersion and antioxidant activity of grape seed oil. • The coating suppressed the formation of spoilage-related volatile compounds. Meat products are prone to drip loss, lipid oxidation, and microbial contamination during storage, leading to quality deterioration and flavor loss, thereby limiting shelf life. To address these issues, a triple-functional “O-O" oil-based coating with antibacterial-antioxidant activity, moisture retention, and flavor preservation was developed by combining β-cyclodextrin/cinnamaldehyde essential oil (β-CD@CEO) with β-carotene/grape seed oil (β-Car/GSO). The coating exhibited sustained release of CEO through β-CD encapsulation, maintaining stable antibacterial activity of approximately 80%–85% against B. thermosphacta and P. fragi within 24 h. β-Car and GSO formed a stable oil phase and exhibited synergistic antioxidant effects, significantly enhancing radical scavenging capacity, with DPPH • and ABTS •+ values of 86.17 ± 1.08% and 85.28 ± 1.20%, while inhibiting lipid oxidation and TVB-N accumulation, thereby extending the shelf life of lamb by 4 days under refrigerated storage at 4 °C. In addition, the coating reduced moisture loss by suppressing water migration, decreasing weight loss by about 19.92% after 9 days of refrigerated storage. GC-O-MS analysis demonstrated that the coating suppressed the formation of spoilage-related volatile compounds while maintaining the relative stability of key aroma compounds. This study provides a novel strategy for the design of novel multifunctional “O-O" type oil-based coatings and highlights their potential application in the preservation of active oil-based meat products. Download: Download high-res image (217KB) Download: Download full-size image
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TALANTA
·
2026
·
IF 6.7
Yu Liu,Qizheng Bi,Xiaoning Chu,Zhihao Dang,Junmin Hui,Zhuo Liu,Congkui Tian
The detection of leucine aminopeptidase (LAP) activity is essential for diagnosing liver cancer and liver injury. This study presents a novel fluorescence-based method designed for the sensitive detection of LAP through cascade catalytic reactions. Leucine-histidine (LeH) was synthesized using histidine and leucine as substrates for LAP. Notably, histidine (His) effectively inhibited the Cu 2+ -catalyzed oxidation of o-phenylenediamine (OPD) to fluorescent 2,3-diaminophenazine (oxOPD), resulting in a diminished fluorescence signal. Given that LAP hydrolyzes LeH to release His, which subsequently inhibits the Cu 2+ -OPD system, LAP activity can be quantitatively assessed by measuring fluorescence changes during the hydrolysis process. The exceptional performance of the Cu 2+ -OPD system in quantifying His allowed for highly sensitive LAP detection, achieving a detection limit as low as 0.05 U/L. Furthermore, the strategy was successfully implemented to evaluate LAP activity in cells.
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